LIBREXIASTROKE: A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack
Sponsor
Janssen Research & Development, LLC (Industry)
Overall Status
Not yet recruiting
CT.gov ID
NCT05702034
Collaborator
Bristol Myers Squibb Company (BMS) (Other)
15,000
600
2
45.1
25
0.6
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
15000 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack
Anticipated Study Start Date
:
Feb 9, 2023
Anticipated Primary Completion Date
:
Nov 11, 2026
Anticipated Study Completion Date
:
Nov 13, 2026
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Milvexian Participants after an acute ischemic stroke or high-risk transient ischemic attack (TIA) who are receiving antiplatelet therapy standard-of-care (SAPT [single antiplatelet therapy] or DAPT [dual antiplatelet therapy]) will receive milvexian orally twice daily. |
Drug: Milvexian
Milvexian will be administered orally.
Other Names:
|
| Placebo Comparator: Placebo Participants after an acute ischemic stroke or high-risk TIA who are receiving antiplatelet therapy standard-of-care (SAPT or DAPT) will receive placebo orally twice daily. |
Drug: Placebo
Placebo will be administered orally
|
Outcome Measures
Primary Outcome Measures
- Time to First Occurrence of Ischemic Stroke [Up to global targeted endpoint date (approximately 41 months)]
Time to first occurrence of ischemic stroke will be reported.
Secondary Outcome Measures
- Time to First Occurrence of any Component of the Composite of Cardiovascular Death (CVD), Myocardial Infraction (MI), or Ischemic Stroke [Up to global targeted endpoint date (approximately 41 months)]
Time to first occurrence of any component of the composite of CVD, MI, or ischemic stroke will be reported.
- Time to First Occurrence of Ischemic Stroke [Up to Day 90]
Time to first occurrence of ischemic stroke in the first 90 days will be reported.
- Time to First Occurrence of any Component of Major Adverse Vascular Events (MAVE) [Up to global targeted endpoint date (approximately 41 months)]
Time to first occurrence of any component of MAVE will be reported. MAVE is a composite of (CVD), myocardial infarction (MI), ischemic stroke, major adverse limb events (MALE), symptomatic pulmonary embolism (PE) or deep vein thrombosis (DVT).
Eligibility Criteria
Criteria
Ages Eligible for Study:
40 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Ischemic Stroke: a neurological deficit attributable to an acute brain infarction and national institute of health stroke score scale (NIHSS) score less than or equal to (<=) 7 and at least 1 of the following: persistent signs or symptoms of the ischemic event at the time of randomization, or acute, ischemic brain lesion determined by standard-of-care neuroimaging, or participant underwent thrombolysis or thrombectomy, or transient ischemic attack (TIA): acute onset neurological deficit attributable to focal ischemia of the brain by history or examination, with complete symptom resolution of the deficit and no brain infarction on neuroimaging (example, computed tomography (CT) scan or magnetic resonance imaging (MRI), performed as part of standard medical practice), and ABCD2 Score greater than or equal to (>=) 6
-
Participants will be randomized as soon as possible after determining eligibility and within 48 hours of onset of event.
-
Current or planned antiplatelet treatment per international and/or local guidelines. If acetyl salicylic acid (ASA) is used, it will be limited to low dose (75 to 100 milligrams (mg)/day). Loading dose of antiplatelet agents (including ASA) are allowed per standard-of-care
-
A female participant must agree not to be pregnant, breastfeeding, or planning to become pregnant until 4 days (5 half lives) after the last dose of study intervention
-
Willing and able to adhere to the lifestyle restrictions specified in this protocol
Exclusion Criteria:
-
Prior history of intracranial hemorrhage except subarachnoid hemorrhage greater than (>) 1 year prior with adequate treatment
-
The index stroke or TIA is considered to have a cardio-embolic etiology based on local standard-of-care investigations and for which guidelines recommend anticoagulation
-
The index stroke or TIA considered to have another known cause, not related to athero-thrombotic sources (treatment of acute stroke trial [TOAST] Other Determined Etiology), based on local standard-of-care investigations
-
Increased risk of bleeding, including clinically significant bleeding within the previous 3 months or known bleeding diathesis or known activated partial thromboplastin time (aPTT) prolongation or spinal cord hemorrhage or retinal hemorrhage
-
Current active liver disease, eg, acute hepatitis, known cirrhosis, including participants receiving antiviral treatment for hepatitis
-
Known allergies, hypersensitivity, or intolerance to milvexian or its excipients
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Arizona | Tucson | Arizona | United States | 85721 |
| 2 | Glendale Adventist Medical Center | Glendale | California | United States | 91206 |
| 3 | Southland Neurology | Los Alamitos | California | United States | 90720 |
| 4 | Kaiser Permanente Northern California | Oakland | California | United States | 94612 |
| 5 | Dignity Health | Sacramento | California | United States | 95816 |
| 6 | University of California Davis Health System | Sacramento | California | United States | 95817 |
| 7 | University of California San Diego Medical Center | San Diego | California | United States | 92103 |
| 8 | California Pacific Medical Center | San Francisco | California | United States | 94115 |
| 9 | Stroke and Neurovascular Center of Central California | Thousand Oaks | California | United States | 91360 |
| 10 | Harbor Ucla Medical Center | Torrance | California | United States | 90502 |
| 11 | University of Colorado | Aurora | Colorado | United States | 80045 |
| 12 | Christiana Care Health Services | Newark | Delaware | United States | 19718 |
| 13 | Nova Clinical Research, LLC | Bradenton | Florida | United States | 34209 |
| 14 | Morton Plant Hospital | Clearwater | Florida | United States | 33756-3394 |
| 15 | Tenet Florida Physician Services LLC | Delray Beach | Florida | United States | 33484 |
| 16 | Visionary Investigators Network | Miami | Florida | United States | 33176 |
| 17 | Advent Health Orlando | Orlando | Florida | United States | 32804-5521 |
| 18 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 19 | Intercoastal Medical Group | Sarasota | Florida | United States | 34239 |
