Liver Regeneration After Liver Resection
Sponsor
Nottingham University Hospitals NHS Trust (Other)
Overall Status
Unknown status
CT.gov ID
NCT01220986
Collaborator
(none)
20
1
24
0.8
Study Details
Study Description
Brief Summary
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Anticipated Enrollment
:
20 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
An Observational Study of Liver Regeneration After Right Hepatectomy: Understanding the Molecular Primers of Liver Regeneration
Study Start Date
:
Aug 1, 2010
Anticipated Primary Completion Date
:
Dec 1, 2011
Anticipated Study Completion Date
:
Aug 1, 2012
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Right hepatectomy Intervals from inflow division. |
Procedure: Liver biopsy
0, 30, 60, 90 min post inflow-division
|
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 75 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- Patients requiring right hepatectomy for colorectal liver metastases
Exclusion Criteria:
- Age >75, neoadjuvant chemotherapy, recurrent disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus | Nottingham | Nottinghamshire | United Kingdom | NG7 2UH |
Sponsors and Collaborators
- Nottingham University Hospitals NHS Trust
Investigators
- Study Chair: Dileep N. Lobo, DM FRCS, Reader in Surgery
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT01220986
Other Study ID Numbers:
- NDDC10/H0403/32
First Posted:
Oct 14, 2010
Last Update Posted:
Oct 14, 2010
Last Verified:
Oct 1, 2010
Keywords provided by ,
,
Additional relevant MeSH terms: