Clincosm LogoSign in Get a demo

Testing Cabozantinib, Crizotinib, Savolitinib and Sunitinib in Kidney Cancer Which Has Progressed

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Active, not recruiting
CT.gov ID
NCT02761057
Collaborator
Canadian Cancer Trials Group (Other)
152
Enrollment
597
Locations
4
Arms
81
Anticipated Duration (Months)
0.3
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This randomized phase II trial studies how well cabozantinib s-malate, crizotinib, savolitinib, or sunitinib malate work in treating patients with kidney cancer that has spread from where it started to nearby tissue or lymph nodes or to other places in the body. Cabozantinib s-malate, crizotinib, savolitinib, and sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving cabozantinib s-malate, crizotinib, or savolitinib will work better in treating patients with kidney cancer compared to sunitinib malate.

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare progression-free survival (PFS) in patients with metastatic papillary renal cell carcinoma (mPRCC) treated with sunitinib malate (sunitinib) to PFS in patients with mPRCC treated with MET kinase inhibitors.
SECONDARY OBJECTIVES:

  1. To compare Response Evaluation Criteria in Solid Tumors (RECIST) response rate (RR; defined as the combined rate of confirmed and unconfirmed partial response [PR] and complete response [CR]) in patients with mPRCC treated with sunitinib to RR in patients treated with putative MET inhibitors.

  2. To compare overall survival (OS) in patients with mPRCC treated with sunitinib to OS in patients with mPRCC treated with putative MET inhibitors.

  3. To compare the safety profile of sunitinib and putative MET inhibitors in patients with mPRCC.

TRANSLATIONAL OBJECTIVES:

  1. To evaluate the prognostic and predictive value of MET mutations, MET copy number or other markers of MET signaling in patients with mPRCC treated with putative MET inhibitors.

  2. To estimate the frequency of high oncometabolite levels in formalin-fixed, paraffin-embedded (FFPE) tissues of patients with advanced papillary renal cell carcinoma by liquid chromatography-mass spectrometry (LC-MS/MS) and estimate progression free survival for those with and without high oncometabolite levels being treated.

  3. To correlate the mutational signature suggestive of a homologous recombination defect with high oncometabolite levels in patients with papillary renal cell carcinoma pRCC.

OUTLINE: Patients are randomized to 1 of 4 treatment arms. As of 12/5/18, patients will only be randomized to Arm I or Arm II.

ARM I: Patients receive sunitinib malate orally (PO) once daily (QD) on days 1-28.

ARM II: Patients receive cabozantinib s-malate PO QD on days 1-42.

ARM III (CLOSED TO ACCRUAL 12/5/18): Patients receive crizotinib PO twice daily (BID) on days 1-42.

ARM IV (CLOSED TO ACCRUAL 12/5/18): Patients receive savolitinib PO QD on days 1-42.

In all arms, cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 3 years.

Study Design

Study Type:
Interventional
Actual Enrollment :
152 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized, Phase II Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib [NSC #761968], Crizotinib [NSC #749005], Savolitinib [NSC #785348], and Sunitinib [NSC #736511]) in Metastatic Papillary Renal Carcinoma (PAPMET)
Actual Study Start Date :
Apr 5, 2016
Actual Primary Completion Date :
Oct 14, 2020
Anticipated Study Completion Date :
Jan 4, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (sunitinib malate)

Patients receive sunitinib malate PO on days 1-28. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

Drug: Sunitinib Malate
Given PO
Other Names:
  • SU011248
  • SU11248
  • sunitinib
  • Sutent

    		•
    Experimental: Arm II (cabozantinib s-malate)

    Patients receive cabozantinib s-malate PO on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

    Drug: Cabozantinib S-malate
    Given PO
    Other Names:
  • BMS-907351
  • Cabometyx
  • Cometriq
  • XL-184
  • XL184

    		•
    Experimental: Arm III (crizotinib closed to accrual 12/5/18)

    Patients receive crizotinib PO BID on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

    Drug: Crizotinib
    Given PO
    Other Names:
  • MET Tyrosine Kinase Inhibitor PF-02341066
  • PF-02341066
  • PF-2341066
  • Xalkori

    		•
    Experimental: Arm IV (savolitinib closed to accrual 12/5/18)

    Patients receive savolitinib PO on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

    Drug: Savolitinib
    Given PO
    Other Names:
  • AZD 6094
  • AZD6094
  • HMPL-504
  • Volitinib

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Progression free survival (PFS) [From date of registration to date of first documentation of progression or symptomatic deterioration, or death due to any cause; assessed up to 3 years]

      A proportional hazards model will be used to evaluate each pair wise treatment comparison of PFS, adjusting for the two stratification factors as covariates in the model.

    Secondary Outcome Measures

    1. Response rate (RR) [Up to 3 years]

      The Chi-Square test will be used to compare RR between the control arm of sunitinib malate and the MET inhibitor treatment arms.

