LCPVIH: Long-term Outcome of AIDS-related Primary Central Nervous System Lymphoma Treated With High Dose Methotrexate and Combined Antiretroviral Therapy
Sponsor
Fondation Ophtalmologique Adolphe de Rothschild (Other)
Overall Status
Completed
CT.gov ID
NCT03690895
Collaborator
(none)
51
1
18.6
2.7
Study Details
Study Description
Brief Summary
This study aims at describing survival rates over time (Kaplan-Meier estimator) in patients suffering from AIDS-related primary central nervous system lymphoma who were diagnosed from 1996 to 2014 and treated with infusions of high-dose methotrexate and combined antiretroviral therapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Actual Enrollment
:
51 participants
Observational Model:
Case-Only
Time Perspective:
Retrospective
Official Title:
Long-term Outcome of AIDS-related Primary Central Nervous System Lymphoma Treated With High Dose Methotrexate and Combined Antiretroviral Therapy
Actual Study Start Date
:
Mar 15, 2015
Actual Primary Completion Date
:
Oct 1, 2016
Actual Study Completion Date
:
Oct 1, 2016
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Cases
|
Other: Retrospective survival analysis
Kaplan-Meier model
|
Outcome Measures
Primary Outcome Measures
- Median duration of survival after diagnosis of lymphoma (years) [At the time of systematic files review (jan 2014) - average follow-up 7 years]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
HIV infection
-
AIDS-related primary central nervous system lymphoma
-
treated with at least one infusion of methotrexate and combine antiretroviral therapy
Exclusion Criteria:
- prior non-Hodgkin lymphoma
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fondation Ophtalmologique A. de Rotchschild | Paris | France | 75019 |
Sponsors and Collaborators
- Fondation Ophtalmologique Adolphe de Rothschild
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Fondation Ophtalmologique Adolphe de Rothschild
ClinicalTrials.gov Identifier:
NCT03690895
Other Study ID Numbers:
- NI_2015_2_AMR
First Posted:
Oct 1, 2018
Last Update Posted:
Oct 1, 2018
Last Verified:
Sep 1, 2018
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: