Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome
Study Details
Study Description
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase III trial to study the effectiveness of combination chemotherapy in treating children who have Down syndrome and myeloproliferative disorder, acute myelogenous leukemia, or myelodysplastic syndrome.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 3 |
Detailed Description
OBJECTIVES:
-
Evaluate the efficacy of reduced-dose induction and intensification chemotherapy, in terms of remission rate, disease-free survival rate, and acute morbidity and mortality, in children with Down syndrome and acute myelogenous leukemia or myelodysplastic syndromes.
-
Define the understanding of the natural history of transient myeloproliferative disorder (TMD) in children with Down syndrome.
-
Determine whether there is a reduction of sequelae in long-term survivors after treatment with this regimen.
-
Determine the incidence of subsequent leukemia in patients with transient myeloproliferative disorder treated with this regimen.
-
Determine the predictive risk factors for developing subsequent leukemia in patients with transient myeloproliferative disorder treated with this regimen.
OUTLINE: This is a multicenter study.
-
Group I: Patients are observed if their transient myeloproliferative disorder (TMD) does not require intervention. Patients who require therapy for TMD undergo leukapheresis or exchange transfusion for up to 3 consecutive days. If the TMD does not resolve or there is significant organ involvement, patients receive low-dose cytarabine IV continuously on days 0-4. Treatment repeats at least every 2 weeks for up to 4 courses. Patients who experience a recurrence of TMD at least 8 weeks after resolution or have refractory disease may proceed to group II for further treatment.
-
Group II (closed to accrual as of 6/24/04 except for patients first enrolled in group I): Patients receive induction therapy comprising cytarabine IV continuously, daunorubicin IV continuously, and oral thioguanine twice daily on days 0-3. Treatment repeats every 28 days for 4 courses. Patients with no CNS disease at diagnosis receive cytarabine intrathecally (IT) on day 0. Patients with CNS disease at diagnosis receive cytarabine IT on days 0, 5, and 7. If CNS disease persists on day 7, patients receive up to 6 courses of cytarabine IT, hydrocortisone IT, and methotrexate IT, twice weekly beginning on day 10.
Patients who achieve remission after induction therapy receive 2 courses of intensification therapy, for approximately 4 months. During the first course, patients receive cytarabine IV over 3 hours twice daily on days 0, 1, 7, and 8. Patients also receive asparaginase intramuscularly on days 1 and 8. The second course of therapy comprises CNS prophylaxis. Patients with no CNS disease at diagnosis or whose CNS disease resolved by day 7 of induction therapy receive cytarabine IT on days 0, 7, and 14. Patients with persistent CNS disease on day 7 of induction therapy receive cytarabine IT, hydrocortisone IT, and methotrexate IT on days 0, 7, and 14.
Patients are followed monthly for 18 months, every 3 months for 1 year, every 6 months for 2.5 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 70 patients with acute myeloid leukemia or myelodysplastic syndromes will be accrued for this study within 3.2 years. A total of 88 patients with transient myeloproliferative disorder who enter remission will be accrued for this study within 5 years.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Arm A: TMD patients only Patients are observed if their transient myeloproliferative disorder (TMD) does not require intervention. Patients who require therapy for TMD undergo leukapheresis or exchange transfusion for up to 3 consecutive days. If the TMD does not resolve or there is significant organ involvement, patients receive low-dose cytarabine IV continuously on days 0-4. Treatment repeats at least every 2 weeks for up to 4 courses. Patients who experience a recurrence of TMD at least 8 weeks after resolution or have refractory disease may proceed to group II for further treatment. patients will continue to be followed for remission induction, EFS, DFS and OS regardless of the type of leukemia that develops. |
Drug: cytarabine
Given IT
Other Names:
|
Experimental: Arm B: AML/MDS patients only (closed to accrual as of 6/24/04 except for patients first enrolled in group I): Patients receive induction therapy comprising cytarabine IV continuously, daunorubicin hydrochloride IV continuously, and oral thioguanine twice daily on days 0-3. Treatment repeats every 28 days for 4 courses. Patients with no CNS disease at diagnosis receive cytarabine intrathecally (IT) on day 0. Patients with CNS disease at diagnosis receive cytarabine IT on days 0, 5, and 7. If CNS disease persists on day 7, patients receive up to 6 courses of cytarabine IT, therapeutic hydrocortisone IT, and methotrexate IT, twice weekly beginning on day 10. Asparaginase during Intensification 1 day 1 hour 18. |
