Longitudinal Changes in Characteristics of COVID-19 Survivors and Their Long-term Follow-up Study
Study Details
Study Description
Brief Summary
Follow-up study of Coronavirus disease 2019 (COVID-19) survivors has rarely been reported. We aimed to investigate longitudinal changes in the characteristics of COVID-19 survivors after discharge.
Detailed Description
From December 2019, coronavirus disease 2019 (COVID-19), caused by a β-coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the globe. Numerous studies have been performed so far to investigate clinical characteristics, risk factors, potential treatment and pathogenesis of COVID-19. However, little information is available on the long-term prognosis and possible sequelae of COVID-19 survivors who have recovered and been discharged from hospital. Hence, the investigators conducted a prospective study to investigate the long-time prognosis and the possible sequelae of COVID-19 survivors. The investigators evaluated Demographic and clinical characteristics, laboratory and radiological findings,pulmonary function tests, electrocardiogram, complications as well as treatment and symptoms and signs of COVID-19 patients.
Study Design
Outcome Measures
Primary Outcome Measures
- symptoms and signs [1-3years]
symptoms and signs will be collected.
- Quality of Life [1-3years]
Quality of Life will be assesed using the MOS item short from health survey（SF-36.Minimum value:0, Maximum value: 100. Higher scores mean a better outcome.
- Mental quality [1-3years]
Mental quality will be assessed using hospital anxiety and depression scale.Minimum value:0, Maximum value: 21. Higher scores mean a worse outcome.
- laboratory findings,change from baseline for blood laboratory measures [1-3years]
the change from baseline for laboratory examination （Hb in g/L, Leukocyte in /L, neutrophil count in /L，lymphocyte count in /L，Platelet count in /L，Creatinine in μmol/L, Bilirubin in mg/dL, ALP in U/L, γ-glutamyl transpeptidase in U/L，AST in U/L, ALT in U/L, Albumin in g/dL, triglycerides in mmol/L, total cholesterol in mmol/L，cardiac troponin I in ng/mL， myoglobin in ng/mL， brain natriuretic peptide precursors in pg/mL， lactate dehydrogenase in U/L, Creatine Kinase in U/L).
- Radiological findings [1-3years]
Radiological findings such as chest computed tomography will be assessed.
- pulmonary function [1-3years]
pulmonary function tests will be assessed.
- Heart function [1-3years]
electrocardiogram including arrhythmia,ST-T change and conduction block will be assessed.
- Abdominal ultrasound [1-3years]
Abdominal ultrasound will be assessed.
Eligibility Criteria
Criteria
Inclusion Criteria:
Patients with confirmed COVID-19 who have complete hospitalization data.
Exclusion Criteria:
Suspected cases of COVID-19.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of infectious disease, Tongji Hospital | Wuhan | Hubei | China | 430030 |
Sponsors and Collaborators
- Tongji Hospital
- First Affiliated Hospital Xi'an Jiaotong University
- Yichang Central People's Hospital
- First Affiliated Hospital of Wenzhou Medical University
- Xiangya Hospital of Central South University
- Shiyan Renmin Hospital
- The second Hospital of JingZhou
- Yunnan Provincial Infectious Disease Hospital
- WUHAN Number Seven HOSPITAL
- Shanxi Bethune hospital, Shanxi, China
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- TJ20210622