Hypofractionated Radiotherapy for Small Cell Lung Cancer

Sponsor

AHS Cancer Control Alberta (Other)

Overall Status

Completed

CT.gov ID

NCT00469222

Collaborator

Cross Cancer Institute (Other)

Enrollment

Location

Duration (Months)

0.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Current treatments for limited stage small cell lung cancer have poor cure rates. The addition of chest radiation to chemotherapy improves cure rates, but these cancers still come back in the chest 30-50% of the time. Two factors which can improve control and cure rates for this cancer are increasing the chest radiation dose and minimizing the overall time it takes to complete radiation treatments. One method to achieve both of these goals is to give more radiation each day. This study is meant to study how tolerable and effective it would be to increase the intensity of chest radiation for small cell lung cancer patients by increasing the daily radiation dose. We aim to find the highest dose of chest radiotherapy that can be safely given with chemotherapy using this strategy. Patients in this trial will be monitored before, during and after their radiation and chemotherapy treatments for treatment side-effects, how effective treatments are at controlling their cancer and quality of life changes. Results from this trial will help to define more effective radiotherapy doses which are tolerable for this type of lung cancer and the quality of life changes patients experience when they undergo these treatments.

Condition or Disease	Intervention/Treatment	Phase
Lung Neoplasm Small Cell Carcinoma	Procedure: hypofractionated external beam	Phase 1

Detailed Description

Local control and overall survival rates associated with the standard chemotherapy and radiotherapy given for limited stage small cell lung cancer are poor and emerging evidence from several studies suggests that intensifying the radiotherapy dose given may further improve patient outcomes, but at the cost of increased radiotherapy side effects. This proposal aims to study a novel method of intensifying chest radiotherapy dose via increasing the daily radiotherapy dose which is directed at regions of visible disease only. This strategy allows for delivery of increased radiation doses without prolonging overall treatment time and allowing potential regrowth of cancer cells. We aim to determine the maximum radiation dose which can be safely given with chemotherapy for limited stage small cell lung cancer and study the effects this type of radiation regimen with chemotherapy has on patient side effects and quality of life. Results from this trial will contribute to the development of the ideal radiotherapy regimen for limited stage small cell lung cancer. Our results will add to the literature studying the effects dose-intense radiation strategies for lung cancer have on patient quality of life.

Study Design

Study Type:

Interventional

Actual Enrollment :

24 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Phase I Dose Escalation Trial of Hypofractionated Limited-field External Beam Thoracic Radiotherapy for Limited Stage Small Cell Carcinoma of the Lung

Study Start Date :

Mar 1, 2007

Actual Primary Completion Date :

Apr 1, 2011

Actual Study Completion Date :

Apr 1, 2011

Outcome Measures

Primary Outcome Measures

Rates of acute grade 3 or higher radiotherapy toxicities []

Secondary Outcome Measures

Overall survival and disease free survival, patient related quality of life []

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

patients with histologically or cytologically proven newly diagnosed small cell lung cancer
confirmation from the treating radiation oncologist that the patient has limited stage disease (i.e. disease that can be encompassed by radiotherapy portals without exposing patient to excessive risk of radiation lung injury)
adequate pulmonary function tests (FEV-1 >1.0, DLCO >50%)
patients of childbearing potential must practice adequate contraception
age greater than 18 years
Karnofsky performance status greater than 70
adequate hematologic, hepatic and renal function: Hb>100g/L, WBC > 4.0x109/L, neutrophils > 1.0x109/L, platelets > 100,000x109/L, calculated GFR based on Cockcroft-Gault formula of >60mL/min (NOTE: for cisplatin, GFR must be above 60ml/min; if less than 60ml/min the patient can not receive cisplatin but could be considered for carboplatin)
patients must sign a study specific informed consent form

Exclusion Criteria:

patient who have undergone complete or subtotal tumour resection
evidence of non-small cell histology
pericardial or pleural effusion on radiologic investigations regardless of cytology
patients cannot be treated with 3DCRT with adherence to the dose volume constraints
prior or concurrent malignancy except non-melanomatous skin cancer unless disease-free for at least 5 years
prior radiotherapy to the thorax or neck
prior chemotherapy
patients with myocardial infarction within the preceding 6 months or symptomatic heart disease, including angina, congestive heart failure, uncontrolled arrhythmias
compromised lung function with inadequate pulmonary function tests (FEV-1<1.0, DLCO <50%)
pregnancy (patients with childbearing potential must practice appropriate contraception)
patients who have not had the pre-treatment evaluations outlined in the protocol