Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors
Study Details
Study Description
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. It is not yet known which therapy regimen is most effective for treating patients with kidney tumors.
PURPOSE: Phase III trial to compare the effectiveness of chemotherapy with or without radiation therapy, surgery, and/or peripheral stem cell or bone marrow transplantation in treating young patients with kidney tumors.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 3 |
Detailed Description
OBJECTIVES:
-
Determine the 2-year second-event-free survival after vincristine (VCR) and dactinomycin (DACT) with or without doxorubicin (DOX), depending on the site of relapse and presence of microscopic residual disease, in children with relapsed Wilm's tumor previously treated with nephrectomy alone as initial therapy.
-
Determine whether the 2-year second-event-free survival after intensive doxorubicin, etoposide (VP-16), cyclophosphamide (CTX), and carboplatin (CBDCA) plus radiotherapy to residual disease is at least 40% higher in patients with relapsed Wilm's tumor previously treated with Regimen EE-4A as initial therapy and without loss of heterozygosity for chromosomes 16q and 1p and increased DNA content in tumor cells than for similarly treated patients with loss of heterozygosity for chromosome 16q or 1p or increased DNA content in tumor cells.
-
Determine whether the 4-year post-relapse survival after intensive VP-16, CTX, and CBDCA is at least 40% higher in patients with relapsed Wilm's tumor previously treated with Regimen DD-4A as initial therapy and without loss of heterozygosity for chromosomes 16q and 1p and increased DNA content in tumor cells than for similarly treated patients with loss of heterozygosity for chromosome 16q or 1p or increased DNA content in tumor cells.
-
Determine whether the rates of complete and partial response exceed 20% in patients with relapsed clear cell sarcoma of the kidney or diffuse anaplastic Wilms' tumor treated with CBDCA combined with VP-16.
OUTLINE: This is a multicenter study.
Patients are assigned to a treatment group based on initial therapy and histology. Patients under age 2 at diagnosis who were previously treated with nephrectomy as initial therapy for stage I favorable histology Wilms' tumor weighing less than 550 grams are assigned to group
- Patients who received Regimen EE-4A as initial therapy for Wilms' tumor are assigned to group B. Patients who received Regimen DD-4A as initial therapy for Wilms' tumor are assigned to group C. Patients with clear cell sarcoma of the kidney or diffuse anaplastic Wilms' tumor are assigned to group D.
Group A
-
Treatment is determined by site of relapse and the presence of microscopic or gross residual disease after attempted resection of relapsed disease. Children with suspected intra-abdominal recurrence undergo exploratory surgery to determine the site of recurrence and to obtain tissue for microscopic examination. Patients with stage I disease after recurrence are treated with regimen EE-4A. Patients with stage II or III disease are treated with regimen DD-4A.
-
Regimen EE-4A: Patients receive dactinomycin (DACT) IV on weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine (VCR) IV on weeks 1-10, 12, 15, and 18 in the absence of disease progression.
-
Regimen DD-4A: Patients receive DACT IV on weeks 0, 6, 12, 18, and 24; VCR IV weekly on weeks 1-10, 12, 15, 18, 21, and 24; doxorubicin (DOX) IV on weeks 3, 9, 15, and 21; and abdominal radiotherapy in the absence of disease progression.
Group B
- Patients undergo resection. After resection, patients receive regimen I comprising DOX IV on weeks 0, 6, 12, 18, and 24; VCR IV on weeks 1, 2, 4, 5-8, 10-13, 18, and 24; cyclophosphamide (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; and etoposide (VP-16) IV over 1 hour (after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21 in the absence of disease progression. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy and continuing until blood counts recover. Patients undergo radiotherapy to site of recurrence beginning within 1 week after initiation of chemotherapy.
Group C
-
Induction: Patients receive CTX IV over 1 hour on days 1-5 of weeks 0 and 3; VP-16 IV over 1 hour (after CTX infusion) on days 1-5 of weeks of 0 and 3 and on days 1-3 of weeks 6 and 9; and carboplatin (CBDCA) IV over 6 hours on days 1 and 2 of weeks 6 and 9 in the absence of disease progression. G-CSF is administered SC beginning 24 hours after completion of CTX/VP-16 or CBDCA/VP-16 and continuing until blood counts recover.
