Interpersonal Psychotherapy for Depressed Adolescents and Parents

Sponsor

New York State Psychiatric Institute (Other)

Overall Status

Completed

CT.gov ID

NCT00619411

Collaborator

Columbia University (Other)

Enrollment

Arm

Duration (Months)

Study Details

Study Description

Brief Summary

The purpose of this study is to examine the feasibility and acceptability of an adaptation of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) that includes greater and more structured involvement of the parents in the treatment.

Condition or Disease	Intervention/Treatment	Phase
Major Depression Dysthymic Disorder Adjustment Disorders Depressive Disorder Not Otherwise Specified	Behavioral: Interpersonal Therapy for Depressed Adolescents & Parents	Phase 1

Detailed Description

Adolescent depression is a significant public health problem, and it increases the risk of poor psychosocial outcomes in adolescence and adulthood. Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) has been found to be an effective treatment for reducing adolescents' depressive symptoms and improving their global and social functioning. The purpose of the current study is to examine the feasibility and acceptability of IPT-A when it is delivered with greater and more structured involvement of the parents in the treatment.

Participants will receive 15 weeks of Interpersonal Psychotherapy for Depressed Adolescents and Parents (IPT-AP). Eight the therapy sessions are conducted with the adolescent individually, two are with the parent(s) individually, and five are conducted with the adolescent and parent(s) together. At the end of the 15 weeks, participants who have demonstrated at least a 50% reduction in depressive symptoms will participate in three booster sessions delivered on a monthly basis. All participants will be assessed at baseline, week 5, week 10, week 15 (post-treatment), and 3 months post-treatment to measure depressive symptoms, global and social functioning, and attitudes toward treatment.

Study Design

Study Type:

Interventional

Actual Enrollment :

10 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

An Open Clinical Trial of Interpersonal Psychotherapy for Depressed Adolescence and Parents

Study Start Date :

Nov 1, 2007

Actual Primary Completion Date :

May 1, 2009

Actual Study Completion Date :

May 1, 2009

Arms and Interventions

Arm	Intervention/Treatment
Experimental: I	Behavioral: Interpersonal Therapy for Depressed Adolescents & Parents 15 weekly psychotherapy sessions

Arm

Intervention/Treatment

Experimental: I

Behavioral: Interpersonal Therapy for Depressed Adolescents & Parents

15 weekly psychotherapy sessions

Outcome Measures

Primary Outcome Measures

Clinical Global Improvement (CGI), Hamilton Rating Scale for Depression (HRSD), Center for Epidemiological Studies - Depression Scale (CES-D) [baseline, week 5, 10, 15]

Secondary Outcome Measures

Global Assessment Scale for Children (C-GAS), Social Adjustment Scale - Self-report (SAS-SR), Conflict Behavior Questionnaire (CBQ-20), Observational assessment of parent-adolescent communication [baseline, week 5, 10, 15]

Eligibility Criteria

Criteria

Ages Eligible for Study:

12 Years to 18 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Meets diagnostic criteria for major depression, dysthymic disorder, depressive disorder not otherwise specified, or adjustment disorder with depressed mood
Score between 10 and 28 on the HRSD
Score of 65 or less on the C-GAS
English-speaking adolescent
Parental or legal guardian consent to participate

Exclusion Criteria:

Actively suicidal
Score greater than 28 on the HRSD
Mentally retarded
Meets diagnostic criteria for current substance abuse, schizophrenia, bipolar disorder, psychosis, conduct disorder, or eating disorder
Currently in active treatment for depression
Taking antidepressant medication at the time of baseline assessment
Medical illness likely to complicate or interfere with treatment
Victim of ongoing or previously undisclosed child abuse
Parent psychiatrically hospitalized within the past 3 months