Chemotherapy Followed by Peripheral Stem Cell or Bone Marrow Transplant Compared With Chemotherapy Alone in Treating Patients With Small Cell Lung Cancer

Sponsor

EBMT Solid Tumors Working Party (Other)

Overall Status

Unknown status

CT.gov ID

NCT00011921

Collaborator

(none)

430

Enrollment

Location

Study Details

Study Description

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy with peripheral stem cell transplant or bone marrow transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. It is not yet known whether high-dose chemotherapy plus peripheral stem cell or bone marrow transplant is more effective than chemotherapy alone in treating small cell lung cancer.

PURPOSE: This randomized phase III trial is studying how well chemotherapy followed by peripheral stem cell or bone marrow transplant works compared to chemotherapy alone in treating patients with limited-stage or extensive-stage small cell lung cancer.

Condition or Disease	Intervention/Treatment	Phase
Lung Cancer	Biological: filgrastim Drug: carboplatin Drug: epirubicin hydrochloride Drug: etoposide Drug: etoposide phosphate Drug: ifosfamide Drug: paclitaxel Procedure: autologous bone marrow transplantation Procedure: bone marrow ablation with stem cell support Procedure: peripheral blood stem cell transplantation Radiation: radiation therapy	Phase 3

Detailed Description

OBJECTIVES:

Compare the overall survival of patients with limited or extensive stage small cell lung cancer treated with sequential high-dose ifosfamide, carboplatin, and etoposide phosphate followed by autologous peripheral blood stem cell or bone marrow transplantation versus standard ifosfamide, carboplatin, and etoposide.
Compare the progression-free survival, time to treatment failure, and response rate in patients treated with these regimens.
Compare the toxic effects of these regimens in these patients.
Compare the quality of life of patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to disease stage (limited disease vs extensive disease with vs without liver metastases), performance status (0 vs 1), gender, LDH level (normal vs abnormal), and participating center. Patients are randomized to 1 of 2 treatment arms.

Arm I: Patients receive induction therapy comprising epirubicin IV over 4 hours on day 1 and paclitaxel IV over 3 hours on day 2. Treatment repeats every 21 days for a total of 2 courses. Patients also receive filgrastim (G-CSF) subcutaneously (SC) beginning on day 3 and continuing for 10 days or during course 2 until peripheral blood stem cell (PBSC) collection is completed. After completion of induction chemotherapy, autologous PBSCs or bone marrow is collected.

Within 28 days of the start of the second course of induction chemotherapy, patients receive high-dose ifosfamide IV over 17 hours, carboplatin IV over 3 hours, and etoposide phosphate IV over 3 hours on days 1-4. At 48 hours after completion of high-dose chemotherapy, patients undergo autologous PBSC or bone marrow transplantation and then receive G-CSF SC for 14 days. Treatment repeats every 28 days for 3 courses.

Arm II: Patients receive ifosfamide IV continuously over 24 hours, carboplatin IV over 1 hour on day 1, and etoposide IV over 45 minutes on days 1 and 2. Treatment repeats every 28 days for 6 courses.

After completion of high-dose or standard chemotherapy, patients with limited disease or extensive disease in complete remission receive thoracic radiotherapy daily on days 1-5 for 6 weeks. All patients in complete remission receive prophylactic cranial radiotherapy daily on days 1-5 for 3 weeks.

Quality of life is assessed at baseline, at the beginning of courses 1 and 3 (high-dose chemotherapy) or courses 3 and 5 (standard chemotherapy), and then at 7, 12, and 18 months.

Patients are followed monthly.

PROJECTED ACCRUAL: A total of 430 patients (215 per treatment arm) will be accrued for this study within 3 years.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

430 participants

Allocation:

Randomized

Primary Purpose:

Treatment

Official Title:

Phase III Randomized Trial of Sequential High-Dose Chemotherapy Versus Standard Chemotherapy for the Treatment of Small Cell Lung Cancer

Study Start Date :

Sep 1, 1997

Outcome Measures

Primary Outcome Measures

Overall survival (OS) at 3 years []

Secondary Outcome Measures

Progression-free survival (PFS) at 3 years []
Toxicity at 3 years []
Quality of life (QOL) at 3 years []

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

DISEASE CHARACTERISTICS:

Histologically confirmed small cell lung cancer
Limited disease or extensive disease with no more than 2 metastatic sites
No CNS metastasis

PATIENT CHARACTERISTICS:

Age:

65 and under

Performance status:

ECOG 0-1

Life expectancy:

Not specified

Hematopoietic:

WBC at least 3,500/mm^3 OR
Platelet count greater than 100,000/mm^3 OR
Hemoglobin at least 10.0 g/dL

Hepatic:

AST/ALT less than 2.5 times upper limit of normal (ULN)
Alkaline phosphatase less than 2.5 times ULN
Bilirubin less than 2.5 times ULN

Renal:

Creatinine clearance at least 60 mL/min
No renal function that would preclude chemotherapy

Cardiovascular:

No congestive heart failure
LVEF at least 50%
No cardiac function that would preclude chemotherapy

Other:

No other malignancy within the past 3 years except for basal cell skin cancer or carcinoma in situ of the cervix
No psychiatric disorder or any other disorder that would preclude study participation
Not pregnant or nursing
Fertile patients must use effective contraception