Lung Cancer Risk and Early Detection in Firefighters
Study Details
Study Description
Brief Summary
This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 560 current and retired firefighters and 1540 matched controls.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Low-Dose CT Low Dose CT Scan of the Chest |
Diagnostic Test: Low Dose CT
All participants will have a low dose chest CT either within one year of enrollment or after enrollment
Other Names:
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Outcome Measures
Primary Outcome Measures
- Nodule detection rate [12 months]
Frequency of nodule detection
- High-risk nodule detection rate [12 months]
Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious
Secondary Outcome Measures
- Interstitial lung disease detection rate [12 months]
Frequency of interstitial lung disease detection
- Coronary artery calcification (CAC) ordinal scores [12 months]
Frequency of high coronary artery calcification (CAC) ordinal scores. Possible scores range from 0 to 12 and high scores are defined as those greater than or equal to 10
Eligibility Criteria
Criteria
Inclusion Criteria:
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40-80 years of age or with 10 years of firefighting experience
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Current or retired firefighters in the Boston/Greater Boston area
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No personal history of lung cancer
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Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study
Exclusion Criteria:
- Any active cancer (undergoing treatment or diagnosed within the past 5 years)
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Massachusetts General Hospital | Boston | Massachusetts | United States | 02114 |
Sponsors and Collaborators
- Massachusetts General Hospital
Investigators
- Principal Investigator: Erica T Warner, ScD, Massachusetts General Hospital
- Principal Investigator: Lecia V Sequist, MD, Massachusetts General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020P002693