Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
Study Details
Study Description
Brief Summary
The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The objective of this proposal is to adapt photoacoustic tomography (PAT), a novel, nonionizing, noninvasive, laser-based technology, for structural and functional imaging of human peripheral joints affected by inflammatory arthritis.
Combining the advantages of both light and ultrasound scanning, PAT holds promise to present objective optical information in subsurface joint tissues with high sensitivity and high spatial resolution.
This could be of considerable help in the early detection of inflammatory joint diseases. PAT may also prove useful in further understanding the pathophysiology of these disorders and assisting with therapeutic decisions, including assessment of new pharmacological therapies.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Rheumatoid Arthritis Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound |
Procedure: Laser Based Photoacoustic Tomography, MRI, Ultrasound
Healthy subjects will have scans on finger joints with any of the scanning methods described above.
Other Names:
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| Normal controls Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand |
Procedure: laser based photoacoustic tomography, MRI, ultrasound
Subjects with arthritis will have scans on finger joints with any of the scanning methods described above.
Other Names:
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Outcome Measures
Primary Outcome Measures
- Photoacoustic Imaging [2 weeks]
To determine if photoacoustic imaging (PAT) can accurately assist in the diagnosis of chronic rheumatoid arthritis
Eligibility Criteria
Criteria
Inclusion Criteria:
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Men and women 18 years of age through age 60 can participate in this study.
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Patients can participate in this study if they have had rheumatoid arthritis for more than 2 years and their rheumatologist has referred them to this study.
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Patients can participate as a healthy volunteer with a known history of rheumatoid arthritis.
Exclusion Criteria:
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Patients, who have electrically, magnetically or mechanically activated implants such as heart pacemaker, magnetic surgical clips, prostheses or implanted neurological stimulator.
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Pregnant patients.
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Patients who is claustrophobic.
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Patients with impaired renal function cannot participate in this study such as elevate creatinine clearance, patients on kidney dialysis etc.
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Patients with shock hypotension or unstable low blood pressure.
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Patients with Rhabdomyolysis.
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Patients who have had a contrast enhanced (with gadolinium) MRA (magnetic resonance angiography)/ or MRI within the last 3 months. (Contrast is a medication injected into a vein during a imaging examination that helps produce clearer images/pictures).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Universtity of Michigan Health System | Ann Arbor | Michigan | United States | 48109 |
Sponsors and Collaborators
- University of Michigan
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Investigators
- Principal Investigator: Xueding Wang, Ph.D, University of Michigan
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HUM00003693
- R01AR060350