Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer
Study Details
Study Description
Brief Summary
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid ?Master Protocol? (S1400). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes a ?non-match? sub-study which will include all screened patients not eligible for any of the biomarker-driven sub-studies. This sub-study will compare a non-match therapy to standard of care also with the goal of approval.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
PRIMARY OBJECTIVES:
Screening component:
- To establish a National Clinical Trials Network (NCTN) mechanism for genomically screening large but homogeneous cancer populations and subsequently assigning and accruing simultaneously to a multi-sub-study ?Master Protocol.? II. To evaluate the screen success rate defined as the percentage of screened patients that register for a therapeutic sub-study.
Sub-study-specific Objectives:
Design #1: Phase II/III Design:
- To evaluate if there is sufficient evidence to continue to the Phase III component of the sub-study by comparing investigator-assessed progression-free survival (IA-PFS) between investigational therapy versus standard therapy (SoC) in patients with advanced stage refractory squamous cell carcinoma (SCCA) of the lung. (Phase II) IV. To determine if there is both a statistically and clinically-meaningful difference in IA-PFS among advanced stage refractory SCCA of the lung randomized to receive investigational therapy versus SoC. (Phase
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- To compare overall survival (OS) in patients with advanced stage refractory SCCA of the lung randomized to investigational therapy versus SoC. (Phase III)
Design #2: Phase II followed by Phase III (Sequential Phase II to Phase III):
- To evaluate the objective response rate (confirmed and unconfirmed, complete and partial). (Phase II) VII. To determine if there is both a statistically and clinically-meaningful difference in IA-PFS among advanced stage refractory SCCA of the lung randomized to receive investigational therapy versus SoC. (Phase III) VIII. To compare overall survival (OS) in patients with advanced stage refractory SCCA of the lung randomized to investigational therapy versus SoC. (Phase III)
SECONDARY OBJECTIVES:
Sub-study-specific Objectives:
Design #1: Phase II/III Design:
- To compare response rates (confirmed and unconfirmed, complete and partial responses) among patients randomized to receive investigational therapy versus SoC. (Phase II) II. To evaluate the frequency and severity of toxicities associated with investigational therapy versus SoC. (Phase II) III. To evaluate the duration of response (DoR) among patients who achieve a complete response (CR) or a partial response (PR) by Response Evaluation Criteria in Solid Tumors (RECIST) (1.1). (Phase II) III. To compare the response rates (confirmed and unconfirmed, complete and partial) among patients randomized to receive investigational therapy versus SoC. (Phase III) IV. To evaluate the frequency and severity of toxicities associated with investigational therapy versus SoC. (Phase III)
Design #2: Phase II followed by Phase III (Sequential Phase II to Phase III):
- To evaluate PFS and OS with investigational therapy. (Phase II) VI. To evaluate the DoR among patients who achieve a CR or PR (confirmed and unconfirmed) by RECIST 1.1. (Phase II)
- To evaluate the frequency and severity of toxicities associated with investigational therapy. (Phase II) VIII. To compare the response rates (confirmed and unconfirmed, complete and partial) among patients randomized to receive investigational therapy versus SoC. (Phase
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- To evaluate the frequency and severity of toxicities associated with investigational therapy versus SoC. (Phase III)
TERTIARY OBJECTIVES:
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To evaluate the treatment arm randomization acceptance rate (TARAR) within each treatment arm of each sub-study defined as the percentage of patients randomized to a treatment arm that receive any protocol treatment. (Design #1: Phase II/III Design) II. To identify additional predictive tumor/blood biomarkers that may modify response or define resistance to the targeted therapy (TT)/targeted therapy combination (TTC) beyond the chosen biomarker for biomarker-driven sub-studies.
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To evaluate potentially predictive biomarkers for non-match therapy (NMT) in the non-match studies.
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To identify potential resistance biomarkers at disease progression. V. To establish a tissue/ blood repository from patients with refractory SCCA of the lung.
OUTLINE: Patients are assigned to a biomarker-driven targeted therapy phase II study. If the objectives response rate observed is judged sufficient, patients proceed to a randomized phase III trial and are randomized to biomarker-driven targeted therapy or standard of care.
S1400A: (CLOSED TO ACCRUAL 12/18/2015) Patients with tumors that do not match one of the currently active drug-biomarker combinations or did not meet the eligibility requirements for that bio-marker driven sub-study are assigned to Arm I. Upon evidence of progression following discontinuation of 12 months of treatment, patients may restart treatment for up to 12 months with the same treatment guidelines followed during the initial 12-month treatment period (Arm III).
ARM I: (CLOSED TO ACCRUAL 12/18/2015) Patients receive anti-B7H1 monoclonal antibody MEDI4736 intravenously (IV) over 60 minutes on day 1. Treatment repeats every 14 days for 12 months in the absence of disease progression or unacceptable toxicity.
ARM II (CLOSED TO ACCRUAL 4/2015): Patients receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #2 4/22/15)
ARM III: For patients assigned to Arm 1, MEDI4736: Upon evidence of progression following discontinuation of 12 months of treatment, patients may restart treatment with Arm 3, MEDI4736 for up to 12 months with the same treatment guidelines followed during the initial 12-month treatment period. Patients will only be able to restart treatment once; thus a maximum of two 12-month periods will be allowed. Patients receive anti-B7H1 monoclonal antibody MEDI4736 intravenously (IV) over 60 minutes on day 1. Treatment repeats every 14 days for 12 months in the absence of disease progression or unacceptable toxicity.
S1400B (CLOSED TO ACCRUAL 12/12/2016): Patients with tumors positive for phosphoinositide 3-kinase (PI3KCA) are assigned to Arm I. Patients currently on Arm 2, docetaxel will be given the option to re-register to Arm 3, GCD-0032 after disease progression on current treatment (Arm III).
ARM I: Patients receive taselisib orally (PO) daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #3 12/18/2015)
ARM III: Re-Registration Treatment with GDC-0032 (Taselisib) Upon progression patients in Arm 2 may be eligible for Re-Registration to receive GDC-0032. Patients receive taselisib orally (PO) daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
S1400C (CLOSED TO ACCRUAL 09/01/2016): Patients with tumors positive for cyclin dependent kinase 4 (CDK4), cyclin D1 (CCND1), cyclin D2 (CCND2), and cyclin D3 (CCND3) are assigned to Arm I. Patients currently on Arm 2, docetaxel will be given the option to re-register to Arm 3, palbociclib, after disease progression on current treatment (Arm III).
ARM I: Patients receive palbociclib PO on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #3 12/18/2015)
ARM III: Re-Registration Treatment with Palbociclib. Upon progression patients in Arm 2 may be eligible for Re-Registration to receive palbociclib. Patients receive palbociclib PO on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
S1400D (CLOSED TO ACCRUAL 10/31/2016): Patients with tumors positive for fibroblast growth factor receptor (FGFR) 1, FGFR2, and FGFR3 are assigned to Arm I. Patients currently on Arm 2, docetaxel will be given the option to re-register to Arm 3, AZD4547, after disease progression on current treatment (Arm III).
ARM I: Patients receive FGFR inhibitor AZD4547 PO BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #3 12/18/2015)
ARM III: Re-Registration Treatment with AZD4547. Upon progression patients in Arm 2 may be eligible for Re-Registration to receive AZD4547. Patients receive FGFR inhibitor AZD4547 PO BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
S1400E (CLOSED TO ACCRUAL 11/25/2014): Patients with tumors positive for met proto-oncogene (MET) are randomized to 1 of 2 treatment arms. (permanently closed to accrual on 11/25/14)
ARM I: Patients receive rilotumumab IV on day 1 and erlotinib hydrochloride PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive erlotinib hydrochloride PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
S1400F: Patients with disease progression during or after prior anti-PD-1 or anti-PD-L1 antibody monotherapy as their most recent line of treatment receive durvalumab (IV over 60 minutes) and tremelimumab (IV over 60 minutes) on day 1 for courses 1-4 and durvalumab IV alone on day 1 of course 5 and subsequent courses until disease progression or unacceptable toxicity. Courses repeat every 28 days.
S1400G: Patients with tumors positive for homologous recombination repair deficiency receive talazoparib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
S1400I: Patients with tumors that do not match one of the currently active drug-biomarker combinations or did not meet the eligibility requirements for that bio-marker driven sub-study are randomized to 1 of 2 treatment arms.
