A Low Interventional Study to Monitor Activity Using Wearable Sensors in Duchenne Muscular Dystrophy
Study Details
Study Description
Brief Summary
The purpose of this low interventional study is to collect data on everyday movement in boys with Duchenne muscular dystrophy (DMD) using wearable activity sensors. The activity sensors could provide useful information beyond what is currently collected by functional (movement, strength) assessments in clinic. This information can help with the understanding of the impact of DMD, and perhaps with how possible treatments can affect this impact.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Single cohort There is no randomization or stratification in this study. All subjects will complete the same study assessments. |
Device: Activity Monitor
Wrist and ankle sensors to be worn continuously for 2-week intervals.
|
Outcome Measures
Primary Outcome Measures
- Mean change from baseline and variability of activity measures [baseline, 3, 6, 9, and 12 months]
Secondary Outcome Measures
- Mean change from baseline in functional assessment scores obtained in the clinic [baseline, 3, 6, 9, and 12 months]
- Comparison of mean changes from baseline and correlation coefficient between activity monitoring data and functional data obtained in clinic [baseline, 3, 6, 9, and 12 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Diagnosis of Duchenne muscular dystrophy confirmed by medical history and genetic testing
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Body weight between 15 and 50 kg
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Receipt of glucocorticoids for 6 months and a stable daily dose for at least 3 months prior to study entry
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Ability to rise from floor within seven (7) seconds and ability to walk
Exclusion Criteria:
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Current exposure to systemic immunosuppressant agents other than glucocorticoids.
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Prior exposure to any gene therapy agent, including exon-skipping and missense agents.
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Exposure to other investigational drugs within 30 days or 5 half-lives, whichever is longer.
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Any injury which may impact functional testing per investigator's judgement. Previous injuries must be fully healed prior to consenting. Prior lower limb fractures must be fully healed and at least 3 months from injury date at screening.
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Any planned surgeries which may impact physical activity and performance.
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Presence or history of musculoskeletal or neurological disease in addition to DMD.
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Any known allergies or skin reactions to stainless steel, versaflex, and silicon that may cause possible discomfort by wearable sensors.
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Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, cancer, autoimmune or allergic disease that may interfere with the study conduct as per investigator's judgment, excluding untreated, asymptomatic, seasonal allergies at time of screening.
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Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or participants who are Pfizer employees, including their family members, directly involved in the conduct of the study.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Nationwide Children's Hospital | Columbus | Ohio | United States | 43205 |
Sponsors and Collaborators
- Pfizer
Investigators
- Study Director: Pfizer CT.gov Call Center, Pfizer
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- C3391005