Magnetic Resonance Imaging in Cerebral Small Vessel Disease
Study Details
Study Description
Brief Summary
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Cerebral small vessel disease group Patients with clinically and radiologically evidenced cerebral small vessel disease. Patients are grouped by severity of cerebral small vessel disease assessed by comprehensive MRI findings. |
Diagnostic Test: Magnetic resonance imaging
Patients recruited will receive Magnetic resonance imaging.
|
Outcome Measures
Primary Outcome Measures
- Progression in total cerebral small vessel disease burden [1 year]
Total cSVD burden assessed by MRI
Secondary Outcome Measures
- Progression in congnitive impairments [1 years]
Global Z-score by cognitive domain
- Recurrent ischemic events [1 year]
Recurrent ischemic stroke, TIA and vascular death
- Modified Rankin Scale [90 days and 1 year after qualifying event]
Disability assessed by modified Rankin Scale (mRS). The scores, ranging from 0 (no symptoms) to 6 (death), were recorded by phone call or outpatient consultation. A favorable outcome was defined as mRS score 0-2, unfavorable outcome was defined as mRS score > 2.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarcts and white matter hyperintensity
-
No disability (modified Rankin's scale < 2)
-
No dementia (MMSE > 24 and absence of dependence in daily activities)
-
Able and willing to consent
Exclusion Criteria:
-
Contraindications to MRI
-
Standard MRI of bad quality due to movement artefacts
-
Pregnant
-
Unable to tolerate MRI
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Chinese PLA General Hospital | Beijing | China | 100853 |
Sponsors and Collaborators
- Chinese PLA General Hospital
Investigators
- Principal Investigator: Xin Lou, MD, PhD, Chinese PLA General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- ChinaPLAGH-Radiology