| 20 | Sarasota Memorial Hospital | Sarasota | Florida | United States | 34239 |
| 21 | Augusta University | Augusta | Georgia | United States | 30912 |
| 22 | Kootenai Heart Clinics, LLC | Coeur d'Alene | Idaho | United States | 83814-4404 |
| 23 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 24 | Evanston Northwestern Healthcare | Glenview | Illinois | United States | 60026 |
| 25 | St. Joseph's Regional Medical Center | Joliet | Illinois | United States | 60435 |
| 26 | Blessing Hospital | Quincy | Illinois | United States | 62301 |
| 27 | Javon Bea Hospital | Rockford | Illinois | United States | 61114 |
| 28 | St John's Hospital | Springfield | Illinois | United States | 62701 |
| 29 | University of Kansas Medical Center Research Institute | Kansas City | Kansas | United States | 66160 |
| 30 | Ascension via Christi Research | Wichita | Kansas | United States | 67214 |
| 31 | University of Louisville | Louisville | Kentucky | United States | 40202 |
| 32 | Pikeville Medical Center | Pikeville | Kentucky | United States | 41537 |
| 33 | Ochsner Health System | New Orleans | Louisiana | United States | 70121 |
| 34 | Johns Hopkins University School of Medicine (JHUSOM) | Baltimore | Maryland | United States | 21211 |
| 35 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 36 | Comprehensive Neurology Services | Silver Spring | Maryland | United States | 20902 |
| 37 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02216 |
| 38 | University of Michigan | Ann Arbor | Michigan | United States | 48109 |
| 39 | Michigan Neurology Associates PC | Clinton Township | Michigan | United States | 48035 |
| 40 | Michigan State University | East Lansing | Michigan | United States | 48824 |
| 41 | Michigan Center of Medical Research | Farmington Hills | Michigan | United States | 48334 |
| 42 | Insight Institute of Neurosurgery & Neuroscience | Flint | Michigan | United States | 48507 |
| 43 | Memorial Institute for Neurosciences and Multiple Sclerosis | Owosso | Michigan | United States | 48867 |
| 44 | Providence & Providence Park Hospital | Southfield | Michigan | United States | 48075 |
| 45 | Cardiology Associates of North Mississippi | Tupelo | Mississippi | United States | 38801 |
| 46 | Mercy Hospital St. Louis | Saint Louis | Missouri | United States | 62701 |
| 47 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 48 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68106 |
| 49 | Thomas Jefferson University Hospital | Hackensack | New Jersey | United States | 07601 |
| 50 | Jersey Shore University Medical Center | Neptune | New Jersey | United States | 07753 |
| 51 | Lincoln Hospital | Bronx | New York | United States | 10451 |
| 52 | SUNY Downstate Medical Center | Brooklyn | New York | United States | 11203 |
| 53 | Mercy Hospital | Buffalo | New York | United States | 14220 |
| 54 | Lenox Hill Hospital | Lake Success | New York | United States | 11041 |
| 55 | Weill Cornell Medical College | New York | New York | United States | 10021 |
| 56 | Columbia University Medical Center | New York | New York | United States | 10032 |
| 57 | Mission Hospital | Asheville | North Carolina | United States | 28801 |
| 58 | Summa Health System | Akron | Ohio | United States | 44304 |
| 59 | Neuroscience Research Institute | Canton | Ohio | United States | 44718 |
| 60 | TriHealth Network | Cincinnati | Ohio | United States | 45220 |
| 61 | The Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 62 | The Ohio State University | Columbus | Ohio | United States | 43210 |
| 63 | Oregon Health & Science University | Portland | Oregon | United States | 97239 |
| 64 | Lehigh Center for Clinical Research | Allentown | Pennsylvania | United States | 18103-6229 |
| 65 | Northshore Neurosciences | Erie | Pennsylvania | United States | 16507 |
| 66 | Glendale Adventist Medical Center | Philadelphia | Pennsylvania | United States | 19107 |
| 67 | Einstein Medical Center | Philadelphia | Pennsylvania | United States | 19141 |
| 68 | Saint Thomas Health | Nashville | Tennessee | United States | 37122 |
| 69 | Tennessee Oncology, PLLC | Nashville | Tennessee | United States | 37207 |
| 70 | Neurology Consultants of Dallas, PA | Dallas | Texas | United States | 75231 |
| 71 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 72 | Sentara Medical Group | Norfolk | Virginia | United States | 23502 |
| 73 | Winchester Medical Center | Winchester | Virginia | United States | 22601 |
| 74 | Mayo Clinic Health System | Eau Claire | Wisconsin | United States | 54703 |
| 75 | Mayo Clinic Health System | La Crosse | Wisconsin | United States | 54601 |
| 76 | Fundacion Favaloro | Buenos Aires | Argentina | 1093 | |
| 77 | Sanatorio de la Trinidad Mitre | Buenos Aires | Argentina | C1039AAO | |
| 78 | Hospital Aleman | Buenos Aires | Argentina | C1118AAT | |
| 79 | Sanatorio Finochietto | Buenos Aires | Argentina | C1187AAN | |
| 80 | Sanatorio Los Arcos | Buenos Aires | Argentina | C1425FSD | |
| 81 | Sanatorio Guemes | Caba | Argentina | C1180AAX | |
| 82 | Sanatorio Mater Dei | Ciudad Autonoma Buenos Aires | Argentina | C1425DND | |
| 83 | Hospital Fleni | Ciudad Autonoma Buenos Aires | Argentina | C1428AQK | |
| 84 | Hospital Gral Agudos Ignacio Pirovano | Ciudad Autonoma Buenos Aires | Argentina | C1430BKC | |
| 85 | Clínica Adventista Belgrano | Ciudad Autonoma Buenos Aires | Argentina | C1430EGF | |
| 86 | Hospital Churruca Visca | Ciudad Autonoma de Buenos Airess | Argentina | ||
| 87 | Hospital Britanico de Buenos Aires | Ciudad Autonoma de Buenos Aires | Argentina | C1280AEB | |
| 88 | CEMIC Saavedra | Ciudad de Buenos Aires | Argentina | 1431 | |
| 89 | Clínica Colombo | Cordoba | Argentina | 5000 | |
| 90 | Hospital San Roque | Cordoba | Argentina | 5000 | |
| 91 | Sanatorio Allende | Cordoba | Argentina | X5000JHQ | |
| 92 | Hospital Cordoba | Cordoba | Argentina | X5004CDT | |
| 93 | Hospital Privado Centro Medico de Cordoba | Cordoba | Argentina | X5016KEH | |
| 94 | Hospital Municipal Dr Raul Alfredo Caccavo | Coronel Suarez | Argentina | B7540GHD | |
| 95 | Clínica Chutro | Córdoba | Argentina | X5000EPU | |
| 96 | Hospital General de Agudos Dr. J. M. Ramos Mejia | Federal | Argentina | 1221 | |
| 97 | Hospital Privado de Comunidad | Mar Del Plata | Argentina | B7602CBM | |
| 98 | Hospital Central de Mendoza | Mendoza | Argentina | 5500 | |
| 99 | Sanatorio Parque | Rosario | Argentina | S2000SDV | |
| 100 | Hospital Privado Santa Clara de Asis | Salta | Argentina | A4402AYT | |
| 101 | Hospital Interzonal General de Agudos Eva Perón | San Martin | Argentina | B1650 NBN | |
| 102 | Royal Adelaide Hospital | Adelaide | Australia | 5000 | |
| 103 | Flinders Medical Centre | Adelaide | Australia | 5042 | |
| 104 | Monash Medical Centre | Clayton | Australia | 3168 | |
| 105 | St Vincent's Hospital - Melbourne | Fitzroy | Australia | 3065 | |
| 106 | Austin Health | Heidelberg | Australia | 3084 | |
| 107 | Royal Brisbane and Women's Hospital | Herston | Australia | 4029 | |
| 108 | Launceston General Hospital | Launceston | Australia | 7250 | |
| 109 | Liverpool Hospital | Liverpool | Australia | 2170 | |
| 110 | Fiona Stanley Hospital | Murdoch | Australia | 6150 | |
| 111 | Royal Melbourne Hospital | Parkville | Australia | 3050 | |
| 112 | Prince Of Wales Hospital | Randwick | Australia | 2031 | |
| 113 | Gold Coast University Hospital | Southport | Australia | 4215 | |
| 114 | Royal North Shore Hospital | St Leonards | Australia | 2065 | |
| 115 | Princess Alexandra Hospital | Woolloongabba | Australia | 4102 | |
| 116 | Landesklinikum Baden | Modling | Austria | 2340 | |
| 117 | Klinikum Wels-Grieskirchen | Wels | Austria | 4600 | |
| 118 | ZNA Middelheim | Antwerpen | Belgium | 2020 | |
| 119 | Centre Hospitalier EPICURA Ath-Baudour-Hornu | Ath | Belgium | 7800 | |
| 120 | Universitair Ziekenhuis Brussel | Brussels | Belgium | 1090 | |
| 121 | C.H.U. Brugmann | Bruxelles | Belgium | 1020 | |
| 122 | AZ Sint-Blasius | Dendermonde | Belgium | 9200 | |
| 123 | UZA | Edegem | Belgium | 2650 | |
| 124 | Universitair Ziekenhuis Gent | Gent | Belgium | 9000 | |
| 125 | Az Groeninge | Kortrijk | Belgium | 8500 | |
| 126 | Chu Tivoli | La Louvière | Belgium | 7100 | |
| 127 | CHC MontLegia | Liege | Belgium | 4000 | |
| 128 | Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa | Belo Horizonte | Brazil | 30380-090 | |
| 129 | Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu) | Botucatu | Brazil | 18618-686 | |
| 130 | Hospital Brasília | Brasília | Brazil | 71.681-603 | |
| 131 | Sociedade Hospitalar Angelina Caron | Campina Grande Do Sul | Brazil | 83430-000 | |
| 132 | Universidade Estadual De Campinas | Campinas | Brazil | 13083-888 | |
| 133 | Hospital São José | Criciúma | Brazil | 88801-250 | |
| 134 | HGF - Hospital Geral de Fortaleza | Fortaleza | Brazil | 60155-290 | |
| 135 | Hospital de Caridade de Ijui | Ijuí | Brazil | 98700-000 | |
| 136 | Clinica Neurologica e Neurocirurgica de Joinville | Joinville | Brazil | 89202-165 | |
| 137 | Complexo Hospitalar de Niterói | Niteroi | Brazil | 24030-103 | |
| 138 | Instituto Mederi de Pesquisa e Saude | Passo Fundo | Brazil | 99010-120 | |
| 139 | Associação Hospitalar Moinhos de Vento | Porto Alegre | Brazil | 90035-001 | |
| 140 | Hospital das Clinicas de Porto Alegre | Porto Alegre | Brazil | 90035-903 | |
| 141 | IMV Pesquisa Neurológica | Porto Alegre | Brazil | 90110-000 | |
| 142 | Associacao Educadora Sao Carlos AESC Hospital Mae De Deus | Porto Alegre | Brazil | 90470-340 | |
| 143 | Hospital das Clínicas da Faculdade de Medicina de RPUSP - HCRP | Ribeirao Preto | Brazil | 14098-900 | |
| 144 | Irmandade Santa Casa de Misericordia de Sao Paulo | Sao Paulo | Brazil | 01221-020 | |
| 145 | Hospital Alemão Oswaldo Cruz | Sao Paulo | Brazil | 01323-903 | |
| 146 | Hospital do Coração - HCor | Sao Paulo | Brazil | 04004-030 | |
| 147 | Fundação Faculdade Regional de Medicina de São José do Rio Preto - Hospital de Base | São José do Rio Preto | Brazil | 15090-000 | |
| 148 | Hospital Nove de Julho | São Paulo | Brazil | 01409902 | |
| 149 | Casa de Saúde Santa Marcelina - Hospital Santa Marcelina | São Paulo | Brazil | 08270-070 | |
| 150 | HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro | Uberaba | Brazil | ||
| 151 | Multiprofile Hospital for Active Treatment Puls | Blagoevgrad | Bulgaria | 2700 | |
| 152 | MHAT Sveti Ivan Rilski | Gorna Oryahovitsa | Bulgaria | 5100 | |
| 153 | Multiprofile Hospital for Active Treatment - Haskovo | Haskovo | Bulgaria | 6300 | |
| 154 | Mhat Sveti Georgi | Montana | Bulgaria | 3400 | |
| 155 | MHAT - Pazardzhik AD | Pazardzhik | Bulgaria | 4400 | |
| 156 | MHAT Avis - Medica OOD | Pleven | Bulgaria | 5800 | |
| 157 | UMHAT 'Dr. Georgi Stranski', EAD | Pleven | Bulgaria | 5800 | |
| 158 | UMHAT Kaspela | Plovdiv | Bulgaria | 4001 | |
| 159 | UMHAT Sveti Georgi | Plovdiv | Bulgaria | 4002 | |
| 160 | UMHAT 'Kanev' EAD | Ruse | Bulgaria | 7002 | |
| 161 | Medical Center St. Naum | Sofia | Bulgaria | 1113 | |
| 162 | Multiprofile Hospital for Active Treatment - Sofia | Sofia | Bulgaria | 1142 | |
| 163 | Multiprofile Hospital For Active Treatment National Cardiology Hospital, Ead | Sofia | Bulgaria | 1309 | |
| 164 | University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD | Sofia | Bulgaria | 1527 | |
| 165 | UMHATEM N I Pirogov | Sofia | Bulgaria | 1606 | |
| 166 | University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD | Sofia | Bulgaria | 1750 | |
| 167 | UMHAT Prof. Dr. St. Kirkovich AD | Stara Zagora | Bulgaria | 6003 | |
| 168 | University of Alberta Hospital | Edmonton | Alberta | Canada | T6G 2B7 |
| 169 | Lethbridge Regional Hospital | Lethbridge | Alberta | Canada | T1J 1W8 |
| 170 | Trillium Health Partners | Mississauga | Ontario | Canada | L5B 1B8 |
| 171 | Hospital Clinico Regional Dr. Guillermo Grant Benavente | Concepcion | Chile | 4030000 | |
| 172 | Corporacion de Investigacion de Neurologia de Santiago | Las Condes | Chile | 7550000 | |
| 173 | Clinica Las Condes | Santiago | Chile | 7550000 | |
| 174 | Clinica Alemana de Santiago S.A. | Santiago | Chile | ||
| 175 | Clinica Alemana de Temuco | Temuco | Chile | 4780000 | |
| 176 | Hospital Clinico Vina del Mar | Vina del Mar | Chile | 2520612 | |
| 177 | Xuanwu Hospital, Capital Medical University | Beijing | China | 100053 | |
| 178 | Beijing Tiantan Hospital, Capital Medical University | Beijing | China | 100070 | |
| 179 | Guangdong Second Provincial General Hospital | Guangzhou | China | 510317 | |
| 180 | The Affiliated Hospital of Hangzhou Normal University | Hangzhou | China | 310000 | |
| 181 | Second Affiliated Hospital of Soochow University | Suzhou | China | 215004 | |
| 182 | Taizhou Hospital of Zhejiang Province | Taizhou | China | 317000 | |
| 183 | Tianjin Medical University General Hospital | Tianjin | China | 300052 | |
| 184 | Clinic hospital Osijek | Osijek | Croatia | 31000 | |
| 185 | OB Varazdin | Varazdin | Croatia | 42000 | |
| 186 | OB Zabok | Zabok | Croatia | 49210 | |
| 187 | Clinical Hospital Centre Zagreb | Zagreb | Croatia | 10000 | |
| 188 | Clinical Hospital Sestre Milosrdnice | Zagreb | Croatia | 10000 | |
| 189 | University Hospital Sveti Duh | Zagreb | Croatia | 10000 | |
| 190 | Fakultni nemocnice Brno | Brno | Czechia | 636 00 | |
| 191 | Fakultni nemocnice u sv. Anny v Brne | Brno | Czechia | 656 91 | |
| 192 | Krajska zdravotni a.s. - Nemocnice Chomutov o.z. Dept of Neurologicke oddeleni | Chomutov | Czechia | 430 12 | |
| 193 | Nemocnice Jihlava | Jihlava | Czechia | 586 33 | |
| 194 | Fakultní nemocnice Olomouc | Olomouc | Czechia | 775 20 | |
| 195 | Vitkovicka nemocnice a.s. | Ostrava - Vitkovice | Czechia | 703 84 | |
| 196 | Fakultni nemocnice Ostrava | Poruba | Czechia | 708 52 | |
| 197 | Fakultni nemocnice Kralovske Vinohrady | Praha 10 | Czechia | 100 34 | |
| 198 | Fakultni Thomayerova nemocnice | Praha 4 | Czechia | 140 59 | |
| 199 | Ústrední vojenské nemocnice Praha | Praha 6 | Czechia | 169 02 | |
| 200 | Nemocnice Pisek, a.s. | Písek | Czechia | 397 23 | |
| 201 | Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z. | Usti Nad Labem | Czechia | 40113 | |
| 202 | Aarhus Universitetshospital | Aarhus | Denmark | 8200 | |
| 203 | Bispebjerg Og Frederiksberg Hospital | Copenhagen NV | Denmark | 2400 | |
| 204 | Rigshospitalet | Copenhagen | Denmark | 2100 | |
| 205 | Herlev Hospital | Herlev | Denmark | 2730 | |
| 206 | Herning Regional Hospital | Herning | Denmark | 7400 | |
| 207 | Odense University Hospital | Odense C | Denmark | 5000 | |
| 208 | Ålborg Universitetshospital | Ålborg | Denmark | 9100 | |
| 209 | West Tallinn Central Hospital | Tallinn | Estonia | 10617 | |
| 210 | North Estonia Medical Centre Foundation | Tallinn | Estonia | 13419 | |
| 211 | Tartu University Hospital | Tartu | Estonia | 50406 | |
| 212 | Helsinki University Hospital | HUS | Finland | 00029 | |
| 213 | Etela Karjalan Keskussairaala South Karelia Central Hospital | Lappeenranta | Finland | 53130 | |
| 214 | Turku University Hospital | Turku | Finland | 20520 | |
| 215 | Centre Hospitalier du Pays d'Aix Service de Neurologie | Aix-en-Provence cedex 01 | France | 13616 | |
| 216 | CHRU Besançon -Hôpital Jean Minjoz | Besançon Cedex | France | 25030 | |
| 217 | Groupe Hospitalier Pellegrin CHU de Bordeaux | Bordeaux Cedex | France | 33076 | |
| 218 | CHU Bourg en Bresse | Bourg en Bresse cedex | France | 01012 | |
| 219 | CHU de Brest - Hôpital de la Cavale Blanche | Brest cedex | France | 29609 | |
| 220 | Hôpital Côte de Nacre | Caen | France | 14033 | |
| 221 | Centre Hospitalier Sud Francilien | Corbeil Essonnes cedex | France | 91106 | |
| 222 | Centre Hospitalier | La Roche sur Yon | France | 85925 | |
| 223 | CHR-Metz-Thionville-Hôpital de Mercy | Laquenexy | France | 57530 | |
| 224 | Hopital Bicêtre - Aphp Hôpitaux Universitaires Paris-Sud | Le Kremlin Bicetre cedex | France | 94275 | |
| 225 | Centre Hospitalier du Mans | Le Mans cedex 9 | France | 72037 | |
| 226 | Hopital Roger Salengro - CHU Lille | Lille Cedex | France | 59037 | |
| 227 | CHU de Limoges, Hopital Dupuytren | Limoges | France | 87000 | |
| 228 | Hopital de la Timone | Marseille cedex 05 | France | 13385 | |
| 229 | Centre Hospitalier Annecy Genevois | Metz-Tessy | France | 74374 | |
| 230 | Hopital Gui de Chauliac | Montpellier | France | 34295 | |
| 231 | Centre Hospitalier Universitaire de Nancy - Hôpital Central | Nancy | France | 54035 | |
| 232 | Hôpital Saint Roch | Nice Cedex 1 | France | 06006 | |
| 233 | Hopital Lariboisiere | Paris | France | 75010 | |
| 234 | Hopital Saint Joseph | Paris | France | 75014 | |
| 235 | Hôpital Bichat - Claude Bernard | Paris | France | 75018 | |
| 236 | Fondation Adolphe de Rothschild Hospital | Paris | France | 75019 | |
| 237 | Centre Hospitalier De Perpignan - Hopital Marechal Joffre | Perpignan | France | 66046 | |
| 238 | CHU Poitiers - Hôpital la Milétrie | Poitiers | France | 86021 | |
| 239 | Chu Rennes - Hopital Pontchaillou | Rennes cedex 09 | France | 35033 | |
| 240 | CHU Rouen - Hopital Charles Nicolle | Rouen Cedex | France | 76031 | |
| 241 | Hopital Pierre Paul Riquet - Purpan | Toulouse cedex 9 | France | 31059 | |
| 242 | Klinikum Altenburger Land GmbH | Altenburg | Germany | 04600 | |
| 243 | Charite Universitaetsmedizin Berlin - Campus Charite Mitte | Berlin | Germany | 10117 | |
| 244 | EPIMED GmbH | Berlin | Germany | 12157 | |
| 245 | Klinikum Bremen Nord gGmbH Klinik fur Neurologie und Klinische Neurophysiologie Stroke Unit | Bremen | Germany | 28755 | |
| 246 | Städtisches Klinikum Dresden | Dresden | Germany | 01067 | |
| 247 | Universitaetsklinikum Carl Gustav Carus TU Dresden | Dresden | Germany | 01307 | |
| 248 | Universitaetsklinikum Essen | Essen | Germany | 45147 | |
| 249 | Klinikum der Johann Wolfgang Goethe -Universitaet | Frankfurt | Germany | 60528 | |
| 250 | Klinikum Frankfurt Hoechst GmbH | Frankfurt | Germany | 65929 | |
| 251 | Klinikum Friedrichshafen GmbH | Friedrichshafen | Germany | 88048 | |
| 252 | Klinikum Fulda - Tumorklinik - Germany | Fulda | Germany | 36043 | |
| 253 | Universitaetsklinikum Giessen und Marburg GmbH | Giessen | Germany | 35392 | |
| 254 | Bezirkskrankenhaus Guenzburg | Guenzburg | Germany | 89312 | |
| 255 | Universitaetsklinikum Hamburg Eppendorf | Hamburg | Germany | 20246 | |
| 256 | Asklepios Klinik Wandsbeck | Hamburg | Germany | 22043 | |
| 257 | Medizinische Hochschule Hannover | Hannover | Germany | 30625 | |
| 258 | Städtisches Klinikum Idar-Obestein GmbH-Klinik für Psychiatrie und Psychotherapie - Germany | Idar-Oberstein | Germany | 55743 | |
| 259 | Universitaetsklinikum Schleswig-Holstein - Campus Luebeck | Luebeck | Germany | 23538 | |
| 260 | Städtisches Klinikum Lüneburg | Lueneburg | Germany | 21339 | |
| 261 | Johannes Wesling Klinikum Minden | Minden | Germany | 32429 | |
| 262 | Universitaetsklinikum Muenster | Muenster | Germany | 48149 | |
| 263 | Klinikverbund Südwest Medical Center Sindelfingen-Böblingen | Sindelfingen | Germany | 71065 | |
| 264 | Universitaetsklinikum Tuebingen | Tuebingen | Germany | 72074 | |
| 265 | Universitaetsklinikum Ulm | Ulm | Germany | 89081 | |
| 266 | Uni General Hospital of Alexandroupolis | Alexandroupolis | Greece | 68100 | |
| 267 | Laiko General Hospital of Athens | Athens | Greece | 11527 | |
| 268 | Tzanio General Hospital of Piraeus | Athens | Greece | 18536 | |
| 269 | University General Hospital of Ioannina | Ioannina | Greece | 45500 | |
| 270 | University Hospital Of Larissa | Larisa | Greece | 41110 | |
| 271 | University Hospital Of Larissa | Larissa | Greece | 41110 | |
| 272 | Ahepa University General Hospital of Thessaloniki | Thessaloniki | Greece | 54636 | |
