Knee Osteoarthritis, Aging and Metabolic Syndrome

Sponsor

Sohag University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05955573

Collaborator

(none)

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis

Condition or Disease	Intervention/Treatment	Phase
Knee Osteoarthritis	Diagnostic Test: xray

Detailed Description

Place of the study: Sohag university hospital.
Type of study: Cross-Sectional Observational study
Study period: Six months to one year The study will include Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA .

The following details will be obtained:

Demographic data : Age ,Sex ,Marital status ,Occupation ,Residence ,Education level

,Anthropometrical measures which included waist circumference (WC) and blood pressure (BP) will be obtained,History of chronic diseases (eg; Diabetes mellites, Hypertension)

Clinical information: Symptom and its Duration. Plain radiographs of at least one knee [anteroposterior (A/P), lateral} will be taken.
Laboratory findings included fasting blood sugar, serum levels of triglycerides, High-density lipoprotein cholesterol and total cholesterol.

Study Design

Study Type:

Observational [Patient Registry]

Anticipated Enrollment :

50 participants

Observational Model:

Case-Only

Time Perspective:

Cross-Sectional

Official Title:

What Affects the Severity of Knee Osteoarthritis? Aging or Associated Metabolic Syndrome

Anticipated Study Start Date :

Aug 1, 2023

Anticipated Primary Completion Date :

Jun 1, 2024

Anticipated Study Completion Date :

Aug 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
knee osteoarthritis Knee osteoarthritis	Diagnostic Test: xray radiological description

Arm

Intervention/Treatment

knee osteoarthritis

Knee osteoarthritis

Diagnostic Test: xray

radiological description

Outcome Measures

Primary Outcome Measures

severity of knee osteoarthritis [8/2023-8/2024]
Kellgren and Lawrence (K/L) grading system of Knee osteoarthritis. It assigned a grade from 0 to 4, which they correlated to increasing severity of OA, with Grade 0 signifying no presence of OA and Grade 4 signifying severe OA .

Eligibility Criteria

Criteria

Ages Eligible for Study:

30 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA and had symptomatic OA of at least 1 knee (index knee), with a Kellgren / Lawrence (K/L) score ≥ 1 in that knee

Exclusion Criteria:

Any patient with a history of trauma to the knee
Any other form of arthritis (e.g., rheumatoid arthritis, seronegative spondyloarthropathies, gout, pyrophosphate disease, or other crystal arthropathy)