ASPEN: Study of LJP 394 in Lupus Patients With History of Renal Disease

Sponsor

La Jolla Pharmaceutical Company (Industry)

Overall Status

Terminated

CT.gov ID

NCT00089804

Collaborator

(none)

943

Enrollment

201

Locations

Arms

Duration (Months)

4.7

Patients Per Site

0.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The primary purpose of this study is to determine whether abetimus sodium is more effective than placebo in delaying time to renal flare in SLE patients with a history of renal disease.

Condition or Disease	Intervention/Treatment	Phase
Lupus Erythematosus, Systemic Lupus Nephritis	Drug: abetimus sodium (LJP 394) and/or placebo solution Drug: abetimus sodium (LJP 394) Drug: Phosphate-buffered saline	Phase 3

Study Design

Study Type:

Interventional

Actual Enrollment :

943 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Triple (Participant, Care Provider, Investigator)

Primary Purpose:

Treatment

Official Title:

A Randomized, Double-Blind, Placebo-Controlled, Three-Arm, Parallel-Group, Multicenter, Multinational Safety and Efficacy Trial of 300 mg and 900 mg of Abetimus Sodium in Systemic Lupus Erythematosus (SLE) Patients With a History of Renal Disease

Study Start Date :

Oct 1, 2004

Actual Primary Completion Date :

Feb 1, 2009

Actual Study Completion Date :

Feb 1, 2009

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: 1 300 mg (three 2 mL vials of abetimus sodium plus six 2 mL vials of normal saline) administered i.v (in the vien) weekly	Drug: abetimus sodium (LJP 394) and/or placebo solution 300 mg (50 mg/mL)abetimus sodium (three 2 mL vials of of abetimus sodium plus six 2 mL vials of normal saline) administered i.v. (in the vien) weekly for 52 weeks
Active Comparator: 2 900 mg (nine 2 mL vials of abetimus sodium) administered i.v. (in the vein) weekly	Drug: abetimus sodium (LJP 394) 900 mg (50 mg/mL) abetimus sodium (nine 2 mL vials) administered i.v. (in the vien) weekly for 52 weeks.
Placebo Comparator: 3 A volume of 18 mL (Nine 2 mL vials) of identically appearing placebo (phosphate-buffered saline) administered i.v. (in the vien) weekly	Drug: Phosphate-buffered saline A volume of 18 mL (nine 2 mL vials of normal saline) of identically appearing placebo (phosphate-buffered saline) administered i.v. (in the vien) weekly for 52 weeks Other Names: Placebo, normal saline

Arm

Intervention/Treatment

Active Comparator: 1

300 mg (three 2 mL vials of abetimus sodium plus six 2 mL vials of normal saline) administered i.v (in the vien) weekly

Drug: abetimus sodium (LJP 394) and/or placebo solution

300 mg (50 mg/mL)abetimus sodium (three 2 mL vials of of abetimus sodium plus six 2 mL vials of normal saline) administered i.v. (in the vien) weekly for 52 weeks

Active Comparator: 2

900 mg (nine 2 mL vials of abetimus sodium) administered i.v. (in the vein) weekly

Drug: abetimus sodium (LJP 394)

900 mg (50 mg/mL) abetimus sodium (nine 2 mL vials) administered i.v. (in the vien) weekly for 52 weeks.

Placebo Comparator: 3

A volume of 18 mL (Nine 2 mL vials) of identically appearing placebo (phosphate-buffered saline) administered i.v. (in the vien) weekly

Drug: Phosphate-buffered saline

A volume of 18 mL (nine 2 mL vials of normal saline) of identically appearing placebo (phosphate-buffered saline) administered i.v. (in the vien) weekly for 52 weeks

Other Names:

Placebo, normal saline

Outcome Measures

Primary Outcome Measures

To determine whether abetimus sodium is more effective than placebo in delaying the time to renal flare in SLE patients with a history of SLE renal disease. Weekly administration with a 52-week treatment duration. [Time to event (12 months fixed treatment duration)]

Secondary Outcome Measures

To determine whether treatment with abetimus sodium is more effective than placebo in delaying the time to Major SLE flare; and to determine whether treatment with abetimus sodium (LJP 394) is more effective than placebo in reducing proteinuria. [12 month fixed treatment duration]

Eligibility Criteria

Criteria

Ages Eligible for Study:

12 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Diagnosis of Systemic Lupus Erythematosus (SLE)
Active SLE renal disease within past 4 years.
Males or females between 12 and 70 years old.
Females must be non-pregnant and non-lactating. Females and males must use adequate birth control methods during course of study.
Ability to have weekly intravenous (IV) administration of study treatment.

Exclusion Criteria:

Active SLE renal disease within past 3 months prior to entering study.
Use of the following therapies within 3 months prior to entering the study: alkylating agents, e.g., cyclophosphamide, TNF inhibitors, cyclosporine.
Use of mycophenolate mofetil that exceeds 1000 mg/day, azathioprine that exceeds 100 mg/day, methotrexate that exceeds 10 mg/week, leflunomide that exceeds 10 mg/day within 2 months prior to entering study.
Use of rituximab within 6 months prior to entering study.
Current abuse of drugs or alcohol.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham	Birmingham	Alabama	United States	35294
2	Wallace Rheumatic Study Center	Los Angeles	California	United States	90048
3	East Bay Rheumatology Medical Group	San Leandro	California	United States	94578
4	Private Practice	San Mateo	California	United States	94401
5	CRIA Research	Fort Lauderdale	Florida	United States	33334
6	Miami Children's Hospital	Miami	Florida	United States	33155
7	Emory University School of Medicine, Renal Division	Atlanta	Georgia	United States	30322
8	Private Practice	Augusta	Georgia	United States	30909
9	Southeast Regional Research Group	Savannah	Georgia	United States	31406
10	Intermountain Orthopedics	Boise	Idaho	United States	83702
11	Rheumatology Associates	Chicago	Illinois	United States	60612
12	Ochsner Clinic Foundation	New Orleans	Louisiana	United States	70121
13	SOMARC Trials, LLC	Greenbelt	Maryland	United States	20770
14	Nephrology Associates, PC	Flushing	New York	United States	11355
15	North Shore - LIJ Health System	Lake Success	New York	United States	11042
16	Feinstein Institute for Medical Research	Manhasset	New York	United States	11030
17	Seligman Center for Advanced Therapeutics, NYU Hospital for Joint Diseases	New York	New York	United States	10003
18	AAIR Research Center	Rochester	New York	United States	14618
19	Suny Upstate Medical University	Syracuse	New York	United States	13210
20	Wake Forest University Health Sciences	Winston Salem	North Carolina	United States	27157
21	Ohio State University Medical Center	Columbus	Ohio	United States	43210
22	Healthcare Research Consultants	Tulsa	Oklahoma	United States	74135
23	Private Practice	Camp Hill	Pennsylvania	United States	17011
24	Altoona Center for Clinical Research	Duncansville	Pennsylvania	United States	16635
25	Arthritis Clinic, 371 North Parkway, Suite 400	Jackson	Tennessee	United States	38305
26	Amarillo Center for Clinical Research	Amarillo	Texas	United States	79124
27	Miracle Medical Clinic, 1170 Blalock Road	Houston	Texas	United States	77055
28	Renal Care Clinic, P.A., 17202 Red Oak Drive	Houston	Texas	United States	77090
29	Texas Tech University Health Sciences Center	Lubbock	Texas	United States	79430
30	San Antonio Kidney Disease Center	San Antonio	Texas	United States	78229
31	Clinical Research & Consulting Center	Fairfax	Virginia	United States	22030
32	Arthritis Northwest PLLC	Spokane	Washington	United States	99204
33	CIR Hospital Sirio Libanes. Campana 4658	Buenos Aires	Ciudad Autonma de	Argentina	C1419AHN
34	Centro de Investigaciones Reumatológicas	San Miguel de Tucumán	Provincia de Tucumán	Argentina	4000
35	Instituto CAICI	Rosario	Santa Fe	Argentina	S2000PBJ
36	Organización Médica de la Investigación	Buenos Aires	Uruguay 725 P.B.	Argentina	C1015ABO
37	Unidad de Alergia, Asma e Inmunología Clínica	Buenos Aires		Argentina	1035
38	Centro de Investigaciones en Enfermedades Reumaticas (CIER)	Buenos Aires		Argentina	C1055AAF
39	Centro de Investigaciones Reumatologicas y Osteologicas	Buenos Aires		Argentina	C11117ABH
40	Investigación Clínica Polivalente	La Plata		Argentina	1902
41	Rheumatology Clinic	Cairns		Australia	QLD 4870
42	Dept Medicine, Level 3 Wallace Freeborn Building, Royal North Shore Hospital, Pacific Highway	St Leonards		Australia	NSW 2065
43	Vincents Hospital Daly Building, 41 Victoria Parade Fitzroy	Victoria		Australia	3065 702
44	Gomel Regional Clinical Hospital	Gomel		Belarus	246029
45	Minsk City Clinical Hospital # 2	Minsk		Belarus	220020
46	Minsk City Clinical Hospital # 164	Minsk		Belarus	220113
47	Minsk City Clinical Hospital # 9	Minsk		Belarus	220116
48	Minsk Regional Clinical Hospital	Minsk		Belarus	223040
49	Vitebsk Regional Clinical Hospital	Vitebsk		Belarus	210037
50	Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul-PUCRS	Porto Alegre-RS	Av. Ipiranga, 6690-Conj. 220-Jardim Botanico	Brazil	90610-000
51	Hospital Universitario Pedro Ernesto	Rio de Janeiro	Avenida 28 de Setembro, 77	Brazil	20.551-030
52	Hospital Hehopolis	Sao Paulo	Avenida Almirante Delamare, 1534-Sacoman	Brazil	04230-000
53	Hospital Geral de Goiania, GO Av Anhanguera 6479 Setor Oeste	Goiania-GO	Goias	Brazil	CEP: 74 110 120
54	Santa Casa de Misericórdia de BeloHorizonte, Av. Francisco Sales, n. 1111 9 andar Ala D/ CCIH	Belo Horizonte	Minas Gerais	Brazil	CEP: 30150 221
55	Hospital das Clinicas da Faculdade de Medicina da Universidade, Federal de Goiás, Servico de Reumatologia / 2 andar	Goiänia, Goiás	Primeira Avenida s/n Setor Universitário	Brazil	74605-020
56	Hospital de Clinicas - Universidade Estadual de Campinas - UNICAMP, Rua Vital Brasil, 250 - 3º andar - Cidade Universitária Zeferin	Campinas - SP		Brazil	Cep: 13083-888
57	Hospital e Maternidade Celso Pierro - PUCCampinas, Av. John Boyd Dunlop, s/n	Campinas - Sāo Paulo		Brazil	13059-740
58	Athritis Clinica de Doenças Reumaticas, Av. Padre Anchieta, 1846 cj 1108	Curitiba - PR		Brazil	80730-000
59	Hospital de Clinicas de Porto Alegre - HCPA	Porto Alegre-RS		Brazil	90035-903
