Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)
Study Details
Study Description
Brief Summary
This phase II/III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving chemoradiation with or without atezolizumab may work better in treating patients with limited stage small cell lung cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Phase 2/Phase 3 |
Detailed Description
PRIMARY OBJECTIVE:
- To compare overall survival (OS) for patients with LS-SCLC treated with chemoradiation +/- atezolizumab.
SECONDARY OBJECTIVES:
-
To compare progression free survival (PFS) for patients with limited stage small cell lung cancer (LS-SCLC) treated with chemoradiation +/- atezolizumab.
-
To determine overall response rate (ORR), rates of local control, and distant metastases free survival with chemoradiation +/- atezolizumab.
-
To characterize immune mediated and non-immune mediated toxicity from chemoradiotherapy plus atezolizumab.
-
To compare quality of life, as measured by the Functional Assessment of Cancer Therapy-Trial Outcome Index (FACT-TOI), for patients undergoing chemoradiation +/- atezolizumab.
-
To evaluate the quality-adjusted survival, using scores from the 5-level EuroQol 5-dimensional questionnaire (EQ-5D-5L), of chemoradiation +/- atezolizumab for patients with LS-SCLC.
-
To characterize fatigue, as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS), following chemoradiation +/- atezolizumab.
-
To determine the association of blood based tumor mutational burden (bTMB) and tissue-based tumor mutational burden (tTMB) with clinical outcome.
EXPLORATORY OBJECTIVES:
-
To collect biospecimens at baseline, day 1 and 3 months after the end of chemoradiotherapy, to allow for future analyses.
-
To characterize patient-reported symptomatic toxicities measured by the Patient-Reported Outcomes - Common Terminology Criteria for Adverse Events (PRO-CTCAE).
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive etoposide intravenously (IV) on days 1-3 and cisplatin IV or carboplatin IV on day 1. Cycles repeat every 21 days for 3 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo three-dimensional conformal radiation therapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) twice daily (BID) for approximately 3 weeks or once daily (QD) for approximately 6-7 weeks in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive treatment as in Arm I. Patients also receive atezolizumab IV over 30-60 minutes on day 1 or 2 of each chemotherapy cycle. Cycles repeat every 3 weeks for 17 cycles (1 year) in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, then every 6 months for 3 years, then annually thereafter.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (etoposide, cisplatin, carboplatin, radiation therapy) Patients receive etoposide IV on days 1-3 and cisplatin IV or carboplatin IV on day 1. Cycles repeat every 21 days for 3 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo 3D-CRT or IMRT BID for approximately 3 weeks or QD for approximately 6-7 weeks in the absence of disease progression or unacceptable toxicity. |
Radiation: 3-Dimensional Conformal Radiation Therapy
Undergo 3D-CRT
Other Names:
Drug: Carboplatin
Given IV
Other Names:
Drug: Cisplatin
Given IV
Other Names:
Drug: Etoposide
Given IV
Other Names:
Radiation: Intensity-Modulated Radiation Therapy
Undergo IMRT
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Other: Questionnaire Administration
Ancillary studies
|
| Active Comparator: Arm II (etoposide, cisplatin, carboplatin, radiation therapy) Patients receive treatment as in Arm I. Patients also receive atezolizumab IV over 30-60 minutes on day 1 or 2 of each chemotherapy cycle. Cycles repeat every 3 weeks for 17 cycles (1 year) in the absence of disease progression or unacceptable toxicity. |
Radiation: 3-Dimensional Conformal Radiation Therapy
Undergo 3D-CRT
Other Names:
Drug: Atezolizumab
Given IV
Other Names:
Drug: Carboplatin
Given IV
Other Names:
Drug: Cisplatin
Given IV
Other Names:
Drug: Etoposide
Given IV
Other Names:
Radiation: Intensity-Modulated Radiation Therapy
Undergo IMRT
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Other: Questionnaire Administration
Ancillary studies
|
Outcome Measures
Primary Outcome Measures
- Overall survival (OS) [Time from randomization to the date of death due to any cause, assessed up to 5 years]
Hazard ratios will be estimated using a stratified Cox regression model. Event rates over time will be estimated within each treatment group using the Kaplan-Meier method.
Secondary Outcome Measures
- Progression free survival (PFS) [Time from randomization to any documented progression or death due to any cause, whichever occurs first, assessed up to 5 years]
Hazard ratios will be estimated using a stratified Cox regression model. Event rates over time will be estimated within each treatment group using the Kaplan-Meier method.
- Incidence of adverse events [Up to 5 years]
For each patient, the maximum severity reported for both immune mediated and non-immune mediated adverse events will be used in the summaries. Adverse events will be summarized regardless of relationship to protocol treatment as assessed by the investigator. All adverse events, adverse events leading to withdrawal, interruption or modification of protocol treatment, Grade >= 3 adverse events, and serious adverse events will be summarized. Deaths and cause of death will be summarized. The rate of treatment-related adverse events using NCI Common Terminology Criteria for Adverse Events (CTCAE, v.5.0) will be reported with the frequency and severity (e.g., type, grade, and attribution) by arm, the analysis will be performed at the time of both phase II and phase III (if applicable) primary endpoint analyses. All adverse events will be classified as either immune or non-immune mediated.
- Objective response rate (ORR) [Up to 5 years]
Will be defined as the proportion of all randomized subjects whose best overall response (BOR) is either a complete response (CR) or partial response (PR) per RECIST 1.1 criteria. ORR will be compared using a two-sided 5% level Cochran-Mantel Haenszel (CMH) test stratified by the same stratification factors used for randomization. An associated odds ratio and 95% CI will be calculated. The ORR and its corresponding 95% exact CI will also be calculated by Clopper-Pearson for each treatment arm. The difference in ORR between the two treatment arms along with the two-sided 95% CI will be estimated using the following CMH method of weighting, adjusting for the stratification factors.
- Local control [Up to 5 years]
Will be defined as freedom from local progression, in which a failure is defined as intrathoracic tumor progression by RECIST 1.1 criteria. Local control will be analyzed as competing risks data based on cause-specific hazards approaches, where deaths without local failure will be considered as a competing event and analyzed as "censoring" of local failure. The rates at various timepoints (e.g., every 6 months after randomization) and medians of PFS for each arm will be estimated using the Kaplan-Meier method (1958). The associated 95% CI will be calculated using Greenwood's formula and based on a log-log transformation applied on the survival function. Results from an unstratified analysis will also be provided.
- Distant metastases-free survival (DMFS) [Time between the date of randomization and the first date of documented distant metastases or death due to any cause, whichever occurs first, assessed up to 5 years]
Will compare the distributions of DMFS between treatment arms using a one-sided stratified log-rank test in all randomized eligible patients. The rates at various timepoints (e.g., every 6 months after randomization) and medians of DMFS for each arm will be estimated using the Kaplan-Meier method (1958). The associated 95% CI will be calculated using Greenwood's formula and based on a log-log transformation applied on the survival function. Results from an unstratified analysis will also be provided.
- Quality of life (QoL) [Up to 15 months after the end of the 4th cycle of chemotherapy]
Will be measured by the Functional Assessment of Cancer Therapy-Trial Outcome Index (FACT-TOI). Fisher's exact test will be used to compare the proportions of patients experiencing clinically meaningful deterioration (CMD) between the two arms. FACT-TOI deterioration rates and associated 95% confidence interval will be calculated for each treatment group, based on all randomized subjects. Clopper-Pearson method will be used for calculating 95% CI. The deterioration rates of each arm will also be compared using the CMH test, stratified by histology. FACT-TOI at baseline and at each subsequent assessment, as well as their change from baseline will be summarized using descriptive statistics by treatment group as randomized. The scores at baseline and subsequent time points, as well the changes from baseline at each time point for each treatment group will be compared using the two-sample t-test.
- Quality-adjusted survival [Up to 2 years]
Assessed using score from the 5-level EuroQol 5-dimensional questionnaire (EQ-5D-5L). Defined as the weighted sum of different time episodes added up to a total quality-adjusted life-year. Subjects' overall health state on a visual analog scale (VAS) at each assessment time point will be summarized using descriptive statistics by treatment group, as randomized. Proportion of subjects reporting problems for the five EQ-5D-5L dimensions at each assessment time point will be summarized by level of problem and by treatment group, as randomized. Percentages will be based on number subjects assessed at assessment time point. Subjects' overall health state on a visual analog scale (EQ-VAS) at each assessment time point will be summarized using descriptive statistics by treatment group, as randomized. Proportion of subjects reporting problems for the five EQ-5D dimensions at each assessment time point will be summarized by level of problem and by treatment group, as randomized.
- Level of fatigue [Up to 2 years]
Will be measured by the Patient-Reported Outcomes Measurement Information System (PROMIS). Baseline and PROMIS at each subsequent assessment, as well as their change from baseline will be summarized using descriptive statistics by treatment group as randomized. The change from baseline to subsequent timepoints may be compared between treatment arms using a t-test, or Wilcoxon test if the data is non-normal.
- Blood based tumor mutational burden (bTMB) and tissue-based tumor mutational burden (tTMB) [Up to 5 years]
Correlation with clinical outcomes will be done by summarizing the statistical power to detect interaction effects (ratio of hazard ratios) of 0.33 when the marker positive prevalence is 20%, at 2-sided significance level of 0.05.
Other Outcome Measures
- Patient-reported symptomatic toxicities [Up to 15 months after completion of chemoradiation therapy]
Will be measured by Patient Reported Outcomes - Common Terminology Criteria for Adverse Events (PRO-CTCAE). For each symptom and each domain (i.e., frequency, severity, and interference), counts and frequencies will be summarized for the worst score experienced by the patient by treatment arm.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Pathologically (histologically or cytologically) proven diagnosis of limited stage small cell lung cancer (Stage Tx, T1-T4, N0-3, M0, American Joint Committee on Cancer [AJCC] staging, 8th edition [Ed.]), within 60 days prior to registration
-
Patients must have received one cycle of platinum/etoposide chemotherapy pre-registration (prior to study entry). Study registration must be within 21 days from day 1 of the pre-registration cycle of chemotherapy.
-
Patients must have had measurable disease (per Response Evaluation Criteria in Solid Tumors [RECIST], version 1.1) prior to the required cycle of platinum/etoposide chemotherapy
-
Minimal staging requirements include:
-
History/physical examination within 30 days prior to registration
-
Positron emission tomography (PET)/computed tomography (CT) scan for staging within 60 days prior to registration
-
CT chest and CT abdomen with IV contrast (unless contraindicated based on kidney function) within 60 days prior to registration; magnetic resonance imaging (MRI) abdomen with IV contrast allowed in place of CT abdomen
-
Note: If contrast allergy exists, premedication per institutional guidelines should be performed prior to obtaining CT with contrast. The only exception to this is a documented life-threatening allergy
-
MRI scan of the brain with contrast (preferred) or CT scan of the brain with contrast (allowable if there is a contraindication with MRI with contrast) within 30 days prior to registration
-
Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 30 days prior to registration
-
Absolute neutrophil count (ANC) >= 1, 500/cells/mm^3 (prior to pre-registration cycle)
-
Platelet count >= 100,000 cells/mm^3 (prior to pre-registration cycle)
-
Hemoglobin >= 9 g/dL (prior to pre-registration cycle)
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) (prior to pre-registration cycle)
-
Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.0 x ULN (prior to pre-registration cycle)
-
Adequate renal function within 30 days prior to registration defined as follows: Creatinine clearance >= 30 mL/min by the Cockcroft-Gault (C-G) equation
-
Patients presenting with a pleural effusion will be eligible if thoracentesis is cytologically negative and non-bloody or if pleural fluid is too small a volume to effectively sample by thoracentesis and does not show increased metabolic activity on CT/PET imaging
-
Negative serum pregnancy test within 14 days of registration for pre-menopausal women of childbearing potential
-
The patient or a legally authorized representative must provide study-specific informed consent prior to study entry
-
Hepatitis B/C testing prior to enrollment for patients that have not been tested before. Note: This is required even if the patient has never shown or had symptoms of hepatitis
-
Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
Exclusion Criteria:
-
Definitive clinical or radiologic evidence of metastatic disease
-
Definitive surgical resection of small cell lung cancer
-
Prior invasive malignancy (except non-melanomatous skin cancer, localized prostate cancer, or any early stage cancer treated with curative intent resection) unless disease free for a minimum of 2 years (carcinoma in situ of the breast, oral cavity, or cervix are all permissible)
-
More than 1 cycle of prior platinum-based chemotherapy for SCLC prior to enrollment; note that prior chemotherapy for a different cancer is allowable
-
Any prior atezolizumab or other immunotherapy agent
-
Prior radiotherapy to the lungs or mediastinum that would result in clinically significant overlap of radiation therapy fields; prior tangent fields for breast cancer with minimal overlap with target volumes are allowed per approval of study principal investigators (PIs)
-
Patients with cytologically positive pleural or pericardial fluid are not eligible
-
An active, known or suspected autoimmune disease. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger
-
Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)
-
History of allogeneic organ transplant
-
History of primary immunodeficiency
-
Severe, active co-morbidity defined as follows:
-
Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis, cirrhosis, fatty liver, and inherited liver disease
-
Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complications
-
Active tuberculosis
-
Active hepatitis B (chronic or acute) or hepatitis C infection. Note that if hepatitis status is unknown, hepatitis B/C testing is required
-
Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HBsAg]) test, a positive anti-HBc (antibody to hepatitis B core antigen), and a negative viral deoxyribonucleic acid (DNA) test (only obtained if HBsAg is found positive) are eligible
-
Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV ribonucleic acid (RNA). (The HCV RNA test must be performed for patients who have a positive HCV antibody test.)
-
Known immunosuppressive disease, for example history of bone marrow transplant or chronic lymphocytic leukemia (CLL)
-
Chronic obstructive pulmonary disease (COPD) requiring chronic oral steroid therapy of > 10 mg prednisone daily or equivalent at the time of registration. Inhaled corticosteroids are not exclusionary
-
Unstable angina and/or congestive heart failure requiring hospitalization within the last 3 months
-
Transmural myocardial infarction within the last 3 months
-
Clinically significant interstitial lung disease
-
A condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease
-
Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception for the duration of study treatment and for 180 days after the last dose of study drug (Arm 2); this exclusion is necessary because the treatment involved in this study may be significantly teratogenic
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 3 | Banner MD Anderson Cancer Center | Gilbert | Arizona | United States | 85234 |
| 4 | CTCA at Western Regional Medical Center | Goodyear | Arizona | United States | 85338 |
| 5 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 6 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 7 | NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | United States | 72401 |
| 8 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 9 | Sutter Auburn Faith Hospital | Auburn | California | United States | 95602 |
| 10 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 11 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 12 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
| 13 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 14 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 15 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 16 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 17 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 18 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 19 | California Pacific Medical Center-Pacific Campus | San Francisco | California | United States | 94115 |
| 20 | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California | United States | 96161 |
| 21 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 22 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 23 | UCHealth Memorial Hospital Central | Colorado Springs | Colorado | United States | 80909 |
| 24 | Memorial Hospital North | Colorado Springs | Colorado | United States | 80920 |
| 25 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 26 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 27 | Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado | United States | 80528 |
| 28 | UCHealth Greeley Hospital | Greeley | Colorado | United States | 80631 |
| 29 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 30 | Medical Center of the Rockies | Loveland | Colorado | United States | 80538 |
| 31 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 32 | Beebe South Coastal Health Campus | Frankford | Delaware | United States | 19945 |
| 33 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 34 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 35 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 36 | GenesisCare USA - Aventura FP | Aventura | Florida | United States | 33180 |
| 37 | GenesisCare USA - Aventura | Aventura | Florida | United States | 33180 |
| 38 | Boca Raton Regional Hospital | Boca Raton | Florida | United States | 33486 |
| 39 | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | United States | 33146 |
| 40 | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | United States | 33442 |
| 41 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 42 | Lee Memorial Health System | Fort Myers | Florida | United States | 33901 |
| 43 | Regional Cancer Center-Lee Memorial Health System | Fort Myers | Florida | United States | 33905 |
| 44 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 45 | The Watson Clinic | Lakeland | Florida | United States | 33805 |
| 46 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 47 | Miami Cancer Institute | Miami | Florida | United States | 33176 |
| 48 | Orlando Health Cancer Institute | Orlando | Florida | United States | 32806 |
| 49 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 50 | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | United States | 33324 |
| 51 | Moffitt Cancer Center | Tampa | Florida | United States | 33612 |
| 52 | Grady Health System | Atlanta | Georgia | United States | 30303 |
| 53 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 54 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 55 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 56 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 57 | Piedmont Fayette Hospital | Fayetteville | Georgia | United States | 30214 |
| 58 | CTCA at Southeastern Regional Medical Center | Newnan | Georgia | United States | 30265 |
| 59 | Piedmont Newnan Hospital | Newnan | Georgia | United States | 30265 |
| 60 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 61 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 62 | Hawaii Cancer Care - Savio | 'Aiea | Hawaii | United States | 96701 |
| 63 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 64 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 65 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
| 66 | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | United States | 96813 |
| 67 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 68 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 69 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 70 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 71 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 72 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 73 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 74 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 75 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 76 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 77 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 78 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 79 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 80 | Alton Memorial Hospital | Alton | Illinois | United States | 62002 |
| 81 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 82 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 83 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 84 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 85 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 86 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 87 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 88 | Advocate Illinois Masonic Medical Center | Chicago | Illinois | United States | 60657 |
| 89 | AMG Crystal Lake - Oncology | Crystal Lake | Illinois | United States | 60014 |
| 90 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 91 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 92 | Advocate Good Samaritan Hospital | Downers Grove | Illinois | United States | 60515 |
| 93 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 94 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 95 | Elmhurst Memorial Hospital | Elmhurst | Illinois | United States | 60126 |
| 96 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 97 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 98 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 99 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 100 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 101 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 102 | Advocate South Suburban Hospital | Hazel Crest | Illinois | United States | 60429 |
| 103 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 104 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 105 | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States | 60045 |
| 106 | AMG Libertyville - Oncology | Libertyville | Illinois | United States | 60048 |
| 107 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 108 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 109 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 110 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 111 | Edward Hospital/Cancer Center | Naperville | Illinois | United States | 60540 |
| 112 | Advocate Christ Medical Center | Oak Lawn | Illinois | United States | 60453-2699 |
| 113 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 114 | Advocate Lutheran General Hospital | Park Ridge | Illinois | United States | 60068 |
| 115 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 116 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 117 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 118 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 119 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 120 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 121 | Edward Hospital/Cancer Center?Plainfield | Plainfield | Illinois | United States | 60585 |
| 122 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 123 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 124 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 125 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
| 126 | Midwestern Regional Medical Center | Zion | Illinois | United States | 60099 |
| 127 | IU Health North Hospital | Carmel | Indiana | United States | 46032 |
| 128 | Parkview Regional Medical Center | Fort Wayne | Indiana | United States | 46845 |
| 129 | Goshen Center for Cancer Care | Goshen | Indiana | United States | 46526 |
| 130 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
| 131 | Community Cancer Center East | Indianapolis | Indiana | United States | 46219 |
| 132 | Community Cancer Center South | Indianapolis | Indiana | United States | 46227 |
| 133 | Franciscan Health Indianapolis | Indianapolis | Indiana | United States | 46237 |
| 134 | Community Cancer Center North | Indianapolis | Indiana | United States | 46256 |
| 135 | Community Howard Regional Health | Kokomo | Indiana | United States | 46904 |
| 136 | Franciscan Health Mooresville | Mooresville | Indiana | United States | 46158 |
| 137 | Baptist Health Floyd | New Albany | Indiana | United States | 47150 |
| 138 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 139 | Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa | United States | 52402 |
| 140 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 141 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 142 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 143 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 144 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 145 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 146 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 147 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 148 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 149 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 150 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 151 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 152 | University of Kansas Health System Saint Francis Campus | Topeka | Kansas | United States | 66606 |
| 153 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 154 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
| 155 | Saint Elizabeth Healthcare Edgewood | Edgewood | Kentucky | United States | 41017 |
| 156 | Baptist Health Hardin | Elizabethtown | Kentucky | United States | 42701 |
| 157 | Baptist Health Lexington | Lexington | Kentucky | United States | 40503 |
| 158 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 159 | Norton Hospital Pavilion and Medical Campus | Louisville | Kentucky | United States | 40202 |
| 160 | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States | 40202 |
| 161 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 162 | Norton Audubon Hospital and Medical Campus | Louisville | Kentucky | United States | 40217 |
| 163 | Norton Brownsboro Hospital and Medical Campus | Louisville | Kentucky | United States | 40241 |
| 164 | Baptist Health Paducah | Paducah | Kentucky | United States | 42003 |
| 165 | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 166 | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | United States | 70809 |
| 167 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 168 | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | United States | 70809 |
| 169 | Medical Center of Baton Rouge | Baton Rouge | Louisiana | United States | 70816 |
| 170 | Mary Bird Perkins Cancer Center - Covington | Covington | Louisiana | United States | 70433 |
| 171 | Mary Bird Perkins Cancer Center - Houma | Houma | Louisiana | United States | 70360 |
| 172 | Terrebonne General Medical Center | Houma | Louisiana | United States | 70360 |
| 173 | University Medical Center New Orleans | New Orleans | Louisiana | United States | 70112 |
| 174 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 175 | MaineHealth Coastal Cancer Treatment Center | Bath | Maine | United States | 04530 |
| 176 | Waldo County General Hospital | Belfast | Maine | United States | 04915 |
| 177 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
| 178 | Stephens Memorial Hospital | Norway | Maine | United States | 04268 |
| 179 | Maine Medical Center-Bramhall Campus | Portland | Maine | United States | 04102 |
| 180 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 181 | MaineHealth Cancer Care Center of York County | Sanford | Maine | United States | 04073 |
| 182 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
| 183 | Maine Medical Center- Scarborough Campus | Scarborough | Maine | United States | 04074 |
| 184 | Maine Medical Partners - South Portland | South Portland | Maine | United States | 04106 |
| 185 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 186 | Saint Agnes Hospital | Baltimore | Maryland | United States | 21229 |
| 187 | UM Upper Chesapeake Medical Center | Bel Air | Maryland | United States | 21014 |
| 188 | Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | United States | 21044 |
| 189 | UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | United States | 21061 |
| 190 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 191 | Steward Saint Elizabeth's Medical Center | Brighton | Massachusetts | United States | 02135 |
| 192 | UMass Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
| 193 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 194 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 195 | McLaren Cancer Institute-Bay City | Bay City | Michigan | United States | 48706 |
| 196 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 197 | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | United States | 48183 |
| 198 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 199 | Caro Cancer Center | Caro | Michigan | United States | 48723 |
| 200 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 201 | GenesisCare USA - Clarkston | Clarkston | Michigan | United States | 48346 |
| 202 | McLaren Cancer Institute-Clarkston | Clarkston | Michigan | United States | 48346 |
| 203 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 204 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 205 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 206 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 207 | GenesisCare USA - Farmington Hills | Farmington Hills | Michigan | United States | 48334 |
| 208 | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan | United States | 48336 |
| 209 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 210 | McLaren Cancer Institute-Flint | Flint | Michigan | United States | 48532 |
| 211 | Singh and Arora Hematology Oncology PC | Flint | Michigan | United States | 48532 |
| 212 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 213 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 214 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 215 | Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | United States | 48910 |
| 216 | Mid-Michigan Physicians-Lansing | Lansing | Michigan | United States | 48912 |
| 217 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 218 | McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | United States | 48446 |
| 219 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 220 | GenesisCare USA - Macomb | Macomb | Michigan | United States | 48044 |
| 221 | GenesisCare USA - Madison Heights | Madison Heights | Michigan | United States | 48071 |
| 222 | McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | United States | 48043 |
| 223 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 224 | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | United States | 49444 |
| 225 | Ascension Providence Hospitals - Novi | Novi | Michigan | United States | 48374 |
| 226 | McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | United States | 49770 |
| 227 | 21st Century Oncology-Pontiac | Pontiac | Michigan | United States | 48341 |
| 228 | McLaren-Port Huron | Port Huron | Michigan | United States | 48060 |
| 229 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 230 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 231 | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | United States | 48604 |
| 232 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 233 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 234 | Henry Ford Macomb Health Center - Shelby Township | Shelby | Michigan | United States | 48315 |
| 235 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 236 | Ascension Saint Joseph Hospital | Tawas City | Michigan | United States | 48764 |
| 237 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 238 | GenesisCare USA - Troy | Troy | Michigan | United States | 48098 |
| 239 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 240 | Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | United States | 48661 |
| 241 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 242 | Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota | United States | 56007 |
| 243 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 244 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 245 | Minnesota Oncology - Burnsville | Burnsville | Minnesota | United States | 55337 |
| 246 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 247 | Saint Luke's Hospital of Duluth | Duluth | Minnesota | United States | 55805 |
| 248 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 249 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 250 | Mayo Clinic Health Systems-Mankato | Mankato | Minnesota | United States | 56001 |
| 251 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 252 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 253 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 254 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 255 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 256 | Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 257 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 258 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 259 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 260 | Baptist Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
| 261 | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | United States | 38652 |
| 262 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
| 263 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
| 264 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 265 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 266 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 267 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 268 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 269 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 270 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 271 | University of Kansas Cancer Center - North | Kansas City | Missouri | United States | 64154 |
| 272 | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 273 | University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri | United States | 64116 |
| 274 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 275 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 276 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 277 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
| 278 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 279 | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri | United States | 63136 |
| 280 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 281 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
| 282 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 283 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 284 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 285 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 286 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 287 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 288 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 289 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 290 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 291 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 292 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 293 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 294 | Cancer Partners of Nebraska - Pine Lake | Lincoln | Nebraska | United States | 68516 |
| 295 | Southeast Nebraska Cancer Center - 68th Street Place | Lincoln | Nebraska | United States | 68516 |
| 296 | Nebraska Methodist Hospital | Omaha | Nebraska | United States | 68114 |
| 297 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 298 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 299 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 300 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 301 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 302 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 303 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 304 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 305 | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | United States | 03301 |
| 306 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 307 | Solinsky Center for Cancer Care | Manchester | New Hampshire | United States | 03103 |
| 308 | Ocean Medical Center | Brick | New Jersey | United States | 08724 |
| 309 | The Cancer Institute of New Jersey Hamilton | Hamilton | New Jersey | United States | 08690 |
| 310 | Monmouth Medical Center Southern Campus | Lakewood | New Jersey | United States | 08701 |
| 311 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740 |
| 312 | Southern Ocean County Medical Center | Manahawkin | New Jersey | United States | 08050 |
| 313 | Jersey Shore Medical Center | Neptune | New Jersey | United States | 07753 |
| 314 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 315 | Capital Health Medical Center-Hopewell | Pennington | New Jersey | United States | 08534 |
| 316 | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | United States | 07701 |
| 317 | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey | United States | 08876 |
| 318 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 319 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 320 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
| 321 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 322 | Cancer Institute at Saint Francis Hospital | East Hills | New York | United States | 11548 |
| 323 | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | United States | 13057 |
| 324 | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | United States | 14905 |
| 325 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 326 | Mount Sinai Chelsea | New York | New York | United States | 10011 |
| 327 | Mount Sinai West | New York | New York | United States | 10019 |
| 328 | Mount Sinai Hospital | New York | New York | United States | 10029 |
| 329 | University of Rochester | Rochester | New York | United States | 14642 |
| 330 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 331 | Good Samaritan Hospital Medical Center | West Islip | New York | United States | 11795 |
| 332 | Atrium Health Stanly/LCI-Albemarle | Albemarle | North Carolina | United States | 28002 |
| 333 | Randolph Hospital | Asheboro | North Carolina | United States | 27203 |
| 334 | Messino Cancer Centers | Asheville | North Carolina | United States | 28806 |
| 335 | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina | United States | 27215 |
| 336 | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | United States | 28203 |
| 337 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 338 | Atrium Health Pineville/LCI-Pineville | Charlotte | North Carolina | United States | 28210 |
| 339 | Levine Cancer Institute-SouthPark | Charlotte | North Carolina | United States | 28211 |
| 340 | Atrium Health University City/LCI-University | Charlotte | North Carolina | United States | 28262 |
| 341 | Levine Cancer Institute-Ballantyne | Charlotte | North Carolina | United States | 28277 |
| 342 | Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | United States | 28025 |
| 343 | Cone Health Cancer Center | Greensboro | North Carolina | United States | 27403 |
| 344 | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 345 | Novant Health Cancer Institute - Kernersville | Kernersville | North Carolina | United States | 27284 |
| 346 | Atrium Health Union/LCI-Union | Monroe | North Carolina | United States | 28112 |
| 347 | Novant Health Cancer Institute - Mount Airy | Mount Airy | North Carolina | United States | 27030 |
| 348 | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | United States | 28374 |
| 349 | Novant Health Cancer Institute - Statesville | Statesville | North Carolina | United States | 28625 |
| 350 | Novant Health Cancer Institute - Thomasville | Thomasville | North Carolina | United States | 27360 |
| 351 | Novant Health Cancer Institute - Wilkesboro | Wilkesboro | North Carolina | United States | 28659 |
| 352 | Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | United States | 27103 |
| 353 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 354 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 355 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 356 | Altru Cancer Center | Grand Forks | North Dakota | United States | 58201 |
| 357 | Trinity Cancer Care Center | Minot | North Dakota | United States | 58701 |
| 358 | Summa Health System - Akron Campus | Akron | Ohio | United States | 44304 |
| 359 | Summa Health System - Barberton Campus | Barberton | Ohio | United States | 44203 |
| 360 | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | United States | 44122 |
| 361 | Cleveland Clinic Mercy Hospital | Canton | Ohio | United States | 44708 |
| 362 | Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 363 | Geauga Hospital | Chardon | Ohio | United States | 44024 |
| 364 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 365 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 366 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 367 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 368 | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | United States | 44111 |
| 369 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 370 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 371 | Mount Carmel East Hospital | Columbus | Ohio | United States | 43213 |
| 372 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 373 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 374 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 375 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 376 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 377 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 378 | Dublin Methodist Hospital | Dublin | Ohio | United States | 43016 |
| 379 | Mount Carmel Grove City Hospital | Grove City | Ohio | United States | 43123 |
| 380 | Cleveland Clinic Cancer Center Independence | Independence | Ohio | United States | 44131 |
| 381 | Saint Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 382 | OhioHealth Mansfield Hospital | Mansfield | Ohio | United States | 44903 |
| 383 | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | United States | 44906 |
| 384 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 385 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
| 386 | Summa Health Medina Medical Center | Medina | Ohio | United States | 44256 |
| 387 | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | United States | 44060 |
| 388 | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | United States | 44130 |
| 389 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 390 | University Hospitals Parma Medical Center | Parma | Ohio | United States | 44129 |
| 391 | Mercy Health Perrysburg Cancer Center | Perrysburg | Ohio | United States | 43551 |
| 392 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 393 | University Hospitals Portage Medical Center | Ravenna | Ohio | United States | 44266 |
| 394 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
| 395 | UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 396 | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | United States | 44136 |
| 397 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 398 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 399 | University Hospitals Sharon Health Center | Wadsworth | Ohio | United States | 44281 |
| 400 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
| 401 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 402 | UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | United States | 44145 |
| 403 | UHHS-Westlake Medical Center | Westlake | Ohio | United States | 44145 |
| 404 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
| 405 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 406 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 407 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 408 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 409 | Cancer Treatment Centers of America | Tulsa | Oklahoma | United States | 74133 |
| 410 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 411 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 412 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 413 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 414 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 415 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 416 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 417 | Crozer-Keystone Regional Cancer Center at Broomall | Broomall | Pennsylvania | United States | 19008 |
| 418 | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | United States | 19010 |
| 419 | Carlisle Regional Cancer Center | Carlisle | Pennsylvania | United States | 17015 |
| 420 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 421 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 422 | Northeast Radiation Oncology Center | Dunmore | Pennsylvania | United States | 18512 |
| 423 | Ephrata Cancer Center | Ephrata | Pennsylvania | United States | 17522 |
| 424 | UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | United States | 16121 |
| 425 | Adams Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 426 | Crozer Regional Cancer Center at Brinton Lake | Glen Mills | Pennsylvania | United States | 19342 |
| 427 | Cherry Tree Cancer Center | Hanover | Pennsylvania | United States | 17331 |
| 428 | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | United States | 17109 |
| 429 | Lancaster General Ann B Barshinger Cancer Institute | Lancaster | Pennsylvania | United States | 17601 |
| 430 | Lancaster General Hospital | Lancaster | Pennsylvania | United States | 17602 |
| 431 | Sechler Family Cancer Center | Lebanon | Pennsylvania | United States | 17042 |
| 432 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 433 | UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | United States | 17050 |
| 434 | Riddle Memorial Hospital | Media | Pennsylvania | United States | 19063 |
| 435 | Bryn Mawr Health Center | Newtown Square | Pennsylvania | United States | 19073 |
| 436 | Paoli Memorial Hospital | Paoli | Pennsylvania | United States | 19301 |
| 437 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 438 | Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | United States | 19114 |
| 439 | Eastern Regional Medical Center | Philadelphia | Pennsylvania | United States | 19124 |
| 440 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 441 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 442 | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | United States | 15232 |
| 443 | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | United States | 18840 |
| 444 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 445 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 446 | Lankenau Medical Center | Wynnewood | Pennsylvania | United States | 19096 |
| 447 | WellSpan Health-York Cancer Center | York | Pennsylvania | United States | 17403 |
| 448 | UPMC Memorial | York | Pennsylvania | United States | 17408 |
| 449 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
| 450 | AnMed Health Cancer Center | Anderson | South Carolina | United States | 29621 |
| 451 | Saint Joseph's/Candler - Bluffton Campus | Bluffton | South Carolina | United States | 29910 |
| 452 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 453 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 454 | Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 455 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 456 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 457 | Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 458 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 459 | South Carolina Cancer Specialists PC | Hilton Head Island | South Carolina | United States | 29926-3827 |
| 460 | The Radiation Oncology Center-Hilton Head/Bluffton | Hilton Head Island | South Carolina | United States | 29926 |
| 461 | Carolina Regional Cancer Center | Myrtle Beach | South Carolina | United States | 29577 |
| 462 | Rock Hill Radiation Therapy Center | Rock Hill | South Carolina | United States | 29730 |
| 463 | Levine Cancer Institute-Rock Hill | Rock Hill | South Carolina | United States | 29732 |
| 464 | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 465 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 466 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 467 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 468 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 469 | Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | United States | 38017 |
| 470 | Thompson Cancer Survival Center | Knoxville | Tennessee | United States | 37916 |
| 471 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 472 | MD Anderson in The Woodlands | Conroe | Texas | United States | 77384 |
| 473 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 474 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 475 | MD Anderson West Houston | Houston | Texas | United States | 77079 |
| 476 | Houston Methodist West Hospital | Houston | Texas | United States | 77094 |
| 477 | MD Anderson League City | League City | Texas | United States | 77573 |
| 478 | Covenant Medical Center-Lakeside | Lubbock | Texas | United States | 79410 |
| 479 | Houston Methodist Saint John Hospital | Nassau Bay | Texas | United States | 77058 |
| 480 | MD Anderson in Sugar Land | Sugar Land | Texas | United States | 77478 |
| 481 | Houston Methodist Sugar Land Hospital | Sugar Land | Texas | United States | 77479 |
| 482 | Houston Methodist The Woodlands Hospital | The Woodlands | Texas | United States | 77385 |
| 483 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 484 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 485 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 486 | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | United States | 05819 |
| 487 | University of Virginia Cancer Center | Charlottesville | Virginia | United States | 22908 |
| 488 | Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia | United States | 22939 |
| 489 | VCU Massey Cancer Center at Stony Point | Richmond | Virginia | United States | 23235 |
| 490 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 491 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 492 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 493 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 494 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 495 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 496 | Edwards Comprehensive Cancer Center | Huntington | West Virginia | United States | 25701 |
| 497 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 498 | Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | United States | 26003 |
| 499 | Langlade Hospital and Cancer Center | Antigo | Wisconsin | United States | 54409 |
| 500 | ThedaCare Regional Cancer Center | Appleton | Wisconsin | United States | 54911 |
| 501 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 502 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 503 | Mayo Clinic Health System-Eau Claire Clinic | Eau Claire | Wisconsin | United States | 54701 |
| 504 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 505 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 506 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
| 507 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 508 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 509 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 510 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 511 | Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin | United States | 54601 |
| 512 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 513 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 514 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 515 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 516 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 517 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 518 | Zablocki Veterans Administration Medical Center | Milwaukee | Wisconsin | United States | 53295 |
| 519 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 520 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 521 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 522 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 523 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 524 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 525 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 526 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 527 | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States | 54482 |
| 528 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 529 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 530 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 531 | Aspirus Regional Cancer Center | Wausau | Wisconsin | United States | 54401 |
| 532 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 533 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 534 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 535 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 536 | Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 537 | Tohoku University School of Medicine | Sendai | Aoba-ku | Japan | 980-8574 |
| 538 | Ehime University Hospital | Toon | Ehime | Japan | 791-0295 |
| 539 | Hokkaido University Hospital | Sapporo | Hokkaido | Japan | 060-8648 |
| 540 | Kagoshima City Hospital | Kagoshima City | Kagoshima | Japan | 890-8760 |
| 541 | Niigata University Medical and Dental Hospital | Niigata City | Niigata | Japan | 951-8520 |
| 542 | Kyorin University Hospital | Mitaka-shi | Tokyo | Japan | 181-8611 |
| 543 | Hiroshima University Hospital | Hiroshima City | Japan | 734-8551 | |
| 544 | Shikoku Cancer Center | Matsuyama | Japan | 791-0280 | |
| 545 | Saitama Medical University International Medical Center | Saitama | Japan | 350-1298 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
- NRG Oncology
Investigators
- Principal Investigator: Kristin A Higgins, NRG Oncology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2019-00178
- NCI-2019-00178
- NRG-LU005
- NRG-LU005
- U10CA180868