LIPSP: Lebanese Interhospital Pneumococcal Surveillance Program

Sponsor

American University of Beirut Medical Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT00901602

Collaborator

PneumoADIP (Other)

300

Enrollment

Location

120

Duration (Months)

2.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection. There are many types of these bacteria defined by the type of sugar coat that they have. These are classified as serotypes. There are common serotypes that cause severe disease and are preventable by vaccination of children. Other less common types are more difficult to prevent. The investigators aim to determine the serotypes that cause invasive pneumococcal disease in Lebanon and to study their sensitivity to different antibiotics. The investigators will collect bacterial isolates from different hospitals in Lebanon isolated from the blood or spinal fluid of patients with invasive pneumococcal disease. This information will help the investigators determine the usefulness of available pneumococcal vaccines in preventing these infections. The data will be distributed to all primary care physicians treating children in Lebanon and will be shared with the Ministry of Health.

Condition or Disease	Intervention/Treatment	Phase
Pneumonia Meningitis Sepsis Bacteremia

Study Design

Study Type:

Observational

Anticipated Enrollment :

300 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Lebanese Interhospital Pneumococcal Surveillance Program (LIPSP)

Study Start Date :

Oct 1, 2004

Anticipated Primary Completion Date :

Oct 1, 2013

Anticipated Study Completion Date :

Oct 1, 2014

Outcome Measures

Primary Outcome Measures

Serotype prevalence of S. pneumoniae in invasive pneumococcal disease [yearly]

Secondary Outcome Measures

Determine the antibiotic sensitivity of S. pneumoniae and the association with specific serotypes [yearly]

Eligibility Criteria

Criteria

Ages Eligible for Study:

1 Day and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Samples included in the study are those that are:
culture proven
invasive pneumococcal infections
in patients of all ages admitted to different hospitals all over Lebanon
Acceptable samples include:
positive isolates from blood
cerebrospinal fluid
other normally sterile body sites such as empyema fluid, abscesses, joint fluid, middle ear fluid obtained by tympanocentesis in the operating room, and lung needle aspiration