Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Sponsor

National Cancer Institute (NCI) (NIH)

Overall Status

Completed

CT.gov ID

NCT00049569

Collaborator

(none)

126

Enrollment

Location

Arms

Study Details

Study Description

Brief Summary

Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. Combining more than one chemotherapy drug with imatinib mesylate may kill more cancer cells. Randomized phase II trial to study the effectiveness of combination chemotherapy and imatinib mesylate in treating children who have relapsed acute lymphoblastic leukemia.

Condition or Disease	Intervention/Treatment	Phase
L1 Childhood Acute Lymphoblastic Leukemia L2 Childhood Acute Lymphoblastic Leukemia Non-T, Non-B Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Lymphoblastic Leukemia T-cell Childhood Acute Lymphoblastic Leukemia	Drug: cytarabine Drug: methotrexate Drug: vincristine sulfate Drug: prednisone Drug: pegaspargase Drug: doxorubicin hydrochloride Drug: imatinib mesylate Drug: cyclophosphamide Drug: etoposide Biological: filgrastim Drug: leucovorin calcium Drug: asparaginase Drug: therapeutic hydrocortisone	N/A

Detailed Description

PRIMARY OBJECTIVES:

To assess the feasibility and safety of using an intensified sequential induction regimen to treat children with acute lymphoblastic leukemia (ALL), who experience an isolated, or combined bone marrow relapse.
To determine the potential of this regimen to serve, as a backbone, for the future testing of novel therapeutic agents.

SECONDARY OBJECTIVES:

To estimate the remission re-induction rates and four-month event-free survival (EFS) for children, stratified by the duration of first remission.
To determine the feasibility of measuring minimal residual disease (MRD) quantitatively in all patients at time points throughout re-induction, and to correlate post-remission events with disease burden during induction.
To use deoxyribonucleic acid (DNA) arrays to characterize patterns of gene expression that predict treatment failure, and to compare gene expression profiles at the time of relapse with those at the time of initial diagnosis to gain an understanding of the pathways that may be involved in disease recurrence.
To determine the feasibility of combining intensive re-induction therapy with imatinib mesylate (STI571) for children with a relapse of Philadelphia chromosome positive (Ph+) ALL.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I:

Treatment Block 1: Patients receive cytarabine intrathecally (IT) on day 1 and methotrexate IT on days 15 and 29. Patients also receive vincristine intravenously (IV) on days 1, 8, 15, and 22; prednisone orally (PO) twice or thrice daily (BID or TID) on days 1-29; pegaspargase intramuscularly (IM) on days 2, 8, 15, and 22; and doxorubicin IV over 15 minutes on day 1. Ph-positive patients also receive imatinib mesylate PO on days 1-14.

Treatment Block 2: Patients receive methotrexate IT on days 1 and 22, cyclophosphamide IV over 30 minutes and etoposide IV over 2 hours on days 1-5, and filgrastim (G-CSF) subcutaneously (SC) beginning on day 6 and continuing until blood counts recover. Patients also receive methotrexate IV over 24 hours on day 22 followed by leucovorin calcium IV every 6 hours on days 24 and 25. Ph-positive patients receive imatinib mesylate PO on days 1-14.

Treatment Block 3a (Ph-negative patients): Patients receive cytarabine IV over 3 hours every 12 hours on days 1, 2, 8, and 9, asparaginase IM on days 2 and 9, and G-CSF SC beginning on day 10 and continuing until blood counts recover.

Treatment Block 3b (Ph-positive patients): Patients receive cytarabine IV over 3 hours every 12 hours on days 1 and 2, asparaginase IM on day 2, and G-CSF SC beginning on day 3 and continuing until blood counts recover. Patients also receive imatinib mesylate PO on days 1-14.

ARM II:

Treatment Block 1: Patients receive cytarabine IT on day 1 and then methotrexate, cytarabine and hydrocortisone IT (triple intrathecal therapy; TIT) on days 8, 15, 22, and 29. Vincristine, prednisone, pegaspargase, doxorubicin, and imatinib mesylate are administered as in arm I.

Treatment Block 3: Patients receive cytarabine, asparaginase, G-CSF, and imatinib mesylate as in arm I.

Treatment Block 2: Patients receive TIT on days 1 and 22. Patients then receive cyclophosphamide, etoposide, G-CSF, methotrexate IV, leucovorin calcium, and imatinib mesylate as in arm I. After each block is completed, disease is assessed. The next block is started on day 36 if blood counts have recovered and marrow during block 1 is at least M2/M3. Patients are removed from protocol therapy if disease progresses, unacceptable toxicity occurs, marrow is M2/M3 at day 15 of the second administered block of treatment, or cerebrospinal fluid blasts persist after 6 weekly doses of TIT.

