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Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

Sponsor
Children's Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00005977
Collaborator
National Cancer Institute (NCI) (NIH)
83
Enrollment
119
Locations
5
Arms
72
Duration (Months)
0.7
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have non-Hodgkin's lymphoma or acute lymphocytic leukemia.

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

OBJECTIVES:

  • Determine if increasing the methotrexate dose in combination with standard treatment is feasible in patients with advanced small noncleaved cell non-Hodgkin's lymphoma or B-cell acute lymphocytic leukemia.

  • Assess the toxicity of this intensified therapy in these patients.

  • Assess the feasibility of treating these patients that have CNS disease at diagnosis with this intensified therapy plus etoposide and ifosfamide.

  • Assess toxicities and late effects of this intensive therapy on the central nervous system, cardiac function, and fertility in these patients.

OUTLINE: This is a multicenter study. Patients are stratified according to stage and disease (stage III non-Hodgkin's lymphoma (NHL) vs stage IV NHL with no CNS involvement vs stage IV NHL with CNS involvement vs B-cell acute lymphocytic leukemia (B-ALL) with no CNS involvement vs B-ALL with CNS involvement).

Patients receive methotrexate and cytarabine intrathecally on days 1, 4, 11, and 36 (on day 40 for patients with stage IV NHL or B-ALL only) in combination with alternating courses of:

  1. cyclophosphamide IV every 12 hours for a total of six doses on days 1-3, doxorubicin IV over 30 minutes on day 4, vincristine IV on days 4 and 11, dexamethasone IV or orally twice daily on days 1-5, and filgrastim (G-CSF) subcutaneously (SQ) or IV over 30 minutes beginning on day 5 and continuing until blood counts recover and B) methotrexate IV over 24 hours on day 18, methotrexate intrathecally on day 18, dexamethasone IV or orally twice daily on days 18-22, leucovorin calcium IV or orally every 6 hours for a total of 6 doses on days 20-21, cytarabine IV over 48 hours on days 20-21, and G-CSF SQ or IV over 30 minutes beginning on day 22 and continuing until blood counts recover. Patients with stage III NHL receive at total of 5 courses of treatment (A-B-A-B-A) and patients with stage IV NHL or B-ALL with no CNS involvement receive a total of 6 courses of treatment (A-B-A-B-A-B).

Patients with CNS involvement receive a third course of treatment: C) etoposide IV over 1 hour on days 36-40, ifosfamide IV over 1 hour on days 36-40, oral dexamethasone twice daily on days 36-40, and G-CSF SQ or IV over 30 minutes beginning on day 41 and continuing until blood counts recover. Patients with CNS involvement receive a total of 7 courses of treatment (A-B-C-A-B-A-B).

Patients are followed every 6 months for 4 years and then annually thereafter.

PROJECTED ACCRUAL: A total of 27-80 patients will be accrued for this study over 24 months.

Study Design

Study Type:
Interventional
Actual Enrollment :
83 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Pilot Study of Dose Intensification of Methotrexate in Patients With Advanced-Stage (III/IV) Small Non-Cleaved Cell Non-Hodgkins Lymphoma and B-Cell All
Study Start Date :
Sep 1, 2000
Actual Primary Completion Date :
Mar 1, 2004
Actual Study Completion Date :
Sep 1, 2006

Arms and Interventions

Arm Intervention/Treatment
Experimental: STAGE III NHL (Trt 1)

A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. Treatment ABABA

Biological: filgrastim
Given IV
Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

    • Drug: cyclophosphamide
    Given IV
    Other Names:
  • CTX
  • Cytoxan
  • NSC #26271
  • IND #7089

    • Drug: cytarabine
    Given IV
    Other Names:
  • cytosine arabinoside
  • Ara-C
  • Cytosar
  • NSC #638

    • Drug: dexamethasone
    Given IV
    Other Names:
  • DECADRON
  • NSC #034521

    • Drug: doxorubicin hydrochloride
    Given IV
    Other Names:
  • Adriamycin
  • NSC #123127
  • IND #7038

    • Drug: leucovorin calcium
    Given IV
    Other Names:
  • LCV
  • Wellcovorin
  • citrovorum factor
  • folinic acid
  • NSC #3590

    • Drug: methotrexate
    Given IV
    Other Names:
  • MTX
  • amethopterin
  • NSC #740
  • IND #4291

    • Drug: vincristine sulfate
    Given IV
    Other Names:
  • VCR
  • Oncovin
  • NSC #67574
  • IND #7161

    		•
    Experimental: STAGE IV NHL, -CNS (Trt 2)

