Enzastaurin, Carboplatin, and Gemcitabine With or Without Bevacizumab in Treating Patients With Recurrent, Stage IIIB, or Stage IV Non-Small Cell Lung Cancer

Sponsor

Eastern Cooperative Oncology Group (Other)

Overall Status

Withdrawn

CT.gov ID

NCT00469976

Collaborator

National Cancer Institute (NCI) (NIH)

Enrollment

Study Details

Study Description

Brief Summary

RATIONALE: Enzastaurin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving enzastaurin together with carboplatin and gemcitabine, with or without bevacizumab, may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving enzastaurin together with carboplatin and gemcitabine, with or without bevacizumab, works in treating patients with recurrent, stage IIIB, or stage IV non-small cell lung cancer.

Condition or Disease	Intervention/Treatment	Phase
Lung Cancer	Drug: bevacizumab Drug: carboplatin Drug: enzastaurin hydrochloride Drug: gemcitabine hydrochloride	Phase 2

Detailed Description

OBJECTIVES:

Primary

Determine the progression-free survival in patients with recurrent or stage IIIB or IV non-small cell lung cancer treated with carboplatin, gemcitabine, and enzastaurin with or without bevacizumab.

Secondary

Determine the toxicity of this regimen in these patients.
Determine the overall survival in patients treated with this regimen.
Determine the response rate in patients treated with this regimen.

OUTLINE: This is a multicenter study. Patients are assigned to 1 of 2 treatment groups based on eligibility for bevacizumab therapy.

Group 1 (bevacizumab-eligible): Patients receive carboplatin IV over 30 minutes and bevacizumab IV over 30-90 minutes on day 1; gemcitabine hydrochloride IV over 30 minutes on days 1 and 8; and oral enzastaurin hydrochloride 3 or 4 times daily on days 1-21 in courses 1-6 and bevacizumab IV over 30-90 minutes on day 1 and oral enzastaurin hydrochloride 3 times daily on days 1-21 in all subsequent courses.
Group 2 (bevacizumab-ineligible): Patients receive carboplatin, gemcitabine hydrochloride, and enzastaurin hydrochloride as in group 1 in courses 1-6 and enzastaurin hydrochloride alone 3 times daily on days 1-21 in all subsequent courses.

In both groups, courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed every 3 months for 2 years and then every 6 months for up to 5 years.

PROJECTED ACCRUAL: A total of 99 patients will be accrued for this study.

Study Design

Study Type:

Interventional

Actual Enrollment :

0 participants

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Phase II Trial of Enzastaurin Plus Carboplatin and Gemcitabine (ECoG) in Bevacizumab-Ineligible Patients and Enzastaurin Plus Carboplatin, Gemcitabine and Bevacizumab (B-ECoG) in Bevacizumab-Eligible Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Study Start Date :

Jun 1, 2007

Outcome Measures

Primary Outcome Measures

Progression-free survival at 6 months (group 1) []
Progression-free survival at 4.5 months (group 2) []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 120 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

DISEASE CHARACTERISTICS:

Histologically or cytologically confirmed non-small cell lung cancer (NSCLC)
Stage IIIB (with confirmed malignant pleural effusion), stage IV, or recurrent disease
Mixed tumors categorized by the predominant cell type are allowed provided no small cell elements exist
Cytologic or histologic elements can be established on metastatic tumor aspirates or biopsy
Measurable disease as defined by RECIST criteria
No squamous cell carcinoma (group 1)
No history of brain metastases (group 1)
History of treated brain metastases allowed provided patient is not taking steroids and anti-seizure mediation (group 2)

PATIENT CHARACTERISTICS:

ECOG performance status 0-1
ANC ≥ 1,500/mm³
Platelet count ≥ 100,000/mm³
Bilirubin ≤ 1.5 mg/dL
Creatinine ≤ 1.5 times upper limit of normal (ULN)
Alkaline phosphatase ≤ 3 times ULN (≤ 5 times ULN with liver metastases)
AST and ALT ≤ 3 times ULN (≤ 5 times ULN with liver metastases)
INR < 1.5 or PTT normal (group 1)
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception during (groups 1 and 2) and for 6 months after completion of study treatment (group 1)
No preexisting peripheral neuropathy ≥ grade 2
Must be able to swallow tablets
No cardiovascular condition, including any of the following:
Myocardial infarction within the past 6 months
Cerebrovascular ischemia or stroke within the past 6 months
NYHA congestive heart failure > class II
Unstable angina pectoris
Serious cardiac arrhythmia requiring medication
Significant vascular disease
Symptomatic peripheral vascular disease
No concurrent medical condition, psychiatric illness, or limitations that would limit study compliance
No ongoing active infection or ongoing fever within the past 6 months
No history of uncontrolled hypertension, defined as blood pressure ≥ 150/90 mm Hg despite being on a stable regimen of anti-hypertensive therapy
No serious nonhealing wound, ulcer, or bone fracture within the past 4 weeks
No ongoing or active infection
No history of thrombotic or hemorrhagic disorders, bleeding diathesis, or coagulopathy (group 1)
No bleeding > grade 2 or any bleeding requiring intervention within the past 4 weeks (group 1)
No history of gross hemoptysis (defined as > ½ teaspoon of bright red blood) (group 1)
Urine protein:creatinine (UPC) ratio < 1.0 by spot urinalysis
For UPC ratio > 0.5, a 24-hour urine protein must be obtained and the urine protein level must be < 1,000 mg (group 1)
None of the following conditions (group 1):
Grade II or greater peripheral vascular disease
Abdominal fistula
Gastrointestinal perforation
Intra-abdominal abscess
No known hypersensitivity to any component of bevacizumab (group 1)
No history of hypertensive crisis or hypertensive encephalopathy (group 1)

PRIOR CONCURRENT THERAPY:

More than 4 weeks since prior major surgical procedure
More than 7 days since prior minor surgical procedure
No prior chemotherapy for advanced NSCLC
Postoperative adjuvant chemotherapy for previously resected NSCLC allowed if last dose was given > 1 year ago
More than 3 weeks since prior radiation therapy and recovered
More than 3 weeks since prior immunotherapy and/or hormonal therapy (not including hormone replacement therapy or contraceptives) and recovered
More than 14 days since prior enzyme inducing anti-epileptic drugs (EIAEDs)
More than 10 days since prior and no concurrent daily treatment with acetylsalicylic acid (> 325 mg/day) or NSAIDs known to inhibit platelet function for chronic conditions (group 1)
No concurrent major surgical procedure (group 1)
No concurrent carbamazepine, phenobarbital, or phenytoin
No concurrent therapeutic anticoagulation (group 1)
Prophylactic anticoagulation of venous access devices is allowed
No concurrent treatment with dipyridamole, ticlopidine, clopidogrel, or cilostazol (group 1)
No concurrent combination antiretroviral therapy for HIV-positive patients