-
Surgery: Patients with detectable disease undergo resection on week 13. If complete resection is not achieved or if it is deemed impossible, resection must be attempted no later than 3 weeks after consolidation radiotherapy.
-
Consolidation: Beginning within 9 days of surgery, patients receive CTX IV over 1 hour on days 1-5 of week 1; VP-16 IV over 1 hour (after CTX infusion) on days 1-5 of week 1 and on days 1-3 of week 4; CBDCA IV over 6 hours on days 1 and 2 of week 4; G-CSF as in induction; and radiotherapy in the absence of disease progression. Patients with complete or partial response after resection and/or radiotherapy proceed to maintenance therapy.
-
Maintenance: Patients receive CTX IV over 1 hour on days 1-5 of weeks 0 and 3; VP-16 IV over 1 hour on days 1-5 of weeks 0 and 3 and on days 1-3 of weeks 6 and 9; CBDCA IV over 6 hours on days 1 and 2 of weeks 6 and 9; and G-CSF as in induction. Treatment continues every 12 weeks for 6 courses in the absence of disease progression.
Group D
- Patients receive CBDCA IV over 6 hours on days 1 and 2 and VP-16 IV over 1 hour (after CBDCA infusion) on days 1-3 of weeks 0 and 3. Treatment continues weekly for 6 courses in the absence of disease progression.
Patients are followed every 3 months for 15 months, every 6 months for 1 year, and then annually for 3 years.
PROJECTED ACCRUAL: Not specified
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: STRATUM A Treatment of children in Stratum A will be determined by the site of relapse and the presence of microscopic or gross residual disease after attempted surgical excision of the relapse. |
Biological: dactinomycin
Other Names:
Drug: doxorubicin hydrochloride
Other Names:
Drug: vincristine sulfate
IV
Other Names:
Procedure: conventional surgery
Radiation: radiation therapy
|
Experimental: Stratum B All children who received combination chemotherapy with Regimen EE - 4A as their initial therapy for Wilms tumor will receive Regimen I and radiation therapy to the site of recurrence. All patients will receive prophylactic trimethoprim /sulfamethoxazole |
Biological: filgrastim
Other Names:
Drug: cyclophosphamide
Other Names:
Drug: doxorubicin hydrochloride
Other Names:
Drug: etoposide
Other Names:
Drug: vincristine sulfate
IV
Other Names:
Procedure: conventional surgery
Radiation: radiation therapy
|
Experimental: STRATUM C All children who received combination chemotherapy with Regimen DD - 4A as their initial therapy for Wilms tumor will be treated with the following chemotherapy. All patients will receive prophylactic trimethoprim/sulfamethoxazole |
Biological: filgrastim
Other Names:
Drug: carboplatin
Other Names:
Drug: cyclophosphamide
Other Names:
Drug: etoposide
Other Names:
Procedure: conventional surgery
Radiation: radiation therapy
|
Experimental: STRATUM D Six week cycles of chemotherapy will be given to all patients who do not have progressive disease at the time of each week 0 re-evaluation. |
Drug: carboplatin
Other Names:
Drug: etoposide
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Event free survival [2 years]
To determine the two-year second event-free survival percentage for children who relapse following initial therapy with nephrectomy only following treatment with vincristine and dactinomycin, with or without doxorubicin, depending upon the site of relapse and presence or absence of microscopic residual disease.
Secondary Outcome Measures
- Event Free Survival [2 years]
To determine if the two-year second event-free survival percentage for children who relapse following initial treatment with Regimen EE-4A who do not have loss of heterozygosity of markers for chromosome 16q, 1p or increased DNA content in tumor cells is not less than 40% higher than that of similar patients who have loss of heterozygosity for chromosome 16q, 1p or increased DNA content following treatment with intensive chemotherapy using doxorubicin, etoposide, cyclophosphamide and carboplatin, and radiation therapy to sites of microscopic or gross residual disease.
- Post-relapse survival [4 years]
To determine if the four-year post-relapse survival percentage for children who relapse following initial treatment with Regimen DD - 4A who do not have loss of heterozygosity of markers for chromosome 16q, 1p or increased DNA content in tumor cells is not less than 40% higher than that of similar patients who have loss of heterozygosity for chromosome 16q, 1p or increased DNA content following treatment with intensive chemotherapy using etoposide, cyclophosphamide and carboplatin.
- Response rate []
To determine if the response rate (CR + PR) of clear cell sarcoma of the kidney and diffuse anaplastic Wilms tumor to the combination of carboplatin and etoposide each exceed 20%.
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
-
Diagnosis of Wilms' tumor
-
Eligible subtypes:
-
Favorable histologies
-
Anaplastic histologies
-
Clear cell sarcoma of the kidney
-
Rhabdoid tumor of the kidney
-
Relapsed disease after entry on protocol NWTS-5 (NWTS-Q9401)
PATIENT CHARACTERISTICS:
Age:
- 21 and under at original diagnosis
Performance status:
- Not specified
Life expectancy:
- At least 4 weeks
Hematopoietic:
-
Absolute neutrophil count at least 1,000/mm^3
-
Platelet count at least 100,000/mm^3
Hepatic:
-
Bilirubin no greater than 1.5 times normal
-
SGOT or SGPT less than 2.5 times normal
Renal:
-
Creatinine no greater than 1.5 times normal OR
-
Creatinine clearance or GFR at least 70 mL/min
Cardiovascular:
-
Shortening fraction at least 27% by echocardiogram OR
-
Ejection fraction greater than 50% by echocardiogram or MUGA scan
Other:
-
Not pregnant
-
Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- At least 2 weeks since prior chemotherapy and recovered
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Other
-
No prior therapy for relapsed Wilms' tumor
-
Recovered from the toxic effects of any other prior therapy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | United States | 35233 |
2 | University of South Alabama Medical Center | Mobile | Alabama | United States | 36604 |
3 | Phoenix Children's Hospital | Phoenix | Arizona | United States | 85016-7710 |
4 | Arizona Cancer Center | Tucson | Arizona | United States | 85724 |
5 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
6 | Southern California Permanente Medical Group | Downey | California | United States | 90242 |
7 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010-3000 |
8 | Rebecca and John Moores UCSD Cancer Center | La Jolla | California | United States | 92093-0658 |
9 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
10 | Jonathan Jaques Children's Cancer Center | Long Beach | California | United States | 90801-1428 |
11 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027-0700 |
12 | Cedars-Sinai Medical Center | Los Angeles | California | United States | 90048 |
13 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
14 | Children's Hospital Central California | Madera | California | United States | 93638-8762 |
15 | Children's Hospital of Oakland | Oakland | California | United States | 94609-1809 |
16 | Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
17 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
18 | Lucile Packard Children's Hospital at Stanford | Palo Alto | California | United States | 94304 |
19 | Sutter Cancer Center | Sacramento | California | United States | 95816 |
20 | University of California Davis Medical Center | Sacramento | California | United States | 95817 |
21 | Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | United States | 92120 |
22 | Children's Hospital San Diego | San Diego | California | United States | 92123-4282 |
23 | Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco | California | United States | 94115 |
24 | UCSF Comprehensive Cancer Center | San Francisco | California | United States | 94143-0128 |
25 | Santa Barbara Cottage Hospital | Santa Barbara | California | United States | 93102 |
26 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051-5386 |
27 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
28 | Children's Hospital of Denver | Denver | Colorado | United States | 80218-1088 |
29 | Childhood Hematology/Oncology Associates | Denver | Colorado | United States | 80218 |
30 | Presbyterian-St Luke's Medical Center | Denver | Colorado | United States | 80218 |
31 | University of Connecticut Health Center | Farmington | Connecticut | United States | 06360-7106 |
32 | Yale Comprehensive Cancer Center | New Haven | Connecticut | United States | 06520-8028 |
33 | Alfred I. Dupont Institute | Wilmington | Delaware | United States | 19899 |
34 | Lombardi Cancer Center | Washington | District of Columbia | United States | 20007 |
35 | Children's National Medical Center | Washington | District of Columbia | United States | 20010-2970 |
36 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5000 |
37 | Broward General Medical Center | Fort Lauderdale | Florida | United States | 33316 |
38 | Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
39 | Shands Hospital and Clinics, University of Florida | Gainesville | Florida | United States | 32610-100277 |
40 | Joe DiMaggio Children's Hospital at Memorial | Hollywood | Florida | United States | 33021 |
41 | Nemours Children's Clinic | Jacksonville | Florida | United States | 32207 |
42 | University of Miami-Jackson Memorial Hospital | Miami | Florida | United States | 33136 |
43 | Miami Children's Hospital | Miami | Florida | United States | 33155-4069 |
44 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
45 | Florida Hospital Cancer Institute | Orlando | Florida | United States | 32803 |
46 | Nemours Children's Clinic-Orlando | Orlando | Florida | United States | 32806 |
47 | Sacred Heart Children's Hospital | Pensacola | Florida | United States | 32504 |
48 | All Children's Hospital | St. Petersburg | Florida | United States | 33701 |
49 | Tampa Children's Hospital | Tampa | Florida | United States | 33677-4227 |
50 | St. Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
51 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
52 | Children's Healthcare of Atlanta - Scottish Rite | Atlanta | Georgia | United States | 30342 |
53 | Medical College of Georgia Comprehensive Cancer Center | Augusta | Georgia | United States | 30912-4000 |
54 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
55 | Memorial Health University Medical Center, Inc. | Savannah | Georgia | United States | 31403-3089 |
56 | Cancer Research Center of Hawaii | Honolulu | Hawaii | United States | 96813 |
57 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
58 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859-5000 |
59 | Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
60 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60601 |
61 | Rush-Presbyterian-St. Luke's Medical Center | Chicago | Illinois | United States | 60612 |
62 | University of Illinois at Chicago | Chicago | Illinois | United States | 60612 |
63 | Children's Memorial Hospital - Chicago | Chicago | Illinois | United States | 60614 |
64 | Hope Children's Hospital | Oak Lawn | Illinois | United States | 60453 |
65 | Lutheran General Hospital | Park Ridge | Illinois | United States | 60068-1174 |
66 | Saint Jude Midwest Affiliate | Peoria | Illinois | United States | 61637 |
67 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62794-9658 |
68 | Indiana University Cancer Center | Indianapolis | Indiana | United States | 46202-5289 |
69 | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
70 | Raymond Blank Memorial Hospital for Children | Des Moines | Iowa | United States | 50308 |
71 | John Stoddard Cancer Center | Des Moines | Iowa | United States | 50309 |
72 | Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242-1009 |
73 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
74 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0284 |
75 | Kosair Children's Hospital | Louisville | Kentucky | United States | 40202-3830 |
76 | Tulane University School of Medicine | New Orleans | Louisiana | United States | 70112 |
77 | Children's Hospital of New Orleans | New Orleans | Louisiana | United States | 70118 |
78 | Ochsner Clinic | New Orleans | Louisiana | United States | 70121 |
79 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
80 | Maine Children's Cancer Program | Scarborough | Maine | United States | 04074 |
81 | Marlene and Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | United States | 21201-1595 |
82 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21225 |
83 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
84 | Floating Hospital for Children | Boston | Massachusetts | United States | 02111 |
85 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
86 | Baystate Medical Center | Springfield | Massachusetts | United States | 01107 |
87 | University of Massachusetts Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
88 | Mott Children's Hospital | Ann Arbor | Michigan | United States | 48109-0914 |
89 | Children's Hospital of Michigan | Detroit | Michigan | United States | 48201 |
90 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
91 | St. John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
92 | Michigan State University | East Lansing | Michigan | United States | 48824 |
93 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
94 | Spectrum Health and DeVos Children's Hospital | Grand Rapids | Michigan | United States | 49503 |
95 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
96 | CCOP - Beaumont | Royal Oak | Michigan | United States | 48073-6769 |
97 | William Beaumont Hospital | Royal Oak | Michigan | United States | 48073-6769 |
98 | St. Mary's/Duluth Clinic Cancer Center | Duluth | Minnesota | United States | 55805-1983 |
99 | Children's Hospitals and Clinics - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
100 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
101 | Children's Hospitals and Clinics of Minnesota | Saint Paul | Minnesota | United States | 55102 |
102 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216-4505 |
103 | Children's Mercy Hospital | Kansas City | Missouri | United States | 64108 |
104 | Cardinal Glennon Children's Hospital | Saint Louis | Missouri | United States | 63104 |
105 | St. Louis Children's Hospital | Saint Louis | Missouri | United States | 63110 |
106 | Children's Hospital of Omaha | Omaha | Nebraska | United States | 68114 |
107 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198-2168 |
108 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109-2306 |
109 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756-0002 |
110 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
111 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
112 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112-2094 |