    A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. Treatment ABABAB

    Biological: filgrastim
    Given IV
    Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

    • Drug: cyclophosphamide
    Given IV
    Other Names:
  • CTX
  • Cytoxan
  • NSC #26271
  • IND #7089

    • Drug: cytarabine
    Given IV
    Other Names:
  • cytosine arabinoside
  • Ara-C
  • Cytosar
  • NSC #638

    • Drug: dexamethasone
    Given IV
    Other Names:
  • DECADRON
  • NSC #034521

    • Drug: doxorubicin hydrochloride
    Given IV
    Other Names:
  • Adriamycin
  • NSC #123127
  • IND #7038

    • Drug: leucovorin calcium
    Given IV
    Other Names:
  • LCV
  • Wellcovorin
  • citrovorum factor
  • folinic acid
  • NSC #3590

    • Drug: methotrexate
    Given IV
    Other Names:
  • MTX
  • amethopterin
  • NSC #740
  • IND #4291

    • Drug: vincristine sulfate
    Given IV
    Other Names:
  • VCR
  • Oncovin
  • NSC #67574
  • IND #7161

    		•
    Experimental: STAGE IV, +CNS (Trt 3)

    A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. C: Etoposide, Ifosfamide, Dexamethasone IT Therapy. Treatment ABCABAB

    Biological: filgrastim
    Given IV
    Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

    • Drug: cyclophosphamide
    Given IV
    Other Names:
  • CTX
  • Cytoxan
  • NSC #26271
  • IND #7089

    • Drug: cytarabine
    Given IV
    Other Names:
  • cytosine arabinoside
  • Ara-C
  • Cytosar
  • NSC #638

    • Drug: dexamethasone
    Given IV
    Other Names:
  • DECADRON
  • NSC #034521

    • Drug: doxorubicin hydrochloride
    Given IV
    Other Names:
  • Adriamycin
  • NSC #123127
  • IND #7038

    • Drug: etoposide
    Given IV
    Other Names:
  • VP-16
  • VePesid
  • NSC #141540
  • IND #9197

    • Drug: ifosfamide
    Given IV
    Other Names:
  • IFX
  • IFOS
  • NSC #109724
  • IND #7887

    • Drug: leucovorin calcium
    Given IV
    Other Names:
  • LCV
  • Wellcovorin
  • citrovorum factor
  • folinic acid
  • NSC #3590

    • Drug: methotrexate
    Given IV
    Other Names:
  • MTX
  • amethopterin
  • NSC #740
  • IND #4291

    • Drug: vincristine sulfate
    Given IV
    Other Names:
  • VCR
  • Oncovin
  • NSC #67574
  • IND #7161

    		•
    Experimental: B-ALL, -CNS (Trt 2)

    A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. Treatment ABABAB

    Biological: filgrastim
    Given IV
    Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

    • Drug: cyclophosphamide
    Given IV
    Other Names:
  • CTX
  • Cytoxan
  • NSC #26271
  • IND #7089

    • Drug: cytarabine
    Given IV
    Other Names:
  • cytosine arabinoside
  • Ara-C
  • Cytosar
  • NSC #638

    • Drug: dexamethasone
    Given IV
    Other Names:
  • DECADRON
  • NSC #034521

    • Drug: doxorubicin hydrochloride
    Given IV
    Other Names:
  • Adriamycin
  • NSC #123127
  • IND #7038

    • Drug: leucovorin calcium
    Given IV
    Other Names:
  • LCV
  • Wellcovorin
  • citrovorum factor
  • folinic acid
  • NSC #3590

    • Drug: methotrexate
    Given IV
    Other Names:
  • MTX
  • amethopterin
  • NSC #740
  • IND #4291

    • Drug: vincristine sulfate
    Given IV
    Other Names:
  • VCR
  • Oncovin
  • NSC #67574
  • IND #7161

    		•
    Experimental: B-ALL, +CNS (Trt 3)

    A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. C: Etoposide, Ifosfamide, Dexamethasone IT Therapy. Treatment ABCABAB

    Biological: filgrastim
    Given IV
    Other Names:
  • GRANULOCYTE COLONY-STIMULATING FACTOR
  • r-metHuG-CSF
  • G-CSF
  • Neupogen
  • NSC #614629

    • Drug: cyclophosphamide
    Given IV
    Other Names:
  • CTX
  • Cytoxan
  • NSC #26271
  • IND #7089

    • Drug: cytarabine
    Given IV
    Other Names:
  • cytosine arabinoside
  • Ara-C
  • Cytosar
  • NSC #638