Drug: asparaginase
Given IV
Other Names:
Drug: cytarabine
Given IT
Other Names:
Drug: daunorubicin hydrochloride
Given IV
Other Names:
Drug: methotrexate
Given IV
Other Names:
Drug: therapeutic hydrocortisone
Given IT
Other Names:
Drug: thioguanine
Given IV
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Event Free Survival [Length of study]
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
-
Cytogenetically proven Down Syndrome (constitutional trisomy 21) with transient myeloproliferative disorder (TMD), myelodysplastic syndromes (MDS), or acute myelogenous leukemia (AML)
-
Must be confirmed by bone marrow aspirate, cerebrospinal fluid exam, or blood test
-
Trisomy 21 mosaicism allowed
-
Group I:
-
Diagnosis of TMD in patients no older than 90 days at initial presentation
-
Must have nonerythroid blasts (any amount) in the peripheral blood and one of the following:
-
Verification with a second sample
-
More than 5% bone marrow blasts
-
Hepatomegaly and/or splenomegaly
-
Lymphadenopathy
-
Cardiac or pleural effusions OR
-
Histologically or cytologically proven TMD with blasts in an affected organ or in fluid (pericardial, pleural, or peritoneal)
-
Bone marrow aspirate is required
-
Group II (closed to accrual as of 6/24/04):
-
Diagnosis of MDS or AML (except M3 subtype) in patients older than 90 days with more than 29% blasts in bone marrow (with or without history of TMD), or any of the following histologies:
-
Refractory anemia (RA)
-
RA with excess blasts (RAEB)
-
RAEB in transformation
-
RA with ringed sideroblasts (RARS)
-
Primary cytopenia (later confirmed by bone marrow aspirate as due to marrow hypoplasia) defined by one or more of the following:
-
Absolute neutrophil count less than 500/mm^3
-
Untransfused platelet count less than 30,000/mm^3
-
Untransfused hemoglobin less than 8 g/dL
-
The following diagnoses will be observed only:
-
RA with mild cytopenias*
-
RARS with mild cytopenias*
-
Mild primary cytopenias (one or more) without dysplasia (confirmed by hypoplastic bone marrow exam) NOTE: * Platelet count 30-150,000/mm3, absolute neutrophil count 500-1,499/mm3, and hemoglobin greater than 8 g/dL
-
Granulocytic sarcoma (chloroma), with or without bone marrow involvement, allowed
PATIENT CHARACTERISTICS:
Age:
-
See Disease Characteristics
-
21 and under
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- See Disease Characteristics
Hepatic:
- See Disease Characteristics
Renal:
- Not specified
Cardiovascular:
-
Shortening fraction greater than 27% by echocardiogram* OR
-
Ejection fraction greater than 47% by radionuclide angiogram* NOTE: *For patients with MDS and AML (as of 2/24/04, previously diagnosed MDS or AML closed to accrual; MDS or AML that develops (secondary to TMD) after study enrollment or MDS that requires initial observation [with or without subsequent treatment] allowed)
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
-
Prior chemotherapy for TMD allowed
-
No prior chemotherapy for malignancy
Endocrine therapy:
- Concurrent topical or inhaled steroids for other conditions allowed
Radiotherapy:
- No prior radiotherapy for malignancy
Surgery:
- Not specified
Other:
-
No prior antileukemic therapy
-
Prior enrollment on this study for TMD allowed
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | United States | 35233 |
2 | University of South Alabama Cancer Research Institute | Mobile | Alabama | United States | 36604 |
3 | Phoenix Children's Hospital | Phoenix | Arizona | United States | 85016-7710 |
4 | Arizona Cancer Center at University of Arizona Health Sciences Center | Tucson | Arizona | United States | 85724 |
5 | Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
6 | Southern California Permanente Medical Group | Downey | California | United States | 90242 |
7 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010-3000 |
8 | Rebecca and John Moores UCSD Cancer Center | La Jolla | California | United States | 92093-0658 |
9 | Loma Linda University Cancer Institute at Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
10 | Jonathan Jaques Children's Cancer Center at Miller Children's Hospital | Long Beach | California | United States | 90801-1428 |
11 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027-0700 |
12 | Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center | Los Angeles | California | United States | 90048 |
13 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
14 | Children's Hospital Central California | Madera | California | United States | 93638-8762 |
15 | Children's Hospital and Research Center at Oakland | Oakland | California | United States | 94609-1809 |
