Long COVID and Its Associations With Health Outcomes in Older Adults
Study Details
Study Description
Brief Summary
The Peking University Health Cohort in Anning, Yunnan (PKUHC-AN) is a prospective cohort study carried out in Anning, Yunnan. The primary aim of this study is to investigate the impact of COVID-19 on older adults' health, and to provide high-quality evidence of real world research for the optimization of prevention and control strategies of COVID-19 and other emerging infectious diseases. Data will be collected regarding health status, history of COVID-19 infections and vaccines, lifestyle and socioeconomic characteristics, as well as the short- and long-term health outcomes.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
COVID-19 pandemic attributed to a great number of mortalities around the world in the last 3 years. About 46% of the global population are estimated to have been infected by the omicron variant and its sublineages. Health outcomes post COVID-19 has been of great concern globally since more and more people infected by SARS-CoV-2. Integrated efforts should be made to estimate the incidence of reinfections and long COVID in China, especially among older adults who are vunlerable and susceptible to COVID-19. In view of this, the Peking University Health Cohort Study in Anning, Yunnan aims to investigate the impact of COVID-19 on older adults' health, and to provide high-quality evidence of real world research for the optimization of prevention and control strategies of COVID-19 and other emerging infectious diseases. Data will be collected regarding health status, history of COVID-19 infections and vaccines, lifestyle and socioeconomic characteristics, as well as the short- and long-term health outcomes.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Exposure group Group with history of COVID-19 infections and vaccines, as well as health-related, behavioral, socioeconomic exposures. |
Other: no interventions
This is an observational study without any intervention.
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| Non-exposure group Group without history of COVID-19 infections and vaccines, as well as health-related, behavioral, socioeconomic exposures. |
Outcome Measures
Primary Outcome Measures
- Incidence of long COVID [From baseline until the date of long COVID symptoms or date of death from any cause, whichever came first, assessed up to 12 months.]
The proportion of participants incurred any symptoms or diagnosed diseases of post-COVID in all infected participants.
Secondary Outcome Measures
- Reinfection incidence of COVID-19 [At 3 months, 6 months, 9 months, 1 year after baseline investigation.]
The proportion of participants infected by COVID-19 at least 2 times. Measured by trained health professionals.
- Cognitive impairment [At 3 months, 6 months, 9 months, 1 year after baseline investigation.]
Measured by health professionals using MMSE (Mini-Mental State Exam). The MMSE cognitive screening test is a 30-point questionnaire for analyzing several cognitive functions including memory, orientation, attention, calculation, and language. MMSE is measured on a scale between 0 and 30, where scores of 0-9, 10-20, 21-26, and 27-30 indicate severe, moderate, mild, and normal cognitive function, respectively.
- Depression [At 3 months, 6 months, 9 months, 1 year after baseline investigation.]
Measured by health professionals using PHQ-9 (Patient Health Questionnaire-9). PHQ-9 provides a score ranging from 0 to 27, where scores of <4, 5-9, 10-14, 15-19, and 20-27 represented no, mild, moderate, moderately severe, and severe depression, respectively.
- Medical expenditure [At 3 months, 6 months, 9 months, 1 year after baseline investigation.]
Measured by health professionals using self-designed questionnaire about their past month outpatient expenditure and past year inpatient expenditure.
- Incidence of catastrophic health expenditure [At 3 months, 6 months, 9 months, 1 year after baseline investigation.]
Measured by health professionals using self-designed questionnaire about their households' past year consumption expenditure (including food expenditure, cloths expenditure, transportation expenditure and so on), and calculated as the proportion of households whose out-of-pocket medical expenditure exceed 40% of household non-food expenditure.
- Sleep quality [At 3 months, 6 months, 9 months, 1 year after baseline investigation.]
Measured by health professionals using PSQI (Pittsburgh Sleep Quality Index). PSQI reflects sleep for a month, includes 18 items (7 subscales): subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, use of sleeping medications, and daytime dysfunction. The range of PSQI global score is 0-21, and a score of >5 or 7 is indicative of poor sleep quality.
Eligibility Criteria
Criteria
Inclusion Criteria:
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- ≥60 years
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- Resided in Anning in the past half year and have no plan to move out in next 1 year
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- Older adults who are willing to participate in this study with informed consent
Exclusion Criteria:
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- Unable to answer questions or communicate
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- Older adults who are not willing to participate in this study or without informed consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Peking University | Beijing | Beijing | China | 100191 |
Sponsors and Collaborators
- Peking University
- National Natural Science Foundation of China
Investigators
- Principal Investigator: Jue Liu, Ph.D, Peking University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NNSF72211540398