    • Drug: dexamethasone
    Given IV
    Other Names:
  • DECADRON
  • NSC #034521

    • Drug: doxorubicin hydrochloride
    Given IV
    Other Names:
  • Adriamycin
  • NSC #123127
  • IND #7038

    • Drug: etoposide
    Given IV
    Other Names:
  • VP-16
  • VePesid
  • NSC #141540
  • IND #9197

    • Drug: ifosfamide
    Given IV
    Other Names:
  • IFX
  • IFOS
  • NSC #109724
  • IND #7887

    • Drug: leucovorin calcium
    Given IV
    Other Names:
  • LCV
  • Wellcovorin
  • citrovorum factor
  • folinic acid
  • NSC #3590

    • Drug: methotrexate
    Given IV
    Other Names:
  • MTX
  • amethopterin
  • NSC #740
  • IND #4291

    • Drug: vincristine sulfate
    Given IV
    Other Names:
  • VCR
  • Oncovin
  • NSC #67574
  • IND #7161

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Event-free survival [1 year]

      Assess the effect of high dose methotrexate in combination with standard treatment per the POG 9317 protocol on 1-year event-free survival (EFS), monitor and assess toxicity, and estimate the hospitalization costs for the treatment of toxicity related side effects.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A to 22 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    DISEASE CHARACTERISTICS:

    • One of the following diagnoses:

    • Histologically confirmed small noncleaved cell non-Hodgkin's lymphoma

    • Stage III or IV

    • Burkitt's or non-Burkitt's by the Working Formulation OR

    • Burkitt's or Burkitt's-like by the REAL classification

    • Histologically confirmed B-cell acute lymphocytic leukemia

    • At least 25% blasts in bone marrow

    • FAB L3 morphology

    • FAB L1 morphology allowed if blasts show B-cell markers (CD19, 20, 22) and surface immunoglobulin positivity

    • Must be registered on POG-9900 in past 8 days

    PATIENT CHARACTERISTICS:
    Age:
    • Under 22 at time of diagnosis
    Performance status:
    • Not specified
    Life expectancy:
    • Not specified
    Hematopoietic:
    • Not specified
    Hepatic:
    • Not specified
    Renal:
    • Not specified
    Other:

    • Not pregnant or nursing

    • Negative pregnancy test

    • HIV positive allowed

    PRIOR CONCURRENT THERAPY:
    Biologic therapy:
    • Not specified
    Chemotherapy:
    • Not specified
    Endocrine therapy:
    • No concurrent use of dexamethasone as antiemetic
    Radiotherapy:
    • Not specified
    Surgery:
    • Prior surgery allowed
    Other:
    • No prior therapy except surgery

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Alabama at Birmingham Comprehensive Cancer Center Birmingham Alabama United States 35294-3300
    2 University of South Alabama Medical Center Mobile Alabama United States 36617-2293
    3 MBCCOP - Gulf Coast Mobile Alabama United States 36688
    4 Arizona Cancer Center Tucson Arizona United States 85724
    5 University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
    6 University of California San Diego Cancer Center La Jolla California United States 92093-0658
    7 Lucile Packard Children's Hospital at Stanford Palo Alto California United States 94304
    8 Sutter Cancer Center Sacramento California United States 95816
    9 University of California Davis Medical Center Sacramento California United States 95817
    10 Kaiser Permanente-Southern California Permanente Medical Group San Diego California United States 92120
    11 Children's Hospital and Health Center San Diego California United States 92123-4282
    12 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051-5386
    13 Yale Comprehensive Cancer Center New Haven Connecticut United States 06520-8028
    14 Walter Reed Army Medical Center Washington District of Columbia United States 20307-5000
    15 Broward General Medical Center Fort Lauderdale Florida United States 33316
    16 Children's Hospital of Southwest Florida Fort Myers Florida United States 33908
    17 Shands Hospital and Clinics, University of Florida Gainesville Florida United States 32610-100277
    18 Nemours Children's Clinic Jacksonville Florida United States 32207
    19 Sylvester Cancer Center, University of Miami Miami Florida United States 33136
    20 University of Miami-Jackson Memorial Hospital Medical Center Miami Florida United States 33136
    21 Miami Children's Hospital Miami Florida United States 33155
    22 Baptist Hospital of Miami Miami Florida United States 33176-2197
    23 Florida Hospital Cancer Institute Orlando Florida United States 32803
    24 All Children's Hospital St. Petersburg Florida United States 33701
    25 CCOP - Florida Pediatric Tampa Florida United States 33682-7757
    26 St. Mary's Hospital West Palm Beach Florida United States 33407
    27 Emory University Hospital - Atlanta Atlanta Georgia United States 30322
    28 Emory University School of Medicine Atlanta Georgia United States 30322
    29 Cancer Research Center of Hawaii Honolulu Hawaii United States 96813
    30 Tripler Army Medical Center Honolulu Hawaii United States 96859-5000
    31 Rush-Presbyterian-St. Luke's Medical Center Chicago Illinois United States 60612
    32 Children's Memorial Hospital, Chicago Chicago Illinois United States 60614
    33 Hope Children's Hospital Oak Lawn Illinois United States 60453
    34 CCOP - Illinois Oncology Research Association Peoria Illinois United States 61602
    35 Saint Jude Midwest Affiliate Peoria Illinois United States 61637
    36 University of Kansas Medical Center Kansas City Kansas United States 66160-7357
    37 CCOP - Wichita Wichita Kansas United States 67214-3882
    38 Via Christi Regional Medical Center Wichita Kansas United States 67214
    39 MBCCOP - LSU Health Sciences Center New Orleans Louisiana United States 70112
    40 Tulane University School of Medicine New Orleans Louisiana United States 70112
    41 CCOP - Ochsner New Orleans Louisiana United States 70121
    42 Eastern Maine Medical Center Bangor Maine United States 04401
    43 Maine Children's Cancer Program Portland Maine United States 04101
    44 Marlene & Stewart Greenebaum Cancer Center, University of Maryland Baltimore Maryland United States 21201
    45 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland United States 21231-2410
    46 Boston Floating Hospital Infants and Children Boston Massachusetts United States 02111
    47 Massachusetts General Hospital Cancer Center Boston Massachusetts United States 02114
    48 Dana-Farber Cancer Institute Boston Massachusetts United States 02115
    49 University of Massachusetts Memorial Medical Center Worcester Massachusetts United States 01655
    50 Children's Hospital of Michigan Detroit Michigan United States 48201
    51 St. John Hospital and Medical Center Detroit Michigan United States 48236
    52 Hurley Medical Center Flint Michigan United States 48503
    53 University of Mississippi Medical Center Jackson Mississippi United States 39216-4505
    54 Keesler Medical Center - Keesler AFB Keesler AFB Mississippi United States 39534-2576
    55 University of Missouri-Columbia Hospital and Clinics Columbia Missouri United States 65212
    56 Cardinal Glennon Children's Hospital Saint Louis Missouri United States 63104
    57 Washington University School of Medicine Saint Louis Missouri United States 63110
    58 Norris Cotton Cancer Center Lebanon New Hampshire United States 03756-0002
    59 CCOP - Northern New Jersey Hackensack New Jersey United States 07601
    60 Hackensack University Medical Center Hackensack New Jersey United States 07601
    61 University of New Mexico School of Medicine Albuquerque New Mexico United States 87131
    62 Roswell Park Cancer Institute Buffalo New York United States 14263-0001
    63 Schneider Children's Hospital New Hyde Park New York United States 11042
    64 Mount Sinai School of Medicine New York New York United States 10029
    65 University of Rochester Cancer Center Rochester New York United States 14642
    66 State University of New York Health Sciences Center - Stony Brook Stony Brook New York United States 11790-7775
    67 State University of New York - Upstate Medical University Syracuse New York United States 13210
    68 Mission Saint Joseph's Health System Asheville North Carolina United States 28801
    69 Carolinas Medical Center Charlotte North Carolina United States 28232-2861
    70 Presbyterian Healthcare Charlotte North Carolina United States 28233-3549
    71 Duke Comprehensive Cancer Center Durham North Carolina United States 27710
    72 East Carolina University School of Medicine Greenville North Carolina United States 27858-4354
    73 Comprehensive Cancer Center at Wake Forest University Winston-Salem North Carolina United States 27157-1082
    74 Oklahoma Memorial Hospital Oklahoma City Oklahoma United States 73126-0307
    75 Natalie Warren Bryant Cancer Center Tulsa Oklahoma United States 74136
    76 CCOP - Columbia River Program Portland Oregon United States 97213
    77 Legacy Emanuel Hospital and Health Center Portland Oregon United States 97227
    78 St. Christopher's Hospital for Children Philadelphia Pennsylvania United States 19134-1095
    79 Medical University of South Carolina Charleston South Carolina United States 29425-0721
    80 Children's Hospital of Greenville Hospital System Greenville South Carolina United States 29605
    81 James H. Quillen College of Medicine Johnson City Tennessee United States 37614-0622
    82 Saint Jude Children's Research Hospital Memphis Tennessee United States 38105-2794
    83 Driscoll Children's Hospital Corpus Christi Texas United States 78466
    84 Texas Oncology P.A. Dallas Texas United States 75230-2503
    85 Medical City Dallas Hospital Dallas Texas United States 75230
    86 Simmons Cancer Center - Dallas Dallas Texas United States 75235-9154
    87 Cook Children's Medical Center - Fort Worth Fort Worth Texas United States 76104
    88 University of Texas Medical Branch Galveston Texas United States 77555-0209
    89 Baylor College of Medicine Houston Texas United States 77030
    90 San Antonio Military Pediatric Cancer and Blood Disorders Center Lackland Air Force Base Texas United States 78236-5300
    91 MBCCOP - South Texas Pediatric San Antonio Texas United States 78229-3900
    92 University of Texas Health Science Center at San Antonio San Antonio Texas United States 78284-7811
    93 Scott and White Clinic Temple Texas United States 76508
    94 Vermont Cancer Center Burlington Vermont United States 05401-3498
    95 Cancer Center at the University of Virginia Charlottesville Virginia United States 22908
    96 Inova Fairfax Hospital Falls Church Virginia United States 22042-3300
    97 Naval Medical Center, Portsmouth Portsmouth Virginia United States 23708-2197
    98 Massey Cancer Center Richmond Virginia United States 23298-0037
    99 Carilion Roanoke Community Hospital Roanoke Virginia United States 24019
    100 Madigan Army Medical Center Tacoma Washington United States 98431-5000
    101 West Virginia University Medical School-Charleston Charleston West Virginia United States 25304
    102 West Virginia University Hospitals Morgantown West Virginia United States 26506-9300
    103 St. Vincent Hospital Green Bay Wisconsin United States 54307-3508
    104 Midwest Children's Cancer Center Milwaukee Wisconsin United States 53226
    105 Royal Children's Hospital Parkville Victoria Australia 3052
    106 Alberta Children's Hospital Calgary Alberta Canada T2T 5C7
    107 Cross Cancer Institute Edmonton Alberta Canada T6G 1Z2
    108 Children's Hospital Hamilton Ontario Canada L8N 3Z5
    109 Children's Hospital of Eastern Ontario Ottawa Ontario Canada K1H 8L1
    110 Hospital for Sick Children Toronto Ontario Canada M5G 1X8
    111 McGill University Health Center - Montreal Children's Hospital Montreal Quebec Canada H3H 1P3
    112 Hopital Sainte Justine Montreal Quebec Canada H3T 1C5
    113 Centre Hospitalier de L'Universite Laval Sainte Foy Quebec Canada GIV 4G2
    114 Laval University Medical Center Sainte-Foy Quebec Canada G1V 4G2
    115 Academisch Ziekenhuis Groningen Groningen Netherlands 9713 EZ
    116 San Jorge Childrens Hospital Santurce Puerto Rico 00912
    117 Swiss Pediatric Oncology Group Bern Bern Switzerland CH 3010
    118 Clinique de Pediatrie Geneva Switzerland 1211
    119 Centre Hospitalier Universitaire Vaudois Lausanne Switzerland CH-1011