    2. Overall survival (OS) [Up to 3 years]

      The method of Kaplan and Meier will be used to estimate survival curves. The log-rank test will be used to compare OS between the 4 treatment arms.

    3. Incidence of toxicity [Up to 3 years]

      Will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. Toxicity defined as any grade 3 or 4 non-hematologic toxicity.

    Other Outcome Measures

    1. MET mutation rate [Up to 3 years]

      The hazard ratio between the MET inhibitor versus (vs.) sunitinib in those with versus without the mutation (i.e., the interaction) will be compared. Response Evaluation Criteria in Solid Tumors (RECIST) response rate (confirmed and unconfirmed partial response and complete response) based on MET mutation/expression level will be compared using the chi-square test.

    2. Assessment of type I and type II renal papillary cancer [Up to 3 years]

      Will be assessed per RECIST 1.1 criteria. The study will pool the three met inhibitor arms and will evaluate the response to these treatments by type I vs. II status. Will primarily look at RECIST response, but will also look at PFS. The study will also describe the response rate and PFS estimates for type I and II for the sunitinib arm along with 95% confidence intervals.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patients must have histologically or cytologically confirmed papillary histology renal cell carcinoma which is metastatic or locally advanced disease not amenable to surgical resection; (NOTE: a designation of type I or type II should be made by the local pathologist if possible); mixed histologies containing type I or type II will be allowed provided that they contain >= 50% of the papillary component

    • Patients must also have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension; disease X-rays, scans or physical examinations used for tumor measurement must have been completed within 28 days prior to registration; if there is clinical suspicion for bone metastases at the time of enrollment (at the discretion of the investigator), bone scan should be performed at baseline (within 42 days prior to registration); all disease must be assessed and documented on the Baseline Tumor Assessment form

    • Patients with a history of treated brain metastases who are asymptomatic and have not received steroid therapy in the 14 days prior to registration are eligible; anti-seizure medications are allowed provided they are non-enzyme inducing (e.g. topiramate, levetiracetam, gabapentin)

    • Patients must not have cavitating pulmonary lesions; patients must not have tumor invading the gastrointestinal (GI) tract or evidence of endotracheal or endobronchial tumor within 28 days prior to registration

    • Patients may have received prior surgery; at least 28 days must have elapsed since surgery and patient must have recovered from any adverse effects of surgery

    • Patients may have received up to one prior systemic therapy for advanced or metastatic renal cell carcinoma with the exception of another VEGF inhibitor Food and Drug Administration (FDA)-approved for advanced RCC (i.e., pazopanib, bevacizumab, sorafenib or axitinib); if a patient develops metastatic disease within six months of discontinuation of adjuvant therapy, this will constitute one prior systemic therapy for advanced or metastatic renal cell carcinoma (RCC); if a patient develops metastatic disease and more than six months has elapsed since discontinuation of adjuvant therapy, this will not constitute prior systemic therapy for advanced or metastatic RCC; patients may have also received prior immunotherapy; patients must not have received a MET/hepatocyte growth factor (HGF) inhibitor or sunitinib as prior therapy; at least 14 days must have elapsed since completion of prior systemic therapy; patients must have recovered from all associated toxicities at the time of registration

    • Patients may have received prior radiation therapy, but must have measurable disease outside the radiation port; at least 14 days must have elapsed since completion of prior radiation therapy; patients must have recovered from all associated toxicities at the time of registration

    • Patients must not be taking, nor plan to take while on protocol treatment, strong CYP3A4 inhibitors (e.g. boceprevir, cobicistat, danoprevir, elvitegravir/RIT, fluvoxamine, indinavir, itraconazole, ketoconazole, lopinavir/RIT, nefazodone, nelfinavir, posaconazole, ritonavir, telaprevir, telithromycin, tipravavir/RIT, or voriconazole); strong CYP3A4 inducers (e.g. avasimibe, phenytoin, rifampin, rifabutin); potent inhibitors of CYP1A2 (e.g. ciprofloxacin); and/or drugs known to be CYP3A4 substrates with a narrow therapeutic range (e.g., diergotamine, ergotamine) within 14 days prior to randomization; moderate inhibitors or inducers of isoenzyme CYP3A4 should be avoided, but if necessary can be used with caution

    • Patients must not be receiving or planning to receive any other investigational agents

    • Patients must have a complete physical examination and medical history within 28 days prior to registration

    • Patients must have a Zubrod performance status of 0 - 1

    • White blood cell count (WBC) >= 2,000/mcL (must be obtained within 28 days prior to registration)

    • Absolute neutrophil count (ANC) >= 1,000/mcL (must be obtained within 28 days prior to registration)

    • Platelet count >= 75,000/mcL (must be obtained within 28 days prior to registration)

    • Serum bilirubin =< 1.5 x institutional upper limits of normal (ULN) (must be obtained within 28 days prior to registration)

    • Serum transaminase (serum glutamic oxaloacetic transaminase [SGOT]/aspartate aminotransferase [AST] and serum glutamate pyruvate transaminase [SGPT]/alanine aminotransferase [ALT]) must be =< 2.5 x the institutional ULN unless the liver is involved with the tumor, in which case serum transaminase (SGOT/SGPT) must be =< 5 x the institutional ULN (must be obtained within 28 days prior to registration)

    • Serum creatinine must be =< 2 x the institutional ULN OR creatinine clearance (either measured or calculated) must be > 30 mL/min (must be obtained within 28 days prior to registration)

    • Patients must not have any clinical evidence of congestive heart failure (CHF) (specifically, New York Heart Association [NYHA] class III [moderate] or class IV [severe]) at the time of registration; baseline echocardiogram within 28 days of registration must demonstrate an ejection fraction (EF) >= 50%; due to the potential cardiac toxicity of the agents utilized in this protocol, patients must have corrected QT (QTc) interval < 500 msec on prestudy electrocardiogram (EKG) and no known history of congenital long QT syndrome; patients must not have experienced unstable angina pectoris, clinically significant cardiac arrhythmias, or stroke (transient ischemic attack [TIA] or other ischemic event) within 3 months prior to registration and not have experienced myocardial infarction or thromboembolic event requiring anticoagulation within 6 months of registration; prestudy EKG must be obtained within 28 days prior to registration

    • Baseline urinalysis should show urine protein < 3+ and must be obtained within 28 days prior to registration; if urine protein is 3+ or greater, then urine protein by 24 hour collection must show less than 3 grams of protein

    • Patients must not have inadequately controlled hypertension; patients must have documented blood pressures of systolic blood pressure (SBP) < 150 and diastolic blood pressure (DBP) < 90 within 14 days of starting randomization; blood pressure medications (any number) are permitted

    • Patients must be able to take oral medications (i.e., swallow pills whole); patients must not have gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for intravenous (IV) alimentation, prior surgical procedures that could in the opinion of the treating investigator affect absorption, or active peptic ulcer disease; patients with intractable nausea or vomiting are not eligible

    • Patients must not have had any clinically-significant GI bleeding within 6 months prior to registration and patients must not have a GI disorder which (at the discretion of the investigator) bears a high risk of perforation or fistula; examples of this include (but are not limited to) Crohn's disease or tumor with transmural extension through the gastrointestinal lining

    • Patients must not have had hemoptysis of >= 0.5 teaspoon (2.5 ml) of red blood within 3 months prior registration

    • Patients must not demonstrate any other signs indicative of pulmonary hemorrhage within 3 months prior to registration

    • Patient's baseline imaging must not indicate the presence of tumor invading or encasing any major blood vessels

    • Patients must not have any unresolved wounds from previous surgery

    • Albumin, alkaline phosphatase, bicarbonate, blood urea (BUN), chloride, glucose, phosphorus, and total protein must be assessed within 28 days of registration

    • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for 3 years; men receiving active surveillance for prostate cancer may also be enrolled

    • Due to the unknown effects of the study drugs, patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method while receiving study drug and for three months after last dose of study drug; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

    • Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with cabozantinib, crizotinib, savolitinib or sunitinib; in addition these patients are at increased risk of lethal infections when treated with marrow suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated

    • Patients must have tissue available and be willing to submit for independent pathologic review in order to classify type I versus type II papillary disease

    • Patients must be offered the opportunity to participate in specimen banking for future translational medicine studies

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

    • As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Kingman Regional Medical Center Kingman Arizona United States 86401
    10 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    11 John L McClellan Memorial Veterans Hospital Little Rock Arkansas United States 72205
    12 PCR Oncology Arroyo Grande California United States 93420
    13 Sutter Auburn Faith Hospital Auburn California United States 95602
    14 Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California United States 95603
    15 AIS Cancer Center at San Joaquin Community Hospital Bakersfield California United States 93301
    16 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    17 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    18 Mills-Peninsula Medical Center Burlingame California United States 94010
    19 Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California United States 95682
    20 Eden Hospital Medical Center Castro Valley California United States 94546
    21 Sutter Davis Hospital Davis California United States 95616
    22 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    23 Epic Care-Dublin Dublin California United States 94568
    24 Bay Area Breast Surgeons Inc Emeryville California United States 94608
    25 Epic Care Partners in Cancer Care Emeryville California United States 94608
    26 Palo Alto Medical Foundation-Fremont Fremont California United States 94538
    27 Los Angeles County-USC Medical Center Los Angeles California United States 90033
    28 USC / Norris Comprehensive Cancer Center Los Angeles California United States 90033
    29 Cedars Sinai Medical Center Los Angeles California United States 90048
    30 Contra Costa Regional Medical Center Martinez California United States 94553-3156
    31 Fremont - Rideout Cancer Center Marysville California United States 95901
    32 Memorial Medical Center Modesto California United States 95355
    33 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    34 Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California United States 94040
    35 USC Norris Oncology/Hematology-Newport Beach Newport Beach California United States 92663
    36 Sutter Cancer Research Consortium Novato California United States 94945
    37 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
    38 Bay Area Tumor Institute Oakland California United States 94609
    39 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    40 Keck Medical Center of USC Pasadena Pasadena California United States 91105
    41 Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California United States 95661
    42 Sutter Roseville Medical Center Roseville California United States 95661
    43 Sutter Medical Center Sacramento Sacramento California United States 95816
    44 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    45 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    46 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    47 Sutter Pacific Medical Foundation Santa Rosa California United States 95403
    48 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    49 Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee California United States 96161
    50 Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California United States 95687
    51 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    52 Epic Care Cyberknife Center Walnut Creek California United States 94597
    53 Grand Valley Oncology Grand Junction Colorado United States 81505
    54 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    55 Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut United States 06510
    56 Yale University New Haven Connecticut United States 06520
    57 Sibley Memorial Hospital Washington District of Columbia United States 20016
    58 Mount Sinai Comprehensive Cancer Center at Aventura Aventura Florida United States 33180
    59 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    60 Mount Sinai Medical Center Miami Beach Florida United States 33140
    61 Low Country Cancer Care Savannah Georgia United States 31404
    62 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    63 Summit Cancer Care-Candler Savannah Georgia United States 31405
    64 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    65 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    66 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    67 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    68 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    69 Island Urology Honolulu Hawaii United States 96813
    70 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    71 Queen's Medical Center Honolulu Hawaii United States 96813
    72 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    73 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    74 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    75 Kuakini Medical Center Honolulu Hawaii United States 96817
    76 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    77 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    78 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    79 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    80 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    81 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    82 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    83 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    84 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    85 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    86 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    87 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    88 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    89 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    90 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    91 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    92 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    93 Rush - Copley Medical Center Aurora Illinois United States 60504
    94 Saint Joseph Medical Center Bloomington Illinois United States 61701
    95 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    96 Illinois CancerCare-Canton Canton Illinois United States 61520
    97 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    98 SIH Cancer Institute Carterville Illinois United States 62918
    99 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    100 Centralia Oncology Clinic Centralia Illinois United States 62801
    101 Northwestern University Chicago Illinois United States 60611
    102 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    103 Carle on Vermilion Danville Illinois United States 61832
    104 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    105 Decatur Memorial Hospital Decatur Illinois United States 62526
    106 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    107 Carle Physician Group-Effingham Effingham Illinois United States 62401
    108 Crossroads Cancer Center Effingham Illinois United States 62401
    109 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    110 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    111 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    112 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    113 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    114 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    115 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    116 Loyola University Medical Center Maywood Illinois United States 60153
    117 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    118 UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois United States 60451
    119 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    120 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    121 Radiation Oncology of Northern Illinois Ottawa Illinois United States 61350
    122 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    123 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    124 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    125 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    126 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    127 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    128 Illinois CancerCare-Peru Peru Illinois United States 61354
    129 Valley Radiation Oncology Peru Illinois United States 61354
    130 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    131 SwedishAmerican Regional Cancer Center/ACT Rockford Illinois United States 61114
    132 Central Illinois Hematology Oncology Center Springfield Illinois United States 62702
    133 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    134 Springfield Clinic Springfield Illinois United States 62702
    135 Memorial Medical Center Springfield Illinois United States 62781
    136 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    137 Carle Cancer Center Urbana Illinois United States 61801
    138 The Carle Foundation Hospital Urbana Illinois United States 61801
    139 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    140 Deaconess Clinic Downtown Evansville Indiana United States 47713
    141 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    142 Franciscan Saint Anthony Health-Michigan City Michigan City Indiana United States 46360
    143 Woodland Cancer Care Center Michigan City Indiana United States 46360
    144 Memorial Regional Cancer Center Day Road Mishawaka Indiana United States 46545
    145 Chancellor Center for Oncology Newburgh Indiana United States 47630
    146 Reid Health Richmond Indiana United States 47374
    147 Memorial Hospital of South Bend South Bend Indiana United States 46601
    148 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    149 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    150 Broadlawns Medical Center Des Moines Iowa United States 50314
    151 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    152 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    153 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    154 Cancer Center of Kansas - Chanute Chanute Kansas United States 66720
    155 Cancer Center of Kansas - Dodge City Dodge City Kansas United States 67801
    156 Cancer Center of Kansas - El Dorado El Dorado Kansas United States 67042
    157 Cancer Center of Kansas - Fort Scott Fort Scott Kansas United States 66701
    158 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    159 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    160 Cancer Center of Kansas-Independence Independence Kansas United States 67301
    161 Cancer Center of Kansas-Kingman Kingman Kansas United States 67068
    162 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    163 Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas United States 66219
    164 Minimally Invasive Surgery Hospital Lenexa Kansas United States 66219
    165 Cancer Center of Kansas-Liberal Liberal Kansas United States 67905
    166 Cancer Center of Kansas-Manhattan Manhattan Kansas United States 66502
    167 Cancer Center of Kansas - McPherson McPherson Kansas United States 67460
    168 Cancer Center of Kansas - Newton Newton Kansas United States 67114
    169 Menorah Medical Center Overland Park Kansas United States 66209
    170 Saint Luke's South Hospital Overland Park Kansas United States 66213
    171 Cancer Center of Kansas - Parsons Parsons Kansas United States 67357
    172 Cancer Center of Kansas - Pratt Pratt Kansas United States 67124
    173 Cancer Center of Kansas - Salina Salina Kansas United States 67401
    174 Cotton O'Neil Cancer Center / Stormont Vail Health Topeka Kansas United States 66606
    175 Cancer Center of Kansas - Wellington Wellington Kansas United States 67152
    176 Associates In Womens Health Wichita Kansas United States 67208
    177 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
    178 Ascension Via Christi Hospitals Wichita Wichita Kansas United States 67214
    179 Cancer Center of Kansas - Wichita Wichita Kansas United States 67214
    180 Cancer Center of Kansas - Winfield Winfield Kansas United States 67156
    181 Oncology Hematology Care Inc-Crestview Crestview Hills Kentucky United States 41017
    182 East Jefferson General Hospital Metairie Louisiana United States 70006
    183 LSU Healthcare Network / Metairie Multi-Specialty Clinic Metairie Louisiana United States 70006
    184 Louisiana State University Health Science Center New Orleans Louisiana United States 70112
    185 University Medical Center New Orleans New Orleans Louisiana United States 70112
    186 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    187 Greater Baltimore Medical Center Baltimore Maryland United States 21204
    188 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland United States 21287
    189 Boston Medical Center Boston Massachusetts United States 02118
    190 Mercy Medical Center Springfield Massachusetts United States 01104
    191 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    192 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    193 Bronson Battle Creek Battle Creek Michigan United States 49017
    194 IHA Hematology Oncology Consultants-Brighton Brighton Michigan United States 48114
    195 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    196 IHA Hematology Oncology Consultants-Canton Canton Michigan United States 48188
    197 Saint Joseph Mercy Canton Canton Michigan United States 48188
    198 Caro Cancer Center Caro Michigan United States 48723
    199 IHA Hematology Oncology Consultants-Chelsea Chelsea Michigan United States 48118
    200 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    201 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    202 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    203 Beaumont Hospital - Dearborn Dearborn Michigan United States 48124
    204 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    205 Ascension Saint John Hospital Detroit Michigan United States 48236
    206 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    207 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    208 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    209 Genesee Hematology Oncology PC Flint Michigan United States 48503
    210 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    211 Hurley Medical Center Flint Michigan United States 48503
    212 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    213 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    214 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    215 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    216 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    217 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    218 Allegiance Health Jackson Michigan United States 49201
    219 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    220 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    221 Borgess Medical Center Kalamazoo Michigan United States 49048
    222 Sparrow Hospital Lansing Michigan United States 48912
    223 Hope Cancer Clinic Livonia Michigan United States 48154
    224 Saint Mary Mercy Hospital Livonia Michigan United States 48154
    225 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    226 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    227 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    228 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    229 Lakeland Hospital Niles Niles Michigan United States 49120
    230 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    231 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    232 Hope Cancer Center Pontiac Michigan United States 48341
    233 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    234 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    235 Huron Medical Center PC Port Huron Michigan United States 48060
    236 Lake Huron Medical Center Port Huron Michigan United States 48060
    237 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    238 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    239 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    240 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    241 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    242 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    243 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    244 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    245 Munson Medical Center Traverse City Michigan United States 49684
