Comparison of PRS According to Inhalation Agent During LDLT

• Sponsor: Seoul National University Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT01886664
• Collaborator: (none)
• Enrollment: 70
• Location: 1
• Arms: 2
• Duration (Months): 12
• Patients Per Site Per Month: 5.8

Study Details

Study Description

Brief Summary

The investigators tried to evaluate the effect of desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation surgery. The investigators used sevoflurane as a comparison.

Condition or Disease	Intervention/Treatment	Phase
Liver Transplantation; Postreperfusion Syndrome	Drug: sevoflurane; Drug: Desflurane	Phase 4

Study Design

• Study Type: Interventional
• Actual Enrollment: 70 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Participant)
• Primary Purpose: Prevention
• Study Start Date: Dec 1, 2012
• Actual Primary Completion Date: Nov 1, 2013
• Actual Study Completion Date: Dec 1, 2013

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Sevoflurane Performing liver transplantation under general anesthesia using sevoflurane	Drug: sevoflurane
Experimental: Desflurane Performing liver transplantation under general anesthesia using desflurane	Drug: Desflurane

Outcome Measures

Primary Outcome Measures

1. frequency of PRS [immediately after reperfusion]

   reperfusion syndrome occurs, if it occurs, immediately after reperfusion. Therefore, the primary outcome, reperfusion syndrome, can only be assessed immediately after reperfusion.

Secondary Outcome Measures

1. ICU length of stay [after LT until the patient is transferred to the ward]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 65 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• elective LDLT

Exclusion Criteria:

• age < 18, age > 65

• patient refusal

• re-transplantation

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Seoul National University Hospital	Seoul		Korea, Republic of	110-744

Sponsors and Collaborators

• Seoul National University Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Seoul National University Hospital
• ClinicalTrials.gov Identifier: NCT01886664
• Other Study ID Numbers: Des vs Sevo PRS
• First Posted: Jun 26, 2013
• Last Update Posted: Jun 26, 2014
• Last Verified: Jun 1, 2014

• Additional relevant MeSH terms: Sevoflurane; Desflurane

Study Results

No Results Posted as of Jun 26, 2014