| 273 | AHEPA University Hospital of Thessaloniki | Thessaloniki | Greece | 54636 | |
| 274 | Hippokration Hospital | Thessaloniki | Greece | 54642 | |
| 275 | Papageorgiou General Hospital | Thessaloniki | Greece | 56429 | |
| 276 | 'G. Papanikolaou' Hospital of Thessaloniki | Thessaloniki | Greece | 57010 | |
| 277 | The University of Hong Kong | Hong Kong | Hong Kong | ||
| 278 | The Chinese University of Hong Kong | N.t. | Hong Kong | ||
| 279 | North District Hospital | New Territories | Hong Kong | ||
| 280 | Péterfy Sándor utcai Kórház | Budapest | Hungary | 1076 | |
| 281 | Semmelweis Egyetem | Budapest | Hungary | 1083 | |
| 282 | Bajcsy-Zsilinszky Kórház és Rendelőintézet | Budapest | Hungary | 1106 | |
| 283 | Esza-Kozep-budai Centrum, Uj Szent Janos Korhaz es Szakrendelo | Budapest | Hungary | 1125 | |
| 284 | Magyar Honvedseg Egeszsegugyi Kozpont | Budapest | Hungary | 1134 | |
| 285 | National Institute of Neurosciences | Budapest | Hungary | 1145 | |
| 286 | Debreceni Egyetem Klinikai Központ,Infektológiai Klinika | Debrecen | Hungary | 4031 | |
| 287 | Szent Pantaleon Kórház-Rendelointézet Dunaújváros | Dunaujvaros | Hungary | 2600 | |
| 288 | Markhot Ferenc Oktatókórház és Rendelőintézet | Eger | Hungary | 3300 | |
| 289 | Petz Aladar Megyei Oktato Korhaz | Gyor | Hungary | 9023 | |
| 290 | Pest Megyei Flor Ferenc Korhaz | Kistarcsa | Hungary | 2143 | |
| 291 | Szent Damjan Gorogkatolikus Korhaz | Kisvarda | Hungary | 4600 | |
| 292 | Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz | Miskolc | Hungary | 3526 | |
| 293 | Pecsi Tudomanyegyetem | Pecs | Hungary | 7623 | |
| 294 | Szent Lazar Megyei Korhaz | Salgotarjan | Hungary | 3100 | |
| 295 | Szent Borbala Hospital Tatabanya | Tatabanya | Hungary | 2800 | |
| 296 | Jávorszky Ödön Kórház | Vac | Hungary | 2600 | |
| 297 | Zydus Hospital-Ahmedabad | Ahmedabad | India | 380054 | |
| 298 | Fortis Escorts Heart Institute and Research Centre | Amritsar | India | 143004 | |
| 299 | Shree Krishna Hospital and Medical Research Center | Anand | India | 388325 | |
| 300 | Bangalore Medical College and Research Institute | Bangalore | India | 560002 | |
| 301 | Fortis Hospital | Bangalore | India | 560052 | |
| 302 | Fortis Hospital | Bangalore | India | 560076 | |
| 303 | KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC) | Belgaum | India | 590010 | |
| 304 | IMS and SUM Hospital | Bhubaneshwar | India | 751003 | |
| 305 | SUM Ultimate Medicare | Bhubaneswar | India | 751003 | |
| 306 | Apollo Hospitals | Bhubaneswar | India | 751005 | |
| 307 | Post Graduate Institute of Medical Education & Research (PGIMER) | Chandigarh | India | 160012 | |
| 308 | SIMS Multispecialty Hospital | Chennai | India | 600026 | |
| 309 | Amrita Institute of Medical Sciences | Cochin | India | 682041 | |
| 310 | K.G. Hospital and PG Medical Institute | Coimbatore | India | 641018 | |
| 311 | Fortis Memorial Research Institute | Gurgaon | India | 122002 | |
| 312 | Paras Hospital | Gurgaon | India | 122002 | |
| 313 | Institute of Neurological Sciences GNRC | Guwahati | India | 781006 | |
| 314 | Sunshine Hospital | Hyderabad | India | 500018 | |
| 315 | Citizen Hospital | Hyderabad | India | 500082 | |
| 316 | CARE Hospitals | Hyderbad | India | 500034 | |
| 317 | Shalby Hospital | Jaipur | India | 302021 | |
| 318 | Institute of Neurosciences Kolkata | Kolkata | India | 700017 | |
| 319 | Baby Memorial Hospital | Kozhikode | India | 673004 | |
| 320 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Lucknow | India | 226014 | |
| 321 | Dayanand Medical College & Hospital, Tagore Nagar, Civil Lines | Ludhiana | India | 141001 | |
| 322 | Mallikatta Neurocentre | Mangalore | India | 575002 | |
| 323 | Manipal Hospital | Mysore | India | 570015 | |
| 324 | JSS Hospital | Mysuru | India | 570004 | |
| 325 | Chopda Medicare & Research Centre | Nashik | India | 422005 | |
| 326 | Siddhi Hospital | Nashik | India | 422007 | |
| 327 | BLK Super Specialty Hospital | New Delhi | India | 110005 | |
| 328 | All India Institute of Medical Sciences | New Delhi | India | 110029 | |
| 329 | Sir Ganga Ram Hospital | New Delhi | India | 110060 | |
| 330 | Ruby Hall Clinic | Pune | India | 411001 | |
| 331 | Deenanath Mangeshkar Hospital and Research Centre | Pune | India | 411004 | |
| 332 | Sahyadri Speciality Hospital | Pune | India | 411004 | |
| 333 | Sahyadri Speciality Hospital | Pune | India | 411014 | |
| 334 | Synergy Superspeciality Hospital | Rajkot | India | 360005 | |
| 335 | Institute of Neuroscience | Surat | India | 395001 | |
| 336 | Kiran Super Multispecialty Hospital | Surat | India | 395004 | |
| 337 | Bhaktivedanta Hospital & Research Institute | Thane | India | 411107 | |
| 338 | City Neurology Centre | Varanasi | India | 221002 | |
| 339 | Galaxy Life Care Services Pvt. Ltd | Varanasi | India | 221010 | |
| 340 | Soroka University Medical Center | Beer sheva | Israel | 151 | |
| 341 | Rambam Health Care Campus | Haifa | Israel | 31096 | |
| 342 | Shaare Zedek Medical Center | Jerusalem | Israel | 9103102 | |
| 343 | Health Corporation of Galilee Medical Center | Naharya | Israel | 2633737 | |
| 344 | Rabin Medical Center | Petah Tikva | Israel | 49100 | |
| 345 | Chaim Sheba Medical Center | Ramat Gan | Israel | 52621 | |
| 346 | Tel Aviv Sourasky Medical Center | Tel Aviv | Israel | 64239 | |
| 347 | Hadassah University Hospita - Ein Kerem | Yerushalayim | Israel | 22100 | |
| 348 | Ospedale Policlinico San Martino IRCCS | Brescia | Italy | 25123 | |
| 349 | Azienda Ospedaliera G. Brotzu | Cagliari | Italy | 09131 | |
| 350 | Nuovo Ospedale San Giovanni Battista | Foligno | Italy | 06034 | |
| 351 | Ospedale Policlinico San Martino IRCCS | Genova | Italy | 16132 | |
| 352 | Ospedale San Salvatore | L'Aquila | Italy | 67100 | |
| 353 | Ospedale Vito Fazzi | Lecce | Italy | 73100 | |
| 354 | Azienda Ospedaliera della Provincia di Lecco_Presidio Ospedaliero 'A. Manzoni' - S.C.di Cardiologia | Lecco | Italy | 23900 | |
| 355 | Ospedale Apuane | Massa | Italy | 54100 | |
| 356 | Ospedale San Raffaele | Milano | Italy | 20132 | |
| 357 | Nuovo Ospedale Civile S.Agostino - Estense | Modena | Italy | 41126 | |
| 358 | IRCCS C. Mondino, Istituto Neurologico Nazionale, Fondazione | Pavia | Italy | 27100 | |
| 359 | Azienda Unita Sanitaria Locale Umbria 1 Ospedale di Citta di Castello | Perugia | Italy | 06012 | |
| 360 | Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia | Perugia | Italy | 06156 | |
| 361 | Azienda Ospedaliera Ospedale Santa Corona | Pietra Ligure | Italy | 17027 | |