    246 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    247 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    248 Macomb Hematology Oncology PC Warren Michigan United States 48093
    249 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    250 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    251 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    252 Metro Health Hospital Wyoming Michigan United States 49519
    253 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    254 IHA Hematology Oncology Consultants-Ann Arbor Ypsilanti Michigan United States 48197
    255 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    256 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    257 Cambridge Medical Center Cambridge Minnesota United States 55008
    258 Mercy Hospital Coon Rapids Minnesota United States 55433
    259 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    260 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    261 Essentia Health Cancer Center Duluth Minnesota United States 55805
    262 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    263 Miller-Dwan Hospital Duluth Minnesota United States 55805
    264 Fairview Southdale Hospital Edina Minnesota United States 55435
    265 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    266 Essentia Health - Fosston Fosston Minnesota United States 56542
    267 Unity Hospital Fridley Minnesota United States 55432
    268 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    269 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    270 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    271 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    272 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    273 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    274 Health Partners Inc Minneapolis Minnesota United States 55454
    275 Monticello Cancer Center Monticello Minnesota United States 55362
    276 New Ulm Medical Center New Ulm Minnesota United States 56073
    277 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    278 Fairview Northland Medical Center Princeton Minnesota United States 55371
    279 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    280 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    281 Regions Hospital Saint Paul Minnesota United States 55101
    282 United Hospital Saint Paul Minnesota United States 55102
    283 Essentia Health Sandstone Sandstone Minnesota United States 55072
    284 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    285 Lakeview Hospital Stillwater Minnesota United States 55082
    286 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    287 Ridgeview Medical Center Waconia Minnesota United States 55387
    288 Rice Memorial Hospital Willmar Minnesota United States 56201
    289 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    290 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    291 University of Mississippi Medical Center Jackson Mississippi United States 39216
    292 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    293 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    294 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    295 Cox Cancer Center Branson Branson Missouri United States 65616
    296 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    297 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    298 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    299 Parkland Health Center - Farmington Farmington Missouri United States 63640
    300 Centerpoint Medical Center LLC Independence Missouri United States 64057
    301 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    302 Freeman Health System Joplin Missouri United States 64804
    303 Mercy Hospital Joplin Joplin Missouri United States 64804
    304 Saint Luke's Hospital of Kansas City Kansas City Missouri United States 64111
    305 Research Medical Center Kansas City Missouri United States 64132
    306 Saint Luke's East - Lee's Summit Lee's Summit Missouri United States 64086
    307 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    308 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    309 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    310 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    311 Washington University School of Medicine Saint Louis Missouri United States 63110
    312 Mercy Hospital South Saint Louis Missouri United States 63128
    313 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    314 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    315 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    316 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    317 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    318 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    319 Mercy Hospital Springfield Springfield Missouri United States 65804
    320 CoxHealth South Hospital Springfield Missouri United States 65807
    321 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    322 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    323 Mercy Hospital Washington Washington Missouri United States 63090
    324 Community Hospital of Anaconda Anaconda Montana United States 59711
    325 Billings Clinic Cancer Center Billings Montana United States 59101
    326 Saint Vincent Healthcare Billings Montana United States 59101
    327 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    328 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    329 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    330 Great Falls Clinic Great Falls Montana United States 59405
    331 Saint Peter's Community Hospital Helena Montana United States 59601
    332 Kalispell Regional Medical Center Kalispell Montana United States 59901
    333 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    334 Community Medical Hospital Missoula Montana United States 59804
    335 Nebraska Hematology and Oncology Lincoln Nebraska United States 68506
    336 Nebraska Cancer Research Center Lincoln Nebraska United States 68510
    337 Southeast Nebraska Cancer Center - 68th Street Place Lincoln Nebraska United States 68516
    338 Faith Regional Health Services Carson Cancer Center Norfolk Nebraska United States 68701
    339 Great Plains Health Callahan Cancer Center North Platte Nebraska United States 69101
    340 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    341 Nebraska Cancer Specialists - Omaha Omaha Nebraska United States 68124
    342 Oncology Hematology West PC Omaha Nebraska United States 68130
    343 Regional West Medical Center Cancer Center Scottsbluff Nebraska United States 69361
    344 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    345 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    346 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    347 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    348 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    349 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    350 21st Century Oncology-Henderson Henderson Nevada United States 89074
    351 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    352 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    353 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    354 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    355 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    356 Desert West Surgery Las Vegas Nevada United States 89102
    357 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    358 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    359 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    360 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    361 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    362 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    363 21st Century Oncology Las Vegas Nevada United States 89109
    364 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    365 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    366 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    367 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    368 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    369 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    370 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    371 Cancer Therapy and Integrative Medicine Las Vegas Nevada United States 89121
