Lung Cancer Screening Eligibility Assessment

Study Details

Study Description

Brief Summary

The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help inform the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Condition or Disease	Intervention/Treatment	Phase
Lung Cancer	Behavioral: Framed Introductory Message A Behavioral: Framed Introductory Message B Behavioral: Framed Introductory Message C Behavioral: Framed Tobacco Use Message A Behavioral: Framed Tobacco Use Message B Behavioral: Financial Incentive	N/A

Detailed Description

Despite growing evidence that lung cancer screening (LCS) reduces lung cancer-specific mortality, LCS across the United States is remarkably low. This is due in part to challenges with identifying adults who meet eligibility criteria for lifetime smoking intensity (i.e., 20 pack-years or greater), which is often missing from the electronic medical record. We have developed a simplified eligibility tool that has shown accuracy in estimating pack-years. But given the potential for low response rates, there is a great need to identify effective strategies to increasing response rates equitably prior to using it in practice or in future studies. The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help to identify the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

6000 participants

Allocation:

Randomized

Intervention Model:

Factorial Assignment

Intervention Model Description:

We will use a randomized factorial design to test the effects of different types of messaging with or without incentives on response rates to an eligibility survey.We will use a randomized factorial design to test the effects of different types of messaging with or without incentives on response rates to an eligibility survey.

Masking:

Single (Outcomes Assessor)

Primary Purpose:

Health Services Research

Official Title:

Using a Simplified Tool to Predict Lung Cancer Screening (LCS) Eligibility: Experiment to Test Effects of Messaging on Response Rates

Actual Study Start Date :

Jul 31, 2023

Anticipated Primary Completion Date :

Dec 31, 2023

Anticipated Study Completion Date :

Feb 28, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive) Participants will receive two framed messages (AA) plus an incentive	Behavioral: Framed Introductory Message A Randomly assign patients to receive introductory message encouraging them to complete the survey (version A). Behavioral: Framed Tobacco Use Message A Randomly assign patients to receive norming message related to tobacco use (version A). Behavioral: Financial Incentive Randomly assigned patients to be entered into a drawing to receive a $100 gift card.
Experimental: Arm 2 (Introductory Message A + Tobacco Use Message A) Participants will receive two framed messages (AA)	Behavioral: Framed Introductory Message A Randomly assign patients to receive introductory message encouraging them to complete the survey (version A). Behavioral: Framed Tobacco Use Message A Randomly assign patients to receive norming message related to tobacco use (version A).
Experimental: Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive) Participants will receive two framed messages (AB) plus an incentive	Behavioral: Framed Introductory Message A Randomly assign patients to receive introductory message encouraging them to complete the survey (version A). Behavioral: Framed Tobacco Use Message B Randomly assign patients to receive norming message related to tobacco use (version B). Behavioral: Financial Incentive Randomly assigned patients to be entered into a drawing to receive a $100 gift card.
Experimental: Arm 4 (Introductory Message A + Tobacco Use Message B) Participants will receive two framed messages (AB)	Behavioral: Framed Introductory Message A Randomly assign patients to receive introductory message encouraging them to complete the survey (version A). Behavioral: Framed Tobacco Use Message B Randomly assign patients to receive norming message related to tobacco use (version B).
Experimental: Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive) Participants will receive two framed messages (BA) plus an incentive	Behavioral: Framed Introductory Message B Randomly assign patients to receive introductory message encouraging them to complete the survey (version B). Behavioral: Framed Tobacco Use Message A Randomly assign patients to receive norming message related to tobacco use (version A). Behavioral: Financial Incentive Randomly assigned patients to be entered into a drawing to receive a $100 gift card.
Experimental: Arm 6 (Introductory Message B + Tobacco Use Message A) Participants will receive two framed messages (BA)	Behavioral: Framed Introductory Message B Randomly assign patients to receive introductory message encouraging them to complete the survey (version B). Behavioral: Framed Tobacco Use Message A Randomly assign patients to receive norming message related to tobacco use (version A).
Experimental: Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive) Participants will receive two framed messages (BB) plus an incentive	Behavioral: Framed Introductory Message B Randomly assign patients to receive introductory message encouraging them to complete the survey (version B). Behavioral: Framed Tobacco Use Message B Randomly assign patients to receive norming message related to tobacco use (version B). Behavioral: Financial Incentive Randomly assigned patients to be entered into a drawing to receive a $100 gift card.
Experimental: Arm 8 (Introductory Message B + Tobacco Use Message B) Participants will receive two framed messages (BB)	Behavioral: Framed Introductory Message B Randomly assign patients to receive introductory message encouraging them to complete the survey (version B). Behavioral: Framed Tobacco Use Message B Randomly assign patients to receive norming message related to tobacco use (version B).
Experimental: Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive) Participants will receive two framed messages (CA) plus an incentive	Behavioral: Framed Introductory Message C Randomly assign patients to receive introductory message encouraging them to complete the survey (version C). Behavioral: Framed Tobacco Use Message A Randomly assign patients to receive norming message related to tobacco use (version A). Behavioral: Financial Incentive Randomly assigned patients to be entered into a drawing to receive a $100 gift card.
Experimental: Arm 10 (Introductory Message C + Tobacco Use Message A) Participants will receive two framed message (CA)	Behavioral: Framed Introductory Message C Randomly assign patients to receive introductory message encouraging them to complete the survey (version C). Behavioral: Framed Tobacco Use Message A Randomly assign patients to receive norming message related to tobacco use (version A).
Experimental: Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive) Participants will receive two framed messages (CB) plus an incentive	Behavioral: Framed Introductory Message C Randomly assign patients to receive introductory message encouraging them to complete the survey (version C). Behavioral: Framed Tobacco Use Message B Randomly assign patients to receive norming message related to tobacco use (version B). Behavioral: Financial Incentive Randomly assigned patients to be entered into a drawing to receive a $100 gift card.
Experimental: Arm 12 (Introductory Message C + Tobacco Use Message B) Participants will receive two framed messages (CB)	Behavioral: Framed Introductory Message C Randomly assign patients to receive introductory message encouraging them to complete the survey (version C). Behavioral: Framed Tobacco Use Message B Randomly assign patients to receive norming message related to tobacco use (version B).

Outcome Measures

Primary Outcome Measures

Full Survey Completion [7 days]
The proportion of participants that answers all three survey questions via text message among all those randomized.

Secondary Outcome Measures

Partial Survey Completion [7 days]
The proportion of participants that answer at least one of three survey questions via text message among all those randomized.

Eligibility Criteria

Criteria

Ages Eligible for Study:

50 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

meet age eligibility (50-80 years old) for LCS based on 2021 USPSTF guidelines; and
have completed at least one primary care visit at Penn Medicine in 2020-2025

Exclusion Criteria:

have a documented history of lung cancer;
have a documented history of completing LCS at Penn Medicine;
are listed as not wanting to be contacted or solicited for research; or
do not otherwise meet inclusion criteria.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Pennsylvania	Philadelphia	Pennsylvania	United States	19104

Sponsors and Collaborators

Abramson Cancer Center at Penn Medicine
National Institutes of Health (NIH)
National Cancer Institute (NCI)

Investigators

Principal Investigator: Katharine A Rendle, PhD,MSW,MPH, University of Pennsylvania

Study Documents (Full-Text)

Statistical Analysis Plan - Nov 25, 2023

More Information

Publications

None provided.

Responsible Party:

Katharine Rendle, Assistant Professor, Abramson Cancer Center at Penn Medicine

ClinicalTrials.gov Identifier:

NCT06133816

Other Study ID Numbers:

850376
P50CA271338-02

First Posted:

Nov 18, 2023

Last Update Posted:

Nov 29, 2023

Last Verified:

Nov 1, 2023

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Katharine Rendle, Assistant Professor, Abramson Cancer Center at Penn Medicine

Lung Cancer Screening

Additional relevant MeSH terms:

Lung Neoplasms

Study Results

No Results Posted as of Nov 29, 2023