Combination Study of GSK1120212 With Gemcitabine in Subjects With Solid Tumors

Sponsor

GlaxoSmithKline (Industry)

Overall Status

Completed

CT.gov ID

NCT01428427

Collaborator

(none)

Enrollment

Locations

Arm

23.2

Actual Duration (Months)

15.5

Patients Per Site

0.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

MEK112111 is a dose-escalation, Phase IB, open-label, single-arm, multi-center study. The primary objective of the study is to determine the recommended dose and regimen for the orally administered MEK inhibitor GSK1120212 dosed in combination with gemcitabine in subjects with solid tumors.

Condition or Disease	Intervention/Treatment	Phase
Leukaemia, Myelocytic, Acute	Drug: GSK1120212 Drug: Gemcitabine	Phase 1

Detailed Description

Subjects will be enrolled using a dose-escalation procedure in which the initial cohort receives a fraction of the GSK1120212 dose that achieved a dose limiting toxicity in a previous study and the recommended dose of gemcitabine. Escalation will proceed until the maximum tolerated doses are identified. These doses will be selected based on emerging safety data. Confirmation of the tolerability of the Recommended Phase II Dose (RP2D) will be explored in approximately 12 subjects. Subjects will continue on treatment until treatment discontinuation criteria are met (disease progression, intercurrent illness, adverse event or consent withdrawal).

Study Design

Study Type:

Interventional

Actual Enrollment :

31 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase IB Combination Study of MEK Inhibitor GSK1120212 With Gemcitabine in Subjects With Solid Tumors

Actual Study Start Date :

Aug 12, 2009

Actual Primary Completion Date :

Jul 18, 2011

Actual Study Completion Date :

Jul 18, 2011

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Cohort Dose escalation to maximum tolerated dose of GSK1120212 and Gemcitabine.	Drug: GSK1120212 Continuous daily oral dosing while on study or disease progression (cycle = 28 days). Drug: Gemcitabine Dosing once weekly for 3 weeks in a 28 day cycle until disease progression.

Arm

Intervention/Treatment

Experimental: Cohort

Dose escalation to maximum tolerated dose of GSK1120212 and Gemcitabine.

Drug: GSK1120212

Continuous daily oral dosing while on study or disease progression (cycle = 28 days).

Drug: Gemcitabine

Dosing once weekly for 3 weeks in a 28 day cycle until disease progression.

Outcome Measures

Primary Outcome Measures

Adverse events (AEs) and changes in laboratory values and vital signs. [From date of randomization until withdrawal from the study due to disease progression, AE, withdrawal of consent or study closure approximately 6 months after last subject was randomized.]

Secondary Outcome Measures

Tumor response as assessed by Response Evaluation Criteria In Solid Tumors (RECIST) v 1.1 [At screening and every 8 weeks until withdrawal from the study due to disease progression, AE, withdrawal of consent or study closure approximately 6 months after last subject was randomized.]
drug levels in blood [first 15 days on study]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
Age 18 years old or older and able to swallow oral medication.
Performance Status score of 0 or 1 according to the Eastern Cooperative Oncology (ECOG) scale.
Histologically or cytologically confirmed diagnosis of a solid tumor malignancy that is either relapsed or refractory, or potentially responsive to gemcitabine.
Tumor Type criteria as listed in protocol.
Male subjects must agree to use one of the contraception methods listed in protocol.
A female subject is eligible to participate if she is of non-childbearing potential as defined in the protocol or postmenopausal as defined in the protocol. If of child-bearing potential, she agrees to use protocol specified contraceptive methods
Adequate organ system function as defined below in the protocol.

Exclusion Criteria:

Chemotherapy, radiotherapy, or immunotherapy within 28 days (or 42 days for prior nitrosoureas or mitomycin C) prior to the first dose of GSK1120212.
Use of an investigational anti-cancer drug within 28 days or five half-lives, whichever is shorter preceding the first dose of GSK1120212 - as long as a minimum of 14 days has passed between the last dose of the prior investigational anti-cancer drug and the first dose of GSK1120212.
History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.
Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to the study drug, dimethy sulfoxide (DMSO), or excipients (See protocol)
Use of a prohibited medication (as defined in protocol) or current use of anticoagulants (e.g. warfarin, heparin, low molecular weight heparin) at therapeutic levels. Low dose (prophylactic) anticoagulants are permitted provided that subject's prothrombin time (PT) and partial thromboplastin time (PTT) meet entry criteria.
Gastrointestinal disease predicted to interfere with absorption of an oral drug.
History of retinal vein occlusion (RVO) or central serous retinopathy.
Visible retinal pathology as assessed by ophthalmologic exam that is considered a risk factor for retinal vein thrombosis.
Glaucoma diagnosed within one month prior to study day 1.
Intraocular pressure > 21mm Hg as measured by tonography.
Symptomatic or untreated leptomeningeal or brain metastases or spinal cord compression. Subjects previously treated for these conditions that are asymptomatic and off corticosteroids for at least two months are permitted. Subjects are not permitted to receive enzyme inducing anti-epileptic drugs (EIAEDs).
Unresolved toxicity greater than common terminology criteria for adverse events (CTCAE v4.0) grade 1 from previous anti-cancer therapy.
History of acute coronary within the past 24 weeks.
QTc interval greater than or equal to 480 mili seconds (msecs).
Class II, III, or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system.
Pregnant or lactating female.
History of hepatitis B or C. NOTE: Subjects with evidence of cleared hepatitis B infection are permitted [Hepatitis B Surface Antigen (HBsAg) negative, anti-HBsAg positive and anti Hepatitis B core antigen (HBc) positive.]