ARM I: Patients receive nivolumab IV over 30 minutes on day 1 and ipilimumab IV over 60 minutes on day 1 of every third course. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive nivolumab IV over 30 minutes on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, all patients are followed up periodically for up to 3 years from date of screening registration.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| S1400A Arm I (MEDI4736) (CLOSED TO ACCRUAL 12/2015) Patients with tumors that do not match one of the currently active drug-biomarker combinations randomized to Arm I receive anti-B7H1 monoclonal antibody MEDI4736 IV over 60 minutes on day 1. Treatment repeats every 14 days for 12 months in the absence of disease progression or unacceptable toxicity. |
Biological: Durvalumab
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400A Arm II (CLOSED TO ACCRUAL 4/2015) Patients with tumors that do not match one of the currently active drug-biomarker combinations randomized to Arm II receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #2 4/22/15) |
Drug: Docetaxel
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400A Arm III (MEDI4736) For patients assigned to Arm 1, MEDI4736: Upon evidence of progression following discontinuation of 12 months of treatment, patients may restart treatment with Arm 3, MEDI4736 for up to 12 months with the same treatment guidelines followed during the initial 12-month treatment period. Patients will only be able to restart treatment once; thus a maximum of two 12- month periods will be allowed. Patients registered to Arm III receive durvalumab IV over 60 minutes on day 1. Treatment repeats every 14 days for 12 months in the absence of disease progression or unacceptable toxicity. |
Biological: Durvalumab
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400B Arm I (taselisib) (CLOSED TO ACCRUAL 12/12/2016) Patients with tumors positive for PI3KCA randomized to Arm I receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Taselisib
Given PO
Other Names:
|
| S1400B Arm II (CLOSED TO ACCRUAL 12/18/2015) Patients with tumors positive for PI3KCA randomized to Arm II receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #3 12/18/2015) |
Drug: Docetaxel
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400B Arm III (taselisib) (CLOSED TO ACCRUAL 12/12/2016) Re-Registration Treatment with GDC-0032 (Taselisib). Upon progression patients in Arm 2 may be eligible for Re-Registration to receive GDC-0032. Patients will receive taselisib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Taselisib
Given PO
Other Names:
|
| S1400C Arm I (palbociclib) Patients with tumors positive for CDK4/6, CCND1, CCND2, and CCND3 randomized to Arm I receive palbociclib PO on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Palbociclib
Given PO
Other Names:
|
| S1400C Arm II (CLOSED TO ACCRUAL 12/18/2015) Patients with tumors positive for CDK4, CCND1, CCND2, and CCND3 randomized to Arm II receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #3 12/18/2015) |
Drug: Docetaxel
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400C Arm III (palbociclib) Re-Registration Treatment with palbociclib. Upon progression patients in Arm 2 may be eligible for Re-Registration to receive palbociclib. Patients will receive palbociclib PO on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Palbociclib
Given PO
Other Names:
|
| S1400D Arm I (AZD4547) (CLOSED TO ACCRUAL 04/12/2017) Patients with tumors positive for FGFR1, FGFR2, and FGFR3 randomized to Arm I receive FGFR inhibitor AZD4547 PO BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. |
Drug: FGFR Inhibitor AZD4547
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400D Arm II (CLOSED TO ACCRUAL 10/31/2016) Patients with tumors positive for FGFR1, FGFR2, and FGFR3 randomized to Arm II receive docetaxel IV on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (closed to accrual with Revision #3 12/18/2015) |
Drug: Docetaxel
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400D Arm III (AZD4547) (CLOSED TO ACCRUAL 10/31/2016) Re-Registration Treatment with AZD4547. Upon progression patients in Arm 2 may be eligible for Re-Registration to receive AZD4547. Patients will receive FGFR inhibitor AZD4547 PO BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. |
Drug: FGFR Inhibitor AZD4547
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400E Arm I (CLOSED TO ACCRUAL 11/2014) Patients with tumors positive for HGF/c-MET randomized to Arm I receive rilotumumab IV on day 1 and erlotinib hydrochloride PO daily. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (permanently closed to accrual on 11/25/14) |
Drug: Erlotinib Hydrochloride
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Biological: Rilotumumab
Given IV
Other Names:
|
| S1400E Arm II (CLOSED TO ACCRUAL 11/2014) Patients with tumors positive for HGF/c-MET randomized to Arm II receive erlotinib hydrochloride PO daily. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. (permanently closed to accrual on 11/25/14) |
Drug: Erlotinib Hydrochloride
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
|
| S1400F (durvalumab, tremelimumab) Patients with disease progression during or after prior anti-PD-1 or anti-PD-L1 antibody monotherapy as their most recent line of treatment receive durvalumab (IV over 60 minutes) and tremelimumab (IV over 60 minutes) on day 1 for courses 1-4 and durvalumab IV alone on day 1 of course 5 and subsequent courses until disease progression or unacceptable toxicity. Courses repeat every 28 days. |
Biological: Durvalumab
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Other: Pharmacological Study
Correlative studies
Biological: Tremelimumab
Given IV
Other Names:
|
| S1400G (talazoparib) Patients with tumors positive for homologous recombination repair deficiency receive talazoparib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Other: Pharmacological Study
Correlative studies
Drug: Talazoparib
Given PO
Other Names:
|
| S1400I Arm I (nivolumab, ipilimumab) Patients with tumors that do not match one of the currently active drug-biomarker combinations or did not meet the eligibility requirements for that bio-marker driven sub-study randomized to Arm I receive nivolumab IV over 30 minutes on day 1 and ipilimumab IV over 60 minutes on day 1 of every third cycle. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity. |
Biological: Ipilimumab
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Biological: Nivolumab
Given IV
Other Names:
|
| S1400I Arm II (nivolumab) Patients with tumors that do not match one of the currently active drug-biomarker combinations or did not meet the eligibility requirements for that bio-marker driven sub-study randomized to Arm II receive nivolumab IV over 30 minutes on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity. |
Other: Laboratory Biomarker Analysis
Correlative studies
Biological: Nivolumab
Given IV
Other Names:
Other: Pharmacological Study
Correlative studies
|
Outcome Measures
Primary Outcome Measures
- Investigator-assessed progression-free survival as defined by Response Evaluation Criteria in Solid Tumors 1.1 (Design #1, Phase II) [From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration, or death due to any cause, assessed up to 18 months since completion of accrual]
A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to investigator-assessed progression-free survival, comparing the two treatment arms.
- Investigator-assessed progression-free survival in patients with advanced stage refractory squamous cell carcinoma of the lung randomized to receive investigational therapy vs standard therapy (Design #2,Phase III,Option for Biomarker-driven sub-studies) [Up to 3 years]
Estimated using the method of Kaplan-Meier. The Brookmeyer-Crowley method will be used to calculate confidence intervals for median investigator-assessed progression-free survival. A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to progression free survival comparing the two treatment arms at the levels specified.
- Less than 33% improvement in median investigator-assessed progression-free survival as defined as Response Evaluation Criteria in Solid Tumors 1.1 (Design #1, Phase III) [From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration, or death due to any cause, assessed up to 18 months since completion of accrual]
A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to investigator-assessed progression-free survival, comparing the two treatment arms. A Cox PH model will be used to estimate the hazard ratios and associated confidence intervals.
- Objective response rate (confirmed and unconfirmed, complete and partial) (Design #2, Phase II, Option for Biomarker-driven Sub-studies) [Up to 3 years]
The investigational therapy arm will be judged to have provided sufficient evidence to proceed to the Phase III component if the objective response rate is at least 25%. Response rates and associated confidence intervals will be calculated.
- Objective response rate (confirmed and unconfirmed, complete and partial) in patients treated with investigational non-match therapy with advanced stage refractory squamous cell carcinoma of the lung (Design #2, Option for Non-Match Sub-Studies) [Up to 3 years]
Response rates and associated confidence intervals will be calculated.
- Overall survival (Design #1, Phase III) [From date of sub-study registration (or date of screening registration if patient never enrolls in a sub-study) to date of death due to any cause, assessed up to 3 years]
A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to overall survival, comparing the two treatment arms. A Cox PH model will be used to estimate the hazard ratios and associated confidence intervals.
- Overall survival in patients with advanced stage refractory squamous cell carcinoma of the lung randomized to receive investigational therapy versus standard therapy (Design #2, Phase III, Option for Biomarker-driven Sub-studies) [Up to 3 years]
The Brookmeyer-Crowley method will be used to calculate confidence intervals for median overall survival. A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to overall survival comparing the two treatment arms at the levels specified.
Secondary Outcome Measures
- Duration of response among patients who achieve a complete response or partial response by Response Evaluation Criteria in Solid Tumors 1.1 (Design #2, Phase II, Option for Biomarker-driven Sub-studies and Design #2, Option for Non-Match Sub-studies) [Up to 3 years]
Estimated using the method of Kaplan-Meier. The Brookmeyer-Crowley method will be used to calculate confidence intervals for median duration of response.
- Frequency and severity of toxicities associated with investigational therapy versus standard therapy (Design #2, Phase III, Option for Biomarker-driven Sub-studies) [Up to 3 years]
Analysis of toxicities will be performed using a chi-square or Fisher?s exact test, as appropriate.
- Investigator-assessed progression-free survival, censoring patients with symptomatic deterioration at the time of symptomatic deterioration (Design #1, Phase III) [From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration, or death due to any cause, assessed up to 3 years]
Descriptive data will be presented.
- Overall survival with investigational therapy (Design #2, Phase II, Option for Biomarker-driven Sub-studies and Design #2, Option for Non-Match Sub-studies) [Up to 3 years]
A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to overall survival comparing the two treatment arms at the levels specified. A Cox PH model will be used to estimate the hazard ratios and associated confidence intervals.
- Progression free survival with investigational therapy (Design #2, Phase II, Option for Biomarker-driven Sub-studies and Design #2, Option for Non-Match Sub-studies) [Up to 3 years]
A stratified (using randomization stratification factors) log-rank test will be used to test the primary hypotheses related to progression free survival comparing the two treatment arms at the levels specified. A Cox PH model will be used to estimate the hazard ratios and associated confidence intervals.
- Response rate (confirmed and unconfirmed) in patients with measurable disease as defined by Response Evaluation Criteria in Solid Tumors 1.1 (Design #1, Phase II and III) [Up to 3 years]
Analysis will be performed using a chi squared or Fisher?s exact test, as appropriate. Response proportions will be compared using a 1-sided Fisher?s exact test at the 0.001 level.
- Response rates (confirmed and unconfirmed, complete and partial) among patients randomized to receive investigational therapy versus standard therapy (Design #2, Phase III, Option for Biomarker-driven Sub-studies) [Up to 3 years]
Analysis of response rates will be performed using a chi-square or Fisher?s exact test, as appropriate.
- Severity of toxicities associated with investigational therapy versus standard therapy (Design #2, Phase II, Option for Biomarker-driven Sub-studies and Design #2, Option for Non-Match Sub-studies) [Up to 3 years]
Analysis of toxicities will be performed using a chi-square or Fisher?s exact test, as appropriate.
- Toxicity frequencies, monitored using National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 (Design #1, Phase II and III) [Up to 3 years]
Analysis will be performed using a chi squared or Fisher?s exact test, as appropriate.
Other Outcome Measures
- Screen success rate, monitored by the percentage of screened patients that register to a therapeutic sub-study [Up to 3 years]
Descriptive data will be presented.
- Treatment arm randomization acceptance rate, monitored by the percentage of patients that receive at least one dose of the treatment they are randomized to (Design #1) [Up to 3 years]
Descriptive data will be presented.
Eligibility Criteria
Criteria
Inclusion Criteria:
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SCREENING/PRE-SCREENING REGISTRATION:
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Patients must have pathologically proven squamous cell carcinoma (SCCA) cancer of the lung confirmed by tumor biopsy and/or fine-needle aspiration; disease must be stage IV SCCA, or recurrent; the primary diagnosis of SCCA should be established using the current World Health Organization (WHO)/International Association for the Study of Lung Cancer (IASLC)-classification of Thoracic Malignancies; the diagnosis is based on hematoxylin and eosin (H&E) stained slides with or without specific defined immunohistochemistry (IHC) characteristic (p40/p63 positive, transcription termination factor [TTF1] negative) if required for diagnosis; mixed histologies are not allowed
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Patients must either be eligible to be screened at progression on prior treatment or to be pre-screened prior to progression on current treatment; patients will either consent to the screening consent or the pre-screening consent, not both; these criteria are:
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Screening at progression on prior treatment: to be eligible for screening at progression, patients must have received at least one line of systemic therapy for any stage of disease (stages I-IV) and must have progressed during or following their most recent line of therapy; for patients whose prior systemic therapy was for stage I-III disease only (i.e. patient has not received any treatment for stage IV or recurrent disease), the prior systemic therapy must have been a platinum-based chemotherapy regimen and disease progression on the platinum-based chemotherapy must have occurred within one year from the last date that patient received that therapy; for patients whose prior therapy was for stage IV or recurrent disease, the patient must have received at least one line of a platinum-based chemotherapy regimen or checkpoint inhibitor therapy (e.g. nivolumab or pembrolizumab)
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Pre-screening prior to progression on current treatment: to be eligible for pre-screening, current treatment must be for stage IV or recurrent disease and patient must have received at least one dose of the current regimen; patients must have previously received or currently be receiving a platinum-based chemotherapy regimen or checkpoint inhibitor therapy (e.g. nivolumab or pembrolizumab); patients on first-line platinum-based treatment are eligible upon receiving cycle 1, day 1 infusion; Note: patients will not receive their sub-study assignment until they progress and the S1400 Notice of Progression is submitted
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Patients must have adequate tumor tissue available, defined as >= 20% tumor cells and
= 0.2 mm^3 tumor volume
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The local interpreting pathologist must review the specimen
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The pathologist must sign the S1400 Local Pathology Review Form confirming tissue adequacy prior to screening/pre-screening registration
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Patients must agree to have this tissue submitted to Foundation Medicine for common broad platform Clinical Laboratory Improvement Act (CLIA) biomarker profiling; if archival tumor material is exhausted, then a new fresh tumor biopsy that is formalin-fixed and paraffin-embedded (FFPE) must be obtained; a tumor block or FFPE slides 4-5 microns thick must be submitted; bone biopsies are not allowed; if FFPE slides are to be submitted, at least 12 unstained slides plus an H&E stained slide, or 13 unstained slides must be submitted; however it is strongly recommended that 20 FFPE slides be submitted; Note: previous next-generation deoxyribonucleic acid (DNA) sequencing (NGS) will be repeated if done outside this study for sub-study assignment; patients must agree to have any tissue that remains after NGS testing retained for the use of the translational medicine (TM) studies (if such TM studies are defined) within any sub-study the patient is enrolled in
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Patients must not have a known epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) fusion; EGFR/ALK testing is not required prior to registration and is included in the Foundation Medicine Incorporated (FMI) testing for screening/prescreening
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Patients must have Zubrod performance status 0-1 documented within 28 days prior to screening/pre-screening registration
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Patients must also be offered participation in banking for future use of specimens
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Patients must be willing to provide prior smoking history as required on the S1400 Onstudy Form
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As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
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Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
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SUB-STUDY REGISTRATION:
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Patients whose biomarker profiling results indicate the presence of an EGFR mutation or echinoderm microtubule-associated protein-like 4 (EML4)/ALK fusion are not eligible
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Patients must have progressed (in the opinion of the treating investigator) following the most recent line of therapy
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Patients must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 21 days prior to sub-study registration; patients must have recovered (=< grade 1) from any side effects of prior therapy; patients must not have received any radiation therapy within 14 days prior to sub-study registration
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Patients must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI); the CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality; measurable disease must be assessed within 28 days prior to sub-study registration; pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease; non-measurable disease must be assessed within 42 days prior to sub-study registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form; patients whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to registration
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Patients must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to sub-study registration; patient must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment and prior to registration, AND (2) patient has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to sub-study registration
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Patient must have fully recovered from the effects of prior surgery at least 14 days prior to sub-study registration
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Patients must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment; concurrent use of hormones for non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement therapy) is acceptable
-
Absolute neutrophil count (ANC) >= 1,500/mcl obtained within 28 days prior to sub-study registration
-
Platelet count >= 100,000 mcl obtained within 28 days prior to sub-study registration
-
Hemoglobin >= 9 g/dL obtained within 28 days prior to sub-study registration
-
Serum bilirubin =< institutional upper limit of normal (IULN) within 28 days prior to sub-study registration; for patients with liver metastases, bilirubin must be =< 5 x IULN
-
Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN within 28 days prior to sub-study registration (if both ALT and AST are done, both must be =< 2 IULN); for patients with liver metastases, either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both must be =< 5 x IULN)
-
Serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min using the following Cockcroft-Gault Formula within 28 days prior to sub-study registration
-
Patients must have Zubrod performance status 0-1 documented within 28 days prior to sub-study registration
-
Patients must not have any grade III/IV cardiac disease as defined by the New York Heart Association Criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia
-
Patients must not have documented evidence of acute hepatitis or have an active or uncontrolled infection
-
Patients with a known history of human immunodeficiency virus (HIV) seropositivity:
-
Must have undetectable viral load using standard HIV assays in clinical practice
-
Must have cluster of differentiation (CD)4 count >= 400/mcL
-
Must not require prophylaxis for any opportunistic infections (i.e., fungal, Mycobacterium avium complex [mAC], or pneumocystis jiroveci pneumonia [PCP] prophylaxis)
-
Must not be newly diagnosed within 12 months prior to sub-study registration
-
Prestudy history and physical exam must be obtained within 28 days prior to sub-study registration
-
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years
-
Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
-
As part of the OPEN registration process the treating institution?s identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the system
-
Patients with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator)
-
Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 3 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 4 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Regional Hospital | Anchorage | Alaska | United States | 99508 |
| 6 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 7 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 8 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 9 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 10 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 11 | The University of Arizona Medical Center-University Campus | Tucson | Arizona | United States | 85724 |
| 12 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 13 | Fowler Family Center for Cancer Care | Jonesboro | Arkansas | United States | 72401 |
| 14 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 15 | Kaiser Permanente-Anaheim | Anaheim | California | United States | 92806 |
| 16 | Kaiser Permanente-Deer Valley Medical Center | Antioch | California | United States | 94531 |
| 17 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 18 | Sutter Auburn Faith Hospital | Auburn | California | United States | 95602 |
| 19 | AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California | United States | 93301 |
| 20 | Kaiser Permanente-Baldwin Park | Baldwin Park | California | United States | 91706 |
| 21 | Kaiser Permanente-Bellflower | Bellflower | California | United States | 90706 |
| 22 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 23 | Mills-Peninsula Medical Center | Burlingame | California | United States | 94010 |
| 24 | City of Hope Corona | Corona | California | United States | 92879 |
| 25 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 26 | Kaiser Permanente-Fontana | Fontana | California | United States | 92335 |
| 27 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 28 | Palo Alto Medical Foundation-Fremont | Fremont | California | United States | 94538 |
| 29 | Washington Hospital | Fremont | California | United States | 94538 |
| 30 | Kaiser Permanente-Fresno | Fresno | California | United States | 93720 |
| 31 | Saint Jude Medical Center | Fullerton | California | United States | 92835 |
| 32 | Kaiser Permanente - Harbor City | Harbor City | California | United States | 90710 |
| 33 | Kaiser Permanente-Irvine | Irvine | California | United States | 92618 |
| 34 | UC San Diego Moores Cancer Center | La Jolla | California | United States | 92093 |
| 35 | City of Hope Antelope Valley | Lancaster | California | United States | 93534 |
| 36 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 37 | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | United States | 90027 |
| 38 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
| 39 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 40 | Kaiser Permanente-Cadillac | Los Angeles | California | United States | 90034 |
| 41 | Fremont - Rideout Cancer Center | Marysville | California | United States | 95901 |
| 42 | City of Hope Mission Hills | Mission Hills | California | United States | 91345 |
| 43 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 44 | Kaiser Permanente-Modesto | Modesto | California | United States | 95356 |
| 45 | Community Hospital of Monterey Peninsula | Monterey | California | United States | 93940 |
| 46 | Pacific Cancer Care-Monterey | Monterey | California | United States | 93940 |
| 47 | Palo Alto Medical Foundation-Camino Division | Mountain View | California | United States | 94040 |
| 48 | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California | United States | 94040 |
| 49 | Sutter Cancer Research Consortium | Novato | California | United States | 94945 |
| 50 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 51 | Saint Joseph Hospital - Orange | Orange | California | United States | 92868 |
| 52 | Palo Alto Medical Foundation Health Care | Palo Alto | California | United States | 94301 |
| 53 | Stanford Cancer Institute Palo Alto | Palo Alto | California | United States | 94304 |
| 54 | Kaiser Permanente - Panorama City | Panorama City | California | United States | 91402 |
| 55 | Feather River Cancer Center | Paradise | California | United States | 95969 |
| 56 | City of Hope Rancho Cucamonga | Rancho Cucamonga | California | United States | 91730 |
| 57 | Eisenhower Medical Center | Rancho Mirage | California | United States | 92270 |
| 58 | Kaiser Permanente-Redwood City | Redwood City | California | United States | 94063 |
| 59 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 60 | Kaiser Permanente-Riverside | Riverside | California | United States | 92505 |
| 61 | Kaiser Permanente-Roseville | Roseville | California | United States | 95661 |
| 62 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 63 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 64 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 65 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 66 | Kaiser Permanente - Sacramento | Sacramento | California | United States | 95825 |
| 67 | Saint Helena Hospital | Saint Helena | California | United States | 94574 |
| 68 | Kaiser Permanente-San Diego Mission | San Diego | California | United States | 92108 |
| 69 | Kaiser Permanente-San Diego Zion | San Diego | California | United States | 92120 |
| 70 | California Pacific Medical Center-Pacific Campus | San Francisco | California | United States | 94115 |
| 71 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 72 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 73 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 74 | Kaiser Permanente-San Marcos | San Marcos | California | United States | 92078 |
| 75 | Kaiser Permanente-San Rafael | San Rafael | California | United States | 94903 |
| 76 | Kaiser San Rafael-Gallinas | San Rafael | California | United States | 94903 |
| 77 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051 |
| 78 | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California | United States | 95065 |
| 79 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 80 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 81 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 82 | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | United States | 94086 |
| 83 | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California | United States | 96161 |
| 84 | Northbay Cancer Center | Vacaville | California | United States | 95687 |
| 85 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 86 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 87 | Sutter Solano Medical Center/Cancer Center | Vallejo | California | United States | 94589 |
| 88 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 89 | Presbyterian Intercommunity Hospital | Whittier | California | United States | 90602 |
| 90 | Kaiser Permanente-Woodland Hills | Woodland Hills | California | United States | 91367 |
| 91 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 92 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 93 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 94 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 95 | UCHealth Memorial Hospital Central | Colorado Springs | Colorado | United States | 80909 |
| 96 | Kaiser Permanente-Franklin | Denver | Colorado | United States | 80205 |
| 97 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 98 | Colorado Cancer Research Program NCORP | Denver | Colorado | United States | 80222 |
| 99 | Comprehensive Cancer Care and Research Institute of Colorado LLC | Englewood | Colorado | United States | 80113 |
| 100 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 101 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 102 | Kaiser Permanente-Rock Creek | Lafayette | Colorado | United States | 80026 |
| 103 | Kaiser Permanente-Lone Tree | Lone Tree | Colorado | United States | 80124 |
| 104 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 105 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 106 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 107 | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | United States | 80501 |
| 108 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 109 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 110 | Rocky Mountain Cancer Centers-Parker | Parker | Colorado | United States | 80138 |
| 111 | Danbury Hospital | Danbury | Connecticut | United States | 06810 |
| 112 | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | United States | 06418 |
| 113 | Yale-New Haven Shoreline Medical Center | Guilford | Connecticut | United States | 06437 |
| 114 | Hartford Hospital | Hartford | Connecticut | United States | 06102 |
| 115 | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | United States | 06105 |
| 116 | Midstate Medical Center | Meriden | Connecticut | United States | 06451 |
| 117 | The Hospital of Central Connecticut | New Britain | Connecticut | United States | 06050 |
| 118 | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | United States | 06510 |
| 119 | Yale University | New Haven | Connecticut | United States | 06520 |
| 120 | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | United States | 06473 |
| 121 | Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | United States | 06360 |
| 122 | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut | United States | 06477 |
| 123 | Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | United States | 06790 |
| 124 | Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | United States | 06708 |
| 125 | Lawrence and Memorial Cancer Center | Waterford | Connecticut | United States | 06385 |
| 126 | Veterans Affairs Connecticut Healthcare System-West Haven Campus | West Haven | Connecticut | United States | 06516 |
| 127 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 128 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 129 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 130 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 131 | Regional Hematology and Oncology PA | Newark | Delaware | United States | 19713 |
| 132 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 133 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 134 | Nanticoke Memorial Hospital | Seaford | Delaware | United States | 19973 |
| 135 | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | United States | 19801 |
| 136 | Kaiser Permanente-Capitol Hill Medical Center | Washington | District of Columbia | United States | 20002 |
| 137 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 138 | Sibley Memorial Hospital | Washington | District of Columbia | United States | 20016 |
| 139 | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida | United States | 33180 |
| 140 | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | United States | 33442 |
| 141 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 142 | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | United States | 33021 |
| 143 | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida | United States | 33021 |
| 144 | Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 145 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 146 | Memorial Hospital West | Pembroke Pines | Florida | United States | 33028 |
| 147 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 148 | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | United States | 33324 |
| 149 | Moffitt Cancer Center | Tampa | Florida | United States | 33612 |
| 150 | Phoebe Putney Memorial Hospital | Albany | Georgia | United States | 31701 |
| 151 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 152 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 153 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 154 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 155 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 156 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
| 157 | John B Amos Cancer Center | Columbus | Georgia | United States | 31904 |
| 158 | Northside Hospital-Forsyth | Cumming | Georgia | United States | 30041 |
| 159 | Dekalb Medical Center | Decatur | Georgia | United States | 30033 |
| 160 | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | United States | 30501 |
| 161 | Gwinnett Medical Center | Lawrenceville | Georgia | United States | 30046 |
| 162 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
| 163 | Harbin Clinic Medical Oncology and Clinical Research | Rome | Georgia | United States | 30165 |
| 164 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 165 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 166 | South Georgia Medical Center/Pearlman Cancer Center | Valdosta | Georgia | United States | 31602 |
| 167 | Hawaii Oncology Inc-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 168 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 169 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 170 | Hawaii Cancer Care Inc-POB II | Honolulu | Hawaii | United States | 96813 |
| 171 | Hawaii Oncology Inc-POB I | Honolulu | Hawaii | United States | 96813 |
| 172 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 173 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 174 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 175 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 176 | Hawaii Oncology Inc-Kuakini | Honolulu | Hawaii | United States | 96817 |
| 177 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 178 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 179 | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | United States | 96819 |
| 180 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 181 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 182 | Saint Luke's Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
| 183 | Kootenai Medical Center | Coeur d'Alene | Idaho | United States | 83814 |
| 184 | Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 185 | Saint Luke's Mountain States Tumor Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 186 | Saint Luke's Mountain States Tumor Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 187 | Kootenai Cancer Center | Post Falls | Idaho | United States | 83854 |
| 188 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 189 | Saint Luke's Mountain States Tumor Institute-Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 190 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 191 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 192 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 193 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 194 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 195 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 196 | Mount Sinai Hospital Medical Center | Chicago | Illinois | United States | 60608 |
| 197 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 198 | John H Stroger Jr Hospital of Cook County | Chicago | Illinois | United States | 60612 |
| 199 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 200 | Swedish Covenant Hospital | Chicago | Illinois | United States | 60625 |
| 201 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 202 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 203 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 204 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 205 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 206 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 207 | Advocate Sherman Hospital | Elgin | Illinois | United States | 60123 |
| 208 | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois | United States | 60007 |
| 209 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 210 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 211 | Saint Francis Hospital | Evanston | Illinois | United States | 60202 |
| 212 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 213 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 214 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 215 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 216 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 217 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 218 | Hines Veterans Administration Hospital | Hines | Illinois | United States | 60141 |
| 219 | AMITA Health Cancer Institute and Outpatient Center | Hinsdale | Illinois | United States | 60521 |
| 220 | Joliet Oncology-Hematology Associates Limited | Joliet | Illinois | United States | 60435 |
| 221 | Presence Saint Mary's Hospital | Kankakee | Illinois | United States | 60901 |
| 222 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 223 | NorthShore Hematology Oncology-Libertyville | Libertyville | Illinois | United States | 60048 |
| 224 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 225 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 226 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 227 | Trinity Medical Center | Moline | Illinois | United States | 61265 |
| 228 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 229 | AMG Oncology - Naperville | Naperville | Illinois | United States | 60540 |
| 230 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 231 | Illinois Cancer Specialists-Niles | Niles | Illinois | United States | 60714 |
| 232 | University of Chicago Medicine-Orland Park | Orland Park | Illinois | United States | 60462 |
| 233 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 234 | Radiation Oncology of Northern Illinois | Ottawa | Illinois | United States | 61350 |
| 235 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 236 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 237 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 238 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 239 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 240 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 241 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 242 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 243 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 244 | Hematology Oncology Associates of Illinois - Skokie | Skokie | Illinois | United States | 60076 |
| 245 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
| 246 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 247 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 248 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 249 | Cancer Care Specialists of Illinois-Swansea | Swansea | Illinois | United States | 62226 |
| 250 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 251 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 252 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 253 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 254 | IU Health North Hospital | Carmel | Indiana | United States | 46032 |
| 255 | Michiana Hematology Oncology PC-Elkhart | Elkhart | Indiana | United States | 46514 |
| 256 | Parkview Hospital Randallia | Fort Wayne | Indiana | United States | 46805 |
| 257 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
| 258 | IU Health Methodist Hospital | Indianapolis | Indiana | United States | 46202 |
| 259 | Richard L. Roudebush Veterans Affairs Medical Center | Indianapolis | Indiana | United States | 46202 |
| 260 | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana | United States | 46202 |
| 261 | IU Health Central Indiana Cancer Centers-East | Indianapolis | Indiana | United States | 46219 |
| 262 | Franciscan Health Indianapolis | Indianapolis | Indiana | United States | 46237 |
| 263 | Springmill Medical Center | Indianapolis | Indiana | United States | 46290 |
| 264 | IU Health Arnett Cancer Care | Lafayette | Indiana | United States | 47904 |
| 265 | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana | United States | 46545 |
| 266 | Michiana Hematology Oncology PC-Mishawaka | Mishawaka | Indiana | United States | 46545 |
| 267 | Franciscan Health Mooresville | Mooresville | Indiana | United States | 46158 |
| 268 | The Community Hospital | Munster | Indiana | United States | 46321 |
| 269 | Michiana Hematology Oncology PC-Plymouth | Plymouth | Indiana | United States | 46563 |
| 270 | Reid Health | Richmond | Indiana | United States | 47374 |
| 271 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 272 | Michiana Hematology Oncology PC-South Bend | South Bend | Indiana | United States | 46601 |
| 273 | Northern Indiana Cancer Research Consortium | South Bend | Indiana | United States | 46628 |
| 274 | Union Hospital | Terre Haute | Indiana | United States | 47804 |
| 275 | Michiana Hematology Oncology PC-Westville | Westville | Indiana | United States | 46391 |
| 276 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 277 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 278 | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 279 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 280 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 281 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 282 | Alegent Health Mercy Hospital | Council Bluffs | Iowa | United States | 51503 |
| 283 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 284 | Genesis Medical Center - East Campus | Davenport | Iowa | United States | 52803 |
| 285 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 286 | Iowa-Wide Oncology Research Coalition NCORP | Des Moines | Iowa | United States | 50309 |
| 287 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 288 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 289 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 290 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 291 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 292 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 293 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 294 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 295 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 296 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 297 | Mercy Medical Center - North Iowa | Mason City | Iowa | United States | 50401 |
| 298 | Siouxland Regional Cancer Center | Sioux City | Iowa | United States | 51101 |
| 299 | Covenant Medical Center | Waterloo | Iowa | United States | 50702 |
| 300 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 301 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 302 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 303 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 304 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 305 | Newman Regional Health | Emporia | Kansas | United States | 66801 |
| 306 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 307 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 308 | Saint Catherine Hospital | Garden City | Kansas | United States | 67846 |
| 309 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 310 | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas | United States | 67530 |
| 311 | Hays Medical Center | Hays | Kansas | United States | 67601 |
| 312 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 313 | University of Kansas Cancer Center-West | Kansas City | Kansas | United States | 66112 |
| 314 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 315 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 316 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 317 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 318 | Minimally Invasive Surgery Hospital | Lenexa | Kansas | United States | 66219 |
| 319 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 320 | Cancer Center of Kansas-Manhattan | Manhattan | Kansas | United States | 66502 |
| 321 | Cancer Center of Kansas - McPherson | McPherson | Kansas | United States | 67460 |
| 322 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 323 | Olathe Medical Center | Olathe | Kansas | United States | 66061 |
| 324 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 325 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 326 | Saint Luke's South Hospital | Overland Park | Kansas | United States | 66213 |
| 327 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 328 | Via Christi Hospital-Pittsburg | Pittsburg | Kansas | United States | 66762 |
| 329 | Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | United States | 66208 |
| 330 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 331 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 332 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 333 | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | United States | 66606 |
| 334 | Saint Francis Hospital and Medical Center - Topeka | Topeka | Kansas | United States | 66606 |
| 335 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 336 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 337 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 338 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 339 | Via Christi Regional Medical Center | Wichita | Kansas | United States | 67214 |
| 340 | Wichita NCI Community Oncology Research Program | Wichita | Kansas | United States | 67214 |
| 341 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 342 | King's Daughter's Medical Center | Ashland | Kentucky | United States | 41101 |
| 343 | Flaget Memorial Hospital | Bardstown | Kentucky | United States | 40004 |
| 344 | Baptist Health Corbin | Corbin | Kentucky | United States | 40701 |
| 345 | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky | United States | 41017 |
| 346 | Hardin Memorial Hospital | Elizabethtown | Kentucky | United States | 42701 |
| 347 | Baptist Health Lexington | Lexington | Kentucky | United States | 40503 |
| 348 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 349 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 350 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 351 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 352 | Norton Hospital Pavilion and Medical Campus | Louisville | Kentucky | United States | 40202 |
| 353 | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States | 40202 |
| 354 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 355 | Norton Suburban Hospital and Medical Campus | Louisville | Kentucky | United States | 40207 |
| 356 | Saints Mary and Elizabeth Hospital | Louisville | Kentucky | United States | 40215 |
| 357 | Jewish Hospital Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 358 | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 359 | Baptist Health Paducah | Paducah | Kentucky | United States | 42003 |
| 360 | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 361 | Hematology/Oncology Clinic LLP | Baton Rouge | Louisiana | United States | 70809 |
| 362 | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | United States | 70809 |
| 363 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 364 | Ochsner Health Center-Summa | Baton Rouge | Louisiana | United States | 70809 |
| 365 | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | United States | 70809 |
| 366 | Medical Center of Baton Rouge | Baton Rouge | Louisiana | United States | 70816 |
| 367 | Mary Bird Cancer Center/Saint Tammany Parish | Covington | Louisiana | United States | 70433 |
| 368 | Northshore Oncology Associates-Covington | Covington | Louisiana | United States | 70433 |
| 369 | Mary Bird Perkins Cancer Center/Terrebonne General Medical Center | Houma | Louisiana | United States | 70360 |
| 370 | Oncology Center of The South Incorporated | Houma | Louisiana | United States | 70360 |
| 371 | Ochsner Medical Center Kenner | Kenner | Louisiana | United States | 70065 |
| 372 | East Jefferson General Hospital | Metairie | Louisiana | United States | 70006 |
| 373 | Robert Veith MD LLC | Metairie | Louisiana | United States | 70006 |
| 374 | University Health-Conway | Monroe | Louisiana | United States | 71202 |
| 375 | Louisiana State University Health Science Center | New Orleans | Louisiana | United States | 70112 |
| 376 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 377 | University Medical Center New Orleans | New Orleans | Louisiana | United States | 70112 |
| 378 | LSU Healthcare Network/Saint Charles | New Orleans | Louisiana | United States | 70115 |
| 379 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 380 | Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana | United States | 71103 |
| 381 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 382 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 383 | Waldo County General Hospital | Belfast | Maine | United States | 04915 |
| 384 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
| 385 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 386 | Mercy Hospital | Portland | Maine | United States | 04101 |
| 387 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 388 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
| 389 | York Hospital | York | Maine | United States | 03909 |
| 390 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 391 | Greater Baltimore Medical Center | Baltimore | Maryland | United States | 21204 |
| 392 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 393 | MedStar Union Memorial Hospital | Baltimore | Maryland | United States | 21218 |
| 394 | Saint Agnes Hospital | Baltimore | Maryland | United States | 21229 |
| 395 | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | United States | 21237 |
| 396 | Kaiser Permanente-Woodlawn Medical Center | Baltimore | Maryland | United States | 21244 |
| 397 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
| 398 | Western Maryland Regional Medical Center | Cumberland | Maryland | United States | 21502 |
| 399 | Frederick Memorial Hospital | Frederick | Maryland | United States | 21701 |
| 400 | Kaiser Permanente-Gaithersburg Medical Center | Gaithersburg | Maryland | United States | 20879 |
| 401 | Kaiser Permanente - Kensington Medical Center | Kensington | Maryland | United States | 20895 |
| 402 | Kaiser Permanente - Largo Medical Center | Largo | Maryland | United States | 20774 |
| 403 | Northwest Hospital Center | Randallstown | Maryland | United States | 21133 |
| 404 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 405 | William E Kahlert Regional Cancer Center/Sinai Hospital | Westminster | Maryland | United States | 21157 |
| 406 | Beverly Hospital | Beverly | Massachusetts | United States | 01915 |
| 407 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 408 | Boston Medical Center | Boston | Massachusetts | United States | 02118 |
| 409 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 410 | Lahey Hospital and Medical Center | Burlington | Massachusetts | United States | 01805 |
| 411 | Simonds-Sinon Regional Cancer Center | Fitchburg | Massachusetts | United States | 01420 |
| 412 | Addison Gilbert Hospital | Gloucester | Massachusetts | United States | 01930 |
| 413 | Lowell General Hospital | Lowell | Massachusetts | United States | 01854 |
| 414 | Dana-Farber/Brigham and Women's Cancer Center at Milford Regional | Milford | Massachusetts | United States | 01757 |
| 415 | Dana-Farber/Brigham and Women's Cancer Center at South Shore | South Weymouth | Massachusetts | United States | 02190 |
| 416 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 417 | University of Massachusetts Medical School | Worcester | Massachusetts | United States | 01655 |
| 418 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 419 | Veteran's Administration Medical Center - Ann Arbor | Ann Arbor | Michigan | United States | 48105 |
| 420 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 421 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 422 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 423 | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan | United States | 48114 |