16 | Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center | Orange | California | United States | 92868 |
17 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
18 | Lucile Packard Children's Hospital at Stanford University Medical Center | Palo Alto | California | United States | 94304 |
19 | Sutter Cancer Center | Sacramento | California | United States | 95816 |
20 | University of California Davis Cancer Center | Sacramento | California | United States | 95817 |
21 | Kaiser Permanente Medical Center - Sacramento | Sacramento | California | United States | 95825 |
22 | Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | United States | 92120 |
23 | Children's Hospital and Health Center, San Diego | San Diego | California | United States | 92123-4282 |
24 | UCSF Comprehensive Cancer Center | San Francisco | California | United States | 94115 |
25 | Santa Barbara Cottage Hospital | Santa Barbara | California | United States | 93102 |
26 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051-5386 |
27 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
28 | Children's Hospital of Denver | Denver | Colorado | United States | 80218-1088 |
29 | Presbyterian - St. Luke's Medical Center | Denver | Colorado | United States | 80218 |
30 | University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center | Farmington | Connecticut | United States | 06360-7106 |
31 | Yale Comprehensive Cancer Center | New Haven | Connecticut | United States | 06520-8028 |
32 | Alfred I. duPont Hospital for Children | Wilmington | Delaware | United States | 19899 |
33 | Lombardi Cancer Center at Georgetown University Medical Center | Washington | District of Columbia | United States | 20007 |
34 | Children's National Medical Center | Washington | District of Columbia | United States | 20010-2970 |
35 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5001 |
36 | Broward General Medical Center | Fort Lauderdale | Florida | United States | 33316 |
37 | Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
38 | Shands Cancer Center at the University of Florida Health Science Center | Gainesville | Florida | United States | 32610-0296 |
39 | Joe DiMaggio Children's Hospital at Memorial | Hollywood | Florida | United States | 33021 |
40 | Nemours Children's Clinic | Jacksonville | Florida | United States | 32207 |
41 | Jackson Memorial Hospital | Miami | Florida | United States | 33136 |
42 | Miami Children's Hospital | Miami | Florida | United States | 33155 |
43 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
44 | Florida Hospital Cancer Institute | Orlando | Florida | United States | 32804 |
45 | Nemours Children's Clinic-Orlando | Orlando | Florida | United States | 32806 |
46 | Sacred Heart Children's Hospital | Pensacola | Florida | United States | 32504 |
47 | All Children's Hospital | St. Petersburg | Florida | United States | 33701 |
48 | St. Joseph's Children's Hospital | Tampa | Florida | United States | 33677-4227 |
49 | St. Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
50 | AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish RiteCampus | Atlanta | Georgia | United States | 30342 |
51 | MBCCOP-Medical College of Georgia Cancer Center | Augusta | Georgia | United States | 30912-4000 |
52 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
53 | Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah | Georgia | United States | 31405 |
54 | Cancer Research Center of Hawaii | Honolulu | Hawaii | United States | 96813 |
55 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
56 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859-5000 |
57 | Mountain States Tumor Institute - Boise | Boise | Idaho | United States | 83712 |
58 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60601 |
59 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
60 | University of Illinois Medical Center | Chicago | Illinois | United States | 60612 |
61 | Children's Memorial Hospital - Chicago | Chicago | Illinois | United States | 60614 |
62 | Advocate Hope Children's Hospital | Oak Lawn | Illinois | United States | 60453 |
63 | Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068-1174 |
64 | Saint Jude Midwest Affiliate | Peoria | Illinois | United States | 61637 |
65 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62794-9658 |
66 | Riley Children Cancer Center at Riley Hospital for Children | Indianapolis | Indiana | United States | 46202-5225 |
67 | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
68 | Blank Children's Hospital | Des Moines | Iowa | United States | 50308 |
69 | John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
70 | Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | United States | 52242-1009 |
71 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
72 | Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | United States | 40536-0284 |
73 | Kosair Children's Hospital | Louisville | Kentucky | United States | 40202-3830 |
74 | MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
75 | Tulane Cancer Center at Tulane University Hospital and Clinic | New Orleans | Louisiana | United States | 70112 |
76 | Children's Hospital of New Orleans | New Orleans | Louisiana | United States | 70118 |
77 | Ochsner Clinic Foundation | New Orleans | Louisiana | United States | 70121 |
78 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
79 | Maine Children's Cancer Program | Scarborough | Maine | United States | 04074-9308 |
80 | Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore | Maryland | United States | 21201-1595 |
81 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21225 |
82 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
83 | Floating Hospital for Children | Boston | Massachusetts | United States | 02111 |
84 | Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
85 | Baystate Regional Cancer Program at Baystate Medical Center | Springfield | Massachusetts | United States | 01107 |
86 | University of Massachusetts Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
87 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109-0914 |
88 | Children's Hospital of Michigan | Detroit | Michigan | United States | 48201 |
89 | Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
90 | Van Elslander Cancer Center at St. John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
91 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
92 | Spectrum Health and DeVos Children's Hospital | Grand Rapids | Michigan | United States | 49503 |
93 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007-5364 |
94 | Breslin Cancer Center at Ingham Regional Medical Center | Lansing | Michigan | United States | 48910 |
95 | CCOP - Beaumont | Royal Oak | Michigan | United States | 48073-6769 |
96 | William Beaumont Hospital - Royal Oak | Royal Oak | Michigan | United States | 48073-6769 |
97 | St. Mary's - Duluth Clinic Cancer Center | Duluth | Minnesota | United States | 55805 |
98 | Children's Hospitals and Clinics - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
99 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
100 | Children's Hospitals and Clinics - Minnesota | Saint Paul | Minnesota | United States | 55102 |
101 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216-4505 |
102 | Children's Mercy Hospital | Kansas City | Missouri | United States | 64108 |
103 | Cardinal Glennon Children's Hospital | Saint Louis | Missouri | United States | 63104 |
104 | St. Louis Children's Hospital | Saint Louis | Missouri | United States | 63110 |
105 | Children's Hospital of Omaha | Omaha | Nebraska | United States | 68114 |
106 | UNMC Eppley Cancer Center at the University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198-2168 |
107 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
108 | Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
109 | Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
110 | Cancer Institute of New Jersey at Robert Wood Johnson University Hospital | New Brunswick | New Jersey | United States | 08903 |
111 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112-2094 |
112 | St. Joseph's Hospital and Medical Center | Paterson | New Jersey | United States | 07503 |
113 | Valerie Fund Children's Center at Atlantic Health | Summit | New Jersey | United States | 07901 |
114 | University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | United States | 87131 |
115 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
116 | Albert Einstein Clinical Cancer Center | Bronx | New York | United States | 10461 |
117 | Brooklyn Hospital Center | Brooklyn | New York | United States | 11201-5493 |
118 | SUNY Downstate Medical Center | Brooklyn | New York | United States | 11203 |
119 | Brookdale University Hospital and Medical Center | Brooklyn | New York | United States | 11212 |
120 | Comprehensive Cancer Center at Maimonides Medical Center | Brooklyn | New York | United States | 11219 |
121 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
122 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
123 | Schneider Children's Hospital | New Hyde Park | New York | United States | 11042 |
124 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
125 | New York Weill Cornell Cancer Center at Cornell University | New York | New York | United States | 10021 |
126 | Mount Sinai School of Medicine | New York | New York | United States | 10029 |
127 | Herbert Irving Comprehensive Cancer Center at Columbia University | New York | New York | United States | 10032 |
128 | James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | United States | 14642 |
129 | Long Island Cancer Center at Stony Brook University Hospital | Stony Brook | New York | United States | 11794 |
130 | University Hospital at State University of New York - Upstate Medical University | Syracuse | New York | United States | 13210 |
131 | New York Medical College | Valhalla | New York | United States | 10595 |
132 | Mission Hospitals | Asheville | North Carolina | United States | 28801 |
133 | Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | United States | 27599-7295 |
134 | Blumenthal Cancer Center at Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
135 | Presbyterian Healthcare | Charlotte | North Carolina | United States | 28233 |
136 | Duke Comprehensive Cancer Center | Durham | North Carolina | United States | 27710 |
137 | Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina | Greenville | North Carolina | United States | 27858-4354 |
138 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1081 |
139 | Dakota Cancer Institute at Innovis Health - Dakota Clinic | Fargo | North Dakota | United States | 58103-4940 |
140 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
141 | Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | United States | 45229-3039 |
142 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
143 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
144 | Children's Hospital of Columbus | Columbus | Ohio | United States | 43205-2696 |
145 | Children's Medical Center - Dayton | Dayton | Ohio | United States | 45404 |
146 | Toledo Children's Hospital | Toledo | Ohio | United States | 43601 |
147 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
148 | Forum Health-Tod Childrens Hospital | Youngstown | Ohio | United States | 44501 |
149 | Children's Hospital at Oklahoma University Medical Center | Oklahoma City | Oklahoma | United States | 73104 |
150 | CCOP - Oklahoma | Tulsa | Oklahoma | United States | 74136 |
151 | Natalie Warren Bryant Cancer Center | Tulsa | Oklahoma | United States | 74136 |
152 | CCOP - Columbia River Oncology Program | Portland | Oregon | United States | 97225 |
153 | Legacy Emanuel Hospital and Health Center & Children's Hospital | Portland | Oregon | United States | 97227 |
154 | Doernbecher Children's Hospital at Oregon Health & Science University | Portland | Oregon | United States | 97239-3098 |
155 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-1320 |
156 | Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033 |
157 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
158 | St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | United States | 19134-1095 |
159 | Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15213-2583 |
160 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
161 | Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
162 | Palmetto Health South Carolina Cancer Center | Columbia | South Carolina | United States | 29203 |
163 | Children's Hospital of Greenville Hospital System | Greenville | South Carolina | United States | 29605 |
164 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105-1080 |
165 | Sioux Valley Hospital at University of South Dakota Medical Center | Sioux Falls | South Dakota | United States | 57117-5039 |
166 | East Tennessee State University Cancer Center at Johnson City Medical Center | Johnson City | Tennessee | United States | 37604 |
167 | East Tennessee Children's Hospital | Knoxville | Tennessee | United States | 37901 |
168 | St. Jude Children's Research Hospital | Memphis | Tennessee | United States | 38105-2794 |
169 | Vanderbilt Children's Hospital | Nashville | Tennessee | United States | 37232-6310 |
170 | Texas Tech University Health Sciences Center School of Medicine | Amarillo | Texas | United States | 79106 |
171 | Children's Hospital of Austin | Austin | Texas | United States | 78701 |
172 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
173 | Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas | Texas | United States | 75390-9063 |
174 | Cook Children's Medical Center - Fort Worth | Fort Worth | Texas | United States | 76104 |
175 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0361 |
176 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
177 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
178 | San Antonio Military Pediatric Cancer and Blood Disorders Center | Lackland Air Force Base | Texas | United States | 78236 |
179 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
180 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78207 |
181 | MBCCOP - South Texas Pediatrics | San Antonio | Texas | United States | 78229-3900 |
182 | Methodist Cancer Center at Methodist Specialty and Transplant Hospital | San Antonio | Texas | United States | 78229-3902 |
183 | CCOP - Scott and White Hospital | Temple | Texas | United States | 76508 |
184 | Center for Cancer Prevention and Care at Scott and White Clinic | Temple | Texas | United States | 76508 |
185 | Huntsman Cancer Institute | Salt Lake City | Utah | United States | 84112 |
186 | Vermont Cancer Center at University of Vermont | Burlington | Vermont | United States | 05401-3498 |
187 | Cancer Center at the University of Virginia | Charlottesville | Virginia | United States | 22908 |
188 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042-3300 |
189 | Children's Hospital of the King's Daughters | Norfolk | Virginia | United States | 23507 |
190 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-5100 |
191 | Massey Cancer Center at Virginia Commonwealth University | Richmond | Virginia | United States | 23298-0121 |
192 | Carilion Medical Center for Children | Roanoke | Virginia | United States | 24029 |
193 | Children's Hospital and Regional Medical Center - Seattle | Seattle | Washington | United States | 98105 |
194 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109-1024 |
195 | Group Health Central Hospital | Seattle | Washington | United States | 98112 |
196 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
197 | Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | United States | 98415-0299 |
198 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431-5000 |
199 | West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division | Charleston | West Virginia | United States | 25302 |
200 | Cabell Huntington Hospital | Huntington | West Virginia | United States | 25701 |
201 | West Virginia University Hospitals | Morgantown | West Virginia | United States | 26506-9300 |
202 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
203 | CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | United States | 54301 |
204 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-9070 |
205 | Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
206 | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792-6164 |
207 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449-5772 |
208 | CCOP - Marshfield Clinic Research Foundation | Marshfield | Wisconsin | United States | 54449 |
209 | Midwest Children's Cancer Center | Milwaukee | Wisconsin | United States | 53226 |
210 | Sydney Children's Hospital | Randwick | New South Wales | Australia | 2031 |
211 | Children's Hospital at Westmead | Westmead | New South Wales | Australia | 2145 |
212 | Royal Children's Hospital | Brisbane | Queensland | Australia | 4029 |
213 | Women's and Children's Hospital | North Adelaide | South Australia | Australia | 5006 |
214 | Royal Children's Hospital | Parkville | Victoria | Australia | 3052 |
215 | Princess Margaret Hospital for Children | Perth | Western Australia | Australia | 6001 |
216 | Alberta Children's Hospital | Calgary | Alberta | Canada | T2T 5C7 |
217 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
218 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
219 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
220 | Janeway Children's Health and Rehabilitation Centre | St. John's | Newfoundland and Labrador | Canada | A1B 3V6 |
221 | IWK Health Centre | Halifax | Nova Scotia | Canada | B3J 3G9 |
222 | McMaster Children's Hospital at Hamilton Health Sciences | Hamilton | Ontario | Canada | L8N 3Z5 |
223 | Children's Hospital of Western Ontario | London | Ontario | Canada | N6C 2V5 |
224 | Children's Hospital of Eastern Ontario | Ottawa | Ontario | Canada | K1H 8L1 |
225 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
226 | McGill University Health Center - Montreal Children's Hospital | Montreal | Quebec | Canada | H3G 1A4 |
227 | Hopital Sainte Justine | Montreal | Quebec | Canada | H3T 1C5 |
228 | Centre de Recherche du Centre Hospitalier de l'Universite Laval | Sainte Foy | Quebec | Canada | GIV 4G2 |
229 | Allan Blair Cancer Centre at Pasqua Hospital | Regina | Saskatchewan | Canada | S4T 7T1 |
230 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
231 | Academisch Ziekenhuis Groningen | Groningen | Netherlands | 9700 RB | |
232 | Starship Children's Hospital | Auckland | New Zealand | ||
233 | Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus | San Juan | Puerto Rico | 00936-5067 | |
234 | San Jorge Childrens Hospital | Santurce | Puerto Rico | 00912 | |
235 | Swiss Pediatric Oncology Group Bern | Bern | Switzerland | CH 3010 | |
236 | Swiss Pediatric Oncology Group Geneva | Geneva | Switzerland | CH 1211 | |
237 | Swiss Pediatric Oncology Group Lausanne | Lausanne | Switzerland | CH 1011 |
Sponsors and Collaborators
- Children's Oncology Group
- National Cancer Institute (NCI)
Investigators
- Study Chair: Alan S. Gamis, MD, MPH, Children's Mercy Hospital Kansas City
Study Documents (Full-Text)
None provided.More Information
Publications
- A2971
- COG-A2971
- CCG-A2971
- POG-A2971
- CCG-29701
- CDR0000066664