| 362 | Arcispedale S Maria Nuova (Civic Hospital) | Reggio Emilia | Italy | 42100 | |
| 363 | Azienda Ospedaliera San Camillo-Forlanini | Roma | Italy | 00152 | |
| 364 | Policlinico Umberto I | Roma | Italy | 00161 | |
| 365 | Istituto Clinico Humanitas | Rozzano | Italy | 20089 | |
| 366 | Azienda Ospedaliera Universitaria Integrata Verona | Verona | Italy | 37126 | |
| 367 | Mazda Hospital of Mazda Motor Corporation | Aki-Gun | Japan | 735-8585 | |
| 368 | Seikeikai Chiba Central Medical Center | Chiba-shi | Japan | 264-0017 | |
| 369 | Funabashi Munitiple Medical Center | Chiba | Japan | 273-8588 | |
| 370 | National Hospital Organization Fukuoka Hospital | Fukuoka-shi | Japan | 815-8555 | |
| 371 | Steel Memorial Yawata Hospital | Fukuoka | Japan | 805-0050 | |
| 372 | Saiseikai Fukuoka General Hospital | Fukuoka | Japan | 810-0001 | |
| 373 | National Hospital Organization Kyushu Medical Center | Fukuoka | Japan | 810-8563 | |
| 374 | Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers | Fukuoka | Japan | 815-8588 | |
| 375 | Tokai University Hachioji Hospital | Hachioji | Japan | 192-0032 | |
| 376 | Seirei Hamamatsu General Hospital | Hamamatsu | Japan | 430-8558 | |
| 377 | NHO Higashihiroshima Medical Center | Higashihiroshima-shi | Japan | 739-0041 | |
| 378 | Hyogo Prefectural Harima-Himeji General Medical Center | Himeji-shi | Japan | 670-8560 | |
| 379 | Hiroshima Prefectural Hospital | Hiroshima-shi | Japan | 734-8530 | |
| 380 | Hiroshima City Hiroshima Citizens Hospital | Hiroshima | Japan | 730-8518 | |
| 381 | Ina Central Hospital | Ina-shi | Japan | 396-8555 | |
| 382 | National Hospital Organization Kanazawa Medical Center | Ishikawa | Japan | 920-8650 | |
| 383 | National Hospital Organization Kagoshima Medical Center | Kagoshima | Japan | 892-0853 | |
| 384 | Fukuoka Tokushukai Hospital | Kasuga-shi | Japan | 816-0864 | |
| 385 | Nagoya Tokushukai General Hospital | Kasugai-shi | Japan | 487-0016 | |
| 386 | St.Marianna University Hospital | Kawasaki-shi | Japan | 216-8511 | |
| 387 | Kokura Memorial Hospital | Kitakyushu-shi | Japan | 802-8555 | |
| 388 | Hospital of the University of Occupational and Enviromental Health | Kitakyushu-shi | Japan | 807-8556 | |
| 389 | Kobe City Medical Center General Hospital | Kobe-shi | Japan | 650-0047 | |
| 390 | Eishokai Yoshida Hospital | Kobe-shi | Japan | 652-0803 | |
| 391 | National Hospital Organization Fukuoka Higashi Medical Center | Koga | Japan | 811-3195 | |
| 392 | Koseikai Takeda Hospital | Kyoto-shi | Japan | 600-8558 | |
| 393 | Maebashi Red Cross Hospital | Maebashi | Japan | 371-0811 | |
| 394 | Tokushukai Matsubara Tokushukai Hospital | Matsubara-shi | Japan | 580-0032 | |
| 395 | Nagano Municipal Hospital | Nagano-shi | Japan | 381-8551 | |
| 396 | NHO Nagoya Medical Center | Nagoya-shi | Japan | 460-0001 | |
| 397 | Okayama City General Medical Center Okayama City Hospital | Okayama-shi | Japan | 700-8557 | |
| 398 | National Hospital Organization Osaka National Hospital | Osaka-shi | Japan | 540-0006 | |
| 399 | Osaka General Medical Center | Osaka-shi | Japan | 558-8558 | |
| 400 | Osaka Metropolitan University Hospital | Osaka | Japan | 545-8586 | |
| 401 | Osaka University Hospital | Osaka | Japan | 565-0871 | |
| 402 | Rinku General Medical Center | Osaka | Japan | 598-8577 | |
| 403 | Kyoyukai Sainokuni Higashiomiya Medical Center | Saitama-shi | Japan | 331-8577 | |
| 404 | Konankai Konan Hospital | Sendai-shi | Japan | 982-8523 | |
| 405 | Shimonoseki City Hospital | Shimonoseki-shi | Japan | 7500061 | |
| 406 | Kanmon Medical Center | Shimonoseki-shi | Japan | 752-8510 | |
| 407 | National Cerebral and Cardiovascular Center Hospital | Suita-Shi | Japan | 564-8565 | |
| 408 | NTT Medical Center Tokyo | Tokyo | Japan | 141-8625 | |
| 409 | National Hospital Organization Tokyo Medical Center | Tokyo | Japan | 152-8902 | |
| 410 | Kyorin University Hospital | Tokyo | Japan | 600-8492 | |
| 411 | Fujita Health University Hospital | Toyoake | Japan | 470-1192 | |
| 412 | NHO Toyohashi Medical Center | Toyohasi-shi | Japan | 440-8510 | |
| 413 | Sanyudo Hospital | Yonezawa-shi | Japan | 992-0045 | |
| 414 | Pusan National University Hospital | Busan | Korea, Republic of | 49241 | |
| 415 | Dong-A University Hospital | Busan | Korea, Republic of | 602-812 | |
| 416 | Kyungpook National University Hospital | Daegu | Korea, Republic of | 41944 | |
| 417 | Yeungnam University Hospital | Daegu | Korea, Republic of | 42415 | |
| 418 | Keimyung University Dongsan Hospital | Daegu | Korea, Republic of | 42601 | |
| 419 | Inje University Ilsan Paik Hospital | Goyang-si | Korea, Republic of | 10380 | |
| 420 | Chosun university hospital | Gwangju | Korea, Republic of | 61453 | |
| 421 | Seoul National University Bundang Hospital | Gyeonggi-do | Korea, Republic of | 13620 | |
| 422 | Inha University Hospital | Incheon | Korea, Republic of | 22322 | |
| 423 | Nowon Eulji Medical Center, Eulji University | Seoul | Korea, Republic of | 01830 | |
| 424 | Korea University Anam Hospital | Seoul | Korea, Republic of | 02841 | |
| 425 | Severance Hospital Yonsei University Health System | Seoul | Korea, Republic of | 03722 | |
| 426 | Hanyang University Medical Center | Seoul | Korea, Republic of | 04763 | |
| 427 | Asan Medical Center | Seoul | Korea, Republic of | 05505 | |
| 428 | Samsung Medical Center | Seoul | Korea, Republic of | 06351 | |
| 429 | The Catholic University of Korea, Seoul St. Mary's Hospital | Seoul | Korea, Republic of | 06591 | |
| 430 | Seoul National University Boramae Hospital | Seoul | Korea, Republic of | 07061 | |
| 431 | Kyung Hee University Hospital | Seoul | Korea, Republic of | 130-872 | |
| 432 | Seoul National University Hospital | Seoul | Korea, Republic of | 3080 | |
| 433 | Korea University Guro Hospital | Seoul | Korea, Republic of | 8308 | |
| 434 | Ulsan University Hospital | Ulsan | Korea, Republic of | 44033 | |
| 435 | Riga East Clinical University Hospital | Riga | Latvia | LV-1038 | |
| 436 | Pauls Stradins Clinical University Hospital | Riga | Latvia | LV1002 | |
| 437 | Vilnius University Hospital Santariskiu Clinic, Public Institution | Vilnius | Lithuania | LT-08661 | |
| 438 | Republican Vilnius University Hospital, Public Institution | Vilnius | Lithuania | LT04130 | |
| 439 | Hospital University Sains Malaysia | Kota Bharu | Malaysia | 15200 | |
| 440 | Hospital Kuala Lumpur | Kuala Lumpur | Malaysia | 50586 | |
| 441 | University Kebangsaan Malaysia Medical Centre | Kuala Lumpur | Malaysia | 56000 | |
