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LOXL1 Polymorphism in Pseudoexfoliation Syndrome

Sponsor
Samsung Medical Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT01515735
Collaborator
(none)
60
Enrollment
1
Location
12
Duration (Months)
5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.

    And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    60 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Evaluation of LOXL1 Polymorphism in Pseudoexfoliation Syndrome in the Korean Population
    Study Start Date :
    Dec 1, 2011
    Anticipated Primary Completion Date :
    Dec 1, 2012
    Anticipated Study Completion Date :
    Dec 1, 2012

    Arms and Interventions

    Arm Intervention/Treatment
    pseudoexfoliation

    The study group composted of the patients with pseudoexfoliation syndrome

    Outcome Measures

    Primary Outcome Measures

    1. Genotypes of the three single nucleotide polymorphisms of LOXL1 (rs1048661, rs3825942, rs2165241) [about 1 year (when all patients were recruited)]

      Genotypes of the three single nucleotide polymorphisms of LOXL1 were analyzed by direct sequencing, after obtained from the peripheral blood sampling from patients.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 70 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Clinical diagnosis of Pseudoexfoliation
    Exclusion Criteria:
    • medical condition that peripheral blood sampling cannot be done

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Samsung medical center Seoul Korea, Republic of 135710

    Sponsors and Collaborators

    • Samsung Medical Center

    Investigators

    • Study Chair: Changwon Kee, M.D., PhD, Samsung Medical Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Samsung Medical Center
    ClinicalTrials.gov Identifier:
    NCT01515735
    Other Study ID Numbers:
    • 2011-06-035
    First Posted:
    Jan 24, 2012
    Last Update Posted:
    Jan 24, 2012
    Last Verified:
    Jan 1, 2012
    Additional relevant MeSH terms:
    Exfoliation Syndrome
    Syndrome

    Study Results

    No Results Posted as of Jan 24, 2012