TAPAS: The Life Paths That Lead Teenagers to Attempted Suicide:Trajectories of Proximal Adversity

Sponsor

University Hospital, Lille (Other)

Overall Status

Recruiting

CT.gov ID

NCT04638205

Collaborator

(none)

120

Enrollment

Location

Anticipated Duration (Months)

3.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. More specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. Studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. To date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).

Condition or Disease	Intervention/Treatment	Phase
Suicide, Attempted

Study Design

Study Type:

Observational

Anticipated Enrollment :

120 participants

Observational Model:

Case-Control

Time Perspective:

Retrospective

Official Title:

The Life Paths That Lead Teenagers to Attempted Suicide: Trajectories of Proximal Adversity

Actual Study Start Date :

Nov 1, 2019

Anticipated Primary Completion Date :

Nov 1, 2022

Anticipated Study Completion Date :

Nov 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Suicide attempt cases Adolescents and young adults who attempted suicide between 7 and 30 days prior the inclusion
Non-suicidal controls Adolescents and young adults without history of suicide attempt or ideation

Outcome Measures

Primary Outcome Measures

Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents [1 year]
We will build growth mixture models to account for the 1-year longitudinal evolution of the Burden of Adversity values. Each group will be characterized by the parameters (intercepts and slopes) of the best-fitting model. We will the compare the parameters of the 2 groups to search for statistical differences

Secondary Outcome Measures

Statistical tests comparing the sociodemographic, vulnerabily and psychopathological indicators between the sub-group of adolescents identified from the mixture model. [1 year]
Growth mixture models will allow for identifying sub-groups of individuals who are similar as regards to their burden of adversity trajectories. We will compare the characteristics of theses subgroups
Growth parameters of the patterns of evolution of psychological pain [1 year]
Parallel to the burden of adversity growth models, we will build, for each group, growth models to predict the longitudinal evolution of psychological pain. We will then test whether the growth parameters of the ideation/pain trajectories correlate with those of the adversity trajectories
Growth parameters of the patterns of evolution of suicidal ideation intensity [1 year]
Parallel to the burden of adversity growth models, we will build, for each group, growth models to predict the longitudinal evolution of the severity of the suicidal ideations. We will then test whether the growth parameters of the ideation/pain trajectories correlate with those of the adversity trajectories

Eligibility Criteria

Criteria

Ages Eligible for Study:

15 Years to 24 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Inclusion criteria for cases
Youth aged 15-24 inclusive
Who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt
Who were discharged less than 15 days ago
Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for controls
Youth aged 15-24 inclusive
Who have never experienced any suicidal ideation or suicide attempt
Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for informants
Close relatives of the participant
Who are major
Who lived in the same household as the participant or have interacted with him/her for more than half the weeks of the year preceding the index suicide attempt