| 442 | Hospital Seberang Jaya | Seberang Jaya | Malaysia | 13700 | |
| 443 | Hospital Pengajar Universiti Putra Malaysia | Serdang | Malaysia | 43400 | |
| 444 | Hospital Sungai Buloh | Sungai Buloh | Malaysia | 47000 | |
| 445 | Centro de Estudios Clinicos y Especialidades Medicas, S.C. | Aguascalientes | Mexico | 020230 | |
| 446 | Centro de Investigación Medica Aguascalientes | Aguascalientes | Mexico | 20116 | |
| 447 | Hospital Cardiologica Aguascalientes | Aguascalientes | Mexico | 20230 | |
| 448 | Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C. | Culiacan | Mexico | 80020 | |
| 449 | Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez | Distrito Federal | Mexico | 14269 | |
| 450 | Hospital Angeles Del Pedregal | Mexico | Mexico | 10700 | |
| 451 | Hospital Universitario de Nuevo Leon 'Dr Jose Eleuterio Gonzalez' | Monterrey | Mexico | 64460 | |
| 452 | Centro de Investigacion Clinica Chapultepec S.A. de C.V. | Morelia | Mexico | 58260 | |
| 453 | Hospital UPAEP Christus Muguerza | Puebla | Mexico | 72000 | |
| 454 | Amphia Ziekenhuis | Breda | Netherlands | 4818 CK | |
| 455 | Bernhoven Uden | Uden | Netherlands | 5406 PT | |
| 456 | Auckland City Hospital | Auckland | New Zealand | 1023 | |
| 457 | Christchurch Hospital | Christchurch | New Zealand | 8011 | |
| 458 | Waikato Hospital | Hamilton | New Zealand | 3200 | |
| 459 | Middlemore Hospital | Otahuhu | New Zealand | 2025 | |
| 460 | Rotorua Hospital | Rotorua | New Zealand | 3010 | |
| 461 | Tauranga Hospital | Tauranga | New Zealand | 3143 | |
| 462 | Wellington Hospital | Wellington | New Zealand | 6021 | |
| 463 | Baguio General Hospital and Medical Center | Baguio City | Philippines | 2600 | |
| 464 | Cebu Doctors University Hospital | Cebu | Philippines | 6000 | |
| 465 | West Visayas State University Medical Center | Iloilo City | Philippines | 5000 | |
| 466 | Chinese General Hospital & Medical Center | Manila | Philippines | 1003 | |
| 467 | Metropolitan Medical Center | Manila | Philippines | 1003 | |
| 468 | San Juan de Dios Educational Foundation, Inc (Hospital) | Pasay City | Philippines | 1300 | |
| 469 | St. Luke's Medical Center | Quezon | Philippines | 1102 | |
| 470 | Uniwersytecki Szpital Kliniczny w Bialymstoku | Bialystok | Poland | 15-276 | |
| 471 | Szpital Sw Lukasza w Boleslawcu Centrum Profilaktyki I leczenia udarów Mózgu | Boleslawiec | Poland | 59-700 | |
| 472 | Szpital Uniwersytecki NR 1 IM. Dr. Antoniego Jurasza | Bydgoszcz | Poland | 85-096 | |
| 473 | Samodzielny Publiczny Wojewodzki Szpital Specjalistyczny w Chelmie | Chelmie | Poland | 22-100 | |
| 474 | Samodzielny Publiczny ZOZ w Dzialdowie | Dzialdowo | Poland | 13-200 | |
| 475 | SP Specjalistyczny Szpital Zachodni im. Jana Pawla II | Grodzisk Mazowiecki | Poland | 05-825 | |
| 476 | Samodzielny Publiczny Zespol Zakladow Opieki Zdrowotnej Medicam Gryfice | Gryfice | Poland | 72-300 | |
| 477 | SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im. Prof. Leszka Gieca | Katowice-Ochojec | Poland | 40635 | |
| 478 | Oddzial Ortopedii i Traumatologii Narzadu Ruchu Szpital Specjalistyczny im. Ludwika Rydygiera | Krakow | Poland | 31-637 | |
| 479 | Wojewodzki Szpital Zespolony w Lesznie Oddzial Neurologiczny z Pododzialem udarowym | Leszno | Poland | 64-100 | |
| 480 | III Szpital Miejski im. Dr. K. Jonschera w Lodzi | Lodz | Poland | 93-113 | |
| 481 | 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie | Lublin | Poland | 20-049 | |
| 482 | Wojewodzki Szpital Specjalistyczny w Olsztynie | Olsztyn | Poland | 10-561 | |
| 483 | Samodzielny Publiczny Zakład Opieki Zdrowotnej Wojewódzki Szpital Specjalistyczny nr 3 w Rybniku | Rybnik | Poland | 44-200 | |
| 484 | Zespol Opieki Zdrowotnej w Skarzysku-Kamiennej Szpital Powiatowy im. M.Curie-Sklodowskiej | Skarzysko-Kamienna | Poland | 26-110 | |
| 485 | KO-MED Centra Kliniczne Staszow | Staszow | Poland | 28-200 | |
| 486 | Specjalistyczny Szpital Miejski im. M.Kopernika | Torun | Poland | 87-100 | |
| 487 | Instytut Psychiatrii I Neurologii | Warszawa | Poland | 02-957 | |
| 488 | Miedzyleski Szpital Specjalistyczny | Warszawa | Poland | 04-749 | |
| 489 | Szpital Specjalistyczny im. F. Ceynowy Szpitale Pomorskie | Wejherowo | Poland | 84-200 | |
| 490 | Hospital de Braga | Braga | Portugal | 4710-243 | |
| 491 | Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra | Coimbra | Portugal | 3040-278 | |
| 492 | Hosp. Sra. Da Oliveira - Guimaraes | Guimarães | Portugal | 4835-044 | |
| 493 | Centro Hospitalar de Lisboa Central | Lisboa | Portugal | 1150-199 | |
| 494 | Chlo - Hosp. Egas Moniz | Lisboa | Portugal | 1349-019 | |
| 495 | Centro Hospitalar de Lisboa Norte - Hospital Santa Maria | Lisboa | Portugal | 1649-035 | |
| 496 | Hospital Beatriz Angelo | Loures | Portugal | 2674-514 | |
| 497 | H. Santo António - Centro Hospitalar do Porto | Porto | Portugal | 4099-001 | |
| 498 | Hospital Garcia de Orta, EPE | Pragal | Portugal | 2808-267 | |
| 499 | Centro Hospitalar de Entre o Douro e Vouga, E.P.E | Santa Maria da Feira | Portugal | 4520-211 | |
| 500 | Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E. | Vila Nova de Gaia | Portugal | 4434-502 | |
| 501 | Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE - Unidade de Vila Real | Vila Real | Portugal | 5000-508 | |
| 502 | Spitalul de Psihiatrie si Neurologie Brasov | Brasov | Romania | 500123 | |
| 503 | Spitalul Clinic Colentina | Bucuresti | Romania | 020125 | |
| 504 | Spitalul Universitar de Urgenta Bucuresti | Bucuresti | Romania | 050098 | |
| 505 | Emergency Clinical County Hospital Constanta | Constanta | Romania | 900591 | |
| 506 | Spitalul Clinic Judetean de Urgenta Oradea | Oradea | Romania | 410167 | |
| 507 | Spitalul Clinic Judetean de Urgenta Targu Mures | Targu Mures | Romania | RO540136 | |
| 508 | Spitalul Clinic Judetean de Urgenta 'Pius Brinzeu' | Timisoara | Romania | 300723 | |
| 509 | Special Hospital for Cerebrovascular Disease Sveti Sava | Belgrade | Serbia | 11000 | |
| 510 | University Clinical Center of Serbia | Belgrade | Serbia | 11000 | |
| 511 | University Clinical Center Kragujevac | Kragujevac | Serbia | 34000 | |
| 512 | General Hospital 'Dr Radivoj Simonovic' | Sombor | Serbia | 25101 | |
| 513 | Singapore General Hospital | Singapore | Singapore | 169608 | |
| 514 | Univerzitna nemocnica Bratislava | Bratislava | Slovakia | 82601 | |
| 515 | Univerzitna nemocnica L. Pasteura Kosice | Kosice | Slovakia | 04011 | |
| 516 | Nemocnica Agel Levoca | Levoca | Slovakia | 054 01 | |
| 517 | Liptovska Nemocnica S Poliklinikou Mudr. Ivana Stodolu | Liptovsky Mikulas | Slovakia | 03123 | |
