Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer
Study Details
Study Description
Brief Summary
The purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Circulating tumor cells (CTCs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. Handling the tumor during a surgery may promote the release of CTCs into the bloodstream. Therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. This multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood CTCs.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Vein ligation first During this procedure, patients undergo lobectomy with the pulmonary vein ligated first. |
Procedure: Vein ligation first
During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.
|
| Active Comparator: Artery ligation first During this procedure, patients undergo lobectomy with the pulmonary artery ligated first. |
Procedure: Artery ligation first
During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.
|
Outcome Measures
Primary Outcome Measures
- The changes of the level of circulating tumor cells in the peripheral blood [Intraoperative]
The changes of the level of circulating tumor cells in the peripheral blood before cutting the skin and after closing the chest
Secondary Outcome Measures
- 3-year Progression-Free-Survival [From date of the recruitment, assessed up to 36 months]
From the date of recruitment until the date of progression of lung cancer assessed up to 36 months
- Blood loss [During the surgery]
Blood loss during the surgery
- Operative time [During the surgery]
Operative time during the surgery
- Length of stay [From date of admission until the date of discharging or date of death from any cause in hospital, whichever came first, assessed up to 30 days]
The length of patients staying in hospital from the date of checking in to the date of checking out
- Morbidity [Within 30 days after surgery]
Complications resulting from surgery, such as pneumonia, air leak and arrhythmia.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients with stage I-IV lung cancer eligible for surgery
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Patients undergoing the completely thoracoscopic lobectomy
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The nodule size was more than 2.5 cm
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Patients consenting for intraoperative blood sampling
Exclusion Criteria:
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Patients who underwent primary wedge resection and open lobectomy
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Patients who received neoadjuvant therapy before surgery
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | West China Hospital, Sichuan University | Chendu | Sichuan | China | 610041 |
Sponsors and Collaborators
- West China Hospital
Investigators
- Principal Investigator: Lunxu Liu, M.D.,Ph.D., West China Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Ackerman NB. Primary arterial ligation in resection of cancer of the colon. Rational and technic. Am J Surg. 1977 Jan;133(1):73-7.
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- Ge MJ, Shi D, Wu QC, Wang M, Li LB. Observation of circulating tumour cells in patients with non-small cell lung cancer by real-time fluorescent quantitative reverse transcriptase-polymerase chain reaction in peroperative period. J Cancer Res Clin Oncol. 2006 Apr;132(4):248-56. Epub 2005 Dec 1.
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- Li F, Jiang G, Chen Y, Wang J. Curative Effects of Different Sequences of Vessel Interruption During the Completely Thoracoscopic Lobectomy on Early Stage Non-Small Cell Lung Cancer. Ann Thorac Cardiovasc Surg. 2015;21(6):536-43. doi: 10.5761/atcs.oa.15-00044. Epub 2015 Aug 18.
- Refaely Y, Sadetzki S, Chetrit A, Simansky DA, Paley M, Modan B, Yellin A. The sequence of vessel interruption during lobectomy for non-small cell lung cancer: is it indeed important? J Thorac Cardiovasc Surg. 2003 Jun;125(6):1313-20.
- Song PP, Zhang W, Zhang B, Liu Q, DU J. Effects of different sequences of pulmonary artery and vein ligations during pulmonary lobectomy on blood micrometastasis of non-small cell lung cancer. Oncol Lett. 2013 Feb;5(2):463-468. Epub 2012 Nov 9.
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