60	Hospital das Clínicas of Medicine School of University of São Paulo (USP) at Ribeirão Preto Rheumatology Department Avenida dos	Ribeirão Preto		Brazil	Cep: 14048-900
61	Hospital Santa Izabel, Praca Almeida Couto, 500 - Naxaré	Salvador - BA		Brazil	CEP: 40050 410
62	Irmandade da Santa Casa de Misericórdia de Sāo Paulo Rua, Dr. Cesário Motta Junior, 112	São Paulo		Brazil	Cep: 01221-020
63	Rua Pedro de Toledo 1800 9 andar/ Ala central - Diretoria de Servico de Reumatologia	Săo Paulo - SP		Brazil	CEP: 04039 004
64	NMTranspH "Tsar Boris Treti", Clinic of Internal Diseases	Sofia	104 "Maria Louisa" blvd.	Bulgaria	1233
65	MHAT "Stara Zagora", Second Clinic of Internal Diseases	Stara Zagora	11 "Armeiska" street	Bulgaria	6000
66	MHAT "Sveti Ivan Rilski", Clinic of Rheumatology	Sofia	13 "Urvich" Street	Bulgaria	1612
67	MHAT "Sveti Georgi", Clinic of Rheumatology	Plovdiv	15A "Vasil Aprilov" blvd.	Bulgaria	4002
68	Military Medical Academy, Clinic of Urology and Nephrology	Sofia	3, Georgi Sofiiski, str.	Bulgaria	1606
69	Clinic of Nephrology, MHAT "Alexandrovska" 1, Georgi Sofiiski, str.,	Sofia		Bulgaria	1431
70	Fakultni nemocnice Plzen, Oddeleni klinické farmakologie	Plzen	Edvarda Benese	Czech Republic	13305 99
71	VFN Prahal Lékarská fakulta, Klinika detského a dorostového lékarstvi,	Praha 2	Ke Karlovu, 09 Praha 2,	Czech Republic	2121
72	Revmatologický ústav	Praha 2		Czech Republic	128 50
73	Academic VL Tsitlanadze Scientific - Practical Center of Rheumatology	Tbilisi		Georgia	0102
74	Herz and Rheumazentrum Kerckhoff-klinik GmbH	Bad Nauheim	Benekestrasse 2-8	Germany	61231
75	Charité-Unversitätmedizin Berlin, CharitéCentrum Inn ere Medizin und Dermatologie	Berlin	Chariteplatz 1	Germany	10117
76	Medizinische Klinik und Poliklinik IV des Universitätsklinikum Lepizig, Rheumatologie	Leipzig	Liebigstrasse 22	Germany	04103
77	Georg August Universität Göttingen Universitätsklinikum, Zentrum Innere Medizin	Göttingen	Robert-Kochstr. 40	Germany	37075
78	Johannes Gutenberg-Universität I. Medizinische Klinik und Poliklinik,Langenbeckstr. 1	Mainz		Germany	55131
79	Hong Kong University, Queen Mary Hospital	Hong Kong		Hong Kong
80	The Chinese University of Hong Kong, Prince of Wales Hospital	Hong Kong		Hong Kong
81	Szent Margit Hospital, Department of Nephrology	Budapest		Hungary	1032
82	Diagnostic Units Hungary Kft.	Budapest		Hungary	1036
83	Szent László Kórház, VI. Fertőző Belosztály	Budapest		Hungary	1097
84	Debrecen Medical University	Debrecen		Hungary	4004
85	Petz Aladar Megyei Oktato Korhaz, Immunnephrologia es Hypertonia Osztaly	Gyor		Hungary	9024
86	Global Hospitals	Hyderabaad	Andhra Pradesh	India	500 004
87	Department of Nephrology, All India Institute of Medical Sciences	New Delhi	Ansari Nagar	India	110029
88	Institute of Kidney Diseases and Research (IKRD) and Institute of Transplantation Sciences (ITS)	Ahmedabad	Asarwa	India	380016
89	Sri Ramachandra Medical College & Research Institute (Deemed University)	Porur	Chennai	India	600 116
90	M.P. Shah Medical College & G.G. Hospital	Jamnagar	Gujarat	India	361001
91	PVS Memorial Hospital Ltd.	Cochin	Kaloor, Kerala	India	682017