113 | St. Joseph's Hospital and Medical Center | Paterson | New Jersey | United States | 07503 |
114 | Atlantic Health System | Summit | New Jersey | United States | 07901 |
115 | University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | United States | 87131 |
116 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
117 | Albert Einstein Clinical Cancer Center | Bronx | New York | United States | 10461 |
118 | Brooklyn Hospital Center | Brooklyn | New York | United States | 11201 |
119 | State University of New York Health Science Center at Brooklyn College of Medicine | Brooklyn | New York | United States | 11203 |
120 | Brookdale University Hospital and Medical Center | Brooklyn | New York | United States | 11212 |
121 | Maimonides Medical Center | Brooklyn | New York | United States | 11219 |
122 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
123 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
124 | Schneider Children's Hospital | New Hyde Park | New York | United States | 11042 |
125 | New York Presbyterian Hospital - Cornell Campus | New York | New York | United States | 10021-4885 |
126 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
127 | Mount Sinai School of Medicine | New York | New York | United States | 10029 |
128 | Columbia Presbyterian Hospital | New York | New York | United States | 10032 |
129 | James P. Wilmot Cancer Center | Rochester | New York | United States | 14642 |
130 | State University of New York Health Sciences Center - Stony Brook | Stony Brook | New York | United States | 11790-7775 |
131 | State University of New York - Upstate Medical University | Syracuse | New York | United States | 13210 |
132 | New York Medical College | Valhalla | New York | United States | 10595 |
133 | Mission Saint Joseph's Health System | Asheville | North Carolina | United States | 28801 |
134 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
135 | Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
136 | Presbyterian Healthcare | Charlotte | North Carolina | United States | 28233-3549 |
137 | Duke Comprehensive Cancer Center | Durham | North Carolina | United States | 27710 |
138 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
139 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1081 |
140 | Dakota Cancer Institute | Fargo | North Dakota | United States | 58103-4940 |
141 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
142 | Children's Hospital Medical Center - Cincinnati | Cincinnati | Ohio | United States | 45229-3039 |
143 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
144 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
145 | Children's Hospital of Columbus | Columbus | Ohio | United States | 43205-2696 |
146 | Children's Medical Center - Dayton | Dayton | Ohio | United States | 45404 |
147 | Toledo Children's Hospital | Toledo | Ohio | United States | 43601 |
148 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
149 | Forum Health-Tod Childrens Hospital | Youngstown | Ohio | United States | 44501 |
150 | Children's Hospital of Oklahoma | Oklahoma City | Oklahoma | United States | 73104 |
151 | CCOP - Oklahoma | Tulsa | Oklahoma | United States | 74136 |
152 | Natalie Warren Bryant Cancer Center | Tulsa | Oklahoma | United States | 74136 |
153 | Doernbecher Children's Hospital | Portland | Oregon | United States | 97201-3098 |
154 | Legacy Emanuel Hospital and Health Center | Portland | Oregon | United States | 97227 |
155 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-1320 |
156 | Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
157 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
158 | St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | United States | 19134-1095 |
159 | Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15213 |
160 | Rhode Island Hospital | Providence | Rhode Island | United States | 02818 |
161 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
162 | Palmetto Health South Carolina Cancer Center | Columbia | South Carolina | United States | 29203 |
163 | Children's Hospital of Greenville Hospital System | Greenville | South Carolina | United States | 29605 |
164 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105-1080 |
165 | Sioux Valley Hospital | Sioux Falls | South Dakota | United States | 57117 |
166 | East Tennessee State University Cancer Center at JCMC | Johnson City | Tennessee | United States | 37604 |
167 | East Tennessee Children's Hospital | Knoxville | Tennessee | United States | 37901 |
168 | Saint Jude Children's Research Hospital | Memphis | Tennessee | United States | 38105-2794 |
169 | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | United States | 37232-6838 |
170 | Texas Tech University Health Sciences Center School of Medicine | Amarillo | Texas | United States | 79106 |
171 | Children's Hospital of Austin | Austin | Texas | United States | 78701 |
172 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
173 | Simmons Cancer Center - Dallas | Dallas | Texas | United States | 75235-9154 |
174 | Cook Children's Medical Center - Fort Worth | Fort Worth | Texas | United States | 76104 |
