Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor

Sponsor

Changhua Christian Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT03793400

Collaborator

(none)

Enrollment

Location

9.5

Actual Duration (Months)

2.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To evaluate the long-term outcome of active choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) after anti-vascular endothelial factor treatment.

Condition or Disease	Intervention/Treatment	Phase
Choroidal Neovascularization Punctate Inner Choroidopathy	Drug: Bevacizumab Injection

Detailed Description

To evaluate the long-term outcome of active choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) after anti-vascular endothelial factor treatment.

The age, sex, best corrected visual acuity (BCVA) in Snellen chart, and refractive status for each patient were recorded. All patients had thorough clinical examinations, including slit lamp biomicroscopy, indirect ophthalmoloscopy, and spectral domain optical coherence tomography during each visit. Fundus photography, fluorescein angiography, and indocyanine angiography were performed on all patients. OCT angiography was performed.

Study Design

Study Type:

Observational

Actual Enrollment :

22 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor

Actual Study Start Date :

Mar 13, 2018

Actual Primary Completion Date :

Apr 13, 2018

Actual Study Completion Date :

Dec 28, 2018

Outcome Measures

Primary Outcome Measures

Wilcoxon Signed-Rank test [Baseline,48 month.]
A statistical comparison of average of two dependent samples

Secondary Outcome Measures

visual acuity [Baseline,48 month.]
visual acuity in logMAR

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients were punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization.
Follow up over 4 years.

Exclusion Criteria:

Patients were not punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization
Patients were punctate inner choroidopathy or multifocal choroiditis with active choroidal neovascularization but loss follow over 1 year.