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Long-term Observation of Patients With Early Rheumatoid Arthritis

Sponsor
University of California, Los Angeles (Other)
Overall Status
Completed
CT.gov ID
NCT00240136
Collaborator
(none)
372
Enrollment
1
Location
333.7
Duration (Months)
1.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this research is to observe the effects of RA over a long period in order to learn which of the early characteristics of patients' early RA predict future joint damage and disability. We also investigate whether certain treatments can prevent or slow the development of joint damage and disability. Additionally, the costs and effects of RA on the patient are studied in order to improve the methods used to measure these effects. Clinical, demographic, radiographic, and laboratory measures are taken by the rheumatologist in the office. In addition, patient questionnaires are mailed & completed by the patient and returned to the coordinating center at UCLA. All information obtained by these means will be studied in their effects on early, severe RA.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    See Publications

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    372 participants
    Observational Model:
    Cohort
    Time Perspective:
    Other
    Official Title:
    Long-term Observation of Patients With Early Rheumatoid Arthritis
    Study Start Date :
    Jan 1, 1993
    Actual Primary Completion Date :
    Oct 23, 2020
    Actual Study Completion Date :
    Oct 23, 2020

    Outcome Measures

    Primary Outcome Measures

    1. Development of joint erosions in the early stages of RA [Baseline, Annual Follow-up]

      Measure joint erosions over time

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • =6 swollen joints & >=9 tender joints

    • symmetrical rheumatoid arthritis (RA)

    • <= 2 years worth of symptoms

    • rheumatoid factor seropositivity

    Exclusion Criteria:

    • <18 years old

    • Inability to see rheumatologist, complete questionnaires (lack of compliance)

    • 2 years worth of symptoms

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 UCLA Los Angeles California United States 90095

    Sponsors and Collaborators

    • University of California, Los Angeles

    Investigators

    • Principal Investigator: Harold E Paulus, MD, University of California, Los Angeles

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    University of California, Los Angeles
    ClinicalTrials.gov Identifier:
    NCT00240136
    Other Study ID Numbers:
    • 91-10-435-32
    First Posted:
    Oct 17, 2005
    Last Update Posted:
    Nov 17, 2020
    Last Verified:
    Nov 1, 2020
    Keywords provided by University of California, Los Angeles
    Early, severe
    Additional relevant MeSH terms:
    Arthritis
    Arthritis, Rheumatoid

    Study Results

    No Results Posted as of Nov 17, 2020