The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation
Sponsor
Johns Hopkins University (Other)
Overall Status
Completed
CT.gov ID
NCT00284726
Collaborator
(none)
57
Study Details
Study Description
Brief Summary
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.
Study Design
Study Type:
Interventional
Official Title:
A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation
Study Start Date
:
Dec 1, 2000
Study Completion Date
:
Sep 1, 2005
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
and Older
Sexes Eligible for Study:
All
Inclusion Criteria:
Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -
Exclusion Criteria:
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Johns Hopkins University
Investigators
- Principal Investigator: John V. Conte, M.D., Johns Hopkins University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00284726
Other Study ID Numbers:
- 00-10-25-03
First Posted:
Feb 1, 2006
Last Update Posted:
Dec 7, 2017
Last Verified:
Dec 1, 2017
Keywords provided by ,
,
Additional relevant MeSH terms: