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Low Flow Anesthesia Without Initial High Flow Phase

Sponsor
Kahramanmaras Sutcu Imam University (Other)
Overall Status
Completed
CT.gov ID
NCT03955406
Collaborator
(none)
80
Enrollment
1
Location
2
Arms
1.3
Actual Duration (Months)
59.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to compare the effectiveness of conventional low flow anesthesia (LFA) with initial high fresh gas flow ( 4L/min) for 10 minutes and LFA with fixed fresh gas flow rate (1L/min).

Condition or Disease Intervention/Treatment Phase
  • Procedure: Conventional Low flow Anesthesia
  • Procedure: Low Flow Anesthesia with fixed fresh gas flow rate
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
80 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Outcomes Assessor)
Primary Purpose:
Other
Official Title:
Comparison of Low Flow Anesthesia With and Without Initial High Flow Phase
Actual Study Start Date :
May 22, 2019
Actual Primary Completion Date :
Jul 2, 2019
Actual Study Completion Date :
Jul 2, 2019

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Conventional group

After standart intravenous anesthesia induction end endotracheal intubation desflurane vaporizer will be set at 6% with fresh gas flow rate 4 L/min (50% O2, 50% air) until the EtAA concentration reaches 0.7 MAC (minimum alveolar concentration) Then, the desflurane vaporizer will be at a 1% higher value than the EtAA concentration required to achieve 0.7 MAC. And after 10 minutes fresh gas flow rate will be reduced to 1L/min.

Procedure: Conventional Low flow Anesthesia
During the initial wash-in period 4 L/min Fresh gas flow will be used.
Active Comparator: Fixed Fresh Gas Flow Rate group

After standart intravenous anesthesia induction end endotracheal intubation desflurane vaporizer will be set at 18% with fresh gas flow rate 1 L/min (50% O2, 50% air) until the EtAA concentration reaches 0.7 MAC (minimum alveolar concentration) Then, the desflurane vaporizer will be at a 2% higher value than the EtAA concentration required to achieve 0.7 MAC.

Procedure: Low Flow Anesthesia with fixed fresh gas flow rate
Fresh gas flow rate will be 1 L/min throughout the procedure.

Outcome Measures

Primary Outcome Measures

  1. The time required to reach 0.7 MAC [perioperative]

  2. number of adjustments made to the vaporizer settings [perioperative]

    MAC will be held between 0.6-0.8 with adjustments at the vaporizer

Secondary Outcome Measures

  1. anesthetic agent consumption [perioperative]

    desfluane consumption at the first hour and at the end of the surgery wil be recorded

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • ASA 1-3

  • scheduled for surgery under general anesthesia with endotracheal intubation

Exclusion Criteria:

  • hemodynamic instability

  • emergency cases

  • expected anesthesia duration < 60 min

  • patient refusal

Contacts and Locations

Locations

Site City State Country Postal Code
1 Kahramanmaras Sutcu Imam University Kahramanmaras In The USA Or Canada, Please Select... Turkey 46100

Sponsors and Collaborators

  • Kahramanmaras Sutcu Imam University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

None provided.
Responsible Party:
MAHMUT ARSLAN, Assistant Professor, Kahramanmaras Sutcu Imam University
ClinicalTrials.gov Identifier:
NCT03955406
Other Study ID Numbers:
  • KSU 2017-15
First Posted:
May 20, 2019
Last Update Posted:
Jul 10, 2019
Last Verified:
Jul 1, 2019
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Anesthetics

Study Results

No Results Posted as of Jul 10, 2019