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Effects of Low LH Serum Levels on Ovarian Pick-up Outcome

Sponsor
University of Palermo (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05755529
Collaborator
(none)
43
Enrollment

Study Details

Study Description

Brief Summary

Luteinizing hormone (LH) plays a key role for normal follicular development and oocyte maturation in controlled ovarian stimulation. In particular, LH stimulates the proliferation and differentiation of theca cells for the secretion of androgens, which synergistically increase the production of estrogen. This study aimed to investigate the effects of low LH concentrations on oocyte retrieval, fertilization and embryo development in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Patients undergoing IVF/ICSI were prospectively analyzed, subdividing them into three groups according to their age. Serum LH levels were evaluated at day 3, during stimulation (day 10) and before ovulation induction (day 12).

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    43 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Effects of Low LH Serum Levels on Oocyte Retrieval, Fertilization Rate and Embryo Quality During Controlled Ovarian Stimulation: Results From a Prospective Cohort Analysis
    Anticipated Study Start Date :
    Mar 1, 2023
    Anticipated Primary Completion Date :
    Mar 1, 2023
    Anticipated Study Completion Date :
    Mar 1, 2023

    Outcome Measures

    Primary Outcome Measures

    1. Oocyte retrieval [immediately after the intervention]

      number of retrieved oocytes after controlled ovarian stimulation

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 40 Years
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    age between 18 and 40 years, body mass index 18-29 kg/m 2 , regular menstrual cycles, normal uterine cavity assess by hysteroscopy, normal uterus and ovaries at transvaginal sonography,

    Exclusion Criteria:

    abnormal cervical cytology, affected by any other endocrinological, metabolic, autoimmune, and gynecological disease.

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • University of Palermo

    Investigators

    • Principal Investigator: Jessica Dragotto, Biologist, Clinica del Mediterraneo - Ragusa
    • Study Director: Giovanni Bracchitta, M.D., Clinica del Mediterraneo - Ragusa
    • Study Chair: Antonio Simone Laganà, M.D., Ph.D., University of Palermo
    • Study Chair: Andrea Etrusco, M.D., University of Palermo

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Andrea Etrusco, Principal investigator, University of Palermo
    ClinicalTrials.gov Identifier:
    NCT05755529
    Other Study ID Numbers:
    • LH-OS-1
    First Posted:
    Mar 6, 2023
    Last Update Posted:
    Mar 6, 2023
    Last Verified:
    Mar 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Andrea Etrusco, Principal investigator, University of Palermo
    embryo quality
    LH levels
    Oocyte retrieval
    Additional relevant MeSH terms:
    Infertility
    Infertility, Female

    Study Results

    No Results Posted as of Mar 6, 2023