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Ketone Supplementation and Exercise Performance

Sponsor
Western University, Canada (Other)
Overall Status
Unknown status
CT.gov ID
NCT03954665
Collaborator
(none)
20
Enrollment
1
Location
2
Arms
6
Anticipated Duration (Months)
3.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).

Condition or Disease Intervention/Treatment Phase
  • Behavioral: 10 km time trial
  • Behavioral: 30s Wingate
  • Dietary Supplement: Ketone
  • Behavioral: Baseline 10 km time trial
  • Behavioral: Baseline 30s Wingate
 N/A

Detailed Description

Some believe very high fat diets (>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to ~15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
20 participants
Allocation:
Randomized
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Other
Official Title:
Can Ketone Supplementation Enhance Exercise Performance?
Anticipated Study Start Date :
Sep 1, 2019
Anticipated Primary Completion Date :
Jan 1, 2020
Anticipated Study Completion Date :
Mar 1, 2020

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Baseline Testing

Baseline testing for a 10km cycle time trial and a 30s Wingate cycle test.

Behavioral: Baseline 10 km time trial
A baseline 10 km Cycling time trial test will be conducted

Behavioral: Baseline 30s Wingate
A baseline 30s all-out test to measure peak power output
Experimental: Dietary Supplement: Exogenous Ketone Salt

Ketone salt supplementation (0.6-0.8g•kg-1•d-1) 7-days. Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) after supplementation.

Behavioral: 10 km time trial
10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time

Behavioral: 30s Wingate
30s all-out test to measure peak power output

Dietary Supplement: Ketone
Supplement containing exogenous ketone salts

Outcome Measures

Primary Outcome Measures

  1. 10 km Time trial [15-20 Minutes]

    10km time trial where participants will be measured on time to completion

  2. 30s Wingate [30 seconds]

    30s Wingate all out test where participants will be measured on their peak power output

Secondary Outcome Measures

  1. Blood Ketones [1-2 hours]

    Blood Ketones will be measured using a ketone meter

  2. Blood Glucose [1-2 hours]

    Blood Glucose will be measured using a Blood glucose meter

  3. Blood Lactate [1-2 hours]

    Blood Lactate will be measured using a lactate meter

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 25 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Healthy male or female Collegiate Endurance Trained Athletes

  • ≥2 year training experience; ≥7 h/week

  • Ages 18-25

Exclusion Criteria:

  • Smoker

  • Injury that will affect exercise performance

  • Sedentary Behaviour

  • Currently following a High Fat diet/Ketogenic diet

  • Taking Beta Blockers or Hypertension Medication

  • Has Respiratory, Cardiovascular and/or Neuromuscular disease that is not cleared for exercise by a physician.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Exercise Nutrition Laboratory, Western University London Ontario Canada N6A3K7

Sponsors and Collaborators

  • Western University, Canada

Investigators

  • Principal Investigator: Peter WR Lemon, PhD, Western University

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Western University, Canada
ClinicalTrials.gov Identifier:
NCT03954665
Other Study ID Numbers:
  • 113761
First Posted:
May 17, 2019
Last Update Posted:
Jul 23, 2019
Last Verified:
Apr 1, 2019
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Western University, Canada
Ketones
Supplementation
Exercise Performance
Additional relevant MeSH terms:
Ketosis

Study Results

No Results Posted as of Jul 23, 2019