| 424 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 425 | Henry Ford Cancer Institute?Downriver | Brownstown | Michigan | United States | 48183 |
| 426 | IHA Hematology Oncology Consultants-Canton | Canton | Michigan | United States | 48188 |
| 427 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 428 | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan | United States | 48118 |
| 429 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 430 | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | United States | 48346 |
| 431 | Newland Medical Associates-Clarkston | Clarkston | Michigan | United States | 48346 |
| 432 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 433 | Beaumont Hospital-Dearborn | Dearborn | Michigan | United States | 48124 |
| 434 | Henry Ford Medical Center-Fairlane | Dearborn | Michigan | United States | 48126 |
| 435 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 436 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 437 | Saint John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
| 438 | Green Bay Oncology - Escanaba | Escanaba | Michigan | United States | 49829 |
| 439 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 440 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 441 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 442 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 443 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 444 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 445 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 446 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 447 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 448 | Saint Mary Mercy Hospital | Livonia | Michigan | United States | 48154 |
| 449 | Mid-Michigan Medical Center - Midland | Midland | Michigan | United States | 48670 |
| 450 | Monroe Cancer Center | Monroe | Michigan | United States | 48162 |
| 451 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 452 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 453 | Assarian Cancer Center | Novi | Michigan | United States | 48374-1236 |
| 454 | Henry Ford Medical Center-Columbus | Novi | Michigan | United States | 48377 |
| 455 | Hope Cancer Center | Pontiac | Michigan | United States | 48341 |
| 456 | Newland Medical Associates-Pontiac | Pontiac | Michigan | United States | 48341 |
| 457 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 458 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 459 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 460 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 461 | Saint Mary's of Michigan | Saginaw | Michigan | United States | 48601 |
| 462 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 463 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 464 | Providence Hospital-Southfield Cancer Center | Southfield | Michigan | United States | 48075 |
| 465 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 466 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48098 |
| 467 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 468 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 469 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 470 | IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | United States | 48197 |
| 471 | Sanford Clinic North-Bemidgi | Bemidji | Minnesota | United States | 56601 |
| 472 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 473 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 474 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 475 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 476 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 477 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 478 | Fairview-Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 479 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 480 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 481 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 482 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 483 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 484 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 485 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 486 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 487 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 488 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 489 | Mayo Clinic | Rochester | Minnesota | United States | 55905 |
| 490 | Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | United States | 55416 |
| 491 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 492 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 493 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 494 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 495 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 496 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 497 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 498 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 499 | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | United States | 39705 |
| 500 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 501 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
| 502 | Singing River Hospital | Pascagoula | Mississippi | United States | 39581 |
| 503 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
| 504 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 505 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 506 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 507 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 508 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 509 | University of Missouri - Ellis Fischel | Columbia | Missouri | United States | 65212 |
| 510 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 511 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 512 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 513 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 514 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 515 | Truman Medical Center | Kansas City | Missouri | United States | 64108 |
| 516 | Saint Luke's Hospital of Kansas City | Kansas City | Missouri | United States | 64111 |
| 517 | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | United States | 64118 |
| 518 | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | United States | 64128 |
| 519 | The University of Kansas Cancer Center-South | Kansas City | Missouri | United States | 64131 |
| 520 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 521 | The University of Kansas Cancer Center-North | Kansas City | Missouri | United States | 64154 |
| 522 | The University of Kansas Cancer Center-Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 523 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 524 | Liberty Radiation Oncology Center | Liberty | Missouri | United States | 64068 |
| 525 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 526 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 527 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64507 |
| 528 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 529 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 530 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 531 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 532 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
| 533 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 534 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 535 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 536 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 537 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 538 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 539 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 540 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 541 | Montana Cancer Consortium NCORP | Billings | Montana | United States | 59102 |
| 542 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 543 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 544 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 545 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 546 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 547 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 548 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 549 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 550 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 551 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 552 | Nebraska Hematology and Oncology | Lincoln | Nebraska | United States | 68506 |
| 553 | Nebraska Cancer Research Center | Lincoln | Nebraska | United States | 68510 |
| 554 | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | United States | 68510 |
| 555 | Southeast Nebraska Cancer Center | Lincoln | Nebraska | United States | 68510 |
| 556 | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska | United States | 68701 |
| 557 | Great Plains Health Callahan Cancer Center | North Platte | Nebraska | United States | 69101 |
| 558 | Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 559 | Nebraska Methodist Hospital | Omaha | Nebraska | United States | 68114 |
| 560 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 561 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 562 | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska | United States | 68124 |
| 563 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 564 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 565 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 566 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 567 | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska | United States | 69361 |
| 568 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 569 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 570 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 571 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 572 | Nevada Cancer Specialists-Saint Rose | Henderson | Nevada | United States | 89052 |
| 573 | 21st Century Oncology-Henderson | Henderson | Nevada | United States | 89074 |
| 574 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 575 | Nevada Cancer Specialists?Oakey | Las Vegas | Nevada | United States | 89102 |
| 576 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
| 577 | Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | United States | 89106 |
| 578 | 21st Century Oncology | Las Vegas | Nevada | United States | 89109 |
| 579 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 580 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 581 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
| 582 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 583 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 584 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 585 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 586 | Nevada Cancer Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 587 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 588 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 589 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 590 | Nevada Cancer Specialists-Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 591 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 592 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 593 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 594 | Alpine Hematology-Oncology | Reno | Nevada | United States | 89503 |
| 595 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 596 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 597 | Reno Oncology Consultants | Reno | Nevada | United States | 89519 |
| 598 | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | United States | 03301 |
| 599 | New Hampshire Oncology Hematology PA-Hooksett | Hooksett | New Hampshire | United States | 03106 |
| 600 | LRGHealthcare-Lakes Region General Hospital | Laconia | New Hampshire | United States | 03246 |
| 601 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 602 | Norris Cotton Cancer Center-Manchester | Manchester | New Hampshire | United States | 03102 |
| 603 | Veterans Adminstration New Jersey Health Care System | East Orange | New Jersey | United States | 07018-1095 |
| 604 | Virtua Memorial | Mount Holly | New Jersey | United States | 08060 |
| 605 | Jersey Shore Medical Center | Neptune | New Jersey | United States | 07753 |
| 606 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 607 | The Valley Hospital-Luckow Pavilion | Paramus | New Jersey | United States | 07652 |
| 608 | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | United States | 07701 |
| 609 | Valley Hospital | Ridgewood | New Jersey | United States | 07450 |
| 610 | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey | United States | 08876 |
| 611 | Virtua Voorhees | Voorhees | New Jersey | United States | 08043 |
| 612 | Valley Health System-Hematology/Oncology | Westwood | New Jersey | United States | 07675 |
| 613 | Lovelace Medical Center-Downtown | Albuquerque | New Mexico | United States | 87102 |
| 614 | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico | United States | 87102 |
| 615 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 616 | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | United States | 87109 |
| 617 | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico | United States | 88011 |
| 618 | New York Oncology Hematology PC -Albany Medical Center | Albany | New York | United States | 12208 |
| 619 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
| 620 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
| 621 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 622 | Bronx Veterans Administration Medical Center | Bronx | New York | United States | 10468 |
| 623 | New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | United States | 11215 |
| 624 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 625 | Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326 |
| 626 | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | United States | 14905 |
| 627 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 628 | Orange Regional Medical Center | Middletown | New York | United States | 10940 |