92	Apollo Gleneagles Hospital	Kolkatta	Kankurgachi	India	700054
93	St. Johns Medical College and Hospital, Dept. of Nephrology	Bangalore	Karnataka	India	560 034
94	M.S. Ramaiah Memorial Hospital	Bangalore	Karnataka	India	560054
95	Amrita Institute of Medical Sciences	Kochin	Kerala	India	682026
96	Consultant and Head Department of Nephrology, Kamineni Hospitals	Hyderabaad	L.B. Nagar	India	500068
97	Apollo Specialty Hospitals, Lake View Road, K.K., Nagar	Madurai	Tamil Nadu	India	625-020
98	Fortis Hospital, Dept. of Nephrology & Hypertension	Noida	Uttar Pradesh	India
99	Post Graduate Institute of Medical Education and Research	Chandigarh		India	160 012
100	Devaki Hospital Ltd., Dept. of Nephrology	Chennai		India	600 004
101	Madras Institute of Nephrology, Vijaya Health Center	Chennai		India	600 026
102	Spectra Apollo Research Foundation	Chennai		India
103	Medwin Hospital	Hyderabaad		India	500 001
104	Nizams Institute of Medical Sciences	Hyderabaad		India	500 082
105	Department of Nephrology, CARE Hospital, Banjara Hills	Hyderabad		India	500034
106	Armenian Church Trauma Center - Unit of Rabindranath Tagore International Institute of Cardiac Sciences	Kolkata		India	700-099
107	Sanjay Ghandi Post Graduate Institute of Medical Sciences	Lucknow		India	226014
108	BYL Nair Charitable Hospital & TN Medical College	Mumbai		India	400 008
109	Seth G.S. Medical College & KEM Hospital	Mumbai		India	400 012
110	P.D. Hinduja National Hospital and Research Center	Mumbai		India	400016
111	Department of Nephrology, JSS Hospital, Ramanuja Road	Mysore		India	570004
112	Indraprastha Apollo Hospital	New Delhi		India	110044
113	Jehangir Hospital, 32 Sassoon Road	Pune		India	411001
114	Medical College Trivandrum	Trivandrum		India	695011
115	King George Hospital	Visakhapatnam		India	530002
116	Dept. of Internal Medicine, Saiful Anwar General Hospital	Malang	Jl. J.A. Suprapto No. 2	Indonesia	65111
117	RS Kramat 128	Jakarta	Jl. Kramat Raya, Pusat	Indonesia	128
118	RS Hasan Sadikin	Bandung	Jl. Pasir Kaliki No. 190, Jawa Barat	Indonesia	40161
119	Arcispedale S. Anna, Divisione di Reumatologia	Ferrara	Corso Giovecca 203	Italy	44100
120	Azienda Ospedaliera Cattedra di Reumatologia	Padova	Via Giustiniani, 2	Italy	35128
121	Universita di Pisa, Dipartimento di Medicina Interna	Pisa	Via Roma 67	Italy	56126
122	Ewha Woman's University College of Medicine, Mockdong Hospital	Seoul	Yangcheon-Gu	Korea, Republic of	158-710
123	Inha University Hospital	In Cheon		Korea, Republic of	400-711
124	Bundang Cha General Hospital, Pochon Cha University	Kyonggi-do		Korea, Republic of	463-712
125	Pusan National University Hospital	Pusan		Korea, Republic of	602-739
126	Seoul National University Hospital, Department of Internal Medicine	Seoul		Korea, Republic of	110-744
127	The Hospital for Rheumatic Disease, Hanyang University Medical Center	Seoul		Korea, Republic of	133-792
128	Kangnam St. Mary's Hospital, Catholic University of Korea	Seoul		Korea, Republic of	137-040
129	St. Mary's Hospital, Catholic University of Korea	Seoul		Korea, Republic of	150-713
130	Ajou University Medical Center, Ajou University School of Medicine	Suwon		Korea, Republic of	442-721
