Magnetic Resonance Imaging Studies of Motor and Thought Processes
Study Details
Study Description
Brief Summary
Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI is especially useful when studying the brain, because it can provide information about certain brain functions. In addition, MRI is much better than standard X-rays at showing areas of the brain close to the skull and detecting changes in the brain associated with neurological diseases. In this study researchers will use MRI to gather information about the processes that control human movement and sensory processing.
The purpose of the study is to investigate how the brain is activated when remembering, thinking, or recognizing objects. Researchers would like to determine what happens to brain functions when patients have trouble remembering, thinking, or recognizing objects following the start of disorders in the brain and nervous system. In addition, this study will investigate the processes of motor control in healthy volunteers and patients with disease.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The main purpose of the studies presented in this protocol is to investigate the physiology of motor control in health as well as the pathophysiological modifications taking place during disease. Patients and normal volunteers will be scanned at rest and during different tasks, either while making repetitive movements or undergoing sensory stimulation. These studies should provide new insight concerning the processes that control human movement and sensory processing. The studies described in this protocol will be conducted by systems operating on 1.5 Tesla up to 4 Tesla, including a system at 3 Tesla which is going to be installed in near future.
Study Design
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Patients with movement disorder and normal volunteers.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland | United States | 20892 |
Sponsors and Collaborators
- National Institute of Neurological Disorders and Stroke (NINDS)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Aquilonius SM. What has PET told us about Parkinson's disease? Acta Neurol Scand Suppl. 1991;136:37-9. Review.
- Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature. 1995 Sep 14;377(6545):155-8.
- Sadato N, IbaƱez V, Campbell G, Deiber MP, Le Bihan D, Hallett M. Frequency-dependent changes of regional cerebral blood flow during finger movements: functional MRI compared to PET. J Cereb Blood Flow Metab. 1997 Jun;17(6):670-9.
- 930010
- 93-N-0010