| 629 | Mount Sinai Union Square | New York | New York | United States | 10003 |
| 630 | Columbia University/Herbert Irving Cancer Center | New York | New York | United States | 10032 |
| 631 | University of Rochester | Rochester | New York | United States | 14642 |
| 632 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 633 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 634 | Faxton-Saint Luke's Healthcare | Utica | New York | United States | 13502 |
| 635 | Randolph Hospital | Asheboro | North Carolina | United States | 27203 |
| 636 | Cancer Care of Western North Carolina | Asheville | North Carolina | United States | 28801 |
| 637 | Mission Hospital Inc-Memorial Campus | Asheville | North Carolina | United States | 28801 |
| 638 | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina | United States | 27215 |
| 639 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 640 | Oncology Specialists of Charlotte | Charlotte | North Carolina | United States | 28207 |
| 641 | Southern Oncology Specialists-Charlotte | Charlotte | North Carolina | United States | 28262 |
| 642 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 643 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 644 | Cape Fear Valley Health System | Fayetteville | North Carolina | United States | 28304 |
| 645 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 646 | Wayne Memorial Hospital | Goldsboro | North Carolina | United States | 27534 |
| 647 | Cone Health Cancer Center | Greensboro | North Carolina | United States | 27403 |
| 648 | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina | United States | 28791 |
| 649 | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 650 | High Point Regional Hospital | High Point | North Carolina | United States | 27262 |
| 651 | Lake Norman Hematology Oncology Specialists-Huntersville | Huntersville | North Carolina | United States | 28078 |
| 652 | Southern Oncology Specialists-Huntersville | Huntersville | North Carolina | United States | 28078 |
| 653 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 654 | Vidant Oncology-Kinston | Kinston | North Carolina | United States | 28501 |
| 655 | Matthews Radiation Oncology Center | Matthews | North Carolina | United States | 28105 |
| 656 | Novant Health Cancer Specialists-Matthews | Matthews | North Carolina | United States | 28105 |
| 657 | Lake Norman Hematology Oncology Specialists-Mooresville | Mooresville | North Carolina | United States | 28117 |
| 658 | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | United States | 28374 |
| 659 | Duke Raleigh Hospital | Raleigh | North Carolina | United States | 27609 |
| 660 | Annie Penn Memorial Hospital | Reidsville | North Carolina | United States | 27320 |
| 661 | Southeastern Medical Oncology Center-Wilson | Wilson | North Carolina | United States | 27893 |
| 662 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 663 | Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 664 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 665 | Sanford Clinic North-Fargo | Fargo | North Dakota | United States | 58122 |
| 666 | Trinity Cancer Care Center | Minot | North Dakota | United States | 58701 |
| 667 | Cleveland Clinic Cancer Center Beachwood | Beachwood | Ohio | United States | 44122 |
| 668 | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | United States | 44122 |
| 669 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 670 | Strecker Cancer Center-Belpre | Belpre | Ohio | United States | 45714 |
| 671 | Mercy Medical Center | Canton | Ohio | United States | 44708 |
| 672 | Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 673 | Geauga Hospital | Chardon | Ohio | United States | 44024 |
| 674 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 675 | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio | United States | 45202 |
| 676 | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio | United States | 45211 |
| 677 | University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio | United States | 45219 |
| 678 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 679 | Oncology Hematology Care Inc - Anderson | Cincinnati | Ohio | United States | 45230 |
| 680 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 681 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 682 | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | United States | 45242 |
| 683 | TriHealth Cancer Institute-Westside | Cincinnati | Ohio | United States | 45247 |
| 684 | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | United States | 45255 |
| 685 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 686 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 687 | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | United States | 44111 |
| 688 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 689 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 690 | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | United States | 43214 |
| 691 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 692 | Columbus NCI Community Oncology Research Program | Columbus | Ohio | United States | 43215 |
| 693 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 694 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 695 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 696 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 697 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 698 | Dayton Physicians LLC-Samaritan North | Dayton | Ohio | United States | 45415 |
| 699 | Samaritan North Health Center | Dayton | Ohio | United States | 45415 |
| 700 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 701 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 702 | Mercy Cancer Center-Elyria | Elyria | Ohio | United States | 44035 |
| 703 | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio | United States | 45014 |
| 704 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 705 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 706 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 707 | Cleveland Clinic Cancer Center Independence | Independence | Ohio | United States | 44131 |
| 708 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 709 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 710 | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | United States | 44906 |
| 711 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 712 | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | United States | 43537 |
| 713 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
| 714 | Ireland Cancer Center Landerbrook Health Center | Mayfield Heights | Ohio | United States | 44124 |
| 715 | Lake University Ireland Cancer Center | Mentor | Ohio | United States | 44060 |
| 716 | Southwest General Health Center Ireland Cancer Center | Middleburg Heights | Ohio | United States | 44130 |
| 717 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 718 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 719 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 720 | Ireland Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 721 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
| 722 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 723 | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | United States | 44136 |
| 724 | Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 725 | The Toledo Hospital/Toledo Children's Hospital | Toledo | Ohio | United States | 43606 |
| 726 | University of Toledo | Toledo | Ohio | United States | 43614 |
| 727 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 728 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 729 | University Hospitals Sharon Health Center | Wadsworth | Ohio | United States | 44281 |
| 730 | South Pointe Hospital | Warrensville Heights | Ohio | United States | 44122 |
| 731 | University Pointe | West Chester | Ohio | United States | 45069 |
| 732 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 733 | UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | United States | 44145 |
| 734 | UHHS-Westlake Medical Center | Westlake | Ohio | United States | 44145 |
| 735 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
| 736 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 737 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 738 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 739 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 740 | Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | United States | 74146 |
| 741 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 742 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 743 | Providence Oncology and Hematology Care Southeast | Clackamas | Oregon | United States | 97015 |
| 744 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 745 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 746 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 747 | Providence Willamette Falls Medical Center | Oregon City | Oregon | United States | 97045 |
| 748 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 749 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 750 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 751 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 752 | Oregon Health and Science University | Portland | Oregon | United States | 97239 |
| 753 | Salem Hospital | Salem | Oregon | United States | 97301 |
| 754 | Legacy Meridian Park Hospital | Tualatin | Oregon | United States | 97062 |
| 755 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 756 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 757 | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | United States | 19010 |
| 758 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 759 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 760 | Ephrata Cancer Center | Ephrata | Pennsylvania | United States | 17522 |
| 761 | Ephrata Community Hospital | Ephrata | Pennsylvania | United States | 17522 |
| 762 | Adams Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 763 | Cherry Tree Cancer Center | Hanover | Pennsylvania | United States | 17331 |
| 764 | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | United States | 17109 |
| 765 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 766 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 767 | Jefferson Hospital | Jefferson Hills | Pennsylvania | United States | 15025 |
| 768 | Sechler Family Cancer Center | Lebanon | Pennsylvania | United States | 17042 |
| 769 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 770 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 771 | Riddle Memorial Hospital | Media | Pennsylvania | United States | 19063 |
| 772 | Forbes Hospital | Monroeville | Pennsylvania | United States | 15146 |
| 773 | Allegheny Valley Hospital | Natrona Heights | Pennsylvania | United States | 15065 |
| 774 | Paoli Memorial Hospital | Paoli | Pennsylvania | United States | 19301 |
| 775 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 776 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 777 | Temple University Hospital | Philadelphia | Pennsylvania | United States | 19140 |
| 778 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 779 | West Penn Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 780 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 781 | Pottstown Hospital | Pottstown | Pennsylvania | United States | 19464 |
| 782 | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 783 | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania | United States | 19605 |
| 784 | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | United States | 18840 |
| 785 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 786 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 787 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 788 | Chester County Hospital | West Chester | Pennsylvania | United States | 19380 |
| 789 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 790 | Wexford Health and Wellness Pavilion | Wexford | Pennsylvania | United States | 15090 |
| 791 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 792 | UPMC Susquehanna | Williamsport | Pennsylvania | United States | 17701 |
| 793 | Lankenau Medical Center | Wynnewood | Pennsylvania | United States | 19096 |
| 794 | WellSpan Health-York Cancer Center | York | Pennsylvania | United States | 17403 |
| 795 | WellSpan Health-York Hospital | York | Pennsylvania | United States | 17403 |
| 796 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
| 797 | Miriam Hospital | Providence | Rhode Island | United States | 02906 |
| 798 | AnMed Health Cancer Center | Anderson | South Carolina | United States | 29621 |
| 799 | Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 800 | Charleston Hematology Oncology Associates-Roper | Charleston | South Carolina | United States | 29403 |
| 801 | Bon Secours Saint Francis Hospital | Charleston | South Carolina | United States | 29414 |
| 802 | Charleston Hematology Oncology Associates PA-Saint Francis | Charleston | South Carolina | United States | 29414 |
| 803 | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina | United States | 29414 |
| 804 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 805 | Greenville Health System Cancer Institute-Laurens | Clinton | South Carolina | United States | 29325 |
| 806 | Greenville Health System Cancer Institute-Easley | Easley | South Carolina | United States | 29640 |
| 807 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 808 | Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | United States | 29440 |
| 809 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 810 | Greenville Health System Cancer Institute-Butternut | Greenville | South Carolina | United States | 29605 |
| 811 | Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | United States | 29605 |
| 812 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 813 | Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | United States | 29615 |
| 814 | Greenville Health System Cancer Institute-Greer | Greer | South Carolina | United States | 29650 |
| 815 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 816 | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina | United States | 29464 |
| 817 | Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina | United States | 29672 |
| 818 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 819 | Greenville Health System Cancer Institute-Spartanburg | Spartanburg | South Carolina | United States | 29307 |
| 820 | MGC Hematology Oncology-Union | Union | South Carolina | United States | 29379 |
| 821 | Lexington Medical Center | West Columbia | South Carolina | United States | 29169 |
| 822 | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 823 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 824 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 825 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 826 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 827 | Boston Baskin Cancer Center-Bartlett | Bartlett | Tennessee | United States | 38133 |
| 828 | Cookeville Regional Medical Center | Cookeville | Tennessee | United States | 38501 |
| 829 | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | United States | 37067 |
| 830 | Thompson Cancer Survival Center | Knoxville | Tennessee | United States | 37916 |
| 831 | Thompson Cancer Survival Center - West | Knoxville | Tennessee | United States | 37932 |
| 832 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 833 | Family Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 834 | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | United States | 37204 |
| 835 | Meharry Medical College | Nashville | Tennessee | United States | 37208 |
| 836 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 837 | Thompson Oncology Group-Oak Ridge | Oak Ridge | Tennessee | United States | 37830 |
| 838 | The Don and Sybil Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 839 | Dell Seton Medical Center at The University of Texas | Austin | Texas | United States | 78701 |
| 840 | Parkland Memorial Hospital | Dallas | Texas | United States | 75235 |
| 841 | Baylor University Medical Center | Dallas | Texas | United States | 75246 |
| 842 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 843 | Brooke Army Medical Center | Fort Sam Houston | Texas | United States | 78234 |
| 844 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0565 |
| 845 | Lyndon Baines Johnson General Hospital | Houston | Texas | United States | 77026-1967 |
| 846 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 847 | Ben Taub General Hospital | Houston | Texas | United States | 77030 |
| 848 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 849 | Memorial Hermann Texas Medical Center | Houston | Texas | United States | 77030 |
| 850 | Michael E DeBakey VA Medical Center | Houston | Texas | United States | 77030 |
| 851 | The Methodist Hospital System | Houston | Texas | United States | 77030 |
| 852 | UTMB Cancer Center at Victory Lakes | League City | Texas | United States | 77573 |
| 853 | Covenant Medical Center-Lakeside | Lubbock | Texas | United States | 79410 |
| 854 | University Medical Center | Lubbock | Texas | United States | 79415 |
| 855 | Texas Tech University Health Sciences Center-Lubbock | Lubbock | Texas | United States | 79430 |
| 856 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 857 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 858 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 859 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 860 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 861 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 862 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 863 | Dixie Medical Center Regional Cancer Center | Saint George | Utah | United States | 84770 |
| 864 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 865 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 866 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 867 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 868 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 869 | University of Vermont College of Medicine | Burlington | Vermont | United States | 05405 |
| 870 | Kaiser Permanente-Burke Medical Center | Burke | Virginia | United States | 22015 |
| 871 | University of Virginia Cancer Center | Charlottesville | Virginia | United States | 22908 |
| 872 | Hematology Oncology Associates of Fredericksburg Inc | Fredericksburg | Virginia | United States | 22408 |
| 873 | Lynchburg Hematology-Oncology Clinic | Lynchburg | Virginia | United States | 24501 |
| 874 | Sovah Health Martinsville | Martinsville | Virginia | United States | 24115 |
| 875 | Kaiser Permanente Tysons Corner Medical Center | McLean | Virginia | United States | 22102 |
| 876 | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia | United States | 23116 |
| 877 | Bon Secours Saint Francis Medical Center | Midlothian | Virginia | United States | 23114 |
| 878 | Bon Secours Saint Mary's Hospital | Richmond | Virginia | United States | 23226 |
| 879 | Virginia Cancer Institute | Richmond | Virginia | United States | 23230 |
| 880 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 881 | VCU Community Memorial Health Center | South Hill | Virginia | United States | 23970 |
| 882 | Shenandoah Oncology PC | Winchester | Virginia | United States | 22601 |
| 883 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 884 | Overlake Hospital Medical Center | Bellevue | Washington | United States | 98004 |
| 885 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 886 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 887 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 888 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 889 | Swedish Medical Center-Edmonds | Edmonds | Washington | United States | 98026 |
| 890 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 891 | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington | United States | 98332 |
| 892 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 893 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 894 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 895 | Northwest Cancer Clinic | Kennewick | Washington | United States | 99336 |
| 896 | Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington | United States | 98034 |
| 897 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 898 | Skagit Valley Hospital Regional Cancer Care Center | Mount Vernon | Washington | United States | 98273 |
| 899 | Skagit Valley Hospital | Mount Vernon | Washington | United States | 98274 |
| 900 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 901 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 902 | Peninsula Cancer Center | Poulsbo | Washington | United States | 98370 |
| 903 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 904 | Tacoma/Valley Radiation Oncology Centers-Puyallup | Puyallup | Washington | United States | 98372 |
| 905 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 906 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 907 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109 |
| 908 | Seattle Cancer Care Alliance | Seattle | Washington | United States | 98109 |
| 909 | Kaiser Permanente Washington | Seattle | Washington | United States | 98112 |
| 910 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 911 | Seattle Cancer Care Alliance at Northwest Hospital | Seattle | Washington | United States | 98133 |
| 912 | University of Washington Medical Center | Seattle | Washington | United States | 98195 |
| 913 | Tacoma/Valley Radiation Oncology Centers-Jackson Hall | Tacoma | Washington | United States | 97405 |
| 914 | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | United States | 98405 |
| 915 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 916 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 917 | Northwest NCI Community Oncology Research Program | Tacoma | Washington | United States | 98405 |
| 918 | Saint Joseph Medical Center | Tacoma | Washington | United States | 98405 |
| 919 | Tacoma/Valley Radiation Oncology Centers-Saint Joe's | Tacoma | Washington | United States | 98405 |
| 920 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 921 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 922 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 923 | Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | United States | 98801 |
| 924 | United Hospital Center | Bridgeport | West Virginia | United States | 26330 |
| 925 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 926 | Edwards Comprehensive Cancer Center | Huntington | West Virginia | United States | 25701 |
| 927 | Saint Mary's Medical Center | Huntington | West Virginia | United States | 25702 |
| 928 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 929 | Camden Clark Medical Center | Parkersburg | West Virginia | United States | 26101 |
| 930 | Langlade Hospital and Cancer Center | Antigo | Wisconsin | United States | 54409 |
| 931 | Fox Valley Hematology and Oncology SC-Appleton | Appleton | Wisconsin | United States | 54913 |
| 932 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 933 | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
| 934 | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin | United States | 54701 |
| 935 | Marshfield Clinic Cancer Center - Eau Claire | Eau Claire | Wisconsin | United States | 54701 |
| 936 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
| 937 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
| 938 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 939 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 940 | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | United States | 54301-3526 |
| 941 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 942 | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 943 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 944 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 945 | Mercy Health System | Janesville | Wisconsin | United States | 53547 |
| 946 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 947 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 948 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 949 | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin | United States | 54848 |
| 950 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792 |
| 951 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54221 |
| 952 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 953 | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin | United States | 54143 |
| 954 | Vince Lombardi Cancer Clinic-Marinette | Marinette | Wisconsin | United States | 54143 |
| 955 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 956 | Marshfield Medical Center | Marshfield | Wisconsin | United States | 54449 |
| 957 | Community Memorial Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 958 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 959 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 960 | Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 961 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 962 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 963 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 964 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 965 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 966 | Green Bay Oncology - Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 967 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 968 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 969 | Ascension Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 970 | Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 971 | Lakeview Medical Center-Marshfield Clinic | Rice Lake | Wisconsin | United States | 54868 |
| 972 | Marshfield Clinic-Rice Lake Center | Rice Lake | Wisconsin | United States | 54868 |
| 973 | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 974 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 975 | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 976 | Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 977 | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | United States | 54482 |
| 978 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
| 979 | Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 980 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 981 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 982 | Aurora Cancer Care-Waukesha | Waukesha | Wisconsin | United States | 53188 |
| 983 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 984 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 985 | Aspirus Regional Cancer Center | Wausau | Wisconsin | United States | 54401 |
| 986 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 987 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 988 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 989 | The Alyce and Elmore Kraemer Cancer Care Center | West Bend | Wisconsin | United States | 53095 |
| 990 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 991 | Marshfield Clinic - Weston Center | Weston | Wisconsin | United States | 54476 |
| 992 | Saint Clare's Hospital | Weston | Wisconsin | United States | 54476 |
| 993 | Aspirus UW Cancer Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 994 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 995 | Rocky Mountain Oncology | Casper | Wyoming | United States | 82609 |
| 996 | Big Horn Basin Cancer Center | Cody | Wyoming | United States | 82414 |
| 997 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 998 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 999 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
| 1000 | Juravinski Cancer Centre at Hamilton Health Sciences | Hamilton | Ontario | Canada | L8V 5C2 |
| 1001 | Ottawa Hospital and Cancer Center-General Campus | Ottawa | Ontario | Canada | K1H 8L6 |
| 1002 | University Health Network-Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 1003 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 1004 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- Southwest Oncology Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Vassiliki Papadimitrakopoulou, Southwest Oncology Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- S1400
- NCI-2014-00627
- S1400A
- S1400E
- S1400I
- S1400C
- S1400
- S1400D
- S1400B
- S1400
- S1400
- U10CA180888