Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

• Sponsor: Southwest Oncology Group (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT03694002
• Collaborator: National Cancer Institute (NCI) (NIH)
• Enrollment: 66
• Locations: 254
• Arms: 2
• Anticipated Duration (Months): 75.7
• Patients Per Site: 0.3
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This randomized phase II trial studies how well carboplatin and paclitaxel with or without ramucirumab work in treating patients with thymic cancer that has spread to other places in the body, has come back, or cannot be removed by surgery. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as ramucirumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known if giving carboplatin and paclitaxel with or without ramucirumab will work better in treating patients with thymic cancer.

Condition or Disease	Intervention/Treatment	Phase
Locally Advanced Thymic Carcinoma; Metastatic Thymic Carcinoma; Recurrent Thymic Carcinoma; Unresectable Thymic Carcinoma	Drug: Carboplatin; Drug: Paclitaxel; Biological: Ramucirumab	Phase 2

Detailed Description

PRIMARY OBJECTIVE:

1. To compare progression-free survival between patients with incurable unresectable locally advanced, or recurrent, or metastatic thymic carcinoma randomized to carboplatin-paclitaxel with or without ramucirumab.

SECONDARY OBJECTIVES:

1. To evaluate the frequency and severity of toxicity of carboplatin-paclitaxel with or without ramucirumab in this patient population.

2. To compare the response rate (complete response, partial response, confirmed and unconfirmed) between treatment arms.

3. To compare disease control rate (complete response, partial response, confirmed or unconfirmed, stable disease) between treatment arms.

4. To compare overall survival between treatment arms.

ADDITIONAL OBJECTIVE:

1. To bank specimens for future research.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive ramucirumab intravenously (IV) over 60 minutes, carboplatin IV, and paclitaxel IV on day 1. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients who have not progressed may continue to receive ramucirumab for up to 1 year.

ARM B: Patients receive carboplatin IV and paclitaxel IV on day 1. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year, and then every 6 months for 1 year.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 66 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Randomized Phase II Trial of Carboplatin-Paclitaxel With or Without Ramucirumab in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic Thymic Carcinoma
• Actual Study Start Date: Aug 9, 2018
• Anticipated Primary Completion Date: Jun 1, 2024
• Anticipated Study Completion Date: Nov 30, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A (ramucirumab, carboplatin, paclitaxel) Patients receive ramucirumab IV over 60 minutes, carboplatin IV, and paclitaxel IV on day 1. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients who have not progressed may continue to receive ramucirumab for up to 1 year.	Drug: Carboplatin; Given IV; Other Names: Blastocarb Carboplat Carboplatin Hexal Carboplatino Carboplatinum Carbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatinum Paraplatin Paraplatin AQ Paraplatine Platinwas Ribocarbo ; Drug: Paclitaxel; Given IV; Other Names: Anzatax Asotax Bristaxol Praxel Taxol Taxol Konzentrat ; Biological: Ramucirumab; Given IV; Other Names: Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B Cyramza IMC-1121B LY3009806 Monoclonal Antibody HGS-ETR2
Active Comparator: Arm B (carboplatin, paclitaxel) Patients receive carboplatin IV and paclitaxel IV on day 1. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.	Drug: Carboplatin; Given IV; Other Names: Blastocarb Carboplat Carboplatin Hexal Carboplatino Carboplatinum Carbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatinum Paraplatin Paraplatin AQ Paraplatine Platinwas Ribocarbo ; Drug: Paclitaxel; Given IV; Other Names: Anzatax Asotax Bristaxol Praxel Taxol Taxol Konzentrat

Outcome Measures

Primary Outcome Measures

1. Progression-free survival [From date of registration to date of first documentation of progression or symptomatic, assessed up to 2 years]

Secondary Outcome Measures

1. Incidence of adverse events [Up to 2 years]

   Binary proportions will be compared between the arms using either a Fisher's exact or Chi-squared test at the 1-sided 0.10 level.

2. Response rate (complete response, partial response, confirmed and unconfirmed) [Up to 2 years]

   Binary proportions will be compared between the arms using either a Fisher's exact or Chi-squared test at the 1-sided 0.10 level.

3. Disease control rate (complete response, partial response, confirmed or unconfirmed, stable disease) [Up to 2 years]

   Binary proportions will be compared between the arms using either a Fisher's exact or Chi-squared test at the 1-sided 0.10 level.

4. Overall survival [Up to 2 years]

   Binary proportions will be compared between the arms using either a Fisher's exact or Chi-squared test at the 1-sided 0.10 level.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients must have histologically or cytologically confirmed thymic carcinoma; thymic carcinoma may be defined as "thymic epithelial malignancy, consistent with thymic carcinoma", or "World Health Organization (WHO) type C thymic epithelial tumor", or "thymic epithelial malignancy" with radiographic imaging consistent with thymic carcinoma

• Patients must have unresectable thymic carcinoma, that is either locally advanced, recurrent, or metastatic

• Patients must not be candidates for localized surgery

• Patients must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI) within 28 calendar days prior to randomization; the CT from a combined positron emission tomography (PET)/CT may be used only if it is of diagnostic quality; non-measurable disease must be assessed within 42 calendar days prior to randomization; all known sites of disease must be assessed and documented on the baseline tumor assessment form (Response Evaluation Criteria in Solid Tumors [RECIST] 1.1)

• Patients must have a Zubrod performance status of 0 to 2

• Patients must not have undergone major surgery within 28 calendar days prior to randomization, or minor surgery/subcutaneous venous access device placement within 7 calendar days prior to randomization; the patient must not have elective or planned major surgery to be performed during the course of the clinical trial

• Patients must not have had prior systemic anti-cancer therapy for locally advanced or metastatic unresectable thymic carcinoma

• If patients have recurrent unresectable thymic carcinoma, patients may have had prior neoadjuvant or adjuvant chemotherapy if treatment concluded >= 6 months prior to randomization

• Patients must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 calendar days prior to registration; patient must not have brain metastases unless: (1) metastases have been treated and have remained controlled for at least two weeks following treatment, AND (2) patient has no residual neurological dysfunction off corticosteroids for at least 1 day

• Patients must not be candidates for radiation therapy with curative intent; prior palliative radiation therapy is allowed as long as a period of 7 days has passed since the last dose was received and the patient has recovered from any associated toxicity at the time of randomization

• Absolute neutrophil count (ANC) >= 1500/mcL documented within 28 calendar days prior to randomization

• Hemoglobin >= 9 g/dL (5.58 mmol/L) documented within 28 calendar days prior to randomization

• Platelets >= 100,000/mcL documented within 28 calendar days prior to randomization

• International normalized ratio (INR) =< 1.5 documented within 28 calendar days prior to randomization

• Partial thromboplastin time (PTT) =< 5 seconds above the institutional upper limit of normal (IULN) (unless receiving anticoagulation therapy) documented within 28 calendar days prior to randomization

• Patients receiving warfarin must be switched to low molecular weight heparin and have achieved stable coagulation profile 14 days prior to randomization

• Patients must not have experienced any grade 3 or above gastrointestinal (GI) bleeding within 84 calendar days prior to randomization

• Patients must not have a history of deep vein thrombosis (DVT), pulmonary embolism (PE), or any other significant thromboembolism (venous port or catheter thrombosis or superficial venous thrombosis are not considered "significant") during the 84 calendar days prior to randomization

• Total bilirubin =< 1.5 x the institutional upper limit normal (IULN) documented within 28 calendar days prior to randomization

• Aspartate aminotransferase (aspartate transaminase [AST]) and alanine aminotransferase (alanine transaminase [ALT]) =< 3.0 x IULN; for patients with liver metastases, total bilirubin and AST or ALT must be =< 5.0 x IULN documented within 28 calendar days prior to randomization

• Patients must not have any of following:

• Cirrhosis at a level of Child-Pugh B (or worse)

• Cirrhosis (any degree) and a history of hepatic encephalopathy; or

• Clinically meaningful ascites resulting from cirrhosis; clinically meaningful ascites is defined as ascites from cirrhosis requiring diuretics or paracentesis

• Serum creatinine =< 1.5 x IULN, or creatinine clearance (measured via 24-hour urine collection) >= 40 mL/minute (that is, if serum creatinine is > 1.5 x ULN, a 24-hour urine collection to calculate creatinine clearance must be performed) documented within 28 calendar days prior to randomization

• Patient urinary protein must be =< 1+ on dipstick or routine urinalysis (UA); if urine dipstick or routine analysis is >= 2+, a 24-hour urine collection for protein must demonstrate < 1000 mg of protein in 24 hours); these tests must be documented within 28 calendar days prior to randomization

• Patients must not have experienced any arterial thromboembolic events, including but not limited to myocardial infarction, transient ischemic attack, cerebrovascular accident, or unstable angina, within 6 months prior to randomization

• Patients must not have a history of uncontrolled or poorly-controlled hypertension (defined as > 160 mmHg systolic or > 100 mmHg diastolic for > 4 weeks) despite standard medical management

• Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method (hormonal or barrier method of birth control; abstinence) prior to randomization, during the study participation and for 4 months after the last dose of protocol treatment; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

• Patients must not have experienced hemoptysis (defined as bright red blood or >= 1/2 teaspoon) within 2 months prior to randomization or with radiographic evidence of intratumor cavitation or has radiologically documented evidence of major blood vessel invasion or encasement by cancer

• Patients must not have a prior history of gastrointestinal perforation/fistula (within 6 months of randomization) or risk factors for perforation

• Patients must not have a serious or nonhealing wound, ulcer, or bone fracture within 28 calendar days prior to randomization

• Patients must not be receiving chronic antiplatelet therapy, including aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs, including ibuprofen, naproxen, and others), dipyridamole or clopidogrel, or similar agents within 7 days prior to randomization; once-daily aspirin use (maximum dose 325 mg/day) is permitted

• Patients must be offered the opportunity to participate in banking of specimens for future research

• Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

• As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
2	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
3	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
4	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
5	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
6	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
7	Katmai Oncology Group	Anchorage	Alaska	United States	99508
8	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
9	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
10	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
11	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
12	PCR Oncology	Arroyo Grande	California	United States	93420
13	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
14	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
15	City of Hope Antelope Valley	Lancaster	California	United States	93534
16	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
17	City of Hope Mission Hills	Mission Hills	California	United States	91345
18	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
19	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
20	City of Hope South Pasadena	South Pasadena	California	United States	91030
21	City of Hope West Covina	West Covina	California	United States	91790
22	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
23	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
24	Porter Adventist Hospital	Denver	Colorado	United States	80210
25	Mercy Medical Center	Durango	Colorado	United States	81301
26	Southwest Oncology PC	Durango	Colorado	United States	81301
27	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
28	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
29	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
30	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
31	Longmont United Hospital	Longmont	Colorado	United States	80501
32	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
33	Parker Adventist Hospital	Parker	Colorado	United States	80138
34	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
35	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
36	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
37	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
38	Moffitt Cancer Center-International Plaza	Tampa	Florida	United States	33607
39	Moffitt Cancer Center - McKinley Campus	Tampa	Florida	United States	33612
40	Moffitt Cancer Center	Tampa	Florida	United States	33612
41	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
42	Saint Luke's Mountain States Tumor Institute	Boise	Idaho	United States	83712
43	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
44	Kootenai Medical Center	Coeur d'Alene	Idaho	United States	83814
45	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
46	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
47	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
48	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
49	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
50	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
51	Kootenai Cancer Center	Post Falls	Idaho	United States	83854
52	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
53	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
54	Northwestern University	Chicago	Illinois	United States	60611
55	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
56	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
57	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
58	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
59	Greater Regional Medical Center	Creston	Iowa	United States	50801
60	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
61	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
62	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
63	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
64	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
65	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
66	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
67	Saint Joseph London	London	Kentucky	United States	40741
68	Jewish Hospital	Louisville	Kentucky	United States	40202
69	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
70	Jewish Hospital Medical Center Northeast	Louisville	Kentucky	United States	40245
71	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
72	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
73	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
74	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
75	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
76	Henry Ford Hospital	Detroit	Michigan	United States	48202
77	Allegiance Health	Jackson	Michigan	United States	49201
78	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
79	Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	United States	48315
80	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
81	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
82	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
83	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
84	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
85	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
86	Unity Hospital	Fridley	Minnesota	United States	55432
87	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
88	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
89	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
90	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
91	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
92	Health Partners Inc	Minneapolis	Minnesota	United States	55454
93	Monticello Cancer Center	Monticello	Minnesota	United States	55362
94	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
95	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
96	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
97	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
98	Regions Hospital	Saint Paul	Minnesota	United States	55101
99	United Hospital	Saint Paul	Minnesota	United States	55102
100	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
101	Lakeview Hospital	Stillwater	Minnesota	United States	55082
102	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
103	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
104	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
105	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
106	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
107	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
108	Billings Clinic Cancer Center	Billings	Montana	United States	59101
109	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
110	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
111	Great Falls Clinic	Great Falls	Montana	United States	59405
112	Saint Peter's Community Hospital	Helena	Montana	United States	59601
113	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
114	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
115	Community Medical Hospital	Missoula	Montana	United States	59804
116	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
117	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
118	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
119	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
120	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
121	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
122	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
123	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
124	Creighton University Medical Center	Omaha	Nebraska	United States	68131
125	Midlands Community Hospital	Papillion	Nebraska	United States	68046
126	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
127	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
128	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
129	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
130	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
131	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
132	21st Century Oncology-Henderson	Henderson	Nevada	United States	89074
133	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
134	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
135	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
136	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
137	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
138	Desert West Surgery	Las Vegas	Nevada	United States	89102
139	OptumCare Cancer Care at Oakey	Las Vegas	Nevada	United States	89102
140	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
141	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
142	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
143	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
144	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
145	21st Century Oncology	Las Vegas	Nevada	United States	89109
146	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
147	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
148	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
149	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
150	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
151	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
152	21st Century Oncology-Vegas Tenaya	Las Vegas	Nevada	United States	89128
153	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
154	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
155	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
156	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
157	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
158	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
159	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
160	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
161	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
162	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
163	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
164	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
165	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
166	21st Century Oncology-Fort Apache	Las Vegas	Nevada	United States	89148
167	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
168	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
169	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89148
170	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
171	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
172	University Cancer Center	Las Vegas	Nevada	United States	89169
173	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
174	Renown Regional Medical Center	Reno	Nevada	United States	89502
175	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
176	Radiation Oncology Associates	Reno	Nevada	United States	89509
177	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
178	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
179	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
180	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
181	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
182	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
183	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
184	Saint Charles Health System	Bend	Oregon	United States	97701
185	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
186	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
187	Bay Area Hospital	Coos Bay	Oregon	United States	97420
188	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
189	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
190	Providence Portland Medical Center	Portland	Oregon	United States	97213
191	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
192	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
193	UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	United States	17109
194	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
195	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
196	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
197	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
198	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
199	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
200	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
201	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
202	Prisma Health Cancer Institute - Spartanburg	Spartanburg	South Carolina	United States	29307
203	Memorial Hospital	Chattanooga	Tennessee	United States	37404
204	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
205	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
206	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
207	M D Anderson Cancer Center	Houston	Texas	United States	77030
208	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
209	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
210	Overlake Medical Center	Bellevue	Washington	United States	98004
211	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
212	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
213	Harrison Medical Center	Bremerton	Washington	United States	98310
214	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
215	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
216	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
217	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
218	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
219	Saint Francis Hospital	Federal Way	Washington	United States	98003
220	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
221	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
222	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
223	Saint Clare Hospital	Lakewood	Washington	United States	98499
224	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
225	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
226	Valley Medical Center	Renton	Washington	United States	98055
227	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
228	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
229	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
230	Seattle Cancer Care Alliance	Seattle	Washington	United States	98109
231	Kaiser Permanente Washington	Seattle	Washington	United States	98112
232	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
233	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
234	University of Washington Medical Center	Seattle	Washington	United States	98195
235	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
236	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
237	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
238	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
239	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
240	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
241	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
242	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
243	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
244	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
245	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
246	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
247	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
248	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
249	Marshfield Clinic Stevens Point Center	Stevens Point	Wisconsin	United States	54482
250	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
251	Marshfield Clinic - Weston Center	Weston	Wisconsin	United States	54476
252	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
253	Billings Clinic-Cody	Cody	Wyoming	United States	82414
254	Welch Cancer Center	Sheridan	Wyoming	United States	82801

Sponsors and Collaborators

• Southwest Oncology Group
• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Anne S Tsao, Southwest Oncology Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Southwest Oncology Group
• ClinicalTrials.gov Identifier: NCT03694002
• Other Study ID Numbers: S1701; NCI-2017-02254; S1701; S1701; S1701; U10CA180888
• First Posted: Oct 3, 2018
• Last Update Posted: Jan 10, 2022
• Last Verified: Jan 1, 2022

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Carcinoma; Thymoma; Recurrence; Paclitaxel; Carboplatin; Albumin-Bound Paclitaxel; Ramucirumab; Antineoplastic Agents, Immunological; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Lexatumumab

Study Results

No Results Posted as of Jan 10, 2022