Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Acute Respiratory Distress Syndrome (ARDS)
Sponsor
Policlinico Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01670747
Collaborator
(none)
30
1
29.9
1
Study Details
Study Description
Brief Summary
In this study gas-exchange and respiratory mechanics variations to PEEP change will be correlated to CT lung morphological modifications assessed at different airway pressures (5, 15, 30 and 45 cmH2O).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Anticipated Enrollment
:
30 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Patients With Acute Respiratory Distress Syndrome
Study Start Date
:
Sep 1, 2012
Actual Primary Completion Date
:
Mar 1, 2015
Actual Study Completion Date
:
Mar 1, 2015
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| ARDS Sedated and mechanically ventilated patients admitted to ICU |
Radiation: Chest computed tomography
|
Outcome Measures
Primary Outcome Measures
- Computer Tomography (CT) scan lung recruitment and CT lung weight [Study day (day 1)]
Aim of the study is to determine the relationship between the opening pressures (recruitment) and closing pressures (PEEP) in order to prevent the opening and closing of the lung parenchyma
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Clinical diagnosis of acute lung injury/ acute respiratory distress syndrome
-
Mechanical ventilation
Exclusion Criteria:
-
Clinical diagnosis of chronic obstructive pulmonary disease
-
Clinical diagnosis of pneumothorax
-
Haemodynamic instability
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Milano | Italy | 20122 |
Sponsors and Collaborators
- Policlinico Hospital
Investigators
- Principal Investigator: Chiumello Davide, MD, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Study Documents (Full-Text)
None provided.More Information
Publications
- Caironi P, Cressoni M, Chiumello D, Ranieri M, Quintel M, Russo SG, Cornejo R, Bugedo G, Carlesso E, Russo R, Caspani L, Gattinoni L. Lung opening and closing during ventilation of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2010 Mar 15;181(6):578-86. doi: 10.1164/rccm.200905-0787OC. Epub 2009 Nov 12.
- Gattinoni L, Caironi P, Cressoni M, Chiumello D, Ranieri VM, Quintel M, Russo S, Patroniti N, Cornejo R, Bugedo G. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med. 2006 Apr 27;354(17):1775-86.
Responsible Party:
Davide Chiumello,
MD,
Policlinico Hospital
ClinicalTrials.gov Identifier:
NCT01670747
Other Study ID Numbers:
- 201208
First Posted:
Aug 22, 2012
Last Update Posted:
Mar 19, 2015
Last Verified:
Mar 1, 2015
Additional relevant MeSH terms: