Cross-sectional Study of Chinese Liver Cancer Patients
Study Details
Study Description
Brief Summary
The goal of this cross-sectional study is to investigate the prevalence and risk factors of anxiety and depression and their relationships with immune functions and quality of life among liver cancer patients in the COVID-19 pandemic era. The objectives of this study are:
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To examine the prevalence of anxiety and depression among patients with liver cancer during the COVID-19 pandemic.
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To identify risk factors associated with anxiety and depression among these patients.
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To determine the association between anxiety, depression, immune function, and quality of life among liver cancer patients.
Participants will be asked to fill a digital questionnaire.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Outcome Measures
Primary Outcome Measures
- Anxiety score [Baseline]
Participants' anxiety status with HADS
- Depression score [Baseline]
Participants' depression status with HADS
Secondary Outcome Measures
- Quality of life score (The EORTC QLQ-C30) [Baseline]
The European Organization for Research and Treatment of Cancer(EORTC) Quality of Life Questionnaire results. Scores range from 0 to 100. A higher score represents a higher ("better") level of functioning, or a higher ("worse") level of symptoms.
- Quality of life score (The EORTC QLQ-HCC18) [Baseline]
The Hepatocellular Carcinoma Module of The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. Scores range from 0 to 100. A higher score represents a high level of symptomatology or problems.
- Immune variables 1 [Baseline]
White blood cell counts (WBC). Collected from daily medical records.
- Immune variables 2 [Baseline]
Total neutrophil count. Collected from daily medical records.
- Immune variables 3 [Baseline]
Total lymphocyte count. Collected from daily medical records.
- Immune variables 4 [Baseline]
Total monocyte count. Collected from daily medical records.
- Immune variables 5 [Baseline]
Neutrophilic granulocyte percentage. Collected from daily medical records.
- Immune variables 6 [Baseline]
Percentage of lymphocytes. Collected from daily medical records.
- Immune variables 7 [Baseline]
Monocyte percentage. Collected from daily medical records.
- Immune variables 8 [Baseline]
C-reactive protein (CRP). Collected from daily medical records.
Eligibility Criteria
Criteria
Inclusion criteria
Participants must meet all the following criteria for study entry:
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Aged 18 or older.
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Participants have a confirmed diagnosis of liver cancer in the medical records.
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Participants are able to communicate with Chinese. Exclusion criteria
Participants who meet any of the following criteria will be excluded from study entry:
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Participant has multiple organ failure which makes him/her incapable to comply with the study protocol.
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Participant has hepatic encephalopathy or severe mental disorder which makes him/her incapable of understanding the meanings of the questionnaires.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Zhuhai People's Hospital | Zhuhai | Guangdong | China | 519000 |
Sponsors and Collaborators
- The Nethersole School of Nursing
Investigators
- Principal Investigator: Hua Yin, Chinese University of Hong Kong
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
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- Cheng HH, Kamarck TW, Gianaros PJ, Roecklein KA, Vanegas Y, Tsung A, Geller DA, Marsh JW, Ahmed NS, Steel JL. Socioeconomic disparities of depressive symptoms and cytokines in hepatocellular carcinoma. Psychooncology. 2019 Aug;28(8):1624-1632. doi: 10.1002/pon.5127. Epub 2019 Jun 18.
- Chu TL, Yu WP, Chen SC, Peng HL, Wu MJ. Comparison of differences and determinants between presence and absence of sleep disturbance in hepatocellular carcinoma patients. Cancer Nurs. 2011 Sep-Oct;34(5):354-60. doi: 10.1097/NCC.0b013e3182037bf3.
- Chung MH, Wang SY, Lin CC. Symptom Clusters and Impact of Fatigue and Sleep Disturbance on Symptom Experiences of Hepatoma Patients in Taiwan. Cancer Nurs. 2017 Sep/Oct;40(5):403-411. doi: 10.1097/NCC.0000000000000417.
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- SBRE-22-0307