PREVAGREF: Impact of Infectious Diseases Consultation on Vaccination Coverage Among People Waiting for a Kidney Transplant at the Clermont-Ferrand Hospital
Study Details
Study Description
Brief Summary
Solid-organ transplant patients are at increased risk of infectious diseases. Among this population, infectious diseases may be life-threatening or lead to graft rejection. Their prevention is an important challenge. Despite specific national recommendations, vaccination is underutilized. That is why we propose a dedicated infectious diseases consultation during pre-kidney transplantation assessment.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The main objective of this study is to impove vaccine coverage before kidney transplantation.
Enrollment was based on the waiting list for a kidney transplant. Patients newly listed are invited to participate by the transplant team (nephrology department) ; for those that are already registered, a notification letter is sent to their home.
All patients included must :
-
complete a health questionnaire
-
take a blood test at day 0 : viral, bacterial and parasitic serologies, QuantiFERON-TB
-
take a chest X-ray and dental panoramic Patients randomized in interventional group will be seen in specific infectious diseases consultation at Clermont Ferrand Hospital. A letter of recommendations is sent to nephrologist for patients randomized in group control.
The primary study endpoint (immunization coverage) is evaluated at 6 months.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Stronger pre-transplant check-up routine patient management + specific infectious diseases consultation |
Other: Specific infectious diseases consultation
Specific infectious diseases consultation at Clermont Ferrand Hospital with a specialist doctor :
Update vaccinations
Advice to travelers
Diagnostic and treatment of latent tuberculosis infection
|
| No Intervention: Standard pre-transplant check-up routine patient management + letter sent to nephrologist |
Outcome Measures
Primary Outcome Measures
- Vaccination coverage [Month 6]
The percentage of fully immunized patients according to the Recommendations of High Council for public Health
Secondary Outcome Measures
- Infectious complications [within the 6 months of the transplantation]
Infectious diseases which require special management (hospitalization, anti-infective treatments)
- Mortality [Month 6]
Mortality after kidney transplantation
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patient over 18
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On the waiting list for kidney transplantation at Clermont-Ferrand
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Free and informed consent
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Affiliation to a social security system
Exclusion Criteria:
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Patient under 18
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Protected adults (individuals under guardianship by court order
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Pregnant and nursing women
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Prior graft (solid organs or hematopoietic stem cells)
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Absence of consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CHU de Clermont-Ferrand | Clermont-Ferrand | France | 63000 |
Sponsors and Collaborators
- University Hospital, Clermont-Ferrand
Investigators
- Principal Investigator: Olivier Lesens, CHU de Clermont-Ferrand
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RBHP 2019 LESENS
- 2019-A02304-53