Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
Study Details
Study Description
Brief Summary
Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation.
In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively.
Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
2% lidocaine drug to suppress the hemodynamic response due to laryngoscopy and endotracheal intubation; patients administered intravenously will be evaluated in one group, and patients administered inhaled through a nebulizer will be evaluated in another group.
Nebulized lidocaine in the researchers' clinic; it is administered by adding 2% lidocaine + physiological saline to a nebulizer and inhaling for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.
Preoperative examination forms and intraoperative follow-up forms of the patients included in the study will be examined by the researchers. The dose of lidocaine applied and the method of administration will be recorded. In addition, the agents used in anesthesia induction (fentanyl, propofol, rocuronium bromide, etc.) and the hemodynamic changes of the patients (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure,oxygen saturation) will be recorded.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Intravenous lidocaine Patients who received lidocaine intravenously before induction of anesthesia will be considered in this group. |
Drug: Iv Lidocaine
Intravenous %2 lidocaine was administered before induction of anesthesia.
|
| Nebulized lidocaine Patients who received lidocaine by inhalation with a nebulizer before induction of anesthesia will be considered in this group. |
Drug: Nebulized Lidocaine
Before induction of anesthesia, 2% lidocaine + physiological saline was added to a nebulizer and inhaled for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.
|
Outcome Measures
Primary Outcome Measures
- Heart Rate [Just before induction of anesthesia]
Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)
- Heart Rate [Immediately after induction of anesthesia]
Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)
- Heart Rate [5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation]
Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)
- Blood Pressure [Just before induction of anesthesia]
The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.
- Blood Pressure [Immediately after induction of anesthesia]
The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.
- Blood Pressure [5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation]
The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.
- Oxygen Saturation [Just before induction of anesthesia]
The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.
- Oxygen Saturation [Immediately after induction of anesthesia]
The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.
- Oxygen Saturation [5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation]
The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia
Exclusion Criteria:
-
Patients under the age of 18 and over the age of 80
-
Patients who are not operated under general anesthesia
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Derince Training and Research Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- DerinceTRH-EAtli-001