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The Longevity Genes in Founder Populations Project

Sponsor
Albert Einstein College of Medicine (Other)
Overall Status
Recruiting
CT.gov ID
NCT00707694
Collaborator
National Institutes of Health (NIH) (NIH)
1,500
Enrollment
4
Locations
291
Anticipated Duration (Months)
375
Patients Per Site
1.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    1500 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
    Actual Study Start Date :
    Jul 1, 1998
    Anticipated Primary Completion Date :
    Oct 1, 2022
    Anticipated Study Completion Date :
    Oct 1, 2022

    Arms and Interventions

    Arm Intervention/Treatment
    Probands

    Ashkenazi Jews ages 95 and older
    Offspring

    Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95
    Controls

    Ashkenazi Jewish people with no family history of longevity

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      65 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • Ashkenazi Jewish, age 95+,

      • Offspring of person age 95+,

      • Offspring of parents who died age 70 or younger.

      Exclusion Criteria:
      • Non-Ashkenazis

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Boston University Medical Center Boston Massachusetts United States 02118-2526
      2 Weill Cornell Medical College New York New York United States 10065
      3 Private Homes New York New York United States
      4 Hebrew Home Riverdale Riverdale New York United States 10471

      Sponsors and Collaborators

      • Albert Einstein College of Medicine
      • National Institutes of Health (NIH)

      Investigators

      • Principal Investigator: Nir Barzilai, MD, Albert Einstein College of Medicine

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Albert Einstein College of Medicine
      ClinicalTrials.gov Identifier:
      NCT00707694
      Other Study ID Numbers:
      • 1998-125
      First Posted:
      Jul 1, 2008
      Last Update Posted:
      Nov 4, 2021
      Last Verified:
      Nov 1, 2021
      Keywords provided by Albert Einstein College of Medicine
      95 years of age and older

      Study Results

      No Results Posted as of Nov 4, 2021