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Effect of High-calcium Intake on Substrate Metabolism During Exercise

Sponsor
Northumbria University (Other)
Overall Status
Completed
CT.gov ID
NCT01779245
Collaborator
(none)
13
Enrollment
1
Location
2
Arms
4
Duration (Months)
3.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Calcium
  • Dietary Supplement: Placebo
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
13 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Basic Science
Official Title:
The Impact of a Calcium Supplementation on Lipid Metabolism During Exercise.
Study Start Date :
Oct 1, 2012
Actual Primary Completion Date :
Feb 1, 2013
Actual Study Completion Date :
Feb 1, 2013

Arms and Interventions

Arm Intervention/Treatment
Placebo Comparator: Control

A chocolate milkshake with a normal calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 400 mg calcium per serving).

Dietary Supplement: Placebo
Experimental: High-Calcium

A chocolate milkshake with a high calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 1400 mg calcium per serving).

Dietary Supplement: Calcium
Milk-extracted calcium supplement will be used to modulate the calcium content of the milkshakes used.

Outcome Measures

Primary Outcome Measures

  1. Substrate metabolism [60 s samples every 3 min for 15 min]

    Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.

Secondary Outcome Measures

  1. Plasma non-esterified fatty acid concentrations [Every 3 min for 15 min]

    Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.

  2. Plasma glycerol concentrations [Every 3 min for 15 min]

    Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.

Other Outcome Measures

  1. Serum parathyroid hormone concentration [Baseline (Pre-post 2 week supplementation)]

    Parathyroid hormone concentrations will be determined at rest before and after supplementation periods as a indicator of calcium status.

  2. Plasma glucose-dependent insulinotropic peptide concentration [Baseline (Pre-post 2 week supplementation)]

    Glucose-dependent insulinotropic peptide concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.

  3. Plasma glucagon-like peptide-1 concentration [Baseline (Pre-post 2 week supplementation)]

    Glucagon-like peptide-1 concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 40 Years
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Physically active (moderate-vigorous exercise >3 time per week)

  • Male

  • 18-40 yrs of age

Exclusion Criteria:

  • Smoker

  • Known Food Allergies

  • Metabolic disorders

Contacts and Locations

Locations

Site City State Country Postal Code
1 Northumbria University Newcastle upon Tyne Tyne and Wear United Kingdom NE1 8ST

Sponsors and Collaborators

  • Northumbria University

Investigators

  • Principal Investigator: Emma J Stevenson, PhD, Northumbria University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Javier Gonzalez, Principal Investigator, Northumbria University
ClinicalTrials.gov Identifier:
NCT01779245
Other Study ID Numbers:
  • 32AN3
First Posted:
Jan 30, 2013
Last Update Posted:
Sep 6, 2013
Last Verified:
Sep 1, 2013
Additional relevant MeSH terms:
Calcium

Study Results

No Results Posted as of Sep 6, 2013