AMBASSADOR: Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT03244384
• Collaborator: (none)
• Enrollment: 739
• Locations: 923
• Arms: 2
• Anticipated Duration (Months): 92.3
• Patients Per Site: 0.8
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase III trial studies how well pembrolizumab works in treating patients with bladder cancer that has spread into the deep muscle of the bladder wall (muscle-invasive) or urothelial cancer that has spread from where it started to nearby tissue or lymph nodes (locally advanced). Monoclonal antibodies recognizing and blocking checkpoint molecules can enhance the patient's immune response and therefore help fight cancer. Pembrolizumab is one of the monoclonal antibodies that block the PD-1 axis and can interfere with the ability of tumor cells to grow.

Condition or Disease	Intervention/Treatment	Phase
Localized Renal Pelvis and Ureter Urothelial Carcinoma; Locally Advanced Bladder Urothelial Carcinoma; Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma; Locally Advanced Ureter Urothelial Carcinoma; Locally Advanced Urothelial Carcinoma; Stage II Bladder Urothelial Carcinoma AJCC v6 and v7; Stage II Renal Pelvis and Ureter Cancer AJCC v7; Stage II Ureter Cancer AJCC v7; Stage III Bladder Urothelial Carcinoma AJCC v6 and v7; Stage III Renal Pelvis and Ureter Cancer AJCC v7; Stage III Ureter Cancer AJCC v7	Other: Clinical Observation; Other: Laboratory Biomarker Analysis; Biological: Pembrolizumab; Other: Pharmacological Study; Other: Quality-of-Life Assessment; Other: Questionnaire Administration	Phase 3

Detailed Description

DUAL PRIMARY OBJECTIVE:

1. To determine disease free survival (DFS) and overall survival (OS) in all patients with muscle-invasive bladder and upper-tract urothelial carcinoma treated with adjuvant pembrolizumab versus (vs.) observation.

SECONDARY OBJECTIVES:

1. To determine DFS and OS in PD-L1 positive and negative patients with muscle-invasive bladder and upper-tract urothelial carcinoma treated with adjuvant pembrolizumab vs. observation.

2. To characterize the safety and tolerability of pembrolizumab when administered in the adjuvant setting in patients with muscle-invasive bladder and upper-tract urothelial carcinoma.

CORRELATIVE SCIENCE OBJECTIVES:

1. To determine if the 12 immune gene signatures are associated with OS and DFS.

2. To determine if tumor molecular subtype is associated with OS and DFS. III. To investigate whether the diversity of T-cell receptor (TCR) clonotypes is associated with OS and DFS.

3. To investigate whether persistence of TCR clonotypes is associated with OS and DFS.

4. To determine if tumor burden and neoantigen burden are associated with OS and DFS.

5. To determine if HLA subtypes are associated with OS and DFS. VII. To conduct exploratory analyses regarding the association of plasma HGF and VEGF levels with IL-10 and IL-17 and OS and DFS and between treated and untreated patients.

PHARMACOGENOMIC STUDY OBJECTIVES:

1. To investigate the effect of PDCD1 single-nucleotide polymorphism (SNP) rs11568821 on severe (grade 3 or higher) immune-related toxicity in the pembrolizumab-treated cohort.

2. To investigate whether other SNPs commonly polymorphic within or near PDCD1 associate with development of pembrolizumab toxicity in the treated cohort.

3. To identify novel germline genetic markers of treatment-related toxicity through genome-wide association analysis of pembrolizumab-treated patients.

4. To identify novel germline genetic markers that are associated with DFS and OS through genome-wide association analysis.

QUALITY OF LIFE CORRELATIVE STUDY OBJECTIVES:

1. To compare health-related quality of life (HRQL) as assessed by the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ)-core (C)30 between patients randomized to pembrolizumab vs. observation.

2. To compare urinary symptoms as assessed by EORTC QLQ- muscle-invasive bladder cancer module (BLM)30 between patients randomized to pembrolizumab vs. observation.

3. To compare patient-reported fatigue, diarrhea, and pain between patients randomized to pembrolizumab vs. observation.

4. To compare health utilities and quality-adjusted life year (QALYs) between patients randomized to pembrolizumab vs. observation.

5. To compare other scale scores of the EORTC QLQ-C30, EORTC QLQ-BLM30, and European Quality of Life 5 Dimensions 5 Levels (EQ5D-5L) between patients randomized to pembrolizumab vs. observation.

6. To compare global quality of life, symptoms, health utilities, QALYs, and other scale scores of the three questionnaires between patients randomized to pembrolizumab vs. observation within subgroups defined by each of the stratification factors.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment repeats every 21 days for up to 18 cycles in the absence of disease progression or unacceptable toxicity.

ARM B: Patients undergo observation.

After completion of study treatment, patients are followed up every 12 weeks for up 2 years, and then annually for 3 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 739 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Phase III Randomized Adjuvant Study of Pembrolizumab in muScle invaSive and locAlly aDvanced urOthelial caRcinoma (AMBASSADOR) Versus Observation
• Actual Study Start Date: Sep 21, 2017
• Anticipated Primary Completion Date: Jun 1, 2025
• Anticipated Study Completion Date: Jun 1, 2025

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A (pembrolizumab) Patients receive pembrolizumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 18 cycles in the absence of disease progression or unacceptable toxicity.	Other: Laboratory Biomarker Analysis; Correlative studies; Biological: Pembrolizumab; Given IV; Other Names: Keytruda Lambrolizumab MK-3475 SCH 900475 ; Other: Pharmacological Study; Correlative studies; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Other: Questionnaire Administration; Ancillary studies
Active Comparator: Arm B (observation) Patients undergo observation.	Other: Clinical Observation; Undergo observation; Other Names: observation ; Other: Laboratory Biomarker Analysis; Correlative studies; Other: Pharmacological Study; Correlative studies; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Other: Questionnaire Administration; Ancillary studies

Outcome Measures

Primary Outcome Measures

1. Overall survival [From randomization to the date of death from any cause, assessed up to 5 years]

   The stratified proportional hazards model will be the primary analysis. The hazard ratio and its 95% confidence interval from the stratified Cox model with a single treatment covariate will be reported. The unstratified hazard ratio will also be presented.

2. Disease-free survival [From randomization to the first metastatic recurrence (presence of any recurrent disease), or death, whichever occurs first, assessed up to 5 years]

   The stratified proportional hazards model will be the primary analysis. The hazard ratio and its 95% confidence interval from the stratified Cox model with a single treatment covariate will be reported. The unstratified hazard ratio will also be presented.

Secondary Outcome Measures

1. Overall survival in PD-L1 positive and negative patients [From randomization to the date of death from any cause, assessed up to 5 years]

   The stratified proportional hazards model will be the primary analysis. The hazard ratio and its 95% confidence interval from the stratified Cox model with a single treatment covariate will be reported. The unstratified hazard ratio will also be presented.

2. Disease-free survival in PD-L1 positive and negative patients [From randomization to the first metastatic recurrence (presence of any recurrent disease), or death, whichever occurs first, assessed up to 5 years]

   The stratified proportional hazards model will be the primary analysis. The hazard ratio and its 95% confidence interval from the stratified Cox model with a single treatment covariate will be reported. The unstratified hazard ratio will also be presented.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• PRE-REGISTRATION ELIGIBILITY CRITERIA

• Histologically confirmed muscle-invasive urothelial carcinoma of the bladder, urethra, upper tract, or lymph node positive (LN+) disease; variant histology allowed as long as urothelial carcinoma is predominant (any amount of squamous differentiation is allowed); any component of neuroendocrine carcinoma is excluded

• Paraffin tissue samples obtained by transurethral resection of muscle-invasive bladder tumor, upper tract resection, or radical cystectomy/nephrectomy/ureterectomy/nephroureterectomy/cystoprostatectomy or urethrectomy must be available; this specimen submission is mandatory prior to registration as results will be used for stratification; specimens from radical/definitive surgery (radical cystectomy/nephrectomy/ureterectomy /nephroureterectomy/cystoprostatectomy and LN dissection) are preferred over transurethral resection, if available

• Patient must fit into one of the following three categories:

• Patients who received neoadjuvant chemotherapy and pathologic stage at surgical resection is >= pT2 and/or N+ OR

• Patients who are not cisplatin-eligible (according to >= 1 of the following criteria: Eastern Cooperative Oncology Group [ECOG] performance status of 2, creatinine clearance < 60 mL/min, grade >= 2 hearing loss, grade >= 2 neuropathy, or New York Heart Association class III heart failure and pathologic stage at surgical resection is >= pT3 or pN+) OR

• Patients that decline adjuvant cisplatin-based or other systemic chemotherapy based on an informed discussion with the physician and pathologic stage at surgical resection is >= pT3 or pN+

• The 7th edition of American Joint Committee on Cancer (AJCC) staging will be utilized; patient must have had radical cystectomy (cystoprostatectomy for men) and lymph node dissection (for bladder primary), or nephrectomy, nephroureterectomy or ureterectomy (for uppertract tumors) or urethrectomy (in addition to a radical cystectomy-either simultaneously or in the past) >= 4 weeks but =< 16 weeks prior to pre-registration; patients who have had a partial cystectomy as definitive therapy are not eligible

• No gross cancer at the surgical margins; microscopic invasive urothelial carcinoma positive margins are allowed; carcinoma in situ (CIS) at margins is considered negative margins

• No evidence of residual cancer or metastasis after surgery; patients with upper tract urothelial carcinoma must have a negative cystoscopy within 3 months prior to pre-registration; if the bladder has been removed a cystoscopy is not required

• No metastatic disease (or radiologic findings "concerning" for metastatic disease) on cross-sectional imaging (according to Response Evaluation Criteria in Solid Tumors [RECIST] version [v]1.1 criteria)

• No active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids; these include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome because of the risk of recurrence or exacerbation of disease; human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible

• No current pneumonitis or prior history of non-infectious pneumonitis that required steroids within the previous 5 years

• Patients with vitiligo, endocrine deficiencies including type I diabetes mellitus, thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible

• Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible

• No known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [RNA] [qualitative] is detected)

• No live vaccine within 30 days prior to the first dose of study drug; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowed

• No postoperative/adjuvant systemic therapy

• No prior treatment with any therapy on the PD-1/PD-L1 axis

• No treatment with any other type of investigational agent =< 4 weeks before pre-registration

• No major surgery =< 4 weeks before pre-registration

• No radiation therapy =< 4 weeks before pre-registration

• No neoadjuvant chemotherapy =< 4 weeks before pre-registration

• Not currently requiring hemodialysis

• Age >= 18 years

• Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown

• ECOG performance status =< 2

• Absolute neutrophil count (ANC) >= 1,200/mm^3

• Leukocytes >= 3,000/ mm^3

• Platelet count >= 75,000/mm^3

• Hemoglobin >= 9 g/dL or >= 5.6 mmol/L

• Total bilirubin =< 1.5 x upper limit of normal (ULN)

• Bilirubin for patients with Gilbert's =< 3.0 x ULN

• Calculated (calc.) creatinine clearance >= 30 mL/min (using either Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] or Cockcroft-Gault formula)

• Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN)

• Serum albumin >= 2.8 g/dL

• For women of childbearing potential only: a negative urine or serum pregnancy test done =< 7 days prior to pre-registration is required

• REGISTRATION ELIGIBILITY CRITERIA: Results of central PD-L1 testing available; Q2 Solutions will forward the PD-L1 results to the statistical center and the statistical center will notify the site that the result is available; since the results with be blinded to the site the notification from the Alliance registration/randomization office will serve as a confirmation of this eligibility criteria; after sites receive the confirmation e-mail from Alliance they can register the patient

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
3	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
4	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
5	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
6	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
7	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
8	Katmai Oncology Group	Anchorage	Alaska	United States	99508
9	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
10	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
11	CTCA at Western Regional Medical Center	Goodyear	Arizona	United States	85338
12	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
13	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
14	Mayo Clinic Hospital in Arizona	Phoenix	Arizona	United States	85054
15	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
16	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
17	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
18	John L McClellan Memorial Veterans Hospital	Little Rock	Arkansas	United States	72205
19	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
20	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
21	PCR Oncology	Arroyo Grande	California	United States	93420
22	AIS Cancer Center at San Joaquin Community Hospital	Bakersfield	California	United States	93301
23	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
24	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
25	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
26	Epic Care-Dublin	Dublin	California	United States	94568
27	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
28	Epic Care Partners in Cancer Care	Emeryville	California	United States	94608
29	Kaiser Permanente-Fontana	Fontana	California	United States	92335
30	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
31	Kaiser Permanente-Irvine	Irvine	California	United States	92618
32	UC San Diego Moores Cancer Center	La Jolla	California	United States	92093
33	Loma Linda University Medical Center	Loma Linda	California	United States	92354
34	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
35	Los Angeles County-USC Medical Center	Los Angeles	California	United States	90033
36	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
37	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
38	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
39	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
40	Community Hospital of Monterey Peninsula	Monterey	California	United States	93940
41	Pacific Cancer Care-Monterey	Monterey	California	United States	93940
42	USC Norris Oncology/Hematology-Newport Beach	Newport Beach	California	United States	92663
43	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
44	Bay Area Tumor Institute	Oakland	California	United States	94609
45	Kaiser Permanente-Ontario	Ontario	California	United States	91761
46	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
47	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
48	Keck Medical Center of USC Pasadena	Pasadena	California	United States	91105
49	Kaiser Permanente-Riverside	Riverside	California	United States	92505
50	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
51	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
52	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
53	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
54	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
55	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
56	Gene Upshaw Memorial Tahoe Forest Cancer Center	Truckee	California	United States	96161
57	Epic Care Cyberknife Center	Walnut Creek	California	United States	94597
58	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
59	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
60	The Medical Center of Aurora	Aurora	Colorado	United States	80012
61	University of Colorado Hospital	Aurora	Colorado	United States	80045
62	Boulder Community Hospital	Boulder	Colorado	United States	80301
63	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
64	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
65	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
66	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
67	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
68	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
69	Memorial Hospital North	Colorado Springs	Colorado	United States	80920
70	Cancer Center of Colorado at Sloan's Lake	Denver	Colorado	United States	80204
71	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
72	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
73	The Women's Imaging Center	Denver	Colorado	United States	80209
74	Porter Adventist Hospital	Denver	Colorado	United States	80210
75	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
76	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
77	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
78	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
79	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
80	Rose Medical Center	Denver	Colorado	United States	80220
81	Western Surgical Care	Denver	Colorado	United States	80220
82	Mercy Medical Center	Durango	Colorado	United States	81301
83	Southwest Oncology PC	Durango	Colorado	United States	81301
84	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
85	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
86	Swedish Medical Center	Englewood	Colorado	United States	80113
87	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
88	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
89	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
90	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
91	Grand Valley Oncology	Grand Junction	Colorado	United States	81505
92	North Colorado Medical Center	Greeley	Colorado	United States	80631
93	UCHealth Highlands Ranch Hospital	Highlands Ranch	Colorado	United States	80129
94	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
95	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
96	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
97	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
98	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
99	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
100	Kaiser Permanente-Lone Tree	Lone Tree	Colorado	United States	80124
101	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
102	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
103	Longmont United Hospital	Longmont	Colorado	United States	80501
104	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
105	McKee Medical Center	Loveland	Colorado	United States	80539
106	Parker Adventist Hospital	Parker	Colorado	United States	80138
107	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
108	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
109	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
110	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
111	Danbury Hospital	Danbury	Connecticut	United States	06810
112	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
113	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
114	Greenwich Hospital	Greenwich	Connecticut	United States	06830
115	Smilow Cancer Hospital Care Center at Greenwich	Greenwich	Connecticut	United States	06830
116	Smilow Cancer Hospital Care Center - Guiford	Guilford	Connecticut	United States	06437
117	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
118	Middlesex Hospital	Middletown	Connecticut	United States	06457
119	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
120	Yale University	New Haven	Connecticut	United States	06520
121	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
122	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
123	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
124	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
125	Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	United States	06385
126	Beebe South Coastal Health Campus	Frankford	Delaware	United States	19945
127	Beebe Medical Center	Lewes	Delaware	United States	19958
128	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
129	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
130	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
131	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
132	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
133	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
134	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
135	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
136	MedStar Washington Hospital Center	Washington	District of Columbia	United States	20010
137	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
138	George Washington University Medical Center	Washington	District of Columbia	United States	20037
139	Mount Sinai Comprehensive Cancer Center at Aventura	Aventura	Florida	United States	33180
140	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
141	University of Florida Health Science Center - Gainesville	Gainesville	Florida	United States	32610
142	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
143	Orlando Health Cancer Institute	Orlando	Florida	United States	32806
144	Grady Health System	Atlanta	Georgia	United States	30303
145	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
146	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
147	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
148	Northside Hospital	Atlanta	Georgia	United States	30342
149	Northside Hospital-Forsyth	Cumming	Georgia	United States	30041
150	Northside Hospital - Duluth	Duluth	Georgia	United States	30096
151	Northside Hospital - Gwinnett	Lawrenceville	Georgia	United States	30046
152	Low Country Cancer Care	Savannah	Georgia	United States	31404
153	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
154	Summit Cancer Care-Memorial	Savannah	Georgia	United States	31404
155	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
156	Summit Cancer Care-Candler	Savannah	Georgia	United States	31405
157	Suburban Hematology Oncology Associates - Snellville	Snellville	Georgia	United States	30078
158	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
159	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
160	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
161	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
162	The Queen's Medical Center - West Oahu	'Ewa Beach	Hawaii	United States	96706
163	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
164	Island Urology	Honolulu	Hawaii	United States	96813
165	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
166	Queen's Medical Center	Honolulu	Hawaii	United States	96813
167	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
168	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
169	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
170	Hawaii Diagnostic Radiology Services LLC	Honolulu	Hawaii	United States	96817
171	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
172	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
173	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
174	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
175	Straub Medical Center - Kahului Clinic	Kahului	Hawaii	United States	96732
176	Castle Medical Center	Kailua	Hawaii	United States	96734
177	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
178	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
179	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
180	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
181	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
182	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
183	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
184	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
185	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
186	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
187	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
188	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
189	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
190	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
191	Saint Anthony's Health	Alton	Illinois	United States	62002
192	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
193	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
194	Loyola Center for Health at Burr Ridge	Burr Ridge	Illinois	United States	60527
195	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
196	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
197	SIH Cancer Institute	Carterville	Illinois	United States	62918
198	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
199	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
200	Northwestern University	Chicago	Illinois	United States	60611
201	Rush University Medical Center	Chicago	Illinois	United States	60612
202	University of Illinois	Chicago	Illinois	United States	60612
203	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
204	Carle on Vermilion	Danville	Illinois	United States	61832
205	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
206	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
207	Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	United States	60115
208	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
209	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
210	Crossroads Cancer Center	Effingham	Illinois	United States	62401
211	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
212	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
213	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
214	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
215	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
216	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
217	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
218	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
219	Edward Hines Jr VA Hospital	Hines	Illinois	United States	60141
220	Loyola Medicine Homer Glen	Homer Glen	Illinois	United States	60491
221	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
222	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
223	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
224	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
225	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
226	Loyola University Medical Center	Maywood	Illinois	United States	60153
227	Marjorie Weinberg Cancer Center at Loyola-Gottlieb	Melrose Park	Illinois	United States	60160
228	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
229	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
230	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
231	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
232	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
233	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
234	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
235	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
236	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
237	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
238	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
239	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
240	Valley Radiation Oncology	Peru	Illinois	United States	61354
241	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
242	West Suburban Medical Center	River Forest	Illinois	United States	60305
243	Genesis Cancer Center - Silvis	Silvis	Illinois	United States	61282
244	North Shore Medical Center	Skokie	Illinois	United States	60076
245	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
246	Springfield Clinic	Springfield	Illinois	United States	62702
247	Memorial Medical Center	Springfield	Illinois	United States	62781
248	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
249	Carle Cancer Center	Urbana	Illinois	United States	61801
250	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
251	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
252	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
253	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
254	Parkview Hospital Randallia	Fort Wayne	Indiana	United States	46805
255	Parkview Regional Medical Center	Fort Wayne	Indiana	United States	46845
256	Community Cancer Center East	Indianapolis	Indiana	United States	46219
257	Community Cancer Center South	Indianapolis	Indiana	United States	46227
258	Community Cancer Center North	Indianapolis	Indiana	United States	46256
259	Community Howard Regional Health	Kokomo	Indiana	United States	46904
260	Baptist Health Floyd	New Albany	Indiana	United States	47150
261	Reid Health	Richmond	Indiana	United States	47374
262	Mary Greeley Medical Center	Ames	Iowa	United States	50010
263	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
264	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
265	Saint Anthony Regional Hospital	Carroll	Iowa	United States	51401
266	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
267	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
268	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
269	Greater Regional Medical Center	Creston	Iowa	United States	50801
270	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
271	Genesis Cancer Care Institute	Davenport	Iowa	United States	52804
272	Iowa Cancer Specialists	Davenport	Iowa	United States	52807
273	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
274	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
275	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
276	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
277	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
278	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
279	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
280	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
281	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
282	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
283	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
284	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
285	Coffeyville Regional Medical Center	Coffeyville	Kansas	United States	67337
286	University of Kansas Clinical Research Center	Fairway	Kansas	United States	66205
287	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
288	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
289	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
290	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
291	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
292	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
293	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
294	Olathe Health Cancer Center	Olathe	Kansas	United States	66061
295	Menorah Medical Center	Overland Park	Kansas	United States	66209
296	University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	United States	66210
297	Saint Luke's South Hospital	Overland Park	Kansas	United States	66213
298	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
299	Salina Regional Health Center	Salina	Kansas	United States	67401
300	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
301	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
302	University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	United States	66205
303	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
304	Baptist Health Corbin	Corbin	Kentucky	United States	40701
305	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
306	Baptist Health Lexington	Lexington	Kentucky	United States	40503
307	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
308	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
309	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
310	Saint Joseph London	London	Kentucky	United States	40741