131	Rayak Hospital	Rayak	Bekaa Valley	Lebanon
132	Albert Haykel Hospital	Haykaliyeh-Tripoli		Lebanon
133	Nabatieh Governmental Hospital	Nabatieh		Lebanon
134	Hammoud Hospital University Medical Center	Saida		Lebanon
135	Labib Medical Center	Saida		Lebanon
136	Department of Medicine, Hospital Pulau Pinang,	Pulau Pinang	Jalan Residensi	Malaysia	10990
137	CAPD Unit, Queen Elizabeth Hospital,	Sabah	Kota Kinabalu	Malaysia	88586
138	Department of Medicine, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce,	Sarawak	Kuching	Malaysia	93586
139	Blvd. Sanchez Taboada 9250-28 - Private Practice	Tijuana	Baja California	Mexico	cp22010
140	Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Departmento de inmunologia y Reumatologia	Delagacion Tlalpan	D.f.	Mexico	CP 14000
141	Clínica de Diagnóstico y Tratamiento de las Enfermedades Reumáticas	Mexico City	D.f.	Mexico	06700
142	Hospital Aranda de la Parra	Leon	Guanajuato	Mexico	CP37000
143	Colomos #2292, Col. Providencia	Guadalajara	Jalisco	Mexico	44620
144	Centro de Estudios de Investigación Básica y Clínica S.C.	Guadalajara	Jalisco	Mexico	44690
145	Hospital Star Medica	Morelia	Michoacan	Mexico	58070
146	Poliplaza Medica	Chihuahua		Mexico	CP 32500
147	Reumatologia	Mexicali		Mexico	CP 21100
148	Hospital Privado San José de Ciudad Obregón, S.A. de C.V. Coahuila No. 263 Sur. Col. Centro. Ciudad Obregón	Sonora		Mexico	C.P. 85000
149	Chung Hua Hospital	Cebu		Philippines	6000
150	Davao Doctors Hospital	Davao		Philippines	8000
151	Philippine General Hospital	Manila		Philippines	1000
152	Joint and Bone Center, University of Santo Tomas Hospital	Manila		Philippines
153	Klinika Medycyny, Transplantacyjnej i Nefrologii in Warszawa, Nowogrodzka 59, At SPZOZ Szpital Kliniczny	Warszawa	Dzieciatka Jezus-Centrum Leczenia Obrażeń, Lindleya 4	Poland	02-005
154	Klinika Nefrologii, Transplantologii i Chorob Wewnetrznych - Akademickie Centrum Kliniczne - Szpital AMG	Gdansk		Poland	80-952
155	Klinika Chorob Wewnetrznych i Reumatologii - Gornoslaskie Centrum Medyczne, SPSK Nr 7 SL A M	Katowice		Poland	40-635
156	Oddzial Kiliniczny Nefrologii Hipertensjologii i Transplantologii Nerek SPZOZ, Uniwersytecki Szpital Kliniczny nr 1	Lodz		Poland	90153
157	Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej	Lublin		Poland	20-954
158	Akademii Medycznej w Poznaniu, Zaklad Reumatologii i Immunologii Klinicznej	Poznan		Poland	61-626
159	Klinika Chorób Tkanki Łącznej	Warszawa		Poland	02-637
160	Klinika Nefrologii Dializoterapii I Chorob Wewnetrznych - Samodzielny Publiczny Centralny Szpital Kliniczny	Warszawa		Poland	02097
161	Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria - Reumatologia	Lisboa	Av. Prof. Egas Moniz	Portugal	1649-035
162	Centro Hospitalar do Porto, EPE - Hospital de Santo Antonio, Departamento de Medicina - Unidade de Imunologia Clinica	Porto	Largo Prof. Abel Salazar	Portugal	4099-001
163	Centro Hospitalar de Vila Nova de Gaia	Vila Nova de Gaia	Rua Conceicao Fernandes	Portugal	4434-502
164	Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Egas Moniz, Unidade de Reumatologia	Lisboa	Rua da Junqueira, 126	Portugal	1300
165	Hospital de Sāo Jeāo, Servico de Nefrologia	Porto		Portugal	4200-319
166	RCMI Clinical Research Center, 1st Floor University Hospital Medical Center	San Juan		Puerto Rico	00935
167	"Sf. Maria" Clinical Hospital	Bucharest		Romania	011172
168	"Ion Stoia" Center of Rheumatic Diseases	Bucharest		Romania	020983
169	Emergency Clinical County Hospital Cluj	Cluj Napoca		Romania	400006
170	Rehabilitation Clinical Hospital	Iasi		Romania	700661
171	Institute of Nephrology and Urology Clinical Centre of Serbia	Belgrade		Serbia	11000
172	Institute of Rheumatology	Belgrade		Serbia	11000
173	University Medical Centre "Zvezdara", Clinical Department for Renal Diseases, Dimitrija Tucovica 161	Belgrade		Serbia	11000
174	Institute of Prevention, Treatment and Rehabilitation of Rheumatoid and Cardiovascular Patients "Niska Banja"	Niska Banja		Serbia	18205
175	Reumatologicka ambulancia Fakultna nemocnica F D Roosevelta	Banska	Bystrica	Slovakia	97517
176	Reumatologicka ambulancia Fakultna nemocnica s poliklinikou Milosrdni bratia spol s r o	Bratislava		Slovakia	81465
177	Hospital Clinic i Provincial de Barcelona, Centre Ciutat, Facultat de Medicina, Servicio de Enfermedades Autoinmunes	Barcelona	Calle Villarroel, 170	Spain	08036
178	Hospital Universitario La Paz, Servico de Medicine Interne Planta 10	Madrid	Paseo de la Castellana 261	Spain	28046
179	Hospital Universitari Vall d'Hebron, Servicia Medicina Interna, Edificio General, 3a Planta	Barcelona	Paseo Valle de Hebron 119-129	Spain	08035
180	University Lupus Clinic of the Department of Clinical Medicine, Faculty of Medicine, University of Colombo, P.O. Box 271, No 25,	Colombo	Kynsey Road	Sri Lanka	08
181	Buddhist Dalin Tzu Chi General Hospital, Vice Superintendent Room	Dalin Town	Chia-Yi county	Taiwan	622
182	Chang Gung Memorial Hospital	Kaohsiung Hsien		Taiwan	833
183	Kaohsiung University Medical Hospital	Kaohsiung		Taiwan	807
184	Kaohsiung Veterans General Hospital	Kaohsiung		Taiwan	813
185	Chang Gung Memorial Hospital - Keelung	Keelung city		Taiwan	204
186	Chung Shan Medical University Hospital	Taichung City		Taiwan	402
187	China Medical University Hospital	Taichung		Taiwan	404
188	National Chang-Kung University Hospital	Tainan		Taiwan
189	Taipei Veterans General Hospital - Immunology & Rheumatology Office	Taipei		Taiwan	112
190	Chang Gung Memorial Hospital - Taipei	Taipei		Taiwan
191	Chang Gung Memorial Hospital	Taoyuan		Taiwan
192	Chi Mei Foundation Hospital	Yongkang City		Taiwan
193	Department of Medicine, King Chulalongkorn Memorial Hospital	Bangkok		Thailand	10330
194	Ramathibodi Hospital - Division of Allergy, Immunology & Rheumatology, Dept. of Medicine	Bangkok		Thailand	10400
195	Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine	Bangkok		Thailand	10400
196	Donetsk Central Municipal Clinical Hospital #1	Donetsk		Ukraine	83114
197	Kyiv Central Municipal Clinical Hospital	Kyiv		Ukraine	01023
198	M.D. Strazhesko Institute of Cardiology AMS Ukraine	Kyiv		Ukraine	03680
199	Kyiv Regional Clinical Hospital	Kyiv		Ukraine	04107
200	Lviv Municipal Public Clinical Hospital	Lviv		Ukraine	79013
201	Vinnitsa Regional Clinical Hospital of MoH of Ukraine	Vinnitsa		Ukraine	21018