Longitudinal Changes of Brain Functional Connectivity in Migraine
Study Details
Study Description
Brief Summary
The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Migraine is associated with functional alterations in specific brain networks. The investigators aimed to identify network abnormalities which remain unchanged throughout the longitudinal course of migraine. The investigators also aimed to identify networks which change in association with changes in migraine frequency and associated psychiatric conditions. The investigators expect these can serve as neuroimaging biomarkers for diagnosis of migraine brain and monitoring of disease severity.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Migraineurs Patients diagnosed with migraine based on the ICHD-3 beta will undergo 3-tesla resting-state functional MRI. |
Diagnostic Test: resting-state functional MRI
To ensure inter-ictal fMRI, confirm that the subject has no migraine for at least 48 hours before the procedure.
Record the time difference between the date on the day of fMRI and the date of the last headache attack and record whether the headache on the day of fMRI is absent or not.
On the third day after MRI, examine whether the subject has headache or not.
|
| Control Normal controls without headaches will undergo 3-tesla resting-state functional MRI. |
Diagnostic Test: resting-state functional MRI
To ensure inter-ictal fMRI, confirm that the subject has no migraine for at least 48 hours before the procedure.
Record the time difference between the date on the day of fMRI and the date of the last headache attack and record whether the headache on the day of fMRI is absent or not.
On the third day after MRI, examine whether the subject has headache or not.
|
Outcome Measures
Primary Outcome Measures
- Core fMRI features for migraine brain [1-year follow-up (2nd year)]
Among significant networks identified by ICA, we will identify altered networks which remain unchanged in follow-up resting-state fMRI in 1 year.
Secondary Outcome Measures
- Candidate fMRI features for migraine [Baseline (1st year)]
Using baseline resting-state fMRI, altered brain networks associated with migraine will be identified by independent component analysis (ICA) between patients and controls.
- Dynamic fMRI features for disease severity [1-year follow-up (2nd year)]
Among significant networks identified by ICA, we will identify altered networks which change in association with changes in headache frequency in follow-up resting-state fMRI in 1 year.
Eligibility Criteria
Criteria
Inclusion Criteria:
Migrainuers :
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age 18-50 years
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migraine with or without aura as defined by the third edition of the International Classification of Headache Disorders (ICHD-3 beta)
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if female, before the onset of menopausal
Controls:
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age 18-50 years
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no headache disorder other than Infrequent episodic tension-type headache as defined by the ICHD-3 beta
Exclusion criteria:
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contraindicated to MRI
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pregnancy
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require sedation treatment because of claustrophobia when performing MRI
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predicted to be unable to write the headache diary due to cognitive decline
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refuse study procedure
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Samsung Medical Center | Seoul | Korea, Republic of |
Sponsors and Collaborators
- Samsung Medical Center
- National Research Foundation of Korea
- Sungkyunkwan University
Investigators
- Principal Investigator: Mi Ji Lee, MD, Samsung Medical Center, Sungkyunkwan University School of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2017-03-113