    372 21st Century Oncology-Vegas Tenaya Las Vegas Nevada United States 89128
    373 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    374 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    375 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    376 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    377 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    378 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    379 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    380 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    381 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    382 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    383 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    384 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    385 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    386 21st Century Oncology-Fort Apache Las Vegas Nevada United States 89148
    387 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    388 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    389 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    390 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    391 University Cancer Center Las Vegas Nevada United States 89169
    392 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    393 Renown Regional Medical Center Reno Nevada United States 89502
    394 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    395 Radiation Oncology Associates Reno Nevada United States 89509
    396 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    397 New Mexico Cancer Care Alliance Albuquerque New Mexico United States 87106
    398 Montefiore Medical Center-Einstein Campus Bronx New York United States 10461
    399 Montefiore Medical Center-Weiler Hospital Bronx New York United States 10461
    400 Montefiore Medical Center - Moses Campus Bronx New York United States 10467
    401 State University of New York Upstate Medical University Syracuse New York United States 13210
    402 SUNY Upstate Medical Center-Community Campus Syracuse New York United States 13215
    403 AdventHealth Infusion Center Asheville Asheville North Carolina United States 28803
    404 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    405 AdventHealth Infusion Center Haywood Clyde North Carolina United States 28721
    406 Duke University Medical Center Durham North Carolina United States 27710
    407 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    408 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    409 Hendersonville Hematology and Oncology at Pardee Hendersonville North Carolina United States 28791
    410 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    411 AdventHealth Hendersonville Hendersonville North Carolina United States 28792
    412 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    413 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    414 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    415 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    416 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    417 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    418 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    419 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    420 Miami Valley Hospital South Centerville Ohio United States 45459
    421 Adena Regional Medical Center Chillicothe Ohio United States 45601
    422 Oncology Hematology Care Inc-Eden Park Cincinnati Ohio United States 45202
    423 Oncology Hematology Care Inc-Mercy West Cincinnati Ohio United States 45211
    424 Oncology Hematology Care Inc-Anderson Cincinnati Ohio United States 45230
    425 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    426 Oncology Hematology Care Inc-Blue Ash Cincinnati Ohio United States 45242
    427 Mount Carmel East Hospital Columbus Ohio United States 43213
    428 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    429 Riverside Methodist Hospital Columbus Ohio United States 43214
    430 Grant Medical Center Columbus Ohio United States 43215
    431 The Mark H Zangmeister Center Columbus Ohio United States 43219
    432 Mount Carmel Health Center West Columbus Ohio United States 43222
    433 Doctors Hospital Columbus Ohio United States 43228
    434 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    435 Miami Valley Hospital Dayton Ohio United States 45409
    436 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    437 Miami Valley Hospital North Dayton Ohio United States 45415
    438 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    439 Delaware Radiation Oncology Delaware Ohio United States 43015
    440 Grady Memorial Hospital Delaware Ohio United States 43015
    441 Dublin Methodist Hospital Dublin Ohio United States 43016
    442 Oncology Hematology Care Inc-Healthplex Fairfield Ohio United States 45014
    443 Armes Family Cancer Center Findlay Ohio United States 45840
    444 Blanchard Valley Hospital Findlay Ohio United States 45840
    445 Orion Cancer Care Findlay Ohio United States 45840
    446 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    447 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    448 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    449 Wayne Hospital Greenville Ohio United States 45331
    450 Greater Dayton Cancer Center Kettering Ohio United States 45409
    451 First Dayton Cancer Care Kettering Ohio United States 45420
    452 Kettering Medical Center Kettering Ohio United States 45429
    453 Fairfield Medical Center Lancaster Ohio United States 43130
    454 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    455 Marietta Memorial Hospital Marietta Ohio United States 45750
    456 OhioHealth Marion General Hospital Marion Ohio United States 43302
    457 Dayton Physicians LLC-Signal Point Middletown Ohio United States 45042
    458 Knox Community Hospital Mount Vernon Ohio United States 43050
    459 Licking Memorial Hospital Newark Ohio United States 43055
    460 Newark Radiation Oncology Newark Ohio United States 43055
    461 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    462 Dayton Physicians LLC-Wilson Sidney Ohio United States 45365
    463 Springfield Regional Cancer Center Springfield Ohio United States 45504
    464 Springfield Regional Medical Center Springfield Ohio United States 45505
    465 Trinity's Tony Teramana Cancer Center Steubenville Ohio United States 43952
    466 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    467 Upper Valley Medical Center Troy Ohio United States 45373
    468 Saint Joseph Warren Hospital Warren Ohio United States 44484
    469 Saint Ann's Hospital Westerville Ohio United States 43081
    470 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    471 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    472 Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma United States 73505
    473 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    474 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    475 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    476 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    477 Saint Charles Health System Bend Oregon United States 97701
    478 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    479 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    480 Bay Area Hospital Coos Bay Oregon United States 97420
    481 Providence Newberg Medical Center Newberg Oregon United States 97132
    482 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    483 Providence Willamette Falls Medical Center Oregon City Oregon United States 97045
    484 Providence Portland Medical Center Portland Oregon United States 97213
    485 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    486 Oregon Health and Science University Portland Oregon United States 97239
    487 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    488 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    489 UPMC-Heritage Valley Health System Beaver Beaver Pennsylvania United States 15009
