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The Application of the New Magnetic Resonance UTE Technique in Thoracic Lesions

Sponsor
Fifth Affiliated Hospital, Sun Yat-Sen University (Other)
Overall Status
Recruiting
CT.gov ID
NCT05998707
Collaborator
(none)
150
Enrollment
1
Location
11.4
Anticipated Duration (Months)
13.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Quantitative characteristic values of lung lesions were obtained by UTE technique, so as to make qualitative diagnosis of benign and malignant lesions. And to explore the clinical feasibility of CT-like technology - high resolution ZTE technology in the diagnosis of pulmonary diseases.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Ultrashort echo time (UTE) sequence can obtain data from T2* for lung imaging before T2* decays in lung parenchyma with extremely short echo time, which makes up for the defect that conventional MRI cannot clearly display short T2 tissue imaging, and can provide more supplementary information for lung CT scan. There has been a lot of research progress in the evaluation of neonatal lung disease, chronic obstructive airway disease and pneumonia. The 3D UTE sequence developed on this basis has made great progress in improving the resolution, signal-to-noise ratio and shortening the scanning time of lung MR Images, and has successfully obtained submillimeter high-resolution images. The purpose of this study was to explore the value of MRI ultra-short echo technology in the qualitative diagnosis of benign and malignant lung lesions, and to explore the clinical application of CT-like technology - high resolution ZTE technology in the lung.

    Study Design

    Study Type:
    Observational [Patient Registry]
    Anticipated Enrollment :
    150 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    The Application of the New Magnetic Resonance Technique-UTE in Thoracic Lesions
    Actual Study Start Date :
    Jul 1, 2023
    Anticipated Primary Completion Date :
    Jun 13, 2024
    Anticipated Study Completion Date :
    Jun 13, 2024

    Arms and Interventions

    Arm Intervention/Treatment
    benign group

    benign lesions in the lung
    malignant group

    malignant tumor in the lung

    Outcome Measures

    Primary Outcome Measures

    1. proton density fat fraction (PDFF) [baseline (before surgery)]

      Determination of proton density fat fraction by magnetic resonance imaging

    2. T2 relaxation rate [baseline (before surgery)]

      R2*

    3. Magnetization Transfer Ratio (MTR) [baseline (before surgery)]

      Magnetization Transfer Ratio

    Secondary Outcome Measures

    1. Subjective rating [baseline (before surgery)]

      rating scale

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    1. Age ≥18 years old;

    2. There are lung lesions, and the solid component is ≥6mm;

    3. Chest CT plain scan or /+ enhanced examination within 4 weeks.

    Exclusion Criteria:

    1. There are metal implants in the corresponding parts of the chest;

    2. MRI contrast agent allergy;

    3. Claustrophobia;

    4. Pregnant women;

    5. High fever;

    6. Respiratory failure;

    7. Lung lesion biopsy within 4 weeks prior to examination.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Radiography department Zhuhai Guangdong China 519000

    Sponsors and Collaborators

    • Fifth Affiliated Hospital, Sun Yat-Sen University

    Investigators

    • Study Director: Shaolin Li, Fifth Affiliated Hospital, Sun Yat-Sen University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Fifth Affiliated Hospital, Sun Yat-Sen University
    ClinicalTrials.gov Identifier:
    NCT05998707
    Other Study ID Numbers:
    • ZDWY.FSK.024
    First Posted:
    Aug 21, 2023
    Last Update Posted:
    Aug 21, 2023
    Last Verified:
    Jul 1, 2023
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Fifth Affiliated Hospital, Sun Yat-Sen University
    Lung mass, UTE, ZTE, nodule, MRI
    Additional relevant MeSH terms:
    Lung Diseases

    Study Results

    No Results Posted as of Aug 21, 2023