Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients

Sponsor

Universitaire Ziekenhuizen Leuven (Other)

Overall Status

Completed

CT.gov ID

NCT00485706

Collaborator

(none)

Location

Study Details

Study Description

Brief Summary

Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.

In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.

Condition or Disease	Intervention/Treatment	Phase
Kidney Disease Hypercalcemia	Procedure: high calcium dialysate	N/A

Detailed Description

Study hypothesis.

Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.

This may result in higher extraosseous calcification and higher pulse wave velocity

∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"

Study Design

Study Type:

Interventional

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients

Study Start Date :

Jun 1, 2007

Outcome Measures

Primary Outcome Measures

correlation between calcium increase and pulse wave velocity []
correlation between calcium increase and pulse wave velocity
correlation between calcium change and pth change []
correlation between calcium change and pth change

Secondary Outcome Measures

correlation between calcium increase and vascular calcifications []
correlation between calcium increase and vascular calcifications
correlation between calcium change and bone markers []
correlation between calcium change and bone markers