    490 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    491 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    492 UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania United States 15601
    493 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    494 UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown Pennsylvania United States 15901
    495 UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania United States 15132
    496 UPMC-Coraopolis/Heritage Valley Radiation Oncology Moon Pennsylvania United States 15108
    497 Penn Presbyterian Medical Center Philadelphia Pennsylvania United States 19104
    498 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    499 Fox Chase Cancer Center Philadelphia Pennsylvania United States 19111
    500 UPMC-Magee Womens Hospital Pittsburgh Pennsylvania United States 15213
    501 UPMC-Presbyterian Hospital Pittsburgh Pennsylvania United States 15213
    502 UPMC-Saint Margaret Pittsburgh Pennsylvania United States 15215
    503 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    504 UPMC-Shadyside Hospital Pittsburgh Pennsylvania United States 15232
    505 UPMC Jefferson Regional Radiation Oncology Pittsburgh Pennsylvania United States 15236
    506 UPMC-Passavant Hospital Pittsburgh Pennsylvania United States 15237
    507 UPMC-Saint Clair Hospital Cancer Center Pittsburgh Pennsylvania United States 15243
    508 UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania United States 16346
    509 UPMC Uniontown Hospital Radiation Oncology Uniontown Pennsylvania United States 15401
    510 UPMC Washington Hospital Radiation Oncology Washington Pennsylvania United States 15301
    511 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    512 Medical University of South Carolina Charleston South Carolina United States 29425
    513 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    514 Saint Francis Hospital Greenville South Carolina United States 29601
    515 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    516 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    517 Prisma Health Greenville Memorial Hospital Greenville South Carolina United States 29605
    518 Saint Francis Cancer Center Greenville South Carolina United States 29607
    519 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    520 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    521 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    522 University of Texas Medical Branch Galveston Texas United States 77555-0565
    523 UTMB Cancer Center at Victory Lakes League City Texas United States 77573
    524 University of Texas Health Science Center at San Antonio San Antonio Texas United States 78229
    525 Farmington Health Center Farmington Utah United States 84025
    526 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    527 South Jordan Health Center South Jordan Utah United States 84009
    528 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    529 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    530 Cancer Care Center at Island Hospital Anacortes Washington United States 98221
    531 Overlake Medical Center Bellevue Washington United States 98004
    532 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    533 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    534 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    535 Providence Regional Cancer Partnership Everett Washington United States 98201
    536 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    537 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    538 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    539 Valley Medical Center Renton Washington United States 98055
    540 Pacific Gynecology Specialists Seattle Washington United States 98104
    541 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    542 Kaiser Permanente Washington Seattle Washington United States 98112
    543 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    544 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    545 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    546 MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington United States 99216
    547 MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington United States 99204
    548 MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington United States 99218
    549 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    550 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    551 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    552 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    553 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    554 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    555 Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin United States 54729
    556 Marshfield Clinic Cancer Center at Sacred Heart Eau Claire Wisconsin United States 54701
    557 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    558 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    559 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    560 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    561 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    562 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    563 Marshfield Clinic - Ladysmith Center Ladysmith Wisconsin United States 54848
    564 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    565 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    566 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    567 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    568 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    569 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    570 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    571 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    572 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    573 Lakeview Medical Center-Marshfield Clinic Rice Lake Wisconsin United States 54868
    574 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    575 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    576 Ascension Saint Michael's Hospital Stevens Point Wisconsin United States 54481
    577 Marshfield Clinic Stevens Point Center Stevens Point Wisconsin United States 54482
    578 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    579 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    580 Aurora Cancer Care-Waukesha Waukesha Wisconsin United States 53188
    581 Marshfield Clinic-Wausau Center Wausau Wisconsin United States 54401
    582 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    583 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    584 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    585 Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin United States 54494
    586 Big Horn Basin Cancer Center Cody Wyoming United States 82414
    587 Billings Clinic-Cody Cody Wyoming United States 82414
    588 Welch Cancer Center Sheridan Wyoming United States 82801
    589 Tom Baker Cancer Centre Calgary Alberta Canada T2N 4N2
    590 Cross Cancer Institute Edmonton Alberta Canada T6G 1Z2
    591 QEII Health Sciences Centre/Nova Scotia Health Authority Halifax Nova Scotia Canada B3H 2Y9
    592 Saint Joseph's Healthcare Charlton Campus Hamilton Ontario Canada L8N 4A6
    593 London Regional Cancer Program London Ontario Canada N6A 4L6
    594 Ottawa Hospital and Cancer Center-General Campus Ottawa Ontario Canada K1H 8L6
    595 Odette Cancer Centre- Sunnybrook Health Sciences Centre Toronto Ontario Canada M4N 3M5
    596 CHUM - Centre Hospitalier de l'Universite de Montreal Montreal Quebec Canada H2X 3E4
    597 Allan Blair Cancer Centre Regina Saskatchewan Canada S4T 7T1

    Sponsors and Collaborators

    • National Cancer Institute (NCI)
    • Canadian Cancer Trials Group

    Investigators

    • Principal Investigator: Sumanta K Pal, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT02761057
    Other Study ID Numbers:
    • NCI-2015-01707
    • NCI-2015-01707
    • S1500
    • S1500
    • U10CA180888
    First Posted:
    May 4, 2016
    Last Update Posted:
    Jan 6, 2022
    Last Verified:
    Jan 1, 2022
    Additional relevant MeSH terms:
    Carcinoma
    Carcinoma, Renal Cell
    Sunitinib
    Crizotinib

    Study Results

    No Results Posted as of Jan 6, 2022