Effects of Joint Effusion on Quadriceps Muscle

• Sponsor: The Catholic University of Korea (Other)
• Overall Status: Completed
• CT.gov ID: NCT01314820
• Collaborator: (none)
• Enrollment: 40
• Location: 1
• Arms: 2
• Duration (Months): 12
• Patients Per Site Per Month: 3.3

Study Details

Study Description

Brief Summary

The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

Condition or Disease	Intervention/Treatment	Phase
Knee Osteoarthritis	Other: normal saline injection; Other: sham injection	N/A

Detailed Description

Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Study Design

• Study Type: Interventional
• Actual Enrollment: 40 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Investigator)
• Primary Purpose: Basic Science
• Official Title: Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis
• Study Start Date: Jun 1, 2009
• Actual Primary Completion Date: Jan 1, 2010
• Actual Study Completion Date: Jun 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: normal saline injection 20 cc normal saline injection into the knee joint	Other: normal saline injection; 20 cc normal saline injection into knee joint; Other Names: normal saline
Sham Comparator: sham injection knee injection without saline	Other: sham injection; no saline injection; Other Names: no normal saline

Outcome Measures

Primary Outcome Measures

1. the peak torque of the knee extensors [within 5 minutes after intervention]

   to evaluate the effect of effusion on the peak torque of the knee extensors

Secondary Outcome Measures

1. the root mean square values of the vastus medialis and vastus lateralis muscles [within 5 minutes after intervention]

   to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles

Eligibility Criteria

Criteria

• Ages Eligible for Study: 50 Years to 75 Years
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• 50 years old or older with knee osteoarthritis

• knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria:

• the presence of knee joint effusion determined using US

• a history of knee injury or surgery

• a history of knee injection within 3 months

• a history of inflammatory arthritis

• taking anticoagulants

• balance or gait disturbance

• diabetes mellitus

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea	Seoul		Korea, Republic of	137-701

Sponsors and Collaborators

• The Catholic University of Korea

Investigators

• Study Director: Jongin Lee, M.D, Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Study Documents (Full-Text)

None provided.

More Information

Publications

• Fahrer H, Rentsch HU, Gerber NJ, Beyeler C, Hess CW, Grünig B. Knee effusion and reflex inhibition of the quadriceps. A bar to effective retraining. J Bone Joint Surg Br. 1988 Aug;70(4):635-8.
• Jones DW, Jones DA, Newham DJ. Chronic knee effusion and aspiration: the effect on quadriceps inhibition. Br J Rheumatol. 1987 Oct;26(5):370-4.
• Rice D, McNair PJ, Dalbeth N. Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling. Arthritis Rheum. 2009 Jan 15;61(1):78-83. doi: 10.1002/art.24168.

• ClinicalTrials.gov Identifier: NCT01314820
• Other Study ID Numbers: KC09OISI0161
• First Posted: Mar 15, 2011
• Last Update Posted: Mar 15, 2011
• Last Verified: Jan 1, 2010

• Keywords provided by , ,: Knee; Osteoarthritis; Effusion.
• Additional relevant MeSH terms: Osteoarthritis; Osteoarthritis, Knee; Hydrarthrosis

Study Results

No Results Posted as of Mar 15, 2011