After completion of study treatment, patients are followed up for 4 months.

PROJECTED ACCRUAL: A total of 63-126 patients will be accrued for this study within 14 months.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

126 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Intensive Induction Therapy for Children With Acute Lymphoblastic Leukemia (ALL) Who Experience a Bone Marrow Relapse

Study Start Date :

Jan 1, 2003

Actual Primary Completion Date :

Mar 1, 2006

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm I See detailed description.	Drug: cytarabine Given IT Drug: methotrexate Given IT Drug: vincristine sulfate Given IV Drug: prednisone Given PO Drug: pegaspargase Given IM Drug: doxorubicin hydrochloride Given IV Drug: imatinib mesylate Given PO Drug: cyclophosphamide Given IV Drug: etoposide Given IV Biological: filgrastim Given SC Drug: leucovorin calcium Given IV Drug: asparaginase Given IM
Experimental: Arm II See detailed description.	Drug: cytarabine Given IT Drug: methotrexate Given IT Drug: vincristine sulfate Given IV Drug: prednisone Given PO Drug: pegaspargase Given IM Drug: doxorubicin hydrochloride Given IV Drug: imatinib mesylate Given PO Drug: cyclophosphamide Given IV Drug: etoposide Given IV Biological: filgrastim Given SC Drug: leucovorin calcium Given IV Drug: asparaginase Given IM Drug: therapeutic hydrocortisone Given IT

Arm

Intervention/Treatment

Experimental: Arm I

See detailed description.

Drug: cytarabine

Given IT

Drug: methotrexate

Given IT

Drug: vincristine sulfate

Given IV

Drug: prednisone

Given PO

Drug: pegaspargase

Given IM

Drug: doxorubicin hydrochloride

Given IV

Drug: imatinib mesylate

Given PO

Drug: cyclophosphamide

Given IV

Drug: etoposide

Given IV

Biological: filgrastim

Given SC

Drug: leucovorin calcium

Given IV

Drug: asparaginase

Given IM

Experimental: Arm II

See detailed description.

Drug: cytarabine

Given IT

Drug: methotrexate

Given IT

Drug: vincristine sulfate

Given IV

Drug: prednisone

Given PO

Drug: pegaspargase

Given IM

Drug: doxorubicin hydrochloride

Given IV

Drug: imatinib mesylate

Given PO

Drug: cyclophosphamide

Given IV

Drug: etoposide

Given IV

Biological: filgrastim

Given SC

Drug: leucovorin calcium

Given IV

Drug: asparaginase

Given IM

Drug: therapeutic hydrocortisone

Given IT

Outcome Measures

Primary Outcome Measures

Feasibility assessed by excessive early deaths, induction failures, and early relapses [Up to 4 months]
Toxicity assessed using CTC version 2.0 [Up to 4 months]
Will be tabulated in detail.

Secondary Outcome Measures

Overall remission reinduction (CR2) rate [Up to 4 months]
EFS [4 months]
The Kaplan-Meier method will be used.
MRD [Up to 4 months]
The percentage of MRD positive patients will be estimated at the end of each block. Cox regression will be utilized to correlate MRD values with EFS.
Feasibility of combining intensive re-induction therapy with imatinib mesylate [Up to 4 months]
Will be determined using descriptive statistics due to the small sample size.
Percentage of patients who were able to complete the triple re-induction therapy with imatinib mesylate [Up to 4 months]
Will be estimated.

Eligibility Criteria

Criteria

Ages Eligible for Study:

1 Year to 21 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients with acute lymphoblastic leukemia (ALL) in first relapse involving the bone marrow (M3 marrow), with or without associated extramedullary disease; this includes patients who are Philadelphia chromosome-positive
Shortening fraction of >= 28% by echocardiogram, or ejection fraction of >= 50% by gated radionuclide study
Cumulative prior anthracycline exposure of =< 350 mg/m^{2 (each 10 mg/m}2 dose of idarubicin should be calculated as the isotoxic equivalent of 50 mg/m^2 of daunorubicin or adriamycin)
All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Exclusion Criteria:

Patients with B-cell ALL (L3 morphology or evidence of myc translocation by molecular or cytogenetic technique) are not eligible
Patients with Down syndrome are excluded due to the administration of methotrexate in Block 2
Patients who have undergone prior stem cell transplantation (SCT) are ineligible if:
They received SCT less than 12 months prior to study entry
They are still receiving immunosuppression for the treatment of graft-versus-host disease (GVHD)
They have active fungal infection at time of study entry
They have had invasive filamentous fungal infection at any time post-SCT
Pregnant or lactating females are ineligible as the medications used in this protocol could be harmful to unborn children and infants
Patients with prior isolated extramedullary relapse are ineligible