| 518 | NZZ - Neurologia | Lucenec | Slovakia | 98401 | |
| 519 | Univerzitná nemocnica Martin | Martin | Slovakia | 036 59 | |
| 520 | Fakultna nemocnica Nitra | Nitra | Slovakia | 95001 | |
| 521 | Fakultna nemocnica s poliklinikou Nove Zamky | Nové Zámky | Slovakia | 940 34 | |
| 522 | Centrum Intervencnej Neuroradiologie a Endovaskularnej Liecby CINRE | Petrzalka | Slovakia | 85105 | |
| 523 | Nemocnica s poliklinikou Spisska Nova Ves, a.s. | Spisska Nova Ves | Slovakia | 05201 | |
| 524 | Fakultna nemocnica s poliklinikou v Ziline | Zilina | Slovakia | 1207 | |
| 525 | Iatros International | Bloemfontein | South Africa | 9324 | |
| 526 | Tread Research | Cape Town | South Africa | 7500 | |
| 527 | TASK Central | George | South Africa | 06530 | |
| 528 | Dr J.M. Engelbrecht Trial Site | Somerset West | South Africa | 7130 | |
| 529 | Mediclinic Victoria Hospital | Tongaat | South Africa | 4399 | |
| 530 | Clinical Projects Research SA (PTY) LTD | Worcester | South Africa | 6850 | |
| 531 | Hosp. Gral. de Albacete | Albacete | Spain | 02008 | |
| 532 | Hosp. Gral. Univ. de Alicante | Alicante | Spain | 03010 | |
| 533 | Hosp. Univ. Germans Trias I Pujol | Badalona | Spain | 08916 | |
| 534 | Hosp. Del Mar | Barcelona | Spain | 08003 | |
| 535 | Hosp. Univ. Vall D Hebron | Barcelona | Spain | 08035 | |
| 536 | Hosp. de La Santa Creu I Sant Pau | Barcelona | Spain | 08041 | |
| 537 | Hosp. Reina Sofia | Cordoba | Spain | 14004 | |
| 538 | Hosp. Univ. Dr. Josep Trueta | Girona | Spain | 17007 | |
| 539 | Hosp. Univ. de Bellvitge | L'Hospitalet de Llobregat | Spain | 08907 | |
| 540 | Hosp. Univ. A Coruña | La Coruña | Spain | 15006 | |
| 541 | Hosp. Univ. Arnau de Vilanova de Lleida | Lleida | Spain | 25198 | |
| 542 | Hosp. Univ. de La Princesa | Madrid | Spain | 28006 | |
| 543 | Hosp. Gral. Univ. Gregorio Marañon | Madrid | Spain | 28007 | |
| 544 | Hosp. Univ. Ramon Y Cajal | Madrid | Spain | 28034 | |
| 545 | Hosp. Clinico San Carlos | Madrid | Spain | 28040 | |
| 546 | Hosp. Univ. 12 de Octubre | Madrid | Spain | 28041 | |
| 547 | Hosp. Univ. de La Paz | Madrid | Spain | 28046 | |
| 548 | Hosp. Univ. Son Espases | Palma de Mallorca | Spain | 07120 | |
| 549 | Corporacio Sanitari Parc Tauli | Sabadell | Spain | 08208 | |
| 550 | Hosp. Clinico Univ. de Salamanca | Salamanca | Spain | 37007 | |
| 551 | Hosp. Clinico Univ. de Santiago | Santiago de Compostela | Spain | 15706 | |
| 552 | Hosp. Virgen Del Rocio | Sevilla | Spain | 41013 | |
| 553 | Hosp Univ de Tarragona Joan Xxiii | Tarragona | Spain | 43005 | |
| 554 | Hosp. Mutua Terrassa | Terrassa | Spain | 08221 | |
| 555 | Hosp. Clinico Univ. de Valencia | Valencia | Spain | 46010 | |
| 556 | Hosp. Univ. I Politecni La Fe | Valencia | Spain | 46026 | |
| 557 | Hosp. Clinico Univ. de Valladolid | Valladolid | Spain | 470003 | |
| 558 | Hosp. Alvaro Cunqueiro | Vigo | Spain | 36213 | |
| 559 | Hosp. Clinico Univ. Lozano Blesa | Zaragoza | Spain | 50009 | |
| 560 | Hosp. Univ. Miguel Servet | Zaragoza | Spain | 50009 | |
| 561 | Sahlgrenska University Hospital | Göteborg | Sweden | 41345 | |
| 562 | Skane University Hospital | Lund | Sweden | 221 85 | |
| 563 | Skanes universitetssjukhus | Malmoe | Sweden | 205 02 | |
| 564 | Skaraborgs sjukhus Skövde | Skövde | Sweden | 54142 | |
| 565 | Uppsala Akademiska Sjukhus | Uppsala | Sweden | 751 85 | |
| 566 | INSELSPITAL, Universitätsspital Bern | Bern | Switzerland | 3010 | |
| 567 | Hôpitaux Universitaires de Genève - HUG | Genève | Switzerland | 1205 | |
| 568 | Changhua Christian Hospital | Changhua | Taiwan | 50006 | |
| 569 | Chang Gung Memorial Hospital, Chiayi Branch | Chiayi | Taiwan | 613 | |
| 570 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | Taiwan | 80756 | |
| 571 | Kaohsiung Chang Gung Memorial Hospital | Kaohsiung | Taiwan | 83301 | |
| 572 | Chang Gung Medical Foundation | Keelung | Taiwan | 20401 | |
| 573 | Taipei Medical University Shuang Ho Hospital | New Taipei City | Taiwan | 23561 | |
| 574 | En Chu Kong Hospital | New Taipei City | Taiwan | 237 | |
| 575 | National Taiwan University Hospital | Taipei | Taiwan | 10002 | |
| 576 | Chang Gung Memorial Hospital- Linkou | Taoyuan County | Taiwan | 33305 | |
| 577 | Siriraj Hospital | Bangkoknoi | Thailand | 10700 | |
| 578 | Phramongkutklao Hospital and Medical College | Bangkok | Thailand | 10400 | |
| 579 | Ramathibodi Hospital | Bangkok | Thailand | 10400 | |
| 580 | Maharaj Nakorn Chiang Mai hospital - Faculty of Medicine | Chiangmai | Thailand | 50200 | |
| 581 | Lampang Hospital | Muang | Thailand | 52000 | |
| 582 | Srinagarind Hospital | Nai Mueang Subdistrict Mueang | Thailand | 40000 | |
| 583 | King Chulalongkorn Memorial Hospital | Pathum Wan | Thailand | 10330 | |
| 584 | Prasat Neurological Institute | Rajathevi | Thailand | 10400 | |
| 585 | University Hospital Monklands | Airdrie | United Kingdom | ML6 0JS | |
| 586 | Royal United Hospital | Bath | United Kingdom | BA1 3NG | |
| 587 | Bury Care Organisation | Bury | United Kingdom | ||
| 588 | Royal Devon and Exeter Hospital(Wonford) | Exeter | United Kingdom | EX2 5DW | |
| 589 | Queen Elizabeth University Hospital | Glasgow | United Kingdom | G51 4TF | |
| 590 | St George's Hospital | London | United Kingdom | SW17 OQT | |
| 591 | Luton and Dunstable Hospital | Luton | United Kingdom | LU4 0DZ | |
| 592 | Royal Cornwall Hospital | Truro | United Kingdom | TR1 3LQ | |
| 593 | Pinderfields General Hospital - Dept. of Neurology | Wakefield | United Kingdom | WF1 4DG | |
| 594 | Saint Paul General Hospital | Ha Noi | Vietnam | 100000 | |
| 595 | Bach Mai Hospital | Hanoi | Vietnam | 100000 | |
| 596 | People's Hospital 115 | Ho Chi Minh | Vietnam | 700000 | |
| 597 | Thong Nhat HOSPITAL | Ho Chi Minh | Vietnam | 700000 | |
| 598 | University Medical Center Ho Chi Minh city | Ho Chi Minh | Vietnam | 748806 | |
| 599 | Gia Dinh People Hospital | Ho Chi Minh | Vietnam | ||
| 600 | Nguyen Tri Phuong Hospital | Ho Chi Minh | Vietnam |
Sponsors and Collaborators
- Janssen Research & Development, LLC
- Bristol Myers Squibb Company (BMS)
Investigators
- Study Director: Janssen Research & Development, LLC Clinical Trial, Janssen Research & Development, LLC
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Janssen Research & Development, LLC
ClinicalTrials.gov Identifier:
NCT05702034
Other Study ID Numbers:
- CR109231
- 70033093STR3001
First Posted:
Jan 27, 2023
Last Update Posted:
Jan 27, 2023
Last Verified:
Jan 1, 2023
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: