Metabolic Study of Concentric and Eccentric Muscle Training

Sponsor

Vorarlberg Institute for Vascular Investigation and Treatment (Other)

Overall Status

Completed

CT.gov ID

NCT00386854

Collaborator

(none)

Enrollment

Location

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Condition or Disease	Intervention/Treatment	Phase
Lipid Metabolism Insulin Resistance Inflammation	Behavioral: physical training	N/A

Detailed Description

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Study Design

Study Type:

Interventional

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

None (Open Label)

Primary Purpose:

Educational/Counseling/Training

Study Start Date :

Apr 1, 2003

Study Completion Date :

Aug 1, 2003

Outcome Measures

Primary Outcome Measures

Metabolic and anti-inflammatory effects induced by eccentric muscle exercise. []

Secondary Outcome Measures

Metabolic and anti-inflammatory effects induced by concentric muscle exercise. []

Eligibility Criteria

Criteria

Ages Eligible for Study:

30 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

healthy men and women
age over 30 years

Exclusion Criteria:

previous systematic endurance training (≥3 times per week ≥30 min)
body mass index >30 kg/m2
heavy smoking (>20 cigarettes per day)
regular alcohol consumption >60g per day
established musculoskeletal disease
history of cardiovascular disease
diabetes mellitus
unwillingness to stay in the area for the whole study period

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Vorarlberg Institute of Vascular Investigation and Treatment	Feldkirch	Vorarlberg	Austria	6807

Sponsors and Collaborators

Vorarlberg Institute for Vascular Investigation and Treatment

Investigators

Principal Investigator: Heinz Drexel, MD, Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

, ,

ClinicalTrials.gov Identifier:

NCT00386854

Other Study ID Numbers:

K01-2003-1

First Posted:

Oct 12, 2006

Last Update Posted:

Oct 12, 2006

Last Verified:

Oct 1, 2006

Keywords provided by , ,

Additional relevant MeSH terms:

Insulin Resistance

Inflammation

Study Results

No Results Posted as of Oct 12, 2006