175 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0361 |
176 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
177 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
178 | San Antonio Military Pediatric Cancer and Blood Disorders Center | Lackland Air Force Base | Texas | United States | 78236-5300 |
179 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
180 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78207 |
181 | Methodist Health Care System | San Antonio | Texas | United States | 78229-3902 |
182 | Scott and White Memorial Hospital | Temple | Texas | United States | 76508 |
183 | Huntsman Cancer Institute | Salt Lake City | Utah | United States | 84112 |
184 | Vermont Cancer Center | Burlington | Vermont | United States | 05401-3498 |
185 | Cancer Center at the University of Virginia | Charlottesville | Virginia | United States | 22908 |
186 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042-3300 |
187 | Children's Hospital of the King's Daughters | Norfolk | Virginia | United States | 23507 |
188 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-5100 |
189 | Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
190 | Carilion Medical Center for Children | Roanoke | Virginia | United States | 24013 |
191 | Children's Hospital and Regional Medical Center - Seattle | Seattle | Washington | United States | 98105 |
192 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109-1024 |
193 | Group Health Cooperative | Seattle | Washington | United States | 98112 |
194 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
195 | Mary Bridge Children's Health Center | Tacoma | Washington | United States | 98415-0299 |
196 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431-5000 |
197 | West Virginia University - Charleston | Charleston | West Virginia | United States | 25302 |
198 | Cabell-Huntington Hospital, Inc | Huntington | West Virginia | United States | 25701 |
199 | West Virginia University Hospitals | Morgantown | West Virginia | United States | 26506-9300 |
200 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
201 | CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | United States | 54301 |
202 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-9070 |
203 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
204 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792-0001 |
205 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449-5772 |
206 | Midwest Children's Cancer Center | Milwaukee | Wisconsin | United States | 53226 |
207 | Sydney Children's Hospital | Randwick | New South Wales | Australia | 2031 |
208 | Children's Hospital at Westmead | Westmead | New South Wales | Australia | 2145 |
209 | Royal Children's Hospital | Brisbane | Queensland | Australia | 4029 |
210 | Women's and Children's Hospital | North Adelaide | South Australia | Australia | 5006 |
211 | Royal Children's Hospital | Parkville | Victoria | Australia | 3052 |
212 | Princess Margaret Hospital for Children | Perth | Western Australia | Australia | 6001 |
213 | Alberta Children's Hospital | Calgary | Alberta | Canada | T2T 5C7 |
214 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
215 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
216 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
217 | Janeway Children's Health and Rehabilitation Centre | St. John's | Newfoundland and Labrador | Canada | A1B 3V6 |
218 | IWK Health Centre | Halifax | Nova Scotia | Canada | B3J 3G9 |
219 | Children's Hospital | Hamilton | Ontario | Canada | L8N 3Z5 |
220 | Children's Hospital of Western Ontario | London | Ontario | Canada | N6C 2V5 |
221 | Children's Hospital of Eastern Ontario | Ottawa | Ontario | Canada | K1H 8L1 |
222 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
223 | McGill University Health Center - Montreal Children's Hospital | Montreal | Quebec | Canada | H3H 1P3 |
224 | Hopital Sainte Justine | Montreal | Quebec | Canada | H3T 1C5 |
225 | Centre Hospitalier de L'Universite Laval | Sainte Foy | Quebec | Canada | GIV 4G2 |
226 | Laval University Medical Center | Sainte-Foy | Quebec | Canada | G1V 4G2 |
227 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
228 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
229 | Academisch Ziekenhuis Groningen | Groningen | Netherlands | 9700 RB | |
230 | Starship Children's Hospital | Auckland | New Zealand | ||
231 | University of Puerto Rico School of Medicine Medical Sciences Campus | San Juan | Puerto Rico | 00936-5067 | |
232 | San Jorge Childrens Hospital | Santurce | Puerto Rico | 00912 | |
233 | Swiss Pediatric Oncology Group Bern | Bern | Switzerland | CH 3010 | |
234 | Swiss Pediatric Oncology Group Geneva | Geneva | Switzerland | CH 1211 | |
235 | Swiss Pediatric Oncology Group Lausanne | Lausanne | Switzerland | CH 1011 |
Sponsors and Collaborators
- Children's Oncology Group
- National Cancer Institute (NCI)
Investigators
- Study Chair: Daniel M. Green, MD, Roswell Park Cancer Institute
Study Documents (Full-Text)
None provided.More Information
Publications
- 9444
- COG-Q9402
- NWTS-Q9402
- CCG-4942
- POG-9444
- INT-0152
- NWTS-5/R
- CDR0000063900