Correlation of Pre- and Post-operative Cancer Imaging Techniques

Sponsor

University of Strathclyde (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT04776291

Collaborator

NHS Greater Glasgow and Clyde (Other)

Enrollment

Arm

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Various imaging modalities are used in medical diagnosis such as MRI, CT and PET. The images are sometimes acquired at different times and in different body positions, and thus need to be aligned for precise diagnosis and treatment planning. Different image modalities provide complementary information about the anatomical structure under study. Image registration techniques enable multimodality images to be projected onto a common coordinate system, so that these images can be aligned and spatial correspondences can be established between the images.

This research project aims to investigate the information provided by functional PET and CT images about the tumour environment in lung cancer patients by registering functional PET and CT images with the pathology images acquired from the same patient. On identification of specific region of interest on the functional imaging the investigators will then be able to interrogate the tumour biology. In many cancers, the tumour environment is usually composed of a heterogeneous mass of tissue. The discrimination and classification of the carcinoma substructures is of paramount importance in the radiotherapy planning stage, as a given treatment may be more or less suitable depending on the local characteristics of the tumour. For instance, in hypoxic regions (areas inside the tumour with very low oxygen supply), radiotherapy performs poorly and strategies to intensify treatment to those areas could be investigated.

This project will develop a framework for automatic registration of pathology images, which are taken from a surgically extracted lung tumour, with the corresponding PET/CT scan acquired from the patient before surgery. The registration of these images is essential for the evaluation of the performance of different PET radiotracers.

Condition or Disease	Intervention/Treatment	Phase
Lung Cancer	Radiation: 4D PET-CT Scan	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

10 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Health Services Research

Official Title:

PET-PATH: Investigation of New Medical Imaging Techniques for Improving Lung Cancer Treatment

Anticipated Study Start Date :

Aug 1, 2021

Anticipated Primary Completion Date :

Jan 1, 2022

Anticipated Study Completion Date :

Jan 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Recruitment and image processing	Radiation: 4D PET-CT Scan The recruited patients will have a 4d PET-CT scan that is additional to the usual care.

Arm

Intervention/Treatment

Experimental: Recruitment and image processing

Radiation: 4D PET-CT Scan

The recruited patients will have a 4d PET-CT scan that is additional to the usual care.

Outcome Measures

Primary Outcome Measures

4D PET-CT images aquired [up to 4 weeks after the PET-CT image is taken.]
The patent needs to have one 4D PET-CT scan, this is the only requirement in the study as the surgery they will undertake is part of standard care.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 99 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patient diagnosed with primary lung cancer and are due to undergo curative surgical resection of the tumour
At least one of the tumour's major axes is larger than 30mm.
The main volume of the tumour is located within the lung tissue.
Tumour is identified primarily as single mass lesion.

Exclusion Criteria:

Patient is under 18 years old.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

University of Strathclyde
NHS Greater Glasgow and Clyde

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Matthew Gil, Principal Investigator, University of Strathclyde

ClinicalTrials.gov Identifier:

NCT04776291

Other Study ID Numbers:

UEC20/51

First Posted:

Mar 1, 2021

Last Update Posted:

Jun 3, 2021

Last Verified:

Jun 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Lung Neoplasms

Study Results

No Results Posted as of Jun 3, 2021