    Sponsors and Collaborators

    • Children's Oncology Group
    • National Cancer Institute (NCI)

    Investigators

    • Study Chair: Hazem H. Mahmoud, MD, Carol G. Simon Cancer Center at Morristown Memorial Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Children's Oncology Group
    ClinicalTrials.gov Identifier:
    NCT00005977
    Other Study ID Numbers:
    • 9917
    • COG-9917
    • CDR0000067965
    First Posted:
    May 21, 2003
    Last Update Posted:
    Aug 21, 2013
    Last Verified:
    Aug 1, 2013
    Keywords provided by Children's Oncology Group
    childhood Burkitt lymphoma
    L3 childhood acute lymphoblastic leukemia
    B-cell childhood acute lymphoblastic leukemia
    L3 adult acute lymphoblastic leukemia
    B-cell adult acute lymphoblastic leukemia
    stage III adult Burkitt lymphoma
    stage IV adult Burkitt lymphoma
    stage III childhood small noncleaved cell lymphoma
    stage IV childhood small noncleaved cell lymphoma
    Additional relevant MeSH terms:
    Lymphoma
    Leukemia
    Lymphoma, Non-Hodgkin
    Leucovorin
    Cytarabine
    Dexamethasone
    Cyclophosphamide
    Ifosfamide
    Doxorubicin
    Liposomal doxorubicin
    Methotrexate
    Etoposide
    Vincristine
    Lenograstim
    Levoleucovorin

    Study Results

    No Results Posted as of Aug 21, 2013