311	Jewish Hospital	Louisville	Kentucky	United States	40202
312	Baptist Health Louisville	Louisville	Kentucky	United States	40207
313	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
314	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
315	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
316	Baptist Health Paducah	Paducah	Kentucky	United States	42003
317	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
318	Christus Saint Frances Cabrini Hospital	Alexandria	Louisiana	United States	71301
319	LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	United States	70805
320	Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	United States	70809
321	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
322	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
323	Our Lady of the Lake Physicians Group - Medical Oncology	Baton Rouge	Louisiana	United States	70809
324	Medical Center of Baton Rouge	Baton Rouge	Louisiana	United States	70816
325	Ochsner High Grove	Baton Rouge	Louisiana	United States	70836
326	Northshore Oncology Associates-Covington	Covington	Louisiana	United States	70433
327	Oncology Center of The South Incorporated	Houma	Louisiana	United States	70360
328	Terrebonne General Medical Center	Houma	Louisiana	United States	70360
329	East Jefferson General Hospital	Metairie	Louisiana	United States	70006
330	LSU Healthcare Network / Metairie Multi-Specialty Clinic	Metairie	Louisiana	United States	70006
331	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
332	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
333	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
334	CHRISTUS Highland Medical Center	Shreveport	Louisiana	United States	71105
335	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
336	Eastern Maine Medical Center	Bangor	Maine	United States	04401
337	Waldo County General Hospital	Belfast	Maine	United States	04915
338	MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford	Biddeford	Maine	United States	04005
339	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
340	Stephens Memorial Hospital	Norway	Maine	United States	04268
341	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
342	MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford	Sanford	Maine	United States	04073
343	Maine Medical Center- Scarborough Campus	Scarborough	Maine	United States	04074
344	Maine Medical Partners - South Portland	South Portland	Maine	United States	04106
345	MedStar Union Memorial Hospital	Baltimore	Maryland	United States	21218
346	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
347	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
348	National Institutes of Health Clinical Center	Bethesda	Maryland	United States	20892
349	UM Saint Joseph Medical Center	Towson	Maryland	United States	21204
350	Massachusetts General Hospital Cancer Center	Boston	Massachusetts	United States	02114
351	Boston Medical Center	Boston	Massachusetts	United States	02118
352	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
353	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
354	Lowell General Hospital	Lowell	Massachusetts	United States	01854
355	Dana-Farber Cancer Institute - Chestnut Hill	Newton	Massachusetts	United States	02467
356	Lahey Medical Center-Peabody	Peabody	Massachusetts	United States	01960
357	Mercy Medical Center	Springfield	Massachusetts	United States	01104
358	Hickman Cancer Center	Adrian	Michigan	United States	49221
359	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
360	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
361	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
362	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
363	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	United States	48114
364	University of Michigan - Brighton Center for Specialty Care	Brighton	Michigan	United States	48116
365	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
366	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
367	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	United States	48188
368	Caro Cancer Center	Caro	Michigan	United States	48723
369	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
370	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	United States	48118
371	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
372	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
373	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
374	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
375	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
376	Henry Ford Hospital	Detroit	Michigan	United States	48202
377	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
378	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
379	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
380	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
381	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
382	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
383	Hurley Medical Center	Flint	Michigan	United States	48503
384	Helen DeVos Children's Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
385	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
386	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
387	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
388	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
389	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
390	Allegiance Health	Jackson	Michigan	United States	49201
391	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
392	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
393	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
394	Sparrow Hospital	Lansing	Michigan	United States	48912
395	Hope Cancer Clinic	Livonia	Michigan	United States	48154
396	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
397	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
398	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
399	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
400	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
401	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
402	Lakeland Hospital Niles	Niles	Michigan	United States	49120
403	Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	United States	49444
404	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
405	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
406	Hope Cancer Center	Pontiac	Michigan	United States	48341
407	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
408	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
409	Huron Medical Center PC	Port Huron	Michigan	United States	48060
410	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
411	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
412	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
413	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
414	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
415	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
416	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
417	Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	United States	48315
418	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
419	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
420	Munson Medical Center	Traverse City	Michigan	United States	49684
421	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
422	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
423	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
424	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
425	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
426	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
427	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
428	Metro Health Hospital	Wyoming	Michigan	United States	49519
429	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
430	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	United States	48197
431	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
432	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
433	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
434	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
435	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
436	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
437	Unity Hospital	Fridley	Minnesota	United States	55432
438	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
439	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
440	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
441	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
442	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
443	Health Partners Inc	Minneapolis	Minnesota	United States	55454
444	Monticello Cancer Center	Monticello	Minnesota	United States	55362
445	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
446	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
447	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
448	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
449	Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
450	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
451	Regions Hospital	Saint Paul	Minnesota	United States	55101
452	United Hospital	Saint Paul	Minnesota	United States	55102
453	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
454	Lakeview Hospital	Stillwater	Minnesota	United States	55082
455	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
456	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
457	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
458	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
459	Sanford Cancer Center Worthington	Worthington	Minnesota	United States	56187
460	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
461	Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	United States	39705
462	Gulfport Memorial Hospital	Gulfport	Mississippi	United States	39502
463	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
464	Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	United States	38652
465	Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	United States	38655
466	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	United States	38671
467	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
468	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
469	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
470	Cox Cancer Center Branson	Branson	Missouri	United States	65616
471	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
472	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
473	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
474	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
475	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
476	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
477	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
478	Freeman Health System	Joplin	Missouri	United States	64804
479	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
480	Truman Medical Centers	Kansas City	Missouri	United States	64108
481	Saint Luke's Hospital of Kansas City	Kansas City	Missouri	United States	64111
482	Research Medical Center	Kansas City	Missouri	United States	64132
483	University of Kansas Cancer Center - North	Kansas City	Missouri	United States	64154
484	University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	United States	64064
485	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
486	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
487	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
488	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
489	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
490	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
491	Mercy Hospital South	Saint Louis	Missouri	United States	63128
492	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
493	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
494	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
495	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
496	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
497	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
498	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
499	CoxHealth South Hospital	Springfield	Missouri	United States	65807
500	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
501	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
502	Mercy Hospital Washington	Washington	Missouri	United States	63090
503	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
504	Billings Clinic Cancer Center	Billings	Montana	United States	59101
505	Saint Vincent Healthcare	Billings	Montana	United States	59101
506	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
507	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
508	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
509	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
510	Great Falls Clinic	Great Falls	Montana	United States	59405
511	Saint Peter's Community Hospital	Helena	Montana	United States	59601
512	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
513	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
514	Community Medical Hospital	Missoula	Montana	United States	59804
515	Nebraska Medicine-Bellevue	Bellevue	Nebraska	United States	68123
516	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
517	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
518	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
519	Nebraska Medicine-Village Pointe	Omaha	Nebraska	United States	68118
520	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
521	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
522	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
523	Creighton University Medical Center	Omaha	Nebraska	United States	68131
524	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
525	Midlands Community Hospital	Papillion	Nebraska	United States	68046
526	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
527	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
528	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
529	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
530	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
531	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
532	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
533	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
534	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
535	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
536	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
537	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
538	Desert West Surgery	Las Vegas	Nevada	United States	89102
539	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
540	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
541	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
542	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
543	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
544	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
545	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
546	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
547	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
548	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
549	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
550	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
551	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89113
552	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
553	Cancer Therapy and Integrative Medicine	Las Vegas	Nevada	United States	89121
554	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
555	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
556	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
557	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
558	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
559	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
560	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
561	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
562	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
563	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
564	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
565	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
566	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
567	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
568	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
569	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
570	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
571	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
572	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
573	University Cancer Center	Las Vegas	Nevada	United States	89169
574	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
575	Renown Regional Medical Center	Reno	Nevada	United States	89502
576	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
577	Radiation Oncology Associates	Reno	Nevada	United States	89509
578	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
579	The Dana-Farber Cancer Institute at Londonderry	Londonderry	New Hampshire	United States	03053
580	Elliot Hospital	Manchester	New Hampshire	United States	03103
581	Solinsky Center for Cancer Care	Manchester	New Hampshire	United States	03103
582	Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	United States	07920
583	Ocean Medical Center	Brick	New Jersey	United States	08724
584	AtlantiCare Health Park-Cape May Court House	Cape May Court House	New Jersey	United States	08210
585	AtlantiCare Surgery Center	Egg Harbor Township	New Jersey	United States	08234
586	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
587	Bayshore Community Hospital	Holmdel	New Jersey	United States	07733
588	Southern Ocean County Medical Center	Manahawkin	New Jersey	United States	08050
589	Memorial Sloan Kettering Monmouth	Middletown	New Jersey	United States	07748
590	Memorial Sloan Kettering Bergen	Montvale	New Jersey	United States	07645
591	Jersey Shore Medical Center	Neptune	New Jersey	United States	07753
592	Riverview Medical Center/Booker Cancer Center	Red Bank	New Jersey	United States	07701
593	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
594	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
595	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
596	James J Peters VA Medical Center	Bronx	New York	United States	10468
597	Maimonides Medical Center	Brooklyn	New York	United States	11219
598	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
599	Memorial Sloan Kettering Commack	Commack	New York	United States	11725
600	Glens Falls Hospital	Glens Falls	New York	United States	12801
601	Memorial Sloan Kettering Westchester	Harrison	New York	United States	10604
602	Northwell Health/Center for Advanced Medicine	Lake Success	New York	United States	11042
603	Garnet Health Medical Center	Middletown	New York	United States	10940
604	Northern Westchester Hospital	Mount Kisco	New York	United States	10549
605	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
606	Memorial Sloan Kettering Cancer Center	New York	New York	United States	10065
607	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
608	Upstate Cancer Center at Oneida	Oneida	New York	United States	13421
609	Rochester General Hospital	Rochester	New York	United States	14621
610	Stony Brook University Medical Center	Stony Brook	New York	United States	11794
611	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
612	Memorial Sloan Kettering Nassau	Uniondale	New York	United States	11553
613	Faxton-Saint Luke's Healthcare	Utica	New York	United States	13502
614	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
615	Mission Hospital	Asheville	North Carolina	United States	28801
616	AdventHealth Infusion Center Asheville	Asheville	North Carolina	United States	28803
617	Messino Cancer Centers	Asheville	North Carolina	United States	28806
618	Duke Cancer Institute Cary	Cary	North Carolina	United States	27518
619	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
620	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
621	AdventHealth Infusion Center Haywood	Clyde	North Carolina	United States	28721
622	Duke University Medical Center	Durham	North Carolina	United States	27710
623	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
624	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
625	East Carolina University	Greenville	North Carolina	United States	27834
626	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
627	AdventHealth Hendersonville	Hendersonville	North Carolina	United States	28792
628	University of North Carolina-Hillsborough Campus	Hillsborough	North Carolina	United States	27278
629	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
630	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
631	Duke Raleigh Hospital	Raleigh	North Carolina	United States	27609
632	AdventHealth Infusion Center Weaverville	Weaverville	North Carolina	United States	28787
633	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
634	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
635	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
636	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
637	Summa Health System - Akron Campus	Akron	Ohio	United States	44304
638	Cleveland Clinic Akron General	Akron	Ohio	United States	44307
639	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
640	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
641	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
642	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
643	Miami Valley Hospital South	Centerville	Ohio	United States	45459
644	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
645	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
646	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
647	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
648	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
649	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
650	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
651	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
652	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
653	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
654	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
655	Grant Medical Center	Columbus	Ohio	United States	43215
656	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
657	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
658	Doctors Hospital	Columbus	Ohio	United States	43228
659	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
660	Miami Valley Hospital	Dayton	Ohio	United States	45409
661	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
662	Miami Valley Hospital North	Dayton	Ohio	United States	45415
663	Dayton Veterans Affairs Medical Center	Dayton	Ohio	United States	45428
664	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
665	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
666	Grady Memorial Hospital	Delaware	Ohio	United States	43015
667	Dublin Methodist Hospital	Dublin	Ohio	United States	43016
668	Armes Family Cancer Center	Findlay	Ohio	United States	45840
669	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
670	Orion Cancer Care	Findlay	Ohio	United States	45840
671	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
672	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
673	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
674	Wayne Hospital	Greenville	Ohio	United States	45331
675	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
676	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
677	First Dayton Cancer Care	Kettering	Ohio	United States	45420
678	Kettering Medical Center	Kettering	Ohio	United States	45429
679	Fairfield Medical Center	Lancaster	Ohio	United States	43130
680	Saint Rita's Medical Center	Lima	Ohio	United States	45801
681	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
682	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
683	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
684	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
685	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
686	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
687	Licking Memorial Hospital	Newark	Ohio	United States	43055
688	Newark Radiation Oncology	Newark	Ohio	United States	43055
689	Mercy Health Perrysburg Cancer Center	Perrysburg	Ohio	United States	43551
690	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
691	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
692	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
693	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
694	ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	United States	43606
695	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
696	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
697	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
698	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
699	Upper Valley Medical Center	Troy	Ohio	United States	45373
700	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
701	Saint Ann's Hospital	Westerville	Ohio	United States	43081
702	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
703	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
704	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
705	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
706	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
707	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
708	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
709	Saint Charles Health System	Bend	Oregon	United States	97701
710	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
711	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
712	Bay Area Hospital	Coos Bay	Oregon	United States	97420
713	Good Samaritan Hospital	Corvallis	Oregon	United States	97330
714	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
715	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
716	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
717	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
718	Providence Portland Medical Center	Portland	Oregon	United States	97213
719	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
720	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
721	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
722	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
723	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
724	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
725	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
726	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
727	Doylestown Hospital	Doylestown	Pennsylvania	United States	18901
728	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
729	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
730	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
731	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
732	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
733	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
734	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
735	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
736	Temple University Hospital	Philadelphia	Pennsylvania	United States	19140
737	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
738	Community Medical Center	Scranton	Pennsylvania	United States	18510
739	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
740	Geisinger Medical Group	State College	Pennsylvania	United States	16801
741	Reading Hospital	West Reading	Pennsylvania	United States	19611
742	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
743	Smilow Cancer Hospital Care Center - Westerly	Westerly	Rhode Island	United States	02891
744	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
745	Medical University of South Carolina	Charleston	South Carolina	United States	29425
746	Prisma Health Cancer Institute - Laurens	Clinton	South Carolina	United States	29325
747	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
748	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
749	Saint Francis Hospital	Greenville	South Carolina	United States	29601
750	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
751	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
752	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
753	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
754	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
755	Self Regional Healthcare	Greenwood	South Carolina	United States	29646
756	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
757	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
758	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
759	North Grove Medical Park	Spartanburg	South Carolina	United States	29303
760	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
761	Spartanburg Medical Center - Mary Black Campus	Spartanburg	South Carolina	United States	29307
762	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
763	Avera Cancer Institute at Pierre	Pierre	South Dakota	United States	57501
764	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
765	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
766	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
767	Bristol Regional Medical Center	Bristol	Tennessee	United States	37620
768	Baptist Memorial Hospital and Cancer Center-Collierville	Collierville	Tennessee	United States	38017
769	Wellmont Medical Associates Oncology and Hematology-Johnson City	Johnson City	Tennessee	United States	37604
770	Ballad Health Cancer Care - Kingsport	Kingsport	Tennessee	United States	37660
771	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
772	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	United States	38120
773	Meharry Medical College	Nashville	Tennessee	United States	37208
774	Hendrick Medical Center	Abilene	Texas	United States	79601
775	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
776	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
777	UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	United States	76104
778	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
779	Ben Taub General Hospital	Houston	Texas	United States	77030
780	Michael E DeBakey VA Medical Center	Houston	Texas	United States	77030
781	UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	United States	75080
782	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
783	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
784	Logan Regional Hospital	Logan	Utah	United States	84321
785	Intermountain Medical Center	Murray	Utah	United States	84107
786	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
787	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
788	Riverton Hospital	Riverton	Utah	United States	84065
789	Saint George Regional Medical Center	Saint George	Utah	United States	84770
790	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
791	LDS Hospital	Salt Lake City	Utah	United States	84143
792	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
793	University of Vermont Medical Center	Burlington	Vermont	United States	05401
794	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
795	Wellmont Medical Associates-Bristol	Bristol	Virginia	United States	24201
796	Inova Schar Cancer Institute	Fairfax	Virginia	United States	22031
797	Inova Fairfax Hospital	Falls Church	Virginia	United States	22042
798	Augusta Health Center for Cancer and Blood Disorders	Fishersville	Virginia	United States	22939
799	Bon Secours Memorial Regional Medical Center	Mechanicsville	Virginia	United States	23116
800	Bon Secours Westchester Emergency Center	Midlothian	Virginia	United States	23113
801	Bon Secours Saint Francis Medical Center	Midlothian	Virginia	United States	23114
802	Bon Secours DePaul Medical Center	Norfolk	Virginia	United States	23505
803	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
804	Bon Secours Saint Mary's Hospital	Richmond	Virginia	United States	23226
805	Virginia Cancer Institute	Richmond	Virginia	United States	23229
806	Bon Secours Cancer Institute at Reynolds Crossing	Richmond	Virginia	United States	23230
807	VCU Massey Cancer Center at Stony Point	Richmond	Virginia	United States	23235
808	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
809	VCU Community Memorial Health Center	South Hill	Virginia	United States	23970
810	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
811	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
812	Virginia Mason Bainbridge Island Medical Center	Bainbridge Island	Washington	United States	98110
813	Overlake Medical Center	Bellevue	Washington	United States	98004
814	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
815	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
816	Harrison Medical Center	Bremerton	Washington	United States	98310
817	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
818	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
819	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
820	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
821	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
822	Virginia Mason Federal Way Medical Center	Federal Way	Washington	United States	98002
823	Saint Francis Hospital	Federal Way	Washington	United States	98003
824	Tacoma/Valley Radiation Oncology Centers-Gig Harbor	Gig Harbor	Washington	United States	98332
825	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
826	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
827	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
828	Northwest Cancer Clinic	Kennewick	Washington	United States	99336
829	Seattle Cancer Care Alliance at EvergreenHealth	Kirkland	Washington	United States	98034
830	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
831	Saint Clare Hospital	Lakewood	Washington	United States	98499
832	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
833	Virginia Mason Lynnwood Medical Center	Lynnwood	Washington	United States	98036
834	Jefferson Healthcare	Port Townsend	Washington	United States	98368
835	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
836	Peninsula Cancer Center	Poulsbo	Washington	United States	98370
837	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
838	Tacoma/Valley Radiation Oncology Centers-Puyallup	Puyallup	Washington	United States	98372
839	Valley Medical Center	Renton	Washington	United States	98055
840	Virginia Mason Medical Center	Seattle	Washington	United States	98101
841	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
842	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
843	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
844	Seattle Cancer Care Alliance	Seattle	Washington	United States	98109
845	Kaiser Permanente Washington	Seattle	Washington	United States	98112
846	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
847	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
848	University of Washington Medical Center - Montlake	Seattle	Washington	United States	98195
849	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
850	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
851	MultiCare Deaconess Cancer and Blood Specialty Center - Valley	Spokane Valley	Washington	United States	99216
852	MultiCare Deaconess Cancer and Blood Specialty Center - Downtown	Spokane	Washington	United States	99204
853	MultiCare Deaconess Cancer and Blood Specialty Center - North	Spokane	Washington	United States	99218
854	Tacoma/Valley Radiation Oncology Centers-Jackson Hall	Tacoma	Washington	United States	97405
855	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
856	Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	United States	98405
857	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
858	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
859	Tacoma/Valley Radiation Oncology Centers-Saint Joe's	Tacoma	Washington	United States	98405
860	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
861	Legacy Cancer Institute Medical Oncology and Day Treatment	Vancouver	Washington	United States	98684
862	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
863	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
864	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
865	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
866	United Hospital Center	Bridgeport	West Virginia	United States	26330
867	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
868	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
869	WVUH-Berkely Medical Center	Martinsburg	West Virginia	United States	25401
870	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
871	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
872	ThedaCare Regional Cancer Center	Appleton	Wisconsin	United States	54911
873	Ascension Southeast Wisconsin Hospital - Elmbrook Campus	Brookfield	Wisconsin	United States	53045
874	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
875	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
876	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
877	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
878	Mayo Clinic Health System-Eau Claire Clinic	Eau Claire	Wisconsin	United States	54701
879	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
880	Ascension Saint Francis - Reiman Cancer Center	Franklin	Wisconsin	United States	53132
881	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
882	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
883	Bellin Memorial Hospital	Green Bay	Wisconsin	United States	54301
884	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
885	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
886	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
887	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
888	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
889	Mayo Clinic Health System-Franciscan Healthcare	La Crosse	Wisconsin	United States	54601
890	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
891	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
892	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
893	Saint Vincent Hospital Cancer Center at Marinette	Marinette	Wisconsin	United States	54143
894	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
895	Froedtert Menomonee Falls Hospital	Menomonee Falls	Wisconsin	United States	53051
896	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
897	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
898	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
899	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
900	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
901	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
902	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
903	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
904	Ascension All Saints Hospital	Racine	Wisconsin	United States	53405
905	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
906	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
907	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
908	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
909	Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	United States	54482
910	Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235-1495
911	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
912	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
913	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
914	Ascension Medical Group Southeast Wisconsin - Mayfair Road	Wauwatosa	Wisconsin	United States	53226
915	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
916	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
917	Froedtert West Bend Hospital/Kraemer Cancer Center	West Bend	Wisconsin	United States	53095
918	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
919	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
920	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
921	Billings Clinic-Cody	Cody	Wyoming	United States	82414
922	Welch Cancer Center	Sheridan	Wyoming	United States	82801
923	FHP Health Center-Guam	Tamuning		Guam	96913

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Andrea B Apolo, Alliance for Clinical Trials in Oncology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT03244384
• Other Study ID Numbers: NCI-2017-01425; NCI-2017-01425; A031501; A031501; A031501; U10CA180821
• First Posted: Aug 9, 2017
• Last Update Posted: Jul 28, 2022
• Last Verified: Jun 1, 2022

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Carcinoma; Carcinoma, Transitional Cell; Ureteral Neoplasms; Kidney Neoplasms; Pembrolizumab

Study Results

